Q8VE62
Gene name |
Paip1 |
Protein name |
Polyadenylate-binding protein-interacting protein 1 |
Names |
PABP-interacting protein 1, PAIP-1, Poly(A)-binding protein-interacting protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:218693 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VE62
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VE62-F1 | Predicted | AlphaFoldDB |
4 variants for Q8VE62
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389316681 | 109 | N>S | No | EVA | |
| rs3389312768 | 228 | L>M | No | EVA | |
| rs265564832 | 362 | T>A | No | EVA | |
| rs1132239104 | 379 | M>I | No | EVA |
No associated diseases with Q8VE62
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mCRD-mediated mRNA stability complex | A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| translation activator activity | Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| CRD-mediated mRNA stabilization | An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). |
| negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. |
| positive regulation of cytoplasmic translation | Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. |
| regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q95L46 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | Bos taurus (Bovine) | PR |
| O43432 | EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 | Homo sapiens (Human) | EV |
| Q04637 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 | Homo sapiens (Human) | EV |
| P78344 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | Homo sapiens (Human) | PR |
| Q9H074 | PAIP1 | Polyadenylate-binding protein-interacting protein 1 | Homo sapiens (Human) | PR |
| Q6NZJ6 | Eif4g1 | Eukaryotic translation initiation factor 4 gamma 1 | Mus musculus (Mouse) | SS |
| Q80XI3 | Eif4g3 | Eukaryotic translation initiation factor 4 gamma 3 | Mus musculus (Mouse) | SS |
| Q62448 | Eif4g2 | Eukaryotic translation initiation factor 4 gamma 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDSFDRAPE | QTKPQRAPPS | SQDKIPQQNS | ESAMAKPQVV | VAPVLMSKLS | ANAPEFYPSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YSSNYTESYE | DGCEDYPTLS | EYVQDFLNHL | TEQPGSFETE | IEQFAETLNG | WVTTDDALQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVELIYQQAT | SIPNFSYMGA | RLCNYLSHHL | TISPQSGNFR | QLLLQRCRTE | YEAKDQAAKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEVTRKRFHA | FVLFLGELYL | NLEIKGTNGQ | VTRADILQVG | LRELLNALFS | NPMDDNLICA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKLLKLTGSV | LEDTWKEKGK | TDMEEIIQRI | ENVVLDANCS | RDVKQMLLKL | VELRSSNWGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VHATSTYREA | TPENDPNYFM | NEPTFYTSDG | VPFTAADPDY | QEKYQELLER | EDFFPDYEEN |
| 370 | 380 | 390 | |||
| GTDLSGAGDP | YLDDIDDEMD | PEIEEAYEKF | CLESERKRKQ |