Q8WXH6
PR
Gene name |
RAB40A |
Protein name |
Ras-related protein Rab-40A |
Names |
SOCS box-containing protein RAR2A, Protein Rar-2 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:142684 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8WXH6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8WXH6-F1 | Predicted | AlphaFoldDB |
184 variants for Q8WXH6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA10478125 rs747768091 |
3 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs151089214 CA10478123 |
4 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs774176105 CA10478124 |
4 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 5 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414094971 rs1255461928 |
6 | S>T | No |
ClinGen gnomAD |
|
|
CA10478121 rs781486877 |
8 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1228326169 CA414094936 |
11 | Y>C | No |
ClinGen gnomAD |
|
|
rs1456977807 CA414094922 |
13 | F>V | No |
ClinGen TOPMed |
|
|
CA10478118 rs747531234 |
15 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA414094877 rs1569373337 |
20 | V>A | No |
ClinGen Ensembl |
|
|
CA10478113 rs754699682 |
20 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478111 rs766145292 |
21 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478108 rs767094102 CA10478109 |
23 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 24 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 25 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1316652276 CA10478105 |
28 | S>G | No |
ClinGen TOPMed |
|
|
CA10478103 rs768429730 |
29 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA414094803 rs1205043704 |
32 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA414094802 rs1205043704 |
32 | E>Q | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 33 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1245934265 CA414094762 |
37 | G>D | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 37 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414094759 rs1476823292 |
38 | A>T | No |
ClinGen TOPMed |
|
|
CA10478096 rs778284959 |
41 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA10478095 rs61739206 |
42 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs61739206 CA414094731 |
42 | P>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA414094734 rs1392747845 |
42 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1180895 VAR_034435 CA10478091 |
45 | H>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA414094710 rs1180895 |
45 | H>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs755888694 CA10478088 |
47 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755888694 CA414094697 |
47 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA414094700 rs1445381780 |
47 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA414094698 rs1445381780 |
47 | G>W | No |
ClinGen TOPMed gnomAD |
|
|
CA10478087 rs750324217 |
48 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA10478086 rs767572744 |
48 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA10478082 rs763759164 |
53 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA10478081 rs762648669 |
55 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA333980494 rs966409211 |
62 | R>L | No |
ClinGen TOPMed |
|
|
rs1424332308 CA414094587 |
64 | K>N | No |
ClinGen TOPMed |
|
|
CA414094572 rs1324052062 |
67 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
CA414094558 rs1569373180 |
68 | W>C | No |
ClinGen Ensembl |
|
|
rs1386208647 CA414094555 |
69 | D>H | No |
ClinGen gnomAD |
|
|
CA10478079 rs150769035 |
70 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA414094533 rs1431826458 |
72 | G>E | No |
ClinGen gnomAD |
|
|
CA414094514 rs1466328604 |
75 | R>K | No |
ClinGen TOPMed |
|
|
rs1429209528 CA414094484 |
79 | I>T | No |
ClinGen gnomAD |
|
|
CA10478076 rs773653058 |
79 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA10478075 rs141221975 |
81 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed |
|
rs1603127895 CA414094459 |
83 | Y>C | No |
ClinGen Ensembl |
|
|
rs1399480392 CA414094447 |
85 | R>C | No |
ClinGen TOPMed |
|
|
rs1250115184 CA414094445 |
85 | R>P | No |
ClinGen gnomAD |
|
|
CA10478071 rs749481852 |
86 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373230359 CA10478073 |
86 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10478072 rs749481852 |
86 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780159934 CA10478070 |
