Q90837

SS
Gene name
ERG
Protein name
Transcriptional regulator Erg
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:374146
EC number
Protein Class

Descriptions

The Ets-Related Gene (ERG) belongs to the Ets family of transcription factors and is critically important for maintenance of the hematopoietic stem cell population. In the presence of the NID (N-terminal inhibitory domain) and CID (C-terminal inhibitory domain), ERG is autoinhibited.

Autoinhibitory domains (AIDs)

271-288 (N-terminal inhibitory domain, NID) SS

Target domain

288-377 (Ets domain)

Relief mechanism

Ligand binding, Others

Assay

377-387 (C-terminal inhibitory domain, CID) SS

Target domain

288-377 (Ets domain)

Relief mechanism

Ligand binding, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q90837

Entry ID Method Resolution Chain Position Source
AF-Q90837-F1 Predicted AlphaFoldDB

6 variants for Q90837

Variant ID(s) Position Change Description Diseaes Association Provenance
rs733763266 121 N>K No Ensembl
rs737339374 144 E>G No Ensembl
rs735313551 145 W>G No Ensembl
rs739976690 155 V>G No Ensembl
rs740353782 398 L>P No Ensembl
rs732134320 440 T>P No Ensembl

No associated diseases with Q90837

3 regional properties for Q90837

Type Name Position InterPro Accession
domain Ets domain 309 - 394 IPR000418
domain Sterile alpha motif domain 134 - 179 IPR001660
domain Pointed domain 113 - 199 IPR003118

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name Definition
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

33 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1A4L6 ETS2 Protein C-ets-2 Bos taurus (Bovine) SS
Q2KIC2 ETV1 ETS translocation variant 1 Bos taurus (Bovine) SS
P10157 ETS2 Protein C-ets-2 Gallus gallus (Chicken) SS
P15062 ETS1 Transforming protein p68/c-ets-1 Gallus gallus (Chicken) SS
A2T762 ETV3 ETS translocation variant 3 Pan troglodytes (Chimpanzee) PR
Q04688 Ets97D DNA-binding protein Ets97D Drosophila melanogaster (Fruit fly) PR
P50548 ERF ETS domain-containing transcription factor ERF Homo sapiens (Human) PR
P41970 ELK3 ETS domain-containing protein Elk-3 Homo sapiens (Human) SS
P41161 ETV5 ETS translocation variant 5 Homo sapiens (Human) SS
P43268 ETV4 ETS translocation variant 4 Homo sapiens (Human) EV
P28324 ELK4 ETS domain-containing protein Elk-4 Homo sapiens (Human) EV
P15036 ETS2 Protein C-ets-2 Homo sapiens (Human) EV
P41162 ETV3 ETS translocation variant 3 Homo sapiens (Human) PR
P14921 ETS1 Protein C-ets-1 Homo sapiens (Human) EV
P50549 ETV1 ETS translocation variant 1 Homo sapiens (Human) EV
P19419 ELK1 ETS domain-containing protein Elk-1 Homo sapiens (Human) EV
Q06546 GABPA GA-binding protein alpha chain Homo sapiens (Human) SS
P11308 ERG Transcriptional regulator ERG Homo sapiens (Human) EV
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
P15037 Ets2 Protein C-ets-2 Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
P81270 Erg Transcriptional regulator ERG Mus musculus (Mouse) SS
P41156 Ets1 Protein C-ets-1 Rattus norvegicus (Rat) SS
A4GTP4 Elk1 ETS domain-containing protein Elk-1 Rattus norvegicus (Rat) PR
Q9PUQ1 etv4 ETS translocation variant 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
A3FEM2 fev Protein FEV Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MASTIKEALS VVSEDQSLFE CAYGSPHLAK TEMTASSSSE YGQTSKMSPR VPQQDWLSQP
70 80 90 100 110 120
PARVTIKMEC NPNQVNGSRN SPDDCSVAKG GKMVSSSDNV GMNYGSYMEE KHIPPPNMTT
130 140 150 160 170 180
NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVDILLF QNIDGKELCK MTKDDFQRLT
190 200 210 220 230 240
PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTGGATFI FPNTSVYPEA
250 260 270 280 290 300
TQRITTRPDL PYEQARRSAW TSHSHPTQSK ATQPSSSTVP KTEDQRPQLD PYQILGPTSS
310 320 330 340 350 360
RLANPGSGQI QLWQFLLELL SDSSNSNCIT WEGTNGEFKM TDPDEVARRW GERKSKPNMN
370 380 390 400 410 420
YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP HPPESSMYKY PSDLPYMSSY
430 440 450 460 470
HAHPQKMNFV APHPPALPVT SSSFFAAPNP YWNSPTGGIY PNTRLPAAHM PSHLGTYY