Q8W4R3
PR
Gene name |
RH30 (At5g63120, MDC12.8) |
Protein name |
DEAD-box ATP-dependent RNA helicase 30 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G63120 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W4R3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W4R3-F1 | Predicted | AlphaFoldDB |
21 variants for Q8W4R3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07471507 | 2 | S>R | No | 1000Genomes | |
| ENSVATH07471506 | 4 | Y>C | No | 1000Genomes | |
| tmp_5_25322059_C_T | 5 | D>N | No | 1000Genomes | |
| ENSVATH12914991 | 9 | A>T | No | 1000Genomes | |
| tmp_5_25321895_G_A | 33 | A>V | No | 1000Genomes | |
| ENSVATH03468076 | 64 | S>T | No | 1000Genomes | |
| tmp_5_25321664_T_G | 110 | D>A | No | 1000Genomes | |
| tmp_5_25321616_T_C | 126 | E>G | No | 1000Genomes | |
| ENSVATH14646461 | 137 | Q>K | No | 1000Genomes | |
| tmp_5_25321560_C_T | 145 | A>T | No | 1000Genomes | |
| ENSVATH03468074 | 153 | I>T | No | 1000Genomes | |
| ENSVATH03468073 | 155 | V>F | No | 1000Genomes | |
| tmp_5_25321491_G_C | 168 | Q>E | No | 1000Genomes | |
| ENSVATH07471502 | 190 | P>S | No | 1000Genomes | |
| ENSVATH07471501 | 228 | S>C | No | 1000Genomes | |
| ENSVATH03468070 | 236 | D>N | No | 1000Genomes | |
| tmp_5_25321013_C_A | 268 | R>I | No | 1000Genomes | |
| ENSVATH12914985 | 311 | K>Q | No | 1000Genomes | |
| tmp_5_25320076_T_A | 428 | R>S | No | 1000Genomes | |
| ENSVATH14646456 | 507 | K>R | No | 1000Genomes | |
| ENSVATH00748940 | 516 | H>L | No | 1000Genomes |
No associated diseases with Q8W4R3
5 regional properties for Q8W4R3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 317 - 325 | IPR000629 |
| domain | Helicase, C-terminal | 395 - 544 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 189 - 360 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 184 - 387 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 165 - 193 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2NL08 | DDX55 | ATP-dependent RNA helicase DDX55 | Bos taurus (Bovine) | PR |
| Q0IIK5 | DDX1 | ATP-dependent RNA helicase DDX1 | Bos taurus (Bovine) | PR |
| Q8NHQ9 | DDX55 | ATP-dependent RNA helicase DDX55 | Homo sapiens (Human) | PR |
| P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | Homo sapiens (Human) | PR |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| Q5QMN3 | Os01g0197200 | DEAD-box ATP-dependent RNA helicase 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q0E2Z7 | Os02g0201900 | DEAD-box ATP-dependent RNA helicase 41 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N7W4 | Os01g0911100 | DEAD-box ATP-dependent RNA helicase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZG7 | RH38 | DEAD-box ATP-dependent RNA helicase 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZB4 | RH43 | Putative DEAD-box ATP-dependent RNA helicase 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU46 | RH35 | DEAD-box ATP-dependent RNA helicase 35 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ92 | RH44 | Putative DEAD-box ATP-dependent RNA helicase 44 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSYDRRFAD | PNSYRQRSGA | PVGSSQPMDP | SAAPYNPRYT | GGGGGYGPSP | VMAGDNSGYN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RYPSFQPPSG | GFSVGRGGGR | GGYGQYGDRN | GGGNWGGGGG | RGGSSKRELD | SVSLPKQNFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLVHFEKNFY | VESPTVQAMT | EQDVAMYRTE | RDISVEGRDV | PKPMKMFQDA | NFPDNILEAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKLGFTEPTP | IQAQGWPMAL | KGRDLIGIAE | TGSGKTLAYL | LPALVHVSAQ | PRLGQDDGPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLILAPTREL | AVQIQEESRK | FGLRSGVRST | CIYGGAPKGP | QIRDLRRGVE | IVIATPGRLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DMLECQHTNL | KRVTYLVLDE | ADRMLDMGFE | PQIRKIVSQI | RPDRQTLLWS | ATWPREVETL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARQFLRDPYK | AIIGSTDLKA | NQSINQVIEI | VPTPEKYNRL | LTLLKQLMDG | SKILIFVETK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RGCDQVTRQL | RMDGWPALAI | HGDKTQSERD | RVLAEFKSGR | SPIMTATDVA | ARGLDVKDIK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CVVNYDFPNT | LEDYIHRIGR | TGRAGAKGMA | FTFFTHDNAK | FARELVKILQ | EAGQVVPPTL |
| 550 | 560 | 570 | 580 | 590 | |
| SALVRSSGSG | YGGSGGGRNF | RPRGGGRGGG | FGDKRSRSTS | NFVPHGGKRT | W |