Q8VZJ9

PR
Gene name
CRCK2 (At4g00330, A_IG005I10.8, F5I10.8)
Protein name
Calmodulin-binding receptor-like cytoplasmic kinase 2
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G00330
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VZJ9

Entry ID Method Resolution Chain Position Source
AF-Q8VZJ9-F1 Predicted AlphaFoldDB

29 variants for Q8VZJ9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06403053 10 T>S No 1000Genomes
ENSVATH06403051 15 A>S No 1000Genomes
ENSVATH06403050 17 T>K No 1000Genomes
tmp_4_144363_C_T 22 S>N No 1000Genomes
ENSVATH10462717 31 F>L No 1000Genomes
ENSVATH02602249 34 T>A No 1000Genomes
ENSVATH06403049 36 A>D No 1000Genomes
ENSVATH02602247 39 S>P No 1000Genomes
ENSVATH10462716 63 S>T No 1000Genomes
tmp_4_144229_T_C 67 N>D No 1000Genomes
ENSVATH00804269 67 N>K No 1000Genomes
tmp_4_144226_A_C 68 Y>D No 1000Genomes
ENSVATH06403045 79 N>D No 1000Genomes
tmp_4_144060_C_A 95 S>I No 1000Genomes
ENSVATH02602242 101 E>A No 1000Genomes
ENSVATH13861127 105 T>R No 1000Genomes
ENSVATH10462674 139 R>K No 1000Genomes
ENSVATH13861125 155 D>V No 1000Genomes
tmp_4_143713_C_A 187 V>F No 1000Genomes
ENSVATH02602233 200 A>P No 1000Genomes
tmp_4_143508_C_A 229 A>S No 1000Genomes
tmp_4_143375_T_C 244 I>V No 1000Genomes
ENSVATH02602222 259 Y>F No 1000Genomes
tmp_4_143180_C_A 309 V>F No 1000Genomes
ENSVATH06403040 347 S>N No 1000Genomes
ENSVATH06403039 363 A>G No 1000Genomes
tmp_4_142846_T_A 393 S>C No 1000Genomes
ENSVATH10462665 408 N>S No 1000Genomes
ENSVATH10462665 408 N>T No 1000Genomes

No associated diseases with Q8VZJ9

3 regional properties for Q8VZJ9

Type Name Position InterPro Accession
domain Protein kinase domain 119 - 398 IPR000719
active_site Serine/threonine-protein kinase, active site 243 - 255 IPR008271
binding_site Protein kinase, ATP binding site 125 - 151 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
pollen development The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
protein phosphorylation The process of introducing a phosphate group on to a protein.

48 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y616 IRAK3 Interleukin-1 receptor-associated kinase 3 Homo sapiens (Human) PR
P53667 LIMK1 LIM domain kinase 1 Homo sapiens (Human) PR
P53671 LIMK2 LIM domain kinase 2 Homo sapiens (Human) PR
Q8K4B2 Irak3 Interleukin-1 receptor-associated kinase 3 Mus musculus (Mouse) PR
Q8CFA1 Irak2 Interleukin-1 receptor-associated kinase-like 2 Mus musculus (Mouse) PR
O54785 Limk2 LIM domain kinase 2 Mus musculus (Mouse) PR
O08644 Ephb6 Ephrin type-B receptor 6 Mus musculus (Mouse) PR
P54763 Ephb2 Ephrin type-B receptor 2 Mus musculus (Mouse) SS
Q03137 Epha4 Ephrin type-A receptor 4 Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
Q61772 Epha7 Ephrin type-A receptor 7 Mus musculus (Mouse) SS
Q8BYG9 Epha10 Ephrin type-A receptor 10 Mus musculus (Mouse) SS
Q8CBF3 Ephb1 Ephrin type-B receptor 1 Mus musculus (Mouse) SS
P54754 Ephb3 Ephrin type-B receptor 3 Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
O09127 Epha8 Ephrin type-A receptor 8 Mus musculus (Mouse) SS
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
Q61527 Erbb4 Receptor tyrosine-protein kinase erbB-4 Mus musculus (Mouse) SS
Q61526 Erbb3 Receptor tyrosine-protein kinase erbB-3 Mus musculus (Mouse) SS
Q01279 Egfr Epidermal growth factor receptor Mus musculus (Mouse) SS
Q62413 Epha6 Ephrin type-A receptor 6 Mus musculus (Mouse) SS
P29319 Epha3 Ephrin type-A receptor 3 Mus musculus (Mouse) SS
Q4QQS0 Irak2 Interleukin-1 receptor-associated kinase-like 2 Rattus norvegicus (Rat) PR
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
Q9ASQ5 CRCK3 Calmodulin-binding receptor-like cytoplasmic kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSV3 WAKL16 Putative wall-associated receptor kinase-like 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STF0 LECRKS3 Receptor like protein kinase S.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCZ4 FER Receptor-like protein kinase FERONIA Arabidopsis thaliana (Mouse-ear cress) PR
Q9M342 WAKL15 Wall-associated receptor kinase-like 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LYN6 At3g56050 Probable inactive receptor-like protein kinase At3g56050 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C25 At5g20050 Probable receptor-like protein kinase At5g20050 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLW0 At5g24010 Probable receptor-like protein kinase At5g24010 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTC0 PBL19 Probable serine/threonine-protein kinase PBL19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIL7 CRCK1 Calmodulin-binding receptor-like cytoplasmic kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFG1 At3g53590 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPSRRRHSYT VGSPATTSSN YSNTTFTDRS FPTTPARTST DTTTSIARRI SGIFINCFTP
70 80 90 100 110 120
PDSVSSNYID NSKSSSDNNI RSRRSSTGSS SVQRSYGNAN ETEHTRFTFD EIYDATKNFS
130 140 150 160 170 180
PSFRIGQGGF GTVYKVKLRD GKTFAVKRAK KSMHDDRQGA DAEFMSEIQT LAQVTHLSLV
190 200 210 220 230 240
KYYGFVVHND EKILVVEYVA NGTLRDHLDC KEGKTLDMAT RLDIATDVAH AITYLHMYTQ
250 260 270 280 290 300
PPIIHRDIKS SNILLTENYR AKVADFGFAR LAPDTDSGAT HVSTQVKGTA GYLDPEYLTT
310 320 330 340 350 360
YQLTEKSDVY SFGVLLVELL TGRRPIELSR GQKERITIRW AIKKFTSGDT ISVLDPKLEQ
370 380 390 400 410
NSANNLALEK VLEMAFQCLA PHRRSRPSMK KCSEILWGIR KDYRELLNTS L