Q8VZZ4

PR
Gene name
ABCC6 (MRP6, MRP8, At3g13090, MJG19.4)
Protein name
ABC transporter C family member 6
Names
ABC transporter ABCC.6, AtABCC6, ATP-energized glutathione S-conjugate pump 8, Glutathione S-conjugate-transporting ATPase 8, Multidrug resistance-associated protein 8
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G13090
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

798-905 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VZZ4

Entry ID Method Resolution Chain Position Source
AF-Q8VZZ4-F1 Predicted AlphaFoldDB

94 variants for Q8VZZ4

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_4208162_G_A 4 P>S No 1000Genomes
tmp_3_4208126_A_G 16 S>P No 1000Genomes
ENSVATH00320358 48 I>V No 1000Genomes
ENSVATH10644240 57 S>P No 1000Genomes
ENSVATH05819615 57 S>Y No 1000Genomes
ENSVATH05819614 60 Y>S No 1000Genomes
tmp_3_4207981_A_G 64 V>A No 1000Genomes
ENSVATH00320357 85 H>Q No 1000Genomes
ENSVATH00320356 88 T>I No 1000Genomes
tmp_3_4207898_G_C 92 P>A No 1000Genomes
ENSVATH05819613 105 S>T No 1000Genomes
tmp_3_4207801_A_C,T 124 F>C No 1000Genomes
tmp_3_4207801_A_C,T 124 F>Y No 1000Genomes
tmp_3_4207791_T_A 127 R>S No 1000Genomes
tmp_3_4207776_G_C 132 F>L No 1000Genomes
ENSVATH02138607 140 H>R No 1000Genomes
ENSVATH02138606 152 E>K No 1000Genomes
ENSVATH05819612 156 V>I No 1000Genomes
ENSVATH05819610 161 S>P No 1000Genomes
tmp_3_4207679_C_T 165 G>S No 1000Genomes
tmp_3_4207651_C_A 174 C>F No 1000Genomes
tmp_3_4207643_A_C 177 L>V No 1000Genomes
tmp_3_4207620_T_A 184 E>D No 1000Genomes
ENSVATH00320355 200 S>T No 1000Genomes
ENSVATH10644239 206 T>N No 1000Genomes
tmp_3_4207553_C_T 207 A>T No 1000Genomes
ENSVATH10644238 238 K>N No 1000Genomes
tmp_3_4207451_G_A 241 P>S No 1000Genomes
ENSVATH00320354 243 L>V No 1000Genomes
ENSVATH05819607 272 F>Y No 1000Genomes
ENSVATH05819606 309 N>S No 1000Genomes
ENSVATH05819605 321 K>N No 1000Genomes
ENSVATH00320353 325 Y>C No 1000Genomes
tmp_3_4207151_T_A 341 T>S No 1000Genomes
tmp_3_4206953_T_C 407 I>V No 1000Genomes
tmp_3_4206938_C_G 412 V>L No 1000Genomes
tmp_3_4206935_T_C 413 S>G No 1000Genomes
ENSVATH13907607 427 S>* No 1000Genomes
ENSVATH02138603 436 L>F No 1000Genomes
ENSVATH02138602 453 S>G No 1000Genomes
ENSVATH05819600 458 S>A No 1000Genomes
tmp_3_4206767_C_A 469 V>F No 1000Genomes
tmp_3_4206708_C_A 488 K>N No 1000Genomes
ENSVATH05819599 502 K>T No 1000Genomes
tmp_3_4206545_C_T 543 A>T No 1000Genomes
ENSVATH02138599 573 N>I No 1000Genomes
ENSVATH02138600 573 N>Y No 1000Genomes
tmp_3_4206413_C_T 587 D>N No 1000Genomes
tmp_3_4206409_A_G 588 V>A No 1000Genomes
ENSVATH00320352 612 D>E No 1000Genomes
tmp_3_4206262_G_C 637 T>S No 1000Genomes
ENSVATH02138596 656 I>T No 1000Genomes
ENSVATH13907564 666 K>N No 1000Genomes
tmp_3_4206126_C_A 682 E>D No 1000Genomes
ENSVATH00320350 696 D>E No 1000Genomes
tmp_3_4206048_C_G 708 L>F No 1000Genomes
tmp_3_4205736_T_A,C 775 H>L No 1000Genomes
tmp_3_4205736_T_A,C 775 H>R No 1000Genomes
ENSVATH10644182 776 K>R No 1000Genomes
ENSVATH00320347 809 H>N No 1000Genomes
ENSVATH02138595 830 A>V No 1000Genomes
ENSVATH05819593 833 D>E No 1000Genomes
ENSVATH02138594 853 L>I No 1000Genomes
ENSVATH02138593 856 K>T No 1000Genomes
ENSVATH02138592 868 S>R No 1000Genomes
tmp_3_4205364_T_C 873 Q>R No 1000Genomes
tmp_3_4205248_G_T 912 L>I No 1000Genomes
ENSVATH10644179 939 T>R No 1000Genomes
ENSVATH10644178 940 L>V No 1000Genomes
tmp_3_4205106_G_A 959 A>V No 1000Genomes
ENSVATH13907561 997 I>L No 1000Genomes
tmp_3_4204793_C_A 1027 L>F No 1000Genomes
tmp_3_4204729_C_T 1049 A>T No 1000Genomes
ENSVATH10644175 1056 Q>H No 1000Genomes
ENSVATH02138587 1076 V>M No 1000Genomes
ENSVATH05819587 1098 R>M No 1000Genomes
tmp_3_4204347_G_A 1138 S>F No 1000Genomes
tmp_3_4204323_G_A 1146 A>V No 1000Genomes
ENSVATH05819580 1202 L>F No 1000Genomes
tmp_3_4204011_C_A 1218 E>D No 1000Genomes
ENSVATH07959986 1222 C>Y No 1000Genomes
ENSVATH10644103 1240 T>R No 1000Genomes
tmp_3_4203916_C_T 1250 G>E No 1000Genomes
ENSVATH05819578 1286 S>F No 1000Genomes
tmp_3_4203704_T_G 1321 T>P No 1000Genomes
ENSVATH05819577 1323 D>N No 1000Genomes
ENSVATH05819576 1323 D>V No 1000Genomes
ENSVATH10644101 1330 D>A No 1000Genomes
ENSVATH10644100 1350 S>C No 1000Genomes
tmp_3_4203427_C_T 1358 V>I No 1000Genomes
tmp_3_4203302_C_A 1399 R>S No 1000Genomes
tmp_3_4203217_G_T 1428 Q>K No 1000Genomes
tmp_3_4203101_G_A 1438 A>V No 1000Genomes
ENSVATH05819575 1460 E>V No 1000Genomes

