Q8W3K3

PR
Gene name
At1g58400 (F9K23.7, X7J.13)
Protein name
Putative disease resistance protein At1g58400
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G58400
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-179 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8W3K3

Entry ID Method Resolution Chain Position Source
AF-Q8W3K3-F1 Predicted AlphaFoldDB

220 variants for Q8W3K3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13632936 2 V>I No 1000Genomes
tmp_1_21699091_C_G 10 V>L No 1000Genomes
tmp_1_21699063_T_G 19 Q>P No 1000Genomes
ENSVATH01394866 29 D>E No 1000Genomes
tmp_1_21699034_C_A 29 D>Y No 1000Genomes
ENSVATH00104807 30 R>Q No 1000Genomes
tmp_1_21698989_A_C 44 F>V No 1000Genomes
ENSVATH01394864 49 E>D No 1000Genomes
ENSVATH04994593 49 E>K No 1000Genomes
ENSVATH04994592 52 K>E No 1000Genomes
ENSVATH01394862 53 N>H No 1000Genomes
ENSVATH01394861 59 R>Q No 1000Genomes
tmp_1_21698939_A_G,C 60 H>Q No 1000Genomes
tmp_1_21698938_A_C 61 C>G No 1000Genomes
tmp_1_21698921_T_G 66 K>N No 1000Genomes
ENSVATH01394859 66 K>Q No 1000Genomes
ENSVATH13632923 69 V>F No 1000Genomes
tmp_1_21698871_T_G 83 E>A No 1000Genomes
ENSVATH04994589 93 R>K No 1000Genomes
ENSVATH01394857 96 T>R No 1000Genomes
tmp_1_21698816_A_C 101 I>M No 1000Genomes
ENSVATH04994588 102 K>E No 1000Genomes
ENSVATH04994587 108 F>L No 1000Genomes
tmp_1_21698793_G_C 109 A>G No 1000Genomes
ENSVATH04994586 111 D>G No 1000Genomes
ENSVATH00104804 113 G>R No 1000Genomes
ENSVATH00104802 123 I>V No 1000Genomes
tmp_1_21698736_C_G 128 S>T No 1000Genomes
tmp_1_21698707_C_A 138 G>C No 1000Genomes
tmp_1_21698685_A_T 145 L>Q No 1000Genomes
ENSVATH01394852 151 E>A No 1000Genomes
ENSVATH04994581 155 T>A No 1000Genomes
ENSVATH04994580 155 T>K No 1000Genomes
ENSVATH04994578 157 S>A No 1000Genomes
tmp_1_21698649_G_C 157 S>C No 1000Genomes
ENSVATH04994577 162 S>R No 1000Genomes
ENSVATH04994576 163 D>G No 1000Genomes
ENSVATH07657698 163 D>N No 1000Genomes
ENSVATH01394848 168 E>D No 1000Genomes
ENSVATH01394847 169 V>A No 1000Genomes
tmp_1_21698608_C_T 171 V>I No 1000Genomes
ENSVATH04994574 181 E>G No 1000Genomes
tmp_1_21698578_C_T 181 E>K No 1000Genomes
ENSVATH01394845 182 D>E No 1000Genomes
ENSVATH01394844 183 D>E No 1000Genomes
ENSVATH01394842 189 V>I No 1000Genomes
tmp_1_21698499_T_C 207 H>R No 1000Genomes
ENSVATH01394836 208 E>D No 1000Genomes
ENSVATH04994572 213 Q>L No 1000Genomes
ENSVATH13632893 215 D>N No 1000Genomes
tmp_1_21698455_C_T 222 V>I No 1000Genomes
ENSVATH13632886 233 Q>E No 1000Genomes
ENSVATH01394833 234 M>K No 1000Genomes
ENSVATH14350832 239 L>I No 1000Genomes
ENSVATH07657691 242 R>K No 1000Genomes
ENSVATH01394831 244 T>K No 1000Genomes
ENSVATH01394830 246 D>G No 1000Genomes
ENSVATH04994568 254 A>P No 1000Genomes
ENSVATH04994567 255 E>Q No 1000Genomes
tmp_1_21698344_C_T 259 E>K No 1000Genomes
tmp_1_21698313_G_T 269 S>* No 1000Genomes
ENSVATH01394827 281 D>E No 1000Genomes
tmp_1_21698278_C_A 281 D>Y No 1000Genomes
ENSVATH01394826 286 N>K No 1000Genomes
ENSVATH04994565 293 K>N No 1000Genomes
tmp_1_21698143_C_T 302 R>Q No 1000Genomes
