Q8WUD1
PR
Gene name |
RAB2B |
Protein name |
Ras-related protein Rab-2B |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:84932 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8WUD1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2A5J | X-ray | 150 A | A | 5-176 | PDB |
| AF-Q8WUD1-F1 | Predicted | AlphaFoldDB |
142 variants for Q8WUD1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA7092385 rs765728809 |
2 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1330690176 CA388882153 |
2 | T>P | No |
ClinGen gnomAD |
|
|
rs1330580863 CA388882126 |
4 | A>P | No |
ClinGen gnomAD |
|
|
rs1464046990 CA388882099 |
6 | L>F | No |
ClinGen gnomAD |
|
|
CA388882085 rs1421352657 |
7 | F>V | No |
ClinGen gnomAD |
|
|
rs1307375624 CA388882074 |
8 | K>E | No |
ClinGen TOPMed |
|
|
CA7092381 rs768849741 |
10 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA388882043 rs1477588576 |
10 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA257546771 rs113296213 |
11 | I>T | No |
ClinGen Ensembl |
|
|
rs1195115863 CA388882025 |
13 | G>R | No |
ClinGen gnomAD |
|
|
CA7092380 rs760404768 |
15 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7092302 rs780406861 |
17 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA388881661 rs1296961036 |
18 | G>E | No |
ClinGen gnomAD |
|
|
CA388881630 rs1463845867 |
20 | S>L | No |
ClinGen TOPMed gnomAD |
|
| rs775664875 | 24 | L>missing | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7092294 rs147475046 |
27 | T>A | No |
ClinGen ESP ExAC TOPMed |
|
|
CA7092293 rs775289828 |
29 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA388881478 rs1480830390 |
31 | F>S | No |
ClinGen gnomAD |
|
|
CA388881446 rs1349539260 |
33 | P>L | No |
ClinGen gnomAD |
|
|
rs1208240033 CA388881450 |
33 | P>S | No |
ClinGen gnomAD |
|
|
rs1280613418 CA388881435 |
34 | V>G | No |
ClinGen gnomAD |
|
|
CA388881387 rs1336665944 |
39 | I>M | No |
ClinGen TOPMed |
|
|
CA7092289 rs773462475 |
40 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA388881386 rs773462475 |
40 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs777309126 CA7092259 |
46 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA388881190 rs755599325 |
46 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA7092258 rs755599325 |
46 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs752634744 CA7092257 |
49 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA7092256 rs767487211 |
49 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA257545946 rs767487211 |
49 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1227197236 CA388881143 |
50 | I>F | No |
ClinGen gnomAD |
|
|
rs191779399 CA7092255 |
50 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1320537592 CA388881129 |
51 | D>V | No |
ClinGen gnomAD |
|
|
CA7092254 rs751381913 |
54 | Q>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 55 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA388881064 rs1393908808 |
55 | I>S | No |
ClinGen TOPMed gnomAD |
|
|
CA388881065 rs1393908808 |
55 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1192900661 CA388881055 |
56 | K>I | No |
ClinGen TOPMed |
|
|
rs762157385 CA7092252 |
61 | D>Y | No |
ClinGen ExAC gnomAD |
|
| rs1167052495 | 62 | T>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7092251 rs201151955 |
62 | T>M | No |
ClinGen ESP ExAC gnomAD |
|
|
rs777391109 CA7092241 |
63 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs988420555 CA257594461 |
66 | E>Q | No |
ClinGen Ensembl |
|
|
CA7092240 rs769361668 |
69 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA7092239 rs747699476 |
69 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA388901797 rs769361668 |
69 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA7092238 rs780512676 |
71 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1436409908 CA388901754 |
73 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA7092236 rs751411253 |
73 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA257594442 rs113497139 |
74 | S>P | No |
ClinGen Ensembl |
|
|
rs780031316 CA7092235 |
74 | S>Y | No |
ClinGen ExAC |
|
|
rs1463034257 CA388901731 |
76 | Y>H | No |
ClinGen TOPMed |
|
|
CA7092234 rs758240846 |
