Q8VDK3
Gene name |
Elf5 |
Protein name |
ETS-related transcription factor Elf-5 |
Names |
E74-like factor 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13711 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
160-246 (Ets domain) |
Relief mechanism |
PTM, Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VDK3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VDK3-F1 | Predicted | AlphaFoldDB |
11 variants for Q8VDK3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388569067 | 2 | L>F | No | EVA | |
| rs13469465 | 31 | D>E | No | EVA | |
| rs3388577782 | 42 | C>Y | No | EVA | |
| rs27356540 | 44 | S>P | No | EVA | |
| rs3388569066 | 59 | V>I | No | EVA | |
| rs3391975551 | 63 | L>I | No | EVA | |
| rs3391978880 | 63 | L>R | No | EVA | |
| rs3388572627 | 68 | D>G | No | EVA | |
| rs3388572627 | 68 | D>V | No | EVA | |
| rs3388571568 | 130 | K>E | No | EVA | |
| rs13469475 | 218 | S>C | No | EVA |
No associated diseases with Q8VDK3
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| ectoderm development | The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. |
| ectodermal cell fate commitment | The cell differentiation process that results in commitment of a cell to become part of the ectoderm. |
| mammary gland epithelial cell differentiation | The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. |
| negative regulation of cell differentiation involved in embryonic placenta development | Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| somatic stem cell population maintenance | Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. |
| trophoblast giant cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VC65 | ETV6 | Transcription factor ETV6 | Bos taurus (Bovine) | SS |
| Q58DT0 | ELF5 | ETS-related transcription factor Elf-5 | Bos taurus (Bovine) | SS |
| P32519 | ELF1 | ETS-related transcription factor Elf-1 | Homo sapiens (Human) | PR |
| Q99607 | ELF4 | ETS-related transcription factor Elf-4 | Homo sapiens (Human) | PR |
| Q9Y603 | ETV7 | Transcription factor ETV7 | Homo sapiens (Human) | SS |
| P78545 | ELF3 | ETS-related transcription factor Elf-3 | Homo sapiens (Human) | SS |
| P41212 | ETV6 | Transcription factor ETV6 | Homo sapiens (Human) | SS |
| Q9UKW6 | ELF5 | ETS-related transcription factor Elf-5 | Homo sapiens (Human) | EV |
| P97360 | Etv6 | Transcription factor ETV6 | Mus musculus (Mouse) | EV |
| Q60775 | Elf1 | ETS-related transcription factor Elf-1 | Mus musculus (Mouse) | PR |
| Q9Z2U4 | Elf4 | ETS-related transcription factor Elf-4 | Mus musculus (Mouse) | PR |
| Q9JHC9 | Elf2 | ETS-related transcription factor Elf-2 | Mus musculus (Mouse) | PR |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| Q9WTP3 | Spdef | SAM pointed domain-containing Ets transcription factor | Mus musculus (Mouse) | PR |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLDSVTHSTF | LPNASFCDPL | MPWTDLFSNE | DYYPAFEHQT | ACDSYWTSVH | PEYWTKRHVW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EWLQFCCDQY | KLDANCISFC | HFNISGLQLC | SMTQEEFIEA | AGICGEYLYF | ILQNIRSQGY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SFFNDAEETK | TGIKDYADSS | CLKTSGIKSQ | DCHSRTSLQS | SHLWEFVRDL | LLSPEENCGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEWEDREQGI | FRVVKSEALA | KMWGQRKKND | RMTYEKLSRA | LRYYYKTGIL | ERVDRRLVYK |
| 250 | |||||
| FGKNAHGWQE | EKL |