tmp_1_21698107_T_C,G 314 Y>C No 1000Genomes
tmp_1_21698107_T_C,G 314 Y>S No 1000Genomes
ENSVATH14350829 315 V>A No 1000Genomes
tmp_1_21698094_T_G 318 K>N No 1000Genomes
tmp_1_21698086_C_T 321 C>Y No 1000Genomes
tmp_1_21698074_A_T 325 L>Q No 1000Genomes
ENSVATH13632883 326 E>G No 1000Genomes
ENSVATH01394821 330 L>I No 1000Genomes
ENSVATH04994557 332 Q>E No 1000Genomes
ENSVATH04994556 334 I>T No 1000Genomes
tmp_1_21698041_A_G 336 M>T No 1000Genomes
tmp_1_21698039_G_A 337 P>S No 1000Genomes
ENSVATH04994555 338 R>G No 1000Genomes
tmp_1_21698021_C_G 343 E>Q No 1000Genomes
tmp_1_21697857_A_C 347 D>E No 1000Genomes
ENSVATH01394819 352 M>K No 1000Genomes
tmp_1_21697835_T_A 355 K>* No 1000Genomes
tmp_1_21697834_T_A 355 K>M No 1000Genomes
ENSVATH14350828 358 I>V No 1000Genomes
ENSVATH04994551 359 K>R No 1000Genomes
tmp_1_21697814_C_T 362 G>R No 1000Genomes
tmp_1_21697800_C_A 366 L>F No 1000Genomes
tmp_1_21697801_A_G 366 L>S No 1000Genomes
ENSVATH00104799 368 V>I No 1000Genomes
tmp_1_21697776_C_G 374 L>F No 1000Genomes
ENSVATH01394814 375 L>V No 1000Genomes
ENSVATH01394813 380 T>N No 1000Genomes
ENSVATH01394813 380 T>S No 1000Genomes
tmp_1_21697735_G_A 388 S>F No 1000Genomes
ENSVATH04994550 392 G>* No 1000Genomes
ENSVATH01394812 393 C>S No 1000Genomes
tmp_1_21697715_T_G 395 I>L No 1000Genomes
ENSVATH04994548 396 V>L No 1000Genomes
tmp_1_21697706_T_A 398 R>* No 1000Genomes
ENSVATH00104798 400 D>N No 1000Genomes
ENSVATH04994547 402 S>G No 1000Genomes
ENSVATH01394811 411 H>R No 1000Genomes
ENSVATH01394810 415 L>M No 1000Genomes
ENSVATH01394807 422 S>I No 1000Genomes
ENSVATH01394802 439 N>K No 1000Genomes
ENSVATH04994543 445 L>F No 1000Genomes
ENSVATH00104795 463 Q>E No 1000Genomes
ENSVATH01394800 471 S>N No 1000Genomes
ENSVATH04994542 477 V>L No 1000Genomes
ENSVATH04994540 484 A>P No 1000Genomes
ENSVATH01394799 486 R>S No 1000Genomes
ENSVATH13632838 488 V>I No 1000Genomes
ENSVATH04994539 489 T>M No 1000Genomes
ENSVATH04994538 491 L>S No 1000Genomes
tmp_1_21697420_A_G 493 F>S No 1000Genomes
ENSVATH01394798 495 A>T No 1000Genomes
ENSVATH04994537 498 L>M No 1000Genomes
tmp_1_21697405_A_G 498 L>S No 1000Genomes
ENSVATH04994536 515 F>V No 1000Genomes
ENSVATH00104793 522 L>F No 1000Genomes
tmp_1_21697322_C_T 526 A>T No 1000Genomes
ENSVATH13632836 542 P>S No 1000Genomes
ENSVATH04994534 543 T>S No 1000Genomes
ENSVATH04994533 544 T>I No 1000Genomes
tmp_1_21697265_A_C 545 L>V No 1000Genomes
tmp_1_21697242_A_C 552 N>K No 1000Genomes
ENSVATH04994529 554 P>S No 1000Genomes
ENSVATH13632835 563 W>R No 1000Genomes
ENSVATH13632824 565 N>D No 1000Genomes
ENSVATH01394795 566 R>K No 1000Genomes
ENSVATH13632823 569 S>I No 1000Genomes
ENSVATH01394794 576 S>N No 1000Genomes
tmp_1_21697162_C_T 579 R>K No 1000Genomes
ENSVATH04994528 592 K>R No 1000Genomes
ENSVATH04994527 597 N>K No 1000Genomes
ENSVATH04994526 598 L>F No 1000Genomes
ENSVATH14350825 602 I>F No 1000Genomes
ENSVATH01394791 604 K>N No 1000Genomes
ENSVATH01394789 612 N>S No 1000Genomes
ENSVATH01394788 614 D>E No 1000Genomes
tmp_1_21697053_C_A 615 L>F No 1000Genomes
ENSVATH01394787 615 L>M No 1000Genomes