91 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA414094406 rs1313185619 |
92 | L>V | No |
ClinGen TOPMed |
|
|
CA414094388 rs1271781241 |
95 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs757251431 CA10478066 |
97 | A>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 97 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1346504989 CA414094366 |
98 | N>H | No |
ClinGen gnomAD |
|
|
CA10478065 COSM1112267 rs751600194 |
99 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA414094358 COSM1222946 rs763629323 |
99 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs763629323 CA10478064 |
99 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA414094360 rs751600194 |
99 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA414094352 rs1189436213 |
100 | W>S | No |
ClinGen TOPMed |
|
|
CA10478063 rs762402139 |
103 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478062 rs752347051 |
104 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1200843598 CA414094310 |
106 | D>N | No |
ClinGen gnomAD |
|
|
rs764812559 CA10478061 COSM456386 |
107 | R>* | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed |
|
rs1369728730 CA414094299 |
108 | W>R | No |
ClinGen gnomAD |
|
|
CA10478060 rs759299291 |
111 | K>N | No |
ClinGen ExAC |
|
|
rs773550779 CA10478059 |
112 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1569373097 CA414094269 |
112 | I>V | No |
ClinGen Ensembl |
|
|
CA10478058 rs767918054 |
114 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478057 rs762276906 |
116 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs774866227 CA10478056 |
119 | V>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 120 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1480170686 CA414094212 |
121 | K>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA414094188 rs1427761871 |
124 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA10478055 rs371275239 |
127 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs761009017 CA10478054 |
129 | H>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 130 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10478053 rs775713127 |
136 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs746153555 CA414094104 |
137 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478051 rs746153555 |
137 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478050 rs781115320 |
139 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs746904012 CA10478048 |
140 | Q>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 141 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777595191 CA10478047 |
142 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764858205 CA414094055 |
145 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764858205 CA10478045 |
145 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764858205 CA10478044 |
145 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs899227657 CA333980492 |
146 | E>K | No |
ClinGen TOPMed |
|
|
CA10478041 rs767829004 |
147 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478042 rs767829004 |
147 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs376866345 CA10478040 |
147 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs774780041 COSM1555927 CA10478039 |
149 | G>D | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs763586428 CA10478037 |
152 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA10478036 rs775421781 |
155 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1264801865 CA414093970 |
159 | C>S | No |
ClinGen TOPMed |
|
|
CA414093962 rs1473994815 |
160 | N>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA10478035 rs769970085 |
161 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA10478034 rs139017752 |
162 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1398173695 CA414093941 COSM754858 |
163 | I>V | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA10478033 rs777025945 |
164 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10478031 rs373670392 |
165 | E>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 166 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs746814533 CA10478030 |
167 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1229771733 CA414093915 |
167 | F>V | No |
ClinGen TOPMed gnomAD |
|
|
rs777702038 CA10478029 |
168 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778254688 CA10478026 |