77 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA257594424 rs867541394 |
83 | L>P | No |
ClinGen Ensembl |
|
|
rs1278875553 CA388901665 |
87 | D>N | No |
ClinGen gnomAD |
|
|
CA388901656 rs1337279030 |
88 | I>V | No |
ClinGen gnomAD |
|
|
CA7092230 rs201625432 |
89 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 90 | R>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767457195 CA7092229 |
90 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1373183820 CA388901643 |
90 | R>T | No |
ClinGen TOPMed gnomAD |
|
|
rs773591681 CA7092207 |
91 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA7092206 rs765476447 |
91 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA388901627 rs773591681 |
91 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA388901613 rs1311014006 |
93 | T>N | No |
ClinGen TOPMed |
|
| TCGA novel | 93 | T>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 94 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1319047963 CA388901607 |
94 | F>Y | No |
ClinGen TOPMed |
|
|
rs140603938 CA7092205 |
95 | N>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1448821715 CA388901587 |
96 | H>Y | No |
ClinGen gnomAD |
|
|
CA388901576 rs1232651415 |
97 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA388901520 rs1294857113 |
102 | E>Q | No |
ClinGen gnomAD |
|
|
rs1485327382 CA388901487 |
104 | A>D | No |
ClinGen gnomAD |
|
|
CA257594046 rs371422675 |
105 | R>Q | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs975474659 CA257594056 |
105 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA388901472 rs1485295292 |
106 | Q>R | No |
ClinGen TOPMed |
|
|
CA388901461 rs1432287514 |
107 | H>R | No |
ClinGen gnomAD |
|
|
rs1388809712 CA388901441 |
109 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
rs934459298 CA257594033 |
109 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1566470132 CA388901424 |
110 | S>C | No |
ClinGen Ensembl |
|
|
CA7092201 rs746513643 |
111 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA388901359 rs1392958858 |
116 | L>F | No |
ClinGen gnomAD |
|
|
rs1424773261 CA388901352 |
117 | I>L | No |
ClinGen gnomAD |
|
|
CA388901344 rs1418993007 |
117 | I>M | No |
ClinGen gnomAD |
|
|
CA7092198 rs745762640 |
121 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA388900547 rs1321464656 |
124 | E>A | No |
ClinGen TOPMed |
|
|
CA257590792 rs994332865 |
124 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs994332865 CA388900552 |
124 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs532949760 CA7092173 |
126 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM1707142 rs755217908 CA7092172 |
126 | R>H | skin [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs747194980 CA7092171 |
127 | R>G | No |
ClinGen ExAC |
|
|
CA7092170 rs570510184 |
128 | D>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA388900452 rs1349507307 |
130 | K>E | No |
ClinGen gnomAD |
|
|
CA257590727 rs957465099 |
135 | E>G | No |
ClinGen Ensembl |
|
|
CA7092165 rs757716327 |
136 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs370351229 CA7092166 |
136 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 136 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA257590709 rs1001717193 |
138 | A>V | No |
ClinGen Ensembl |
|
|
CA388900276 rs1173317346 |
139 | R>K | No |
ClinGen gnomAD |
|
|
rs754166518 CA7092164 |
141 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs906086442 CA257590662 |
143 | L>V | No |
ClinGen Ensembl |
|
| TCGA novel | 144 | I>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 144 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs376962028 CA388899573 |
144 | I>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376962028 CA7092162 |
144 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1184008823 CA388899530 |
146 | M>K | No |
ClinGen TOPMed gnomAD |
|
|
CA7092161 rs752376606 |
146 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA388899538 rs752376606 |
146 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA388899492 rs1413047156 |
148 | T>A | No |
ClinGen TOPMed |
|
|
CA7092160 rs767194602 |
155 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs1256366026 CA388899368 |
155 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA388899189 rs1332868702 |
