Q8VI63
Gene name |
Mob2 (Mmh) |
Protein name |
MOB kinase activator 2 |
Names |
Mob2 homolog , Mps one binder kinase activator-like 2 , Ovary-specific MOB-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:101513 |
EC number |
|
Protein Class |
MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB (PTHR22599) |
Descriptions
Autoinhibition of MOB1 is facilitated by the N-terminal extension that forms a switch helix which blocks the LATS1 binding surface. MST1/2-mediated phosphorylation at Thr12 and Thr35 leads to the dissociation of this helix, allowing binding to LATS1, which is critical for pathway activation.
Autoinhibitory domains (AIDs)
Target domain |
524-786 (LATS1 binding surface) |
Relief mechanism |
PTM, Partner binding, Ligand binding |
Assay |
Structural analysis, Mutagenesis experiment, Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VI63
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VI63-F1 | Predicted | AlphaFoldDB |
9 variants for Q8VI63
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388965050 | 67 | I>N | No | EVA | |
| rs3388960077 | 71 | Y>F | No | EVA | |
| rs3388957076 | 118 | V>L | No | EVA | |
| rs3388961298 | 131 | K>R | No | EVA | |
| rs3388949920 | 145 | K>N | No | EVA | |
| rs3398660128 | 201 | D>H | No | EVA | |
| rs3398646150 | 204 | T>S | No | EVA | |
| rs249114266 | 222 | N>S | No | EVA | |
| rs3398635592 | 232 | V>M | No | EVA |
No associated diseases with Q8VI63
No regional properties for Q8VI63
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8VI63 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR22599 | MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB |
| PANTHER Subfamily | PTHR22599:SF21 | MOB KINASE ACTIVATOR 2 |
| PANTHER Protein Class |
kinase modulator
kinase activator |
|
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| neuron projection terminus | The specialized, terminal region of a neuron projection such as an axon or a dendrite. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43563 | MOB2 | CBK1 kinase activator protein MOB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P40484 | MOB1 | DBF2 kinase activator protein MOB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q95RA8 | mats | MOB kinase activator-like 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q9H8S9 | MOB1A | MOB kinase activator 1A | Homo sapiens (Human) | EV |
| Q7L9L4 | MOB1B | MOB kinase activator 1B | Homo sapiens (Human) | SS |
| Q8BJG4 | Mob3c | MOB kinase activator 3C | Mus musculus (Mouse) | SS |
| Q8BSU7 | Mob3a | MOB kinase activator 3A | Mus musculus (Mouse) | SS |
| Q8VE04 | Mob3b | MOB kinase activator 3B | Mus musculus (Mouse) | SS |
| Q921Y0 | Mob1a | MOB kinase activator 1A | Mus musculus (Mouse) | SS |
| Q8BPB0 | Mob1b | MOB kinase activator 1B | Mus musculus (Mouse) | EV |
| Q3T1J9 | Mob1a | MOB kinase activator 1A | Rattus norvegicus (Rat) | SS |
| Q8GYX0 | MOB1B | MOB kinase activator-like 1B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHI1 | MOB1A | MOB kinase activator-like 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDWLMGKSKA | KPNGKKPAAE | EKKVYLEPEH | TKSRITDFEF | KELVVLPREI | DLNEWLASNT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTFFHHINLQ | YSTISEFCTG | ETCQTMAVCN | TQYYWYDERG | KKVKCTAPQY | VDFVMSSVQK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVTDEDVFPT | KYGREFPSSF | ESLVKKICKY | LFHVLGHIYW | AHFKETLALE | LHGHLNTLYV |
| 190 | 200 | 210 | 220 | 230 | |
| HFILFAREFN | LLDPKETAVM | DDLTEVLCSS | PGNSGATGDG | ANSGASGAQN | HVKER |