177 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 178 | H>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414092957 rs1345071785 |
179 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA414092945 rs1157580185 |
179 | R>T | No |
ClinGen gnomAD |
|
|
CA10478024 CA10478023 rs774456340 |
180 | M>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200052902 CA333980491 |
181 | N>Y | No |
ClinGen 1000Genomes |
|
|
CA414092855 rs1182591922 |
182 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
CA414092849 rs1182591922 CA414092852 |
182 | W>C | No |
ClinGen TOPMed gnomAD |
|
|
rs866456214 CA333980490 |
183 | L>F | No |
ClinGen Ensembl |
|
|
rs751863768 CA10478021 |
183 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs1188683667 CA414092836 |
184 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA414092807 rs1430458386 |
185 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1166826409 CA414092784 |
186 | P>L | No |
ClinGen gnomAD |
|
|
CA333980489 rs866129912 |
186 | P>S | No |
ClinGen gnomAD |
|
|
CA414092706 rs1240228395 |
191 | S>G | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 194 | D>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1187911246 COSM1464547 CA414092621 |
195 | L>I | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA10478019 rs369502037 |
198 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
| TCGA novel | 198 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1290842331 CA414092567 |
198 | R>L | No |
ClinGen gnomAD |
|
|
CA414092563 rs1245494208 |
199 | T>N | No |
ClinGen gnomAD |
|
|
rs1357612739 CA414092559 |
200 | I>L | No |
ClinGen gnomAD |
|
|
CA333980487 rs200705021 |
202 | S>C | No |
ClinGen Ensembl |
|
|
rs1457170112 CA10478017 |
203 | C>Y | No |
ClinGen TOPMed |
|
|
rs1382796878 CA414092509 |
204 | T>A | No |
ClinGen gnomAD |
|
| TCGA novel | 204 | T>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414092497 rs1361369886 |
205 | P>T | No |
ClinGen gnomAD |
|
|
rs753291130 CA10478015 |
206 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs765372204 CA10478014 |
208 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1170727541 CA414092395 |
215 | P>S | No |
ClinGen gnomAD |
|
|
rs200647197 CA333980485 |
216 | S>I | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA333980484 rs201466501 |
217 | T>A | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs761047526 CA10478011 |
218 | L>* | No |
ClinGen ExAC gnomAD |
|
|
rs761047526 CA10478010 |
218 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA10478009 rs139389579 |
220 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1169195385 CA414092342 |
223 | K>R | No |
ClinGen TOPMed |
|
|
rs61735524 CA10478008 |
224 | S>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA414092338 rs1423465648 |
224 | S>T | No |
ClinGen TOPMed |
|
|
rs1445321985 CA414092318 |
227 | M>V | No |
ClinGen TOPMed |
|
|
rs150450642 CA333980483 |
229 | K>E | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA10478005 rs778931704 |
233 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA414092270 rs1306984673 |
234 | R>T | No |
ClinGen gnomAD |
|
|
rs1355573610 CA414092263 |
235 | M>K | No |
ClinGen TOPMed |
|
| TCGA novel | 236 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs182368469 CA10478004 COSM3390349 |
237 | R>* | pancreas [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA414092246 rs1221413109 COSM1112264 |
237 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA333980482 rs914972603 |
238 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA414092240 rs914972603 |
238 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA10478003 rs748797927 |
239 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 241 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414092202 rs1372804171 |
245 | T>A | No |
ClinGen gnomAD |
|
|
CA10478002 rs199669744 |
245 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs755752786 CA10478001 |
246 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10477999 rs777972100 |
249 | H>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1177657701 CA414092172 |
249 | H>Q | No |
ClinGen gnomAD |
|
|
CA414092167 rs1480497772 |
250 | K>R | No |
ClinGen gnomAD |
|
| TCGA novel | 252 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414092147 rs1197202899 |
253 | L>I | No |
ClinGen gnomAD |
|
|
rs1603127288 CA414092140 |
254 | C>R | No |
ClinGen Ensembl |
|
|
CA414092138 rs1263187895 |