159 | A>T | No |
ClinGen TOPMed |
|
|
rs373173462 CA7092145 |
164 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs778333223 CA7092144 |
167 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA7092143 rs756534731 |
168 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA257589431 rs916951265 |
170 | K>T | No |
ClinGen TOPMed |
|
|
CA7092140 rs759211157 |
174 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA388899003 rs376962626 |
175 | L>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376962626 CA7092139 |
175 | L>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA257589380 rs924330981 COSM1222917 |
177 | D>N | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs1255861420 CA388898982 |
177 | D>V | No |
ClinGen TOPMed |
|
|
rs76264149 CA257589371 |
178 | V>I | No |
ClinGen Ensembl |
|
|
CA388898650 rs1323883958 |
182 | A>E | No |
ClinGen gnomAD |
|
|
rs1406863303 CA388898592 |
186 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA388898564 rs1166924911 |
189 | P>S | No |
ClinGen gnomAD |
|
|
rs765853146 CA7092120 |
191 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA388898499 rs1252921233 |
194 | S>A | No |
ClinGen gnomAD |
|
|
CA7092119 rs757910545 |
195 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA7092118 rs750423406 |
196 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs1443538793 CA388898462 |
198 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1041182311 CA257588335 |
199 | P>T | No |
ClinGen TOPMed |
|
|
rs776432456 CA388898388 |
204 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7092115 rs776432456 |
204 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs761679847 CA7092116 |
204 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA388898379 rs1277037140 |
205 | N>I | No |
ClinGen TOPMed gnomAD |
|
|
CA7092112 rs140211092 |
207 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs140211092 CA7092114 |
207 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7092113 rs140211092 |
207 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA257588297 rs891284144 |
209 | I>V | No |
ClinGen gnomAD |
|
|
CA7092111 rs770985562 |
210 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749391593 CA7092110 |
211 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7092109 rs773369232 |
212 | N>H | No |
ClinGen ExAC gnomAD |
|
|
rs17106411 VAR_051709 CA7092108 |
212 | N>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
No associated diseases with Q8WUD1
1 regional properties for Q8WUD1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 7 - 160 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| acrosomal vesicle | A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| positive regulation of type I interferon production | Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6IMM1 | DNAJC27 | DnaJ homolog subfamily C member 27 | Gallus gallus (Chicken) | PR |
| Q90965 | RAB2A | Ras-related protein Rab-2A | Gallus gallus (Chicken) | PR |
| P61019 | RAB2A | Ras-related protein Rab-2A | Homo sapiens (Human) | PR |
| P20338 | RAB4A | Ras-related protein Rab-4A | Homo sapiens (Human) | PR |
| P61018 | RAB4B | Ras-related protein Rab-4B | Homo sapiens (Human) | PR |
| P62491 | RAB11A | Ras-related protein Rab-11A | Homo sapiens (Human) | PR |
| Q15907 | RAB11B | Ras-related protein Rab-11B | Homo sapiens (Human) | PR |
| Q8CFP6 | Dnajc27 | DnaJ homolog subfamily C member 27 | Mus musculus (Mouse) | PR |
| P53994 | Rab2a | Ras-related protein Rab-2A | Mus musculus (Mouse) | PR |
| Q6IML7 | Dnajc27 | DnaJ homolog subfamily C member 27 | Rattus norvegicus (Rat) | PR |
| P05712 | Rab2a | Ras-related protein Rab-2A | Rattus norvegicus (Rat) | PR |
| Q6IMK3 | dnajc27 | DnaJ homolog subfamily C member 27 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTYAYLFKYI | IIGDTGVGKS | CLLLQFTDKR | FQPVHDLTIG | VEFGARMVNI | DGKQIKLQIW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTAGQESFRS | ITRSYYRGAA | GALLVYDITR | RETFNHLTSW | LEDARQHSSS | NMVIMLIGNK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDLESRRDVK | REEGEAFARE | HGLIFMETSA | KTACNVEEAF | INTAKEIYRK | IQQGLFDVHN |
| 190 | 200 | 210 | |||
| EANGIKIGPQ | QSISTSVGPS | ASQRNSRDIG | SNSGCC |