Q8W110
PR
Gene name |
FRO4 (At5g23980, MZF18.140) |
Protein name |
Ferric reduction oxidase 4 |
Names |
AtFRO4, Ferric-chelate reductase 4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G23980 |
EC number |
1.16.1.7: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W110
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W110-F1 | Predicted | AlphaFoldDB |
70 variants for Q8W110
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07025017 | 8 | V>M | No | 1000Genomes | |
| ENSVATH03104527 | 21 | L>F | No | 1000Genomes | |
| tmp_5_8101219_C_T | 22 | V>I | No | 1000Genomes | |
| ENSVATH03104523 | 52 | G>D | No | 1000Genomes | |
| ENSVATH03104522 | 75 | I>L | No | 1000Genomes | |
| tmp_5_8100842_C_T | 90 | R>K | No | 1000Genomes | |
| ENSVATH07025011 | 91 | I>K | No | 1000Genomes | |
| ENSVATH03104516 | 106 | T>I | No | 1000Genomes | |
| ENSVATH14150770 | 107 | A>T | No | 1000Genomes | |
| tmp_5_8100779_G_C | 111 | T>S | No | 1000Genomes | |
| tmp_5_8100723_G_A | 130 | L>F | No | 1000Genomes | |
| tmp_5_8100681_T_A | 144 | I>L | No | 1000Genomes | |
| ENSVATH10970365 | 147 | A>S | No | 1000Genomes | |
| tmp_5_8100303_C_A | 164 | W>C | No | 1000Genomes | |
| ENSVATH03104488 | 177 | I>M | No | 1000Genomes | |
| tmp_5_8100146_T_C | 217 | I>V | No | 1000Genomes | |
| ENSVATH03104482 | 228 | P>A | No | 1000Genomes | |
| tmp_5_8099969_G_A | 237 | T>I | No | 1000Genomes | |
| ENSVATH07025000 | 247 | W>* | No | 1000Genomes | |
| tmp_5_8099933_G_C | 249 | T>R | No | 1000Genomes | |
| ENSVATH07024999 | 250 | S>N | No | 1000Genomes | |
| tmp_5_8099922_A_C | 253 | S>A | No | 1000Genomes | |
| tmp_5_8099868_G_T | 271 | L>I | No | 1000Genomes | |
| ENSVATH10970322 | 274 | V>I | No | 1000Genomes | |
| tmp_5_8099849_A_G | 277 | V>A | No | 1000Genomes | |
| ENSVATH03104478 | 286 | C>G | No | 1000Genomes | |
| ENSVATH07024997 | 291 | N>K | No | 1000Genomes | |
| tmp_5_8099794_A_T | 295 | F>L | No | 1000Genomes | |
| ENSVATH03104477 | 296 | F>L | No | 1000Genomes | |
| ENSVATH07024996 | 331 | P>Q | No | 1000Genomes | |
| ENSVATH07024991 | 358 | I>R | No | 1000Genomes | |
| ENSVATH07024991 | 358 | I>T | No | 1000Genomes | |
| tmp_5_8099394_G_T | 361 | S>R | No | 1000Genomes | |
| tmp_5_8099391_G_T | 362 | S>R | No | 1000Genomes | |
| tmp_5_8099389_T_G | 363 | N>T | No | 1000Genomes | |
| ENSVATH03104474 | 371 | V>I | No | 1000Genomes | |
| tmp_5_8099319_A_C | 386 | H>Q | No | 1000Genomes | |
| ENSVATH07024990 | 391 | I>M | No | 1000Genomes | |
| ENSVATH07024989 | 433 | E>Q | No | 1000Genomes | |
| ENSVATH07024988 | 443 | T>R | No | 1000Genomes | |
| tmp_5_8099007_A_C | 458 | H>Q | No | 1000Genomes | |
| ENSVATH10970280 | 468 | P>Q | No | 1000Genomes | |
| tmp_5_8098963_G_C | 473 | A>G | No | 1000Genomes | |
| ENSVATH07024985 | 483 | I>V | No | 1000Genomes | |
| ENSVATH03104461 | 485 | A>V | No | 1000Genomes | |
| ENSVATH07024984 | 496 | T>R | No | 1000Genomes | |
| ENSVATH14150766 | 498 | D>H | No | 1000Genomes | |
| tmp_5_8098871_G_T | 504 | Q>K | No | 1000Genomes | |
| ENSVATH10970278 | 534 | L>I | No | 1000Genomes | |
| tmp_5_8098694_A_T | 563 | Y>N | No | 1000Genomes | |
| ENSVATH07024983 | 597 | E>D | No | 1000Genomes | |
| tmp_5_8098578_C_A | 601 | E>D | No | 1000Genomes | |
| tmp_5_8098576_A_G | 602 | F>S | No | 1000Genomes | |
| tmp_5_8098569_A_C | 604 | N>K | No | 1000Genomes | |
| tmp_5_8098564_A_T | 606 | V>E | No | 1000Genomes | |
| ENSVATH07024981 | 608 | S>N | No | 1000Genomes | |
| ENSVATH10970277 | 618 | P>S | No | 1000Genomes | |
| tmp_5_8098522_G_A | 620 | S>L | No | 1000Genomes | |
| tmp_5_8098301_G_A | 656 | L>F | No | 1000Genomes | |