254 | C>Y | No |
ClinGen TOPMed |
|
|
CA10477993 rs765895461 |
255 | K>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA414092118 rs1423462888 |
257 | E>A | No |
ClinGen TOPMed |
|
|
rs140511113 CA10477992 |
257 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1410927619 CA414092106 |
259 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA10477991 rs753964301 |
261 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA414092091 rs753964301 |
261 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs969310648 CA333980480 |
263 | Q>K | No |
ClinGen Ensembl |
|
|
rs1249656909 CA414092073 |
264 | S>G | No |
ClinGen gnomAD |
|
|
CA414092068 rs1603127205 |
264 | S>R | No |
ClinGen Ensembl |
|
|
CA414092070 rs1375613587 |
264 | S>T | No |
ClinGen TOPMed |
|
|
rs758294266 CA10477990 |
266 | P>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs758294266 CA333980479 |
266 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA414092029 rs1339817420 |
270 | T>N | No |
ClinGen TOPMed |
|
|
rs1283130941 CA414092021 |
271 | R>S | No |
ClinGen TOPMed gnomAD |
No associated diseases with Q8WXH6
6 regional properties for Q8WXH6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FKBP-type peptidyl-prolyl cis-trans isomerase domain | 46 - 147 | IPR001179-1 |
| domain | FKBP-type peptidyl-prolyl cis-trans isomerase domain | 175 - 256 | IPR001179-2 |
| domain | FKBP-type peptidyl-prolyl cis-trans isomerase domain | 291 - 383 | IPR001179-3 |
| repeat | Tetratricopeptide repeat | 400 - 433 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 449 - 482 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 483 - 516 | IPR019734-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07560 | SEC4 | Ras-related protein SEC4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2HJI8 | RAB8B | Ras-related protein Rab-8B | Bos taurus (Bovine) | PR |
| A4FV54 | RAB8A | Ras-related protein Rab-8A | Bos taurus (Bovine) | PR |
| Q1RMR4 | RAB15 | Ras-related protein Rab-15 | Bos taurus (Bovine) | PR |
| Q5F470 | RAB8A | Ras-related protein Rab-8A | Gallus gallus (Chicken) | PR |
| P0C0E4 | RAB40AL | Ras-related protein Rab-40A-like | Homo sapiens (Human) | PR |
| Q12829 | RAB40B | Ras-related protein Rab-40B | Homo sapiens (Human) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| Q92930 | RAB8B | Ras-related protein Rab-8B | Homo sapiens (Human) | PR |
| Q96S21 | RAB40C | Ras-related protein Rab-40C | Homo sapiens (Human) | PR |
| P61006 | RAB8A | Ras-related protein Rab-8A | Homo sapiens (Human) | PR |
| P59190 | RAB15 | Ras-related protein Rab-15 | Homo sapiens (Human) | PR |
| P55258 | Rab8a | Ras-related protein Rab-8A | Mus musculus (Mouse) | PR |
| Q8K386 | Rab15 | Ras-related protein Rab-15 | Mus musculus (Mouse) | PR |
| P61028 | Rab8b | Ras-related protein Rab-8B | Mus musculus (Mouse) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| Q9DD03 | Rab13 | Ras-related protein Rab-13 | Mus musculus (Mouse) | PR |
| Q8CB87 | Rab44 | Ras-related protein Rab-44 | Mus musculus (Mouse) | PR |
| Q8VHQ4 | Rab40c | Ras-related protein Rab-40C | Mus musculus (Mouse) | PR |
| Q8VHP8 | Rab40b | Ras-related protein Rab-40B | Mus musculus (Mouse) | PR |
| P35289 | Rab15 | Ras-related protein Rab-15 | Rattus norvegicus (Rat) | PR |
| P35280 | Rab8a | Ras-related protein Rab-8A | Rattus norvegicus (Rat) | PR |
| P70550 | Rab8b | Ras-related protein Rab-8B | Rattus norvegicus (Rat) | PR |
| P35284 | Rab12 | Ras-related protein Rab-12 | Rattus norvegicus (Rat) | PR |
| P35281 | Rab10 | Ras-related protein Rab-10 | Rattus norvegicus (Rat) | PR |
| O24466 | RABE1A | Ras-related protein RABE1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SF91 | RABE1E | Ras-related protein RABE1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZD4 | RABE1D | Ras-related protein RABE1d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAPGSPDQA | YDFLLKFLLV | GDRDVGKSEI | LESLQDGAAE | SPYSHLGGID | YKTTTILLDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QRVKLKLWDT | SGQGRFCTIF | RSYSRGAQGV | ILVYDIANRW | SFEGMDRWIK | KIEEHAPGVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KILVGNRLHL | AFKRQVPREQ | AQAYAERLGV | TFFEVSPLCN | FNIIESFTEL | ARIVLLRHRM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NWLGRPSKVL | SLQDLCCRTI | VSCTPVHLVD | KLPLPSTLRS | HLKSFSMAKG | LNARMMRGLS |
| 250 | 260 | 270 | |||
| YSLTTSSTHK | SSLCKVEIVC | PPQSPPKNCT | RNSCKIS |