AiPD: Autoinhibited Protein Database

Gene name	Tesk2
Protein name	Dual specificity testis-specific protein kinase 2
Names	Testicular protein kinase 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:230661
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-78 (Predicted disordered autoinhibitory region) PR

1-78 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VCT9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388692348	19	L>V	No	EVA
rs3388705137	20	E>G	No	EVA
rs3388696327	124	G>R	No	EVA
rs3388701633	192	S>Y	No	EVA
rs3388702630	195	V>A	No	EVA
rs3388691300	196	A>S	No	EVA
rs3388701585	197	D>V	No	EVA
rs3388706868	238	D>N	No	EVA
rs3388705110	248	E>D	No	EVA
rs3388691247	274	Q>R	No	EVA
rs3388705646	295	D>E	No	EVA
rs258287514	317	P>S	No	EVA
rs3388702558	359	R>*	No	EVA
rs3388710541	364	L>M	No	EVA
rs3388703717	389	P>L	No	EVA
rs3388699159	394	T>R	No	EVA
rs3388702952	404	A>E	No	EVA
rs3394576091	412	K>*	No	EVA
rs3388682579	426	L>H	No	EVA
rs3388702988	481	P>S	No	EVA
rs3388701572	523	F>L	No	EVA
rs3388703008	561	S>G	No	EVA

Type	Name	Position	InterPro Accession
domain	XPG, N-terminal	1 - 107	IPR006085
domain	XPG-I domain	146 - 233	IPR006086
conserved_site	Helix-hairpin-helix motif, class 2	220 - 253	IPR008918
conserved_site	XPG conserved site	79 - 93	IPR019974-1
conserved_site	XPG conserved site	149 - 163	IPR019974-2

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
focal adhesion assembly	The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53667	LIMK1	LIM domain kinase 1	Homo sapiens (Human)	PR
P53671	LIMK2	LIM domain kinase 2	Homo sapiens (Human)	PR
Q96S53	TESK2	Dual specificity testis-specific protein kinase 2	Homo sapiens (Human)	PR
O54785	Limk2	LIM domain kinase 2	Mus musculus (Mouse)	PR
Q924U5	Tesk2	Dual specificity testis-specific protein kinase 2	Rattus norvegicus (Rat)	PR
Q8RWW0	ALE2	Receptor-like serine/threonine-protein kinase ALE2	Arabidopsis thaliana (Mouse-ear cress)	PR
P93050	BSH	Probable LRR receptor-like serine/threonine-protein kinase RKF3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SCZ4	FER	Receptor-like protein kinase FERONIA	Arabidopsis thaliana (Mouse-ear cress)	PR