Q90643

SS
Gene name
IRF3
Protein name
Interferon regulatory factor 3
Names
IRF-3
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396330
EC number
Protein Class

Descriptions

IRF7 is the master regulator of type I interferon-dependent immune responses controlling both innate and adaptive immunity. Deletion of the autoinhibitory region makes IRF-7 constitutively super-active. The autoinhibitory region contains α-helices H3 and H4, and two β-sheets (S10 and S11) between the helices, which mediate intramolecular interactions that keep the protein in an inactive form. The autoinhibitory region interacts with N-terminal DNA-binding domain and C-terminal signal response domain.

Autoinhibitory domains (AIDs)

302-457 (Autoinhibitory region) SS

Target domain

2-138 (N-terminal DNA-binding domain);459-491 (Signal response domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q90643

Entry ID Method Resolution Chain Position Source
AF-Q90643-F1 Predicted AlphaFoldDB

No variants for Q90643

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90643

No associated diseases with Q90643

7 regional properties for Q90643

Type Name Position InterPro Accession
domain Protein kinase domain 652 - 908 IPR000719
active_site Serine/threonine-protein kinase, active site 769 - 781 IPR008271
binding_site Protein kinase, ATP binding site 658 - 681 IPR017441
domain MAP3K, TRAFs-binding domain 136 - 514 IPR025136
domain MAP3K, PH domain 527 - 624 IPR043969
domain MAP3K, deoxyribohydrolase domain 86 - 121 IPR046872
domain MAP3K, HisK-N-like globin domain 1003 - 1134 IPR046873

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect
  • When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

7 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
TRIF-dependent toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90871 IRF8 Interferon regulatory factor 8 Gallus gallus (Chicken) PR
Q98925 IRF2 Interferon regulatory factor 2 Gallus gallus (Chicken) PR
Q92985 IRF7 Interferon regulatory factor 7 Homo sapiens (Human) EV
P70434 Irf7 Interferon regulatory factor 7 Mus musculus (Mouse) SS
10 20 30 40 50 60
MAALDSEGDA QKLRFGPWLL NAVSSGLYRG LCWIDPDRRI FRIPWKHNAR KDVTSSDVEI
70 80 90 100 110 120
FKAWAKASGR YEGNAEDPAK WKTNFRCALR STHMFMLLED RSKCNDDPHK VYAVASGVPN
130 140 150 160 170 180
DRGSGGPVAG ALQQQPQLLL NHHDLALENT PTDSTEGVAA AALTQVDLDL LQSVLQHCNI
190 200 210 220 230 240
SALGSQPTLW AHTGDALPED ALLLPGQDGC LPGPQFQDWR QLEEPLLLGN QPLTGGGCGQ
250 260 270 280 290 300
DGAGALPVSE ECAIPAPSPA EELLFQSANP APPPPAGDIG GLPPLLDITI YYRGKMVYQE
310 320 330 340 350 360
QVDDSRCVLA YQPLDPAVAE QRLVLFPSPA SLPDPRQRRY TEDLLEVAGL RLEQRAGQLL
370 380 390 400 410 420
ATRLKKCKVF WALSQQLEGG EPPLNLLHRD QETTIFDFRV FCTELRDFRD SRRERSPDFT
430 440 450 460 470 480
IFLCFGQCFS STKPKESKLI LVKLVPQFCE YWYEQVQRGG ASSLNSGNVS LQLSDSFNLF
490
ELIEQYHMQT D