Q8VYA3
PR
Gene name |
WAKL10 (At1g79680, F20B17.10) |
Protein name |
Wall-associated receptor kinase-like 10 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G79680 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
576-600 (Activation loop from InterPro)
Target domain |
433-718 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8VYA3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VYA3-F1 | Predicted | AlphaFoldDB |
78 variants for Q8VYA3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05175711 | 11 | S>N | No | 1000Genomes | |
| ENSVATH01560445 | 21 | L>F | No | 1000Genomes | |
| ENSVATH00150319 | 25 | S>N | No | 1000Genomes | |
| ENSVATH01560444 | 63 | F>L | No | 1000Genomes | |
| ENSVATH14494871 | 67 | I>V | No | 1000Genomes | |
| ENSVATH00150316 | 69 | R>K | No | 1000Genomes | |
| ENSVATH05175709 | 86 | V>I | No | 1000Genomes | |
| ENSVATH01560442 | 96 | P>Q | No | 1000Genomes | |
| ENSVATH05175708 | 103 | S>* | No | 1000Genomes | |
| ENSVATH13840829 | 106 | G>V | No | 1000Genomes | |
| tmp_1_29982380_C_T | 124 | D>N | No | 1000Genomes | |
| ENSVATH01560441 | 162 | N>I | No | 1000Genomes | |
| tmp_1_29982226_C_G | 175 | G>A | No | 1000Genomes | |
| tmp_1_29982215_A_G | 179 | Y>H | No | 1000Genomes | |
| ENSVATH05175704 | 185 | I>S | No | 1000Genomes | |
| ENSVATH13840828 | 201 | L>F | No | 1000Genomes | |
| tmp_1_29982031_T_C | 240 | D>G | No | 1000Genomes | |
| ENSVATH05175702 | 240 | D>N | No | 1000Genomes | |
| ENSVATH05175701 | 253 | D>G | No | 1000Genomes | |
| tmp_1_29981945_G_T | 269 | L>I | No | 1000Genomes | |
| tmp_1_29981917_G_C | 278 | T>R | No | 1000Genomes | |
| ENSVATH05175698 | 290 | G>D | No | 1000Genomes | |
| ENSVATH00150315 | 299 | T>I | No | 1000Genomes | |
| tmp_1_29981662_C_T | 328 | V>I | No | 1000Genomes | |
| tmp_1_29981658_C_T | 329 | R>K | No | 1000Genomes | |
| ENSVATH00150313 | 332 | D>E | No | 1000Genomes | |
| tmp_1_29981643_T_A | 334 | N>I | No | 1000Genomes | |
| ENSVATH05175693 | 341 | K>N | No | 1000Genomes | |
| tmp_1_29981619_C_G | 342 | C>S | No | 1000Genomes | |
| tmp_1_29981394_G_T | 368 | S>R | No | 1000Genomes | |
| tmp_1_29981381_T_C | 373 | I>V | No | 1000Genomes | |
| ENSVATH01560437 | 374 | G>A | No | 1000Genomes | |
| ENSVATH13840819 | 379 | L>S | No | 1000Genomes | |
| tmp_1_29981347_C_T | 384 | R>K | No | 1000Genomes | |
| ENSVATH01560436 | 387 | R>M | No | 1000Genomes | |
| ENSVATH01560436 | 387 | R>T | No | 1000Genomes | |
| ENSVATH00150312 | 435 | L>F | No | 1000Genomes | |
| ENSVATH14494869 | 446 | T>A | No | 1000Genomes | |
| tmp_1_29981117_T_C | 461 | K>E | No | 1000Genomes | |
| tmp_1_29981079_C_A | 473 | E>D | No | 1000Genomes | |
| tmp_1_29981006_C_A | 498 | E>* | No | 1000Genomes | |
| ENSVATH05175687 | 516 | E>K | No | 1000Genomes | |
| ENSVATH05175686 | 523 | D>N | No | 1000Genomes | |
| tmp_1_29980916_T_C | 528 | T>A | No | 1000Genomes | |
| ENSVATH00150311 | 538 | V>L | No | 1000Genomes | |
| tmp_1_29980840_G_A | 553 | S>F | No | 1000Genomes | |
| ENSVATH13840817 | 572 | R>G | No | 1000Genomes | |
| tmp_1_29980745_T_A | 585 | T>S | No | 1000Genomes | |
| ENSVATH09365820 | 602 | M>I | No | 1000Genomes | |
| ENSVATH05175684 | 605 | E>K | No | 1000Genomes | |
| tmp_1_29980668_G_T | 610 | S>R | No | 1000Genomes | |
| ENSVATH05175683 | 628 | L>I | No | 1000Genomes | |
| tmp_1_29980598_AT_TT,A | 634 | S>T | No | 1000Genomes | |
| ENSVATH13840815 | 637 | F>S | No | 1000Genomes | |
| ENSVATH01560431 | 647 | A>E | No | 1000Genomes | |
| ENSVATH01560431 | 647 | A>V | No | 1000Genomes | |
| ENSVATH05175682 | 649 | Y>H | No | 1000Genomes | |
| ENSVATH05175681 | 652 | L>F | No | 1000Genomes | |
| tmp_1_29980434_A_T | 688 | N>K | No | 1000Genomes | |
| tmp_1_29980401_T_A | 699 | Q>H | No | 1000Genomes | |
| ENSVATH14494868 | 709 | S>P | No | 1000Genomes | |
| ENSVATH00150306 | 714 | M>L | No | 1000Genomes | |
| ENSVATH00150305 | 718 | E>* | No | 1000Genomes | |
| ENSVATH05175680 | 721 | S>N | No | 1000Genomes | |
| ENSVATH13840813 | 724 | E>* | No | 1000Genomes | |
| ENSVATH14494867 | 726 | E>D | No | 1000Genomes | |
| ENSVATH14494866 | 727 | K>E | No | 1000Genomes | |
| tmp_1_29980313_C_G | 729 | E>Q | No | 1000Genomes | |
| tmp_1_29980309_G_T | 730 | T>K | No | 1000Genomes | |
| ENSVATH13840812 | 735 | N>D | No | 1000Genomes | |
| ENSVATH05175679 | 739 | R>I | No | 1000Genomes | |
| tmp_1_29980264_G_T | 745 | T>N | No | 1000Genomes | |
| ENSVATH13840811 | 749 | S>F | No | 1000Genomes | |
| tmp_1_29980242_G_C | 752 | S>R | No | 1000Genomes | |
| ENSVATH00150303 | 760 | R>W | No | 1000Genomes | |
| ENSVATH01560430 | 764 | E>D | No | 1000Genomes | |
| ENSVATH01560427 | 768 | P>R | No | 1000Genomes | |
| ENSVATH01560428 | 768 | P>S | No | 1000Genomes |
No associated diseases with Q8VYA3
5 regional properties for Q8VYA3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 433 - 718 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 555 - 567 | IPR008271 |
| domain | Wall-associated receptor kinase | 188 - 295 | IPR013695 |
| conserved_site | EGF-like calcium-binding, conserved site | 323 - 351 | IPR018097 |
| domain | Wall-associated receptor kinase, galacturonan-binding domain | 27 - 76 | IPR025287 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| guanylate cyclase activity | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. |
| polysaccharide binding | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
| response to salicylic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P00533 | EGFR | Epidermal growth factor receptor | Homo sapiens (Human) | EV |
| Q15303 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens (Human) | SS |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (Human) | SS |
| P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens (Human) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSNCSCSLL | SLFSLLLIID | LTVASSCPKT | CGGIDIPYPF | GIGTGCYLEK | WYEIICVNNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPFLSIINRE | VVSISFSDMY | RRFFNVGYGS | IRIRNPIASK | GCSSGGQEFG | SLLNMTGYPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLGDNNMLIA | VGCNNTASLT | NVEPSIVGCE | STCSTNQDIP | INDYLGVLYC | NARYGDSEYC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNISIMNDTS | CNGIGCCKAS | LPARYQQIIG | VEIDDSNTES | KGCKVAFITD | EEYFLSNGSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PERLHANGYD | TVDLRWFIHT | ANHSFIGSLG | CKSIDEYTIL | RRDNREYGIG | CLCDYNSTTT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GYATCSCASG | FEGNPYIPGE | CKDINECVRG | IDGNPVCTAG | KCVNLLGGYT | CEYTNHRPLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGLSTSFSTL | VFIGGIYWLY | KFIRRQRRLN | QKKKFFKRNG | GLLLQQQLTT | TEGNVDSTRV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FNSRELEKAT | ENFSLTRILG | EGGQGTVYKG | MLVDGRIVAV | KKSKVVDEDK | LEEFINEVVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSQINHRNIV | KLLGCCLETD | VPILVYEFIP | NGNLFEHLHD | DSDDYTMTTW | EVRLRIAVDI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AGALSYLHSA | ASSPIYHRDI | KSTNIMLDEK | HRAKVSDFGT | SRTVTVDHTH | LTTVVSGTVG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YMDPEYFQSS | QFTDKSDVYS | FGVVLAELIT | GEKSVSFLRS | QEYRTLATYF | TLAMKENRLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DIIDARIRDG | CKLNQVTAAA | KIARKCLNMK | GRKRPSMRQV | SMELEKIRSY | SEDMQPYEYA |
| 730 | 740 | 750 | 760 | ||
| SENEEEKKET | LVDVNVESRN | YVSVTAASSQ | YSIATTSSSR | SDVEPLFPR |