tmp_1_21697051_G_C 616 A>G No 1000Genomes
ENSVATH13632819 617 R>C No 1000Genomes
tmp_1_21697027_G_A 624 S>F No 1000Genomes
ENSVATH04994525 626 G>R No 1000Genomes
ENSVATH04994524 631 L>M No 1000Genomes
ENSVATH01394786 635 D>N No 1000Genomes
ENSVATH13632818 636 I>T No 1000Genomes
ENSVATH00104790 639 C>F No 1000Genomes
tmp_1_21696975_T_G 641 K>N No 1000Genomes
tmp_1_21696959_T_A 647 N>Y No 1000Genomes
tmp_1_21696950_T_C 650 M>V No 1000Genomes
tmp_1_21696937_T_A 654 E>V No 1000Genomes
tmp_1_21696919_A_G 660 L>P No 1000Genomes
tmp_1_21696849_A_T 683 N>K No 1000Genomes
ENSVATH13632815 686 T>R No 1000Genomes
ENSVATH00104788 688 N>I No 1000Genomes
tmp_1_21696832_C_A 689 S>I No 1000Genomes
ENSVATH04994521 692 E>K No 1000Genomes
tmp_1_21696815_G_A 695 R>C No 1000Genomes
ENSVATH13632792 698 V>L No 1000Genomes
ENSVATH00104787 699 S>R No 1000Genomes
ENSVATH01394782 701 R>S No 1000Genomes
tmp_1_21696790_A_C 703 L>R No 1000Genomes
tmp_1_21696778_A_T 707 L>* No 1000Genomes
tmp_1_21696773_T_A 709 K>* No 1000Genomes
tmp_1_21696754_G_A 715 T>I No 1000Genomes
ENSVATH13632790 720 I>T No 1000Genomes
ENSVATH00104785 721 L>R No 1000Genomes
ENSVATH04994519 731 I>K No 1000Genomes
tmp_1_21696700_G_A 733 T>I No 1000Genomes
ENSVATH13632788 734 P>L No 1000Genomes
tmp_1_21696695_C_T 735 D>N No 1000Genomes
ENSVATH01394779 746 D>E No 1000Genomes
tmp_1_21696647_C_T 751 D>N No 1000Genomes
ENSVATH04994517 763 Y>S No 1000Genomes
ENSVATH00104783 770 E>Q No 1000Genomes
tmp_1_21696574_G_A 775 S>F No 1000Genomes
ENSVATH13632771 778 T>K No 1000Genomes
ENSVATH01394777 783 D>Y No 1000Genomes
tmp_1_21696517_A_C 794 I>S No 1000Genomes
ENSVATH13632770 804 V>I No 1000Genomes
ENSVATH00104781 810 A>S No 1000Genomes
ENSVATH01394776 813 G>R No 1000Genomes
ENSVATH01394775 814 K>E No 1000Genomes
ENSVATH01394773 818 S>C No 1000Genomes
ENSVATH13632768 823 F>V No 1000Genomes
ENSVATH13632766 827 H>P No 1000Genomes
ENSVATH00104780 828 R>K No 1000Genomes
ENSVATH14350802 828 R>S No 1000Genomes
ENSVATH01394770 832 W>* No 1000Genomes
ENSVATH01394769 832 W>C No 1000Genomes
ENSVATH01394771 832 W>G No 1000Genomes
ENSVATH09345324 833 G>R No 1000Genomes
ENSVATH01394768 835 A>D No 1000Genomes
ENSVATH13632765 835 A>T No 1000Genomes
ENSVATH01394766 845 G>S No 1000Genomes
ENSVATH13632761 849 R>C No 1000Genomes
ENSVATH07657663 849 R>L No 1000Genomes
ENSVATH01394762 854 T>A No 1000Genomes
ENSVATH01394761 854 T>N No 1000Genomes
ENSVATH04994514 856 W>C No 1000Genomes
ENSVATH04994513 857 N>D No 1000Genomes
ENSVATH04994510 861 L>* No 1000Genomes
ENSVATH04994509 862 K>N No 1000Genomes
ENSVATH13632760 865 P>H No 1000Genomes
tmp_1_21696302_C_T 866 D>N No 1000Genomes
ENSVATH01394758 871 I>N No 1000Genomes
ENSVATH04994508 879 M>I No 1000Genomes
ENSVATH00104779 886 I>R No 1000Genomes
ENSVATH01394757 888 S>L No 1000Genomes
ENSVATH14350801 895 Y>* No 1000Genomes
ENSVATH04994507 896 K>E No 1000Genomes
tmp_1_21696209_C_G 897 V>L No 1000Genomes
ENSVATH04994506 901 P>L No 1000Genomes
tmp_1_21696183_G_T 905 F>L No 1000Genomes
ENSVATH00104778 907 K>N No 1000Genomes
ENSVATH13632744 908 D>Y No 1000Genomes

