AiPD: Autoinhibited Protein Database

Q8TE76

Gene name	MORC4 (ZCW4, ZCWCC2)
Protein name	MORC family CW-type zinc finger protein 4
Names	Zinc finger CW-type coiled-coil domain protein 2 , Zinc finger CW-type domain protein 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

420-472 (CW domain) SS

Target domain	38-307 (C-terminal ATPase domain)
Relief mechanism	Partner binding
Assay

AID

420-472 (CW domain)

Target domain

38-307 (C-terminal ATPase domain)

Relief mechanism

Partner binding (Binding of CW domain to histone H3 tail)

Assay

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Zhang Y et al. (2019) "Mechanism for autoinhibition and activation of the MORC3 ATPase", Proceedings of the National Academy of Sciences of the United States of America, 116, 6111-6119

Zhang Y et al. (2019) "MORC3 Is a Target of the Influenza A Viral Protein NS1", Structure (London, England : 1993), 27, 1029-1033.e3

Zhang Y et al. (2019) "MORC3 Forms Nuclear Condensates through Phase Separation", iScience, 17, 182-189

Autoinhibited structure

Activated structure

2 structures for Q8TE76

Entry ID	Method	Resolution	Chain	Position	Source
7K7T	X-ray	294 A	A/B	29-486	PDB
AF-Q8TE76-F1	Predicted				AlphaFoldDB

478 variants for Q8TE76

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel rs759643903	1	M>?	Variant assessed as Somatic; 0.0 impact. Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413826550 rs1391236025	2	L>V		No	ClinGen TOPMed
CA333029400 rs866406477	6	G>E		No	ClinGen Ensembl
CA10484183 rs761899546	7	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10484181 rs768563476	8	P>L		No	ClinGen ExAC gnomAD
rs1321574236 CA413826319	10	G>R		No	ClinGen TOPMed
CA413826244 rs1351796664	12	G>A		No	ClinGen TOPMed
CA413826189 rs1409910384	15	G>D		No	ClinGen TOPMed
CA10484179 rs780536050	17	G>R		No	ClinGen ExAC TOPMed gnomAD
rs770202249 CA10484178	18	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1237287621 CA413826056	20	R>W		No	ClinGen TOPMed
CA413825985 rs1230695993	23	G>S		No	ClinGen TOPMed gnomAD
rs1602515378 CA413825953	24	G>A		No	ClinGen Ensembl
CA413825796 rs1211842691	31	R>H		No	ClinGen gnomAD
rs1393165487 CA413825604	38	R>G		No	ClinGen TOPMed gnomAD
CA333029359 rs376089604	38	R>H		No	ClinGen ESP TOPMed
CA413825520 rs1191868515	41	Q>H		No	ClinGen gnomAD
CA333029317 CA10484169 rs765243603	45	S>R		No	ClinGen ExAC gnomAD
rs1233720736 CA413825452	45	S>T		No	ClinGen gnomAD
CA413825430 rs1436254848	46	S>N		No	ClinGen gnomAD
rs1282943835 CA413825393	48	T>M		No	ClinGen gnomAD
CA413825386 rs1419622188	49	R>Q		No	ClinGen gnomAD
rs1235457210 CA413825361	51	F>L		No	ClinGen gnomAD
TCGA novel	61	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	61	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413823309 rs1176646393	61	A>V		No	ClinGen gnomAD
rs770257615 CA10484160	62	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10484159 rs746337047	64	P>L		No	ClinGen ExAC
rs972834159 CA333026180	70	T>A		No	ClinGen TOPMed gnomAD
rs374661200 CA10484157	70	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1569309451 CA413822926	73	I>M		No	ClinGen Ensembl
TCGA novel	76	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413822786 rs1305698962	78	V>I		No	ClinGen gnomAD
rs1221552288 CA413822550	82	S>C		No	ClinGen TOPMed gnomAD
rs777274791 CA10484155	86	F>L		No	ClinGen ExAC TOPMed gnomAD
CA413822404 rs1288839901	88	D>A		No	ClinGen gnomAD
CA10484152 rs375777883	88	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs753768943 CA10484150	96	H>P		No	ClinGen ExAC gnomAD
rs766203494 CA10484149	99	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs370972961 CA10484147	100	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA413820153 rs1287035593	105	G>C		No	ClinGen gnomAD
TCGA novel	105	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1349468110 CA413820100	107	T>A		No	ClinGen TOPMed
rs1221763330 CA413820014	109	K>E		No	ClinGen TOPMed
rs747310435 CA10484138	110	V>I		No	ClinGen ExAC gnomAD
rs772957150 CA10484137	111	I>V		No	ClinGen ExAC gnomAD
CA413819905 rs1461141438	112	K>Q		No	ClinGen gnomAD
CA10484135 rs200086481	114	S>R		No	ClinGen ExAC TOPMed gnomAD
CA10484134 rs202090135	115	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	117	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754473466 CA10484133	118	I>T		No	ClinGen ExAC
CA413819334 rs1261706056	123	N>D		No	ClinGen gnomAD
rs779842475 CA10484131	129	S>T		No	ClinGen ExAC gnomAD
rs1212501397 CA413818949	133	G>R		No	ClinGen gnomAD
rs758644429 CA10484128	135	D>E		No	ClinGen ExAC TOPMed gnomAD
rs772136688 CA413818751	136	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772136688 CA10484126	136	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10484125 rs765364667	141	K>R		No	ClinGen ExAC TOPMed gnomAD
CA413818392 rs1293094322	142	N>S		No	ClinGen gnomAD
CA10484123 rs777239435	143	G>E		No	ClinGen ExAC gnomAD
CA10484122 rs188311784	144	G>V		No	ClinGen 1000Genomes ExAC
CA413818248 rs1371577648	146	L>V		No	ClinGen gnomAD
rs761203934 CA10484121	150	L>I		No	ClinGen ExAC gnomAD
CA333023039 rs865943957	161	A>S		No	ClinGen Ensembl
CA413817503 rs1388924663	163	A>G		No	ClinGen gnomAD
CA413817455 rs1300102854	165	I>V		No	ClinGen gnomAD
CA413817354 rs1462635445	166	V>A		No	ClinGen gnomAD
CA10484119 rs200674942	168	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA333023000 rs1052404028	170	P>L		No	ClinGen TOPMed gnomAD
CA413817225 rs1052404028	170	P>Q		No	ClinGen TOPMed gnomAD
TCGA novel	172	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10484116 rs768341641	172	N>K		No	ClinGen ExAC gnomAD
CA10484117 rs755868962	172	N>S		No	ClinGen ExAC TOPMed gnomAD
rs748784874 CA10484115	175	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	177	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	178	M>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358621294 CA413815584	178	M>I		No	ClinGen TOPMed
TCGA novel	178	M>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10484106 rs755086686	179	I>T		No	ClinGen ExAC gnomAD
rs1213312931 CA413815548	179	I>V		No	ClinGen gnomAD
CA413815456 rs1365067980	181	T>S		No	ClinGen gnomAD
CA10484103 rs773446384	182	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10484104 rs773446384	182	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs750874612 CA10484102	183	D>E		No	ClinGen ExAC gnomAD
CA413815417 rs1194750690	183	D>G		No	ClinGen TOPMed
CA413815427 rs1333819638	183	D>N		No	ClinGen TOPMed gnomAD
rs1212835875 CA413815338	186	P>S		No	ClinGen gnomAD
CA413815254 rs1185777322	190	A>V		No	ClinGen TOPMed
CA10484098 rs762257593	196	I>V		No	ClinGen ExAC gnomAD
CA10484097 rs201795914	199	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10484095 rs762630243	199	R>H		No	ClinGen ExAC TOPMed gnomAD
rs201795914 CA10484096	199	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774889617 CA10484094	201	N>Y		No	ClinGen ExAC gnomAD
rs745800625 CA10484092	202	D>E		No	ClinGen ExAC gnomAD
CA10484093 rs769292722	202	D>V		No	ClinGen ExAC
rs756872914 CA10484091	205	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10484090 rs756872914	205	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	210	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413815032 rs1158680358	211	P>L		No	ClinGen TOPMed gnomAD
CA10484087 rs755215424	212	G>D		No	ClinGen ExAC TOPMed gnomAD
CA413815025 rs1569307132	213	K>E		No	ClinGen Ensembl
TCGA novel	215	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1381720212 CA413815000	216	T>S		No	ClinGen TOPMed
rs780001500 COSM1112696 CA10484