Q8VBY2

PR
Gene name
Camkk1 (Camkk)
Protein name
Calcium/calmodulin-dependent protein kinase kinase 1
Names
CaM-KK 1, CaM-kinase kinase 1, CaMKK 1, CaM-kinase IV kinase, Calcium/calmodulin-dependent protein kinase kinase alpha, CaM-KK alpha, CaM-kinase kinase alpha, CaMKK alpha
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:55984
EC number
2.7.11.17: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

292-315 (Activation loop from InterPro)

Target domain

128-409 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8VBY2

Entry ID Method Resolution Chain Position Source
AF-Q8VBY2-F1 Predicted AlphaFoldDB

26 variants for Q8VBY2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389114904 3 S>N No EVA
rs3389181148 30 E>D No EVA
rs3389183482 43 D>E No EVA
rs3389170386 44 P>A No EVA
rs3389183499 44 P>H No EVA
rs3389139810 46 P>H No EVA
rs3389178568 58 A>D No EVA
rs3389181162 81 G>V No EVA
rs3389177225 84 L>P No EVA
rs3389188462 86 A>G No EVA
rs3389139792 105 R>L No EVA
rs3389151833 110 E>* No EVA
rs3402421665 186 P>S No EVA
rs3389177267 217 V>I No EVA
rs3389181099 272 V>I No EVA
rs3389177202 285 D>E No EVA
rs3402421679 287 G>R No EVA
rs3389114985 316 F>L No EVA
rs3402056398 322 I>M No EVA
rs3401792299 323 S>T No EVA
rs3402196371 323 S>Y No EVA
rs3402589869 363 R>H No EVA
rs3389191569 377 E>* No EVA
rs3389188421 392 K>M No EVA
rs3389173228 450 V>I No EVA
rs3389177268 491 K>T No EVA

No associated diseases with Q8VBY2

3 regional properties for Q8VBY2

Type Name Position InterPro Accession
domain Protein kinase domain 128 - 409 IPR000719
active_site Serine/threonine-protein kinase, active site 271 - 283 IPR008271
binding_site Protein kinase, ATP binding site 134 - 157 IPR017441

Functions

Description
EC Number 2.7.11.17 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity.
protein phosphorylation The process of introducing a phosphate group on to a protein.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96RR4 CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens (Human) PR
Q8N5S9 CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 Homo sapiens (Human) SS
Q8C078 Camkk2 Calcium/calmodulin-dependent protein kinase kinase 2 Mus musculus (Mouse) PR
Q8CIP4 Mark4 MAP/microtubule affinity-regulating kinase 4 Mus musculus (Mouse) SS
Q8VHJ5 Mark1 Serine/threonine-protein kinase MARK1 Mus musculus (Mouse) SS
Q05512 Mark2 Serine/threonine-protein kinase MARK2 Mus musculus (Mouse) SS
Q8CEE6 Pask PAS domain-containing serine/threonine-protein kinase Mus musculus (Mouse) SS
Q03141 Mark3 MAP/microtubule affinity-regulating kinase 3 Mus musculus (Mouse) SS
10 20 30 40 50 60
MESGPAVCCQ DPRAELVDRV AAINVAHLEE ADEGPEPARN GVDPPPRARA ASVIPGSASR
70 80 90 100 110 120
PTPVRPSLSA RKFSLQERPA GSCLGAQVGP YSTGPASHIS PRSWRRPTIE SHRVAISDTE
130 140 150 160 170 180
DCVQLNQYKL QSEIGKGAYG VVRLAYNESE DRHYAMKVLS KKKLLKQYGF PRRPPPRGSQ
190 200 210 220 230 240
ATQGGPAKQL LPLERVYQEI AILKKLDHVN VVKLIEVLDD PAEDNLYLVF DLLRKGPVME
250 260 270 280 290 300
VPCDKPFPEE QARLYLRDII LGLEYLHCQK IVHRDIKPSN LLLGDDGHVK IADFGVSNQF
310 320 330 340 350 360
EGNDAQLSST AGTPAFMAPE AISDSGQSFS GKALDVWATG VTLYCFVYGK CPFIDDYILT
370 380 390 400 410 420
LHRKIKNEAV VFPEEPEVSE DLKDLILRML DKNPETRIGV SDIKLHPWVT KHGEEPLPSE
430 440 450 460 470 480
EEHCSVVEVT EEEVKNSVRL IPSWTTVILV KSMLRKRSFG NPFEPQARRE ERSMSAPGSL
490 500
LMKEGCGEGC KSPELPGVQE DEAAS