No associated diseases with Q8W3K3

3 regional properties for Q8W3K3

Type Name Position InterPro Accession
domain NB-ARC 169 - 419 IPR002182
domain Virus X resistance protein-like, coiled-coil domain 3 - 123 IPR038005
domain Rx, N-terminal 5 - 88 IPR041118

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
response to other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MHT9 NLRC4 NLR family CARD domain-containing protein 4 Bos taurus (Bovine) SS
O14727 APAF1 Apoptotic protease-activating factor 1 Homo sapiens (Human) EV
Q9NPP4 NLRC4 NLR family CARD domain-containing protein 4 Homo sapiens (Human) SS
Q3UP24 Nlrc4 NLR family CARD domain-containing protein 4 Mus musculus (Mouse) EV
F1M649 Nlrc4 NLR family CARD domain-containing protein 4 Rattus norvegicus (Rat) SS
O22727 At1g61190 Probable disease resistance protein At1g61190 Arabidopsis thaliana (Mouse-ear cress) PR
O64790 At1g61300 Probable disease resistance protein At1g61300 Arabidopsis thaliana (Mouse-ear cress) PR
O64973 RPS5 Disease resistance protein RPS5 Arabidopsis thaliana (Mouse-ear cress) PR
P0C8S1 RPP8L2 Probable disease resistance RPP8-like protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
P60838 SUMM2 Disease resistance protein SUMM2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38834 RPP13L4 Disease resistance RPP13-like protein 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q39214 RPM1 Disease resistance protein RPM1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C646 RXW24L Probable disease resistance protein RXW24L Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJB5 RPP8L3 Disease resistance RPP8-like protein 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR4 RPPL1 Putative disease resistance RPP13-like protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9T048 At4g27190 Disease resistance protein At4g27190 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIF0 At1g59780 Putative disease resistance protein At1g59780 Arabidopsis thaliana (Mouse-ear cress) PR
O64789 At1g61310 Probable disease resistance protein At1g61310 Arabidopsis thaliana (Mouse-ear cress) PR
Q940K0 UNI Disease resistance protein UNI Arabidopsis thaliana (Mouse-ear cress) PR
Q9I9H8 apaf1 Apoptotic protease-activating factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVEAIVSFGV EKLWDRLTQE YEQFQGVEDR IAELKSNLNL LKSFLKDAEA KKNTSQMVRH
70 80 90 100 110 120
CVEEIKEIVY DTENMIETFI LKEAARKRSG IIRRITKLTC IKVHRWEFAS DIGGISKRIS
130 140 150 160 170 180
KVIQDMHSFG VQQMISDGSQ SSHLLQERER EMRQTFSRGY ESDFVGLEVN VKKLVGYLVE
190 200 210 220 230 240
EDDIQIVSVT GMGGLGKTTL ARQVFNHEDV KHQFDRLAWV CVSQEFTRKN VWQMILQNLT
250 260 270 280 290 300
SRETKDEILQ MEEAELHDEL FQLLETSKSL IVFDDIWKEE DWGLINPIFP PKKGWKVLIT
310 320 330 340 350 360
SRTETIAMHG NRRYVNFKPE CLTILESWIL FQRIAMPRVD ESEFKVDKEM EMMGKQMIKY
370 380 390 400 410 420
CGGLPLAVKV LGGLLAAKYT FHDWKRLSEN IGCHIVGRTD FSDGNNSSVY HVLSLSFEEL
430 440 450 460 470 480
PSYLKHCFLY LAHFPEDHNI KVEKLSYCWA AEGILEPRHY HGQTIRDVGE SYIEELVRRN
490 500 510 520 530 540
MVIAERDVTT LRFEACHLHD MMREVCLLKA KEENFVQIAS ILPPTANSQY PGTSRRFVSQ
550 560 570 580 590 600
NPTTLHVSRD INNPKLQSLL IVWENRRKSW KLLGSSFIRL ELLRVLDLYK AKFEGRNLPS
610 620 630 640 650 660
GIGKLIHLRY LNLDLARVSR LPSSLGNLRL LIYLDINVCT KSLFVPNCLM GMHELRYLRL
670 680 690 700 710 720
PFNTSKEIKL GLCNLVNLET LENFSTENSS LEDLRGMVSL RTLTIGLFKH ISKETLFASI
730 740 750 760 770 780
LGMRHLENLS IRTPDGSSKF KRIMEDGIVL DAIHLKQLNL RLYMPKLPDE QHFPSHLTSI
790 800 810 820 830 840
SLDGCCLVED PLPILEKLLE LKEVRLDFRA FCGKRMVSSD GGFPQLHRLY IWGLAEWEEW
850 860 870 880 890 900
IVEEGSMPRL HTLTIWNCQK LKQLPDGLRF IYSIKDLDMD KKWKEILSEG GEEYYKVQHI
PSVKFEKDYK