Q8VCH9

PR
Gene name
Lrrc3b (Lrp15)
Protein name
Leucine-rich repeat-containing protein 3B
Names
Leucine-rich repeat protein 15
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:218763
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VCH9

Entry ID Method Resolution Chain Position Source
AF-Q8VCH9-F1 Predicted AlphaFoldDB

22 variants for Q8VCH9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389316728 34 C>R No EVA
rs3389233909 41 S>Y No EVA
rs3389305358 54 N>Y No EVA
rs3389279659 80 P>H No EVA
rs3389289651 86 D>N No EVA
rs3389308895 90 L>Q No EVA
rs3389303440 116 Q>R No EVA
rs3404546509 129 H>P No EVA
rs3404816529 130 K>* No EVA
rs3404760817 135 N>Y No EVA
rs3389305398 153 L>I No EVA
rs3389304341 161 A>V No EVA
rs3389300866 175 S>* No EVA
rs3389321387 181 A>D No EVA
rs3410685698 183 R>G No EVA
rs3389298596 185 F>L No EVA
rs3389233938 190 N>K No EVA
rs3404546531 218 I>T No EVA
rs3404008544 243 P>L No EVA
rs3404676026 244 S>G No EVA
rs3404931782 246 Q>E No EVA
rs3389298676 247 K>R No EVA

No associated diseases with Q8VCH9

6 regional properties for Q8VCH9

Type Name Position InterPro Accession
domain Leucine-rich repeat N-terminal domain 33 - 68 IPR000372
repeat Leucine-rich repeat 69 - 111 IPR001611-1
repeat Leucine-rich repeat 114 - 136 IPR001611-2
repeat Leucine-rich repeat, typical subtype 67 - 86 IPR003591-1
repeat Leucine-rich repeat, typical subtype 87 - 110 IPR003591-2
repeat Leucine-rich repeat, typical subtype 115 - 135 IPR003591-3

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6H789 LRRC3B Leucine-rich repeat-containing protein 3B Bos taurus (Bovine) PR
Q8IWK6 ADGRA3 Adhesion G protein-coupled receptor A3 Homo sapiens (Human) PR
Q96PB8 LRRC3B Leucine-rich repeat-containing protein 3B Homo sapiens (Human) PR
Q7TT36 Adgra3 Adhesion G protein-coupled receptor A3 Mus musculus (Mouse) PR
Q9D1T0 Lingo1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MNLVDLWLSR SLSMCLLLQS FVLMILCFHS ASMCPKGCLC SSSGGLNVTC SNANLKEIPR
70 80 90 100 110 120
DLPPETVLLY LDSNQITSIP NEIFKDLHQL RVLNLSKNGI EFIDEHAFKG VAETLQTLDL
130 140 150 160 170 180
SDNRIQSVHK NAFNNLKARA RIANNPWHCD CTLQQVLRSM ASNHETAHNV ICKTSVLDEH
190 200 210 220 230 240
AGRPFLNAAN DADLCNLPKK TTDYAMLVTM FGWFTMVISY VVYYVRQNQE DARRHLEYLK
250
SLPSRQKKAD EPDDISTVV