| tmp_5_8098294_G_C | 658 | A>G | No | 1000Genomes | |
| tmp_5_8098283_C_G | 662 | E>Q | No | 1000Genomes | |
| tmp_5_8098273_C_T | 665 | G>E | No | 1000Genomes | |
| tmp_5_8098264_A_G | 668 | V>A | No | 1000Genomes | |
| ENSVATH03104456 | 676 | H>Y | No | 1000Genomes | |
| tmp_5_8098232_C_T | 679 | A>T | No | 1000Genomes | |
| tmp_5_8098222_C_T | 682 | C>Y | No | 1000Genomes | |
| tmp_5_8098214_C_T | 685 | G>S | No | 1000Genomes | |
| ENSVATH10970274 | 693 | E>G | No | 1000Genomes | |
| ENSVATH07024977 | 699 | W>L | No | 1000Genomes | |
| ENSVATH07024978 | 699 | W>R | No | 1000Genomes |
No associated diseases with Q8W110
4 regional properties for Q8W110
Functions
| Description | ||
|---|---|---|
| EC Number | 1.16.1.7 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ferric-chelate reductase (NADH) activity | Catalysis of the reaction: 2 Fe3+-siderophore + NAD(+) + H(+) -> 2 Fe2+-siderophore + NADH. |
| ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ion transport | The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96PH1 | NOX5 | NADPH oxidase 5 | Homo sapiens (Human) | EV |
| Q948U0 | RBOHA | Respiratory burst oxidase homolog protein A | Solanum tuberosum (Potato) | PR |
| Q948T9 | RBOHB | Respiratory burst oxidase homolog protein B | Solanum tuberosum (Potato) | PR |
| Q5ZAJ0 | RBOHB | Respiratory burst oxidase homolog protein B | Oryza sativa subsp japonica (Rice) | PR |
| O48538 | RBOHF | Respiratory burst oxidase homolog protein F | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P92949 | CDC5 | Ferric reduction oxidase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIJ0 | RBOHD | Respiratory burst oxidase homolog protein D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJD6 | RBOHH | Putative respiratory burst oxidase homolog protein H | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUT8 | RBOHI | Probable respiratory burst oxidase homolog protein I | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4K7 | FRO3 | Ferric reduction oxidase 3, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81211 | RBOHE | Respiratory burst oxidase homolog protein E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNMRSLVKT | LMVVLFLGWI | LVWIMISTNL | FKSKWTPKLS | KYLNTTYFGP | QGTNLVLLTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PMMFIAVLSC | VYLHIQKKPT | QPQREWKLKR | IMGRVIMVMN | PLGIVTATEL | TFSLLFVALL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AWSLYNYLYL | SYHVHLHNDD | NAKIWQAKFR | AFGLRIGYVG | NICWAFLFFP | VTRASTILPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VGLTSESSIK | YHIWLGHVSN | FCFLVHTVVF | LIYWAMINKL | METFAWNPTY | VPNLAGTIAM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIGIAMWVTS | LPSFRRKKFE | IFFYTHHLYG | LYIVFYVIHV | GDSWFCMILP | NIFLFFIDRY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRFLQSTKRS | RLVSARILPS | DNLELTFSKT | PGLHYTPTSI | LFLHVPSISK | IQWHPFTITS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSNLEKDTLS | VVIRRQGSWT | QKLYTHLSSS | IDSLEVSTEG | PYGPNSFDVS | RHNSLILVSG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GSGITPFISV | IRELISQSQN | KSTKLPDVLL | VCSFKHYHDL | AFLDLIFPLD | MSASDISRLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LRIEAYITRE | DKKPETTDDH | RLLQTKWFKP | QPLDSPISPV | LGPNNFLWLG | VVILSSFVMF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLLIGIVTRY | YIYPVDHNTG | SIYNFSYRGL | WDMFLGSACI | FISSSVVFLW | RKKQNKEGDK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EFKNQVQSVE | FQTPTSSPGS | WFHGHERELE | SVPYQSIVQA | TSVHFGSKPN | LKKILLEAEG |
| 670 | 680 | 690 | |||
| SEDVGVMVCG | PRKMRHEVAK | ICSSGLAKNL | HFEAISFNW |