Q8VIH1
PR
Gene name |
Nobox (Og2x) |
Protein name |
Homeobox protein NOBOX |
Names |
Homeodomain-containing protein OG-2, Newborn ovary homeobox protein, Oocyte-specific homeobox protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18291 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VIH1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VIH1-F1 | Predicted | AlphaFoldDB |
48 variants for Q8VIH1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs254151438 | 29 | G>E | No | EVA | |
| rs3388828203 | 36 | L>M | No | EVA | |
| rs236944041 | 36 | L>P | No | EVA | |
| rs259619245 | 41 | D>E | No | EVA | |
| rs3388821806 | 41 | D>G | No | EVA | |
| rs262027508 | 74 | H>L | No | EVA | |
| rs244109099 | 79 | A>P | No | EVA | |
| rs250327603 | 83 | G>S | No | EVA | |
| rs235401608 | 93 | P>L | No | EVA | |
| rs38359649 | 96 | R>T | No | EVA | |
| rs240109349 | 101 | L>V | No | EVA | |
| rs36643565 | 113 | T>A | No | EVA | |
| rs228725477 | 120 | H>R | No | EVA | |
| rs3388794468 | 135 | F>Y | No | EVA | |
| rs3388823760 | 171 | Q>H | No | EVA | |
| rs3396658072 | 210 | S>C | No | EVA | |
| rs3396743030 | 212 | D>G | No | EVA | |
| rs3396679435 | 213 | S>C | No | EVA | |
| rs3412758210 | 214 | S>C | No | EVA | |
| rs3396526963 | 217 | R>* | No | EVA | |
| rs257166243 | 222 | L>P | No | EVA | |
| rs3388827842 | 224 | D>N | No | EVA | |
| rs3388825837 | 233 | G>D | No | EVA | |
| rs3396618066 | 246 | E>V | No | EVA | |
| rs3388834460 | 274 | P>L | No | EVA | |
| rs3388828166 | 290 | L>P | No | EVA | |
| rs219628607 | 304 | D>N | No | EVA | |
| rs3388827753 | 314 | D>N | No | EVA | |
| rs3388794535 | 322 | T>I | No | EVA | |
| rs241983895 | 328 | P>S | No | EVA | |
| rs37174741 | 338 | S>P | No | EVA | |
| rs3388834490 | 356 | P>R | No | EVA | |
| rs225174988 | 358 | L>S | No | EVA | |
| rs3388807367 | 411 | P>Q | No | EVA | |
| rs1132792018 | 414 | Q>H | No | EVA | |
| rs3388827310 | 439 | F>Y | No | EVA | |
| rs3388820359 | 441 | R>P | No | EVA | |
| rs230049496 | 450 | Q>H | No | EVA | |
| rs3388834505 | 456 | G>D | No | EVA | |
| rs3388831257 | 464 | T>N | No | EVA | |
| rs255644025 | 465 | P>S | No | EVA | |
| rs3396865009 | 476 | L>* | No | EVA | |
| rs3396285191 | 476 | L>I | No | EVA | |
| rs3396864970 | 477 | G>D | No | EVA | |
| rs218072452 | 477 | G>S | No | EVA | |
| rs263097304 | 503 | S>P | No | EVA | |
| rs214533629 | 517 | N>H | No | EVA | |
| rs37175561 | 525 | A>S | No | EVA |
No associated diseases with Q8VIH1
1 regional properties for Q8VIH1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 48 - 118 | IPR009071 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| ovarian follicle development | The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNI8 | LHX9 | LIM/homeobox protein Lhx9 | Bos taurus (Bovine) | PR |
| Q90881 | LHX9 | LIM/homeobox protein Lhx9 | Gallus gallus (Chicken) | PR |
| F1NEA7 | DMBX1 | Diencephalon/mesencephalon homeobox protein 1 | Gallus gallus (Chicken) | PR |
| Q90963 | PRRX2 | Paired mesoderm homeobox protein 2 | Gallus gallus (Chicken) | PR |
| Q8IRC7 | Awh | LIM/homeobox protein Awh | Drosophila melanogaster (Fruit fly) | PR |
| Q8NHV9 | RHOXF1 | Rhox homeobox family member 1 | Homo sapiens (Human) | PR |
| Q9NQ69 | LHX9 | LIM/homeobox protein Lhx9 | Homo sapiens (Human) | PR |
| O95076 | ALX3 | Homeobox protein aristaless-like 3 | Homo sapiens (Human) | PR |
| Q9BQY4 | RHOXF2 | Rhox homeobox family member 2 | Homo sapiens (Human) | PR |
| Q99811 | PRRX2 | Paired mesoderm homeobox protein 2 | Homo sapiens (Human) | PR |
| P50458 | LHX2 | LIM/homeobox protein Lhx2 | Homo sapiens (Human) | PR |
| O15266 | SHOX | Short stature homeobox protein | Homo sapiens (Human) | PR |
| P63013 | Prrx1 | Paired mesoderm homeobox protein 1 | Mus musculus (Mouse) | PR |
| Q06348 | Prrx2 | Paired mesoderm homeobox protein 2 | Mus musculus (Mouse) | PR |
| O88933 | Esx1 | Extraembryonic, spermatogenesis, homeobox 1 (Homeobox protein SPX1) (Homeodomain protein EPX) | Mus musculus (Mouse) | EV |
| Q9WUH2 | Lhx9 | LIM/homeobox protein Lhx9 | Mus musculus (Mouse) | PR |
| Q80W90 | Lhx9 | LIM/homeobox protein Lhx9 | Rattus norvegicus (Rat) | PR |
| P36198 | Lhx2 | LIM/homeobox protein Lhx2 | Rattus norvegicus (Rat) | PR |
| Q28G02 | siamois | Homeobox protein siamois | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q566X8 | dmbx1b | Diencephalon/mesencephalon homeobox protein 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1LWV4 | lhx9 | LIM/homeobox protein Lhx9 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPTEKLCKK | MQGQEAGDKP | RTAALETEGP | LQDSALPIQD | DQDKQSSLPR | ASLGKRPLSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSEELMDAGT | CRVHKAPTAA | ACGPQSEEEG | CSPPERKAES | LKPSISAVPG | QATAGSLNSH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGDLKKESLE | VTCQFRKKTR | TLYRSDQLEE | LERIFQEDHY | PDSDKRHEIS | QMVGVTPQRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MVWFQNRRAK | WRKVEKLNEK | ETKNGPAAPS | ADSSQHRSAP | ELLDPMPTDL | EPGPVPPENI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDVFPEPPML | LTSEQTLTPF | QNNEGAERVA | VTPPLLSPPP | IRRANLPLPL | GPVQTPQVLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PMRDVPGSDS | IYKDKAYVSW | GTSIASPPTY | SNLEDLGSQD | YQASSQLGSF | QLSQAPHLPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPSLQSQFPY | LPPFPYPIPS | SMPFLPPEDS | LFSFPFGFSG | DSSQDYCPGP | PPGQILLQPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AENMGTGPWS | GHCLPEPPFP | RPHYPQALGQ | PLGAEGYFPN | LLPTPYALTM | SKQSSLGLNG |
| 490 | 500 | 510 | 520 | ||
| LLEGTRVETG | SSLSKMSDEQ | TSSSLEQPAL | EEVRDKNKNS | HAAGAKE |