Q8VHQ4
PR
Gene name |
Rab40c |
Protein name |
Ras-related protein Rab-40C |
Names |
SOCS box-containing protein RAR3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:224624 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VHQ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VHQ4-F1 | Predicted | AlphaFoldDB |
12 variants for Q8VHQ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389357668 | 78 | T>I | No | EVA | |
| rs3389413473 | 86 | G>A | No | EVA | |
| rs3389438037 | 113 | D>Y | No | EVA | |
| rs3389460781 | 127 | R>L | No | EVA | |
| rs3389454469 | 129 | H>Q | No | EVA | |
| rs3389460722 | 133 | K>R | No | EVA | |
| rs3389436847 | 168 | T>I | No | EVA | |
| rs864280435 | 173 | I>V | No | EVA | |
| rs3389448426 | 216 | V>L | No | EVA | |
| rs3389448341 | 217 | T>I | No | EVA | |
| rs3389445730 | 231 | M>I | No | EVA | |
| rs3389436903 | 247 | A>G | No | EVA |
No associated diseases with Q8VHQ4
9 regional properties for Q8VHQ4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 225 - 293 | IPR001452 |
| domain | PDZ domain | 140 - 219 | IPR001478 |
| domain | L27 domain | 8 - 121 | IPR004172 |
| domain | Guanylate kinase-like domain | 350 - 537 | IPR008144 |
| domain | Guanylate kinase/L-type calcium channel beta subunit | 349 - 540 | IPR008145 |
| domain | L27 domain, C-terminal | 12 - 63 | IPR014775-1 |
| domain | L27 domain, C-terminal | 69 - 120 | IPR014775-2 |
| conserved_site | Guanylate kinase, conserved site | 385 - 402 | IPR020590 |
| domain | MPP2, SH3 domain | 229 - 287 | IPR035602 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07560 | SEC4 | Ras-related protein SEC4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2HJI8 | RAB8B | Ras-related protein Rab-8B | Bos taurus (Bovine) | PR |
| A4FV54 | RAB8A | Ras-related protein Rab-8A | Bos taurus (Bovine) | PR |
| Q1RMR4 | RAB15 | Ras-related protein Rab-15 | Bos taurus (Bovine) | PR |
| Q5F470 | RAB8A | Ras-related protein Rab-8A | Gallus gallus (Chicken) | PR |
| P61006 | RAB8A | Ras-related protein Rab-8A | Homo sapiens (Human) | PR |
| Q92930 | RAB8B | Ras-related protein Rab-8B | Homo sapiens (Human) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| P0C0E4 | RAB40AL | Ras-related protein Rab-40A-like | Homo sapiens (Human) | PR |
| Q12829 | RAB40B | Ras-related protein Rab-40B | Homo sapiens (Human) | PR |
| Q8WXH6 | RAB40A | Ras-related protein Rab-40A | Homo sapiens (Human) | PR |
| Q96S21 | RAB40C | Ras-related protein Rab-40C | Homo sapiens (Human) | PR |
| Q8CB87 | Rab44 | Ras-related protein Rab-44 | Mus musculus (Mouse) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| P55258 | Rab8a | Ras-related protein Rab-8A | Mus musculus (Mouse) | PR |
| P61028 | Rab8b | Ras-related protein Rab-8B | Mus musculus (Mouse) | PR |
| Q9DD03 | Rab13 | Ras-related protein Rab-13 | Mus musculus (Mouse) | PR |
| Q8VHP8 | Rab40b | Ras-related protein Rab-40B | Mus musculus (Mouse) | PR |
| Q8K386 | Rab15 | Ras-related protein Rab-15 | Mus musculus (Mouse) | PR |
| P35289 | Rab15 | Ras-related protein Rab-15 | Rattus norvegicus (Rat) | PR |
| P35280 | Rab8a | Ras-related protein Rab-8A | Rattus norvegicus (Rat) | PR |
| P70550 | Rab8b | Ras-related protein Rab-8B | Rattus norvegicus (Rat) | PR |
| P35284 | Rab12 | Ras-related protein Rab-12 | Rattus norvegicus (Rat) | PR |
| P35281 | Rab10 | Ras-related protein Rab-10 | Rattus norvegicus (Rat) | PR |
| O24466 | RABE1A | Ras-related protein RABE1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SF91 | RABE1E | Ras-related protein RABE1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZD4 | RABE1D | Ras-related protein RABE1d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGTQGSPVKS | YDYLLKFLLV | GDSDVGKGEI | LESLQDGAAE | SPYAYSNGID | YKTTTILLDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRVKLELWDT | SGQGRFCTIF | RSYSRGAQGI | LLVYDITNRW | SFDGIDRWIK | EIDEHAPGVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RILVGNRLHL | AFKRQVPTEQ | ARAYAEKNCM | TFFEVSPLCN | FNVIESFTEL | SRIVLMRHGM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKIWRPNRVF | SLQDLCCRAI | VSCTPVHLID | KLPLPVTIKS | HLKSFSMANG | MNAVMMHGRS |
| 250 | 260 | 270 | 280 | ||
| YSLASGAGGS | GSKGNSLKRS | KSIRPPQSPP | QNCSRSNCKI | S |