Q90660
Gene name |
ITA (IAP1) |
Protein name |
Inhibitor of apoptosis protein |
Names |
IAP , Inhibitor of T-cell apoptosis protein |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:374012 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
564-609 (RING domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
564-609 (RING domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q90660
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q90660-F1 | Predicted | AlphaFoldDB |
No variants for Q90660
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q90660 | |||||
No associated diseases with Q90660
7 regional properties for Q90660
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CARD domain | 446 - 536 | IPR001315 |
| repeat | BIR repeat | 28 - 99 | IPR001370-1 |
| repeat | BIR repeat | 174 - 244 | IPR001370-2 |
| repeat | BIR repeat | 260 - 331 | IPR001370-3 |
| domain | Zinc finger, RING-type | 564 - 599 | IPR001841 |
| domain | BIRC2/BIRC3, UBA domain | 384 - 430 | IPR041933 |
| domain | BIRC2/3-like, UBA domain | 381 - 433 | IPR048875 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. |
| metal ion binding | Binding to a metal ion. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of necroptotic process | Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. |
| positive regulation of protein ubiquitination | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A1E2V0 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q96P09 | BIRC8 | Baculoviral IAP repeat-containing protein 8 | Homo sapiens (Human) | PR |
| Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Homo sapiens (Human) | SS |
| Q13490 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | Homo sapiens (Human) | EV |
| O08863 | Birc3 | Baculoviral IAP repeat-containing protein 3 | Mus musculus (Mouse) | SS |
| Q62210 | Birc2 | Baculoviral IAP repeat-containing protein 2 | Mus musculus (Mouse) | SS |
| O62640 | PIAP | Putative inhibitor of apoptosis | Sus scrofa (Pig) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNIMDSSPLL | ASVMKQNAHC | GELKYDFSCE | LYRMSTFSTF | PVNVPVSERR | LARAGFYYTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VQDKVKCFSC | GLVLDNWQPG | DNAMEKHKQV | YPSCSFVQNM | LSLNNLGLST | HSAFSPLVAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLSPSLRSMT | LSPSFEQVGY | FSGSFSSFPR | DPVTTRAAED | LSHLRSKLQN | PSMSTEEARL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RTSHAWPLMC | LWPAEVAKAG | LDDLGTADKV | ACVNCGVKLS | NWEPKDNAMS | EHRRHFPNCP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FVENLMRDQP | SFNVSNVTMQ | THEARVKTFI | NWPTRIPVQP | EQLADAGFYY | VGRNDDVKCF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CCDGGLRCWE | SGDDPWIEHA | KWFPRCEYLL | RVKGGEFVSQ | VQARFPHLLW | NSSCTTSDKP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VDENMDPIIH | FEPGESPSED | AIMMNTPVVK | AALEMGFSRR | LIKQTVQSKI | LATEENYKTV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NDLVSELLTA | EDEKREEEKE | RQFEEVASDD | LSLIRKNRMA | LFQRLTSVLP | ILGSLLSAKV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ITELEHDVIK | QTTQTPSQAR | ELIDTVLVKG | NAAASIFRNC | LKDFDPVLYK | DLFVEKSMKY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VPTEDVSGLP | MEEQLRRLQE | ERTCKVCMDK | EVSIVFIPCG | HLVVCKECAP | SLRKCPICRG |
| 610 | |||||
| TIKGTVRTFL | S |