Q8VHA6
Gene name |
Asb18 |
Protein name |
Ankyrin repeat and SOCS box protein 18 |
Names |
ASB-18 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:208372 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VHA6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VHA6-F1 | Predicted | AlphaFoldDB |
26 variants for Q8VHA6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs30342351 | 16 | I>V | No | EVA | |
| rs221293321 | 29 | E>K | No | EVA | |
| rs251248927 | 46 | V>I | No | EVA | |
| rs3388487388 | 48 | E>K | No | EVA | |
| rs3413022404 | 53 | D>V | No | EVA | |
| rs3388486631 | 66 | V>I | No | EVA | |
| rs30344665 | 81 | C>Y | No | EVA | |
| rs3388486291 | 95 | E>G | No | EVA | |
| rs248526865 | 117 | Q>K | No | EVA | |
| rs3388486936 | 139 | L>Q | No | EVA | |
| rs3388486802 | 143 | K>N | No | EVA | |
| rs261777225 | 168 | A>V | No | EVA | |
| rs3390315257 | 172 | L>Q | No | EVA | |
| rs3390294210 | 178 | P>L | No | EVA | |
| rs3388489973 | 190 | H>Y | No | EVA | |
| rs30345543 | 191 | L>Q | No | EVA | |
| rs3390160566 | 211 | V>L | No | EVA | |
| rs3390228574 | 244 | R>P | No | EVA | |
| rs259588048 | 252 | G>S | No | EVA | |
| rs235698167 | 257 | S>G | No | EVA | |
| rs259025067 | 315 | R>Q | No | EVA | |
| rs235040396 | 320 | A>S | No | EVA | |
| rs222966963 | 343 | P>R | No | EVA | |
| rs3388486123 | 375 | Q>R | No | EVA | |
| rs3390301725 | 435 | K>R | No | EVA | |
| rs30345337 | 467 | C>R | No | EVA |
No associated diseases with Q8VHA6
3 regional properties for Q8VHA6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SOCS box domain | 406 - 462 | IPR001496 |
| repeat | Ankyrin repeat | 119 - 213 | IPR002110-1 |
| repeat | Ankyrin repeat | 218 - 325 | IPR002110-2 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04861 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Gallus gallus (Chicken) | SS |
| P98150 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Gallus gallus (Chicken) | SS |
| Q94527 | Rel | Nuclear factor NF-kappa-B p110 subunit | Drosophila melanogaster (Fruit fly) | EV |
| P19838 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (Human) | SS |
| Q99549 | MPHOSPH8 | M-phase phosphoprotein 8 | Homo sapiens (Human) | PR |
| Q00653 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (Human) | SS |
| Q8N9B4 | ANKRD42 | Ankyrin repeat domain-containing protein 42 | Homo sapiens (Human) | PR |
| Q6ZVZ8 | ASB18 | Ankyrin repeat and SOCS box protein 18 | Homo sapiens (Human) | PR |
| Q9CZK6 | Anks3 | Ankyrin repeat and SAM domain-containing protein 3 | Mus musculus (Mouse) | PR |
| P25799 | Nfkb1 | Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | Mus musculus (Mouse) | EV |
| Q9WTK5 | Nfkb2 | Nuclear factor NF-kappa-B p100 subunit [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | Mus musculus (Mouse) | EV |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| O22265 | CAO | Signal recognition particle 43 kDa protein, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZI3 | NPR2 | Regulatory protein NPR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSWDSPPDY | PLSSDIVRRL | KSALATGDED | TVQKLICTEV | EPVDAVIELA | NDDWMKEPSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELPTGVLLGD | LDHIRLLMDQ | CFWDANAVFE | ISNGEMEWQV | TSLATFGLSG | LWTLEYQREL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTPLCIAAAH | GHESCVRHLL | SRKADPNASP | GGRGALHEAC | LGNHTACARL | LLQHGADPDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNSEGLAPLH | LCRTPASLGC | ARELLEHGAT | VQLEGGPGRD | TPLHVAAQRG | LDEHAQLYLG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGARVDARNG | RGETALSAAC | GAAARSPDEH | ARCLRLCALL | LRGGAAADAR | DEDERSPLHK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ACGHARPGLC | TLLLRHGADA | GALDYGGASP | LARALQTATC | APPTAPQRTV | QVLLNHGSRS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VWPDAFPKVL | RTCAQVPEVI | EVLFNSYTQL | PVSESWREAI | PEEVYQMHKP | FYRSLFALAH |
| 430 | 440 | 450 | 460 | ||
| TPRCLQHLCR | CTIRKLFGKE | SVHLVPQLPL | PETLQNYLLL | EPEGVLC |