No associated diseases with Q8VZZ4

1 regional properties for Q8VZZ4

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 32 - 199 IPR005225

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

3 GO annotations of molecular function

Name Definition
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

1 GO annotations of biological process

Name Definition
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38735 VMR1 ABC transporter ATP-binding protein/permease VMR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0CE68 NFT1 ABC transporter NFT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MENPIDSLLL QPIYLSVLSF FLNLVLLLIL FGSWLFKKRV ACEDTDAIMN EEFKHISFSY
70 80 90 100 110 120
NKLVLICCVS LSVFYSVLSL LSCLHWHTNG WPFLDLLLAA LTWGSISVYL FGRYTNSCEQ
130 140 150 160 170 180
KVLFLLRVWW VFFFVVSCYH LVVDFVLYKK QEMVSVHFVI SDLVGVCAGL FLCCSCLWKK
190 200 210 220 230 240
GEGERIDLLK EPLLSSAESS DNEEVTAPFS KAGILSRMSF SWMSPLITLG NEKIIDIKDV
250 260 270 280 290 300
PQLDRSDTTE SLFWIFRSKL EWDDGERRIT TFKLIKALFL SVWRDIVLSA LLAFVYTVSC
310 320 330 340 350 360
YVAPYLMDNF VQYLNGNRQY KNQGYVLVTT FFVAKLVECQ TQRQWFFRGQ KAGLGMRSVL
370 380 390 400 410 420
VSMIYEKGLT LPCHSKQGHT SGEIINLMAV DADRISAFSW FMHDPWILVL QVSLALWILY
430 440 450 460 470 480
KSLGLGSIAA FPATILVMLA NYPFAKLEEK FQSSLMKSKD NRMKKTSEVL LNMKILKLQG
490 500 510 520 530 540
WEMKFLSKIL ELRHIEAGWL KKFVYNSSAI NSVLWAAPSF ISATAFGACL LLKIPLESGK
550 560 570 580 590 600
ILAALATFRI LQGPIYKLPE TISMIVQTKV SLNRIASFLC LDDLQQDVVG RLPSGSSEMA
610 620 630 640 650 660
VEISNGTFSW DDSSPIPTLR DMNFKVSQGM NVAICGTVGS GKSSLLSSIL GEVPKISGNL
670 680 690 700 710 720
KVCGRKAYIA QSPWIQSGKV EENILFGKPM EREWYDRVLE ACSLNKDLEI LPFHDQTVIG
730 740 750 760 770 780
ERGINLSGGQ KQRIQIARAL YQDADIYLFD DPFSAVDAHT GSHLFKEVLL GLLRHKTVIY
790 800 810 820 830 840
VTHQVEFLPE ADLILVMKDG KITQAGKYHE ILDSGTDFME LVGAHTEALA TIDSCETGYA
850 860 870 880 890 900
SEKSTTDKEN EVLHHKEKQE NGSDNKPSGQ LVQEEEREKG KVGFTVYKKY MALAYGGAVI
910 920 930 940 950 960
PLILVVQVLF QLLSIGSNYW MTWVTPVSKD VEPPVSGFTL ILVYVLLAVA SSFCILIRAL
970 980 990 1000 1010 1020
LVAMTGFKMA TELFTQMHLR IFRASMSFFD ATPMGRILNR ASTDQSVADL RLPGQFAYVA
1030 1040 1050 1060 1070 1080
IAAINILGII GVIVQVAWQV LIVFIPVVAA CAWYRQYYIS AARELARLAG ISRSPVVHHF
1090 1100 1110 1120 1130 1140
SETLSGITTI RSFDQEPRFR GDIMRLSDCY SRLKFHSTGA MEWLCFRLEL LSTFAFASSL
1150 1160 1170 1180 1190 1200
VILVSAPEGV INPSLAGLAI TYALNLNTLQ ATLIWTLCDL ENKMISVERM LQYTNIPSEP
1210 1220 1230 1240 1250 1260
PLVIETTRPE KSWPSRGEIT ICNLQVRYGP HLPMVLHGLT CTFPGGLKTG IVGRTGCGKS
1270 1280 1290 1300 1310 1320
TLIQTLFRIV EPAAGEIRID GINILSIGLH DLRSRLSIIP QDPTMFEGTI RSNLDPLEEY
1330 1340 1350 1360 1370 1380
TDDQIWEALD NCQLGDEVRK KELKLDSPVS ENGQNWSVGQ RQLVCLGRVL LKRSKLLVLD
1390 1400 1410 1420 1430 1440
EATASIDTAT DNLIQETLRH HFADCTVITI AHRISSVIDS DMVLLLDQGL IKEHDSPARL
1450 1460
LEDRSSLFSK LVAEYTTSSE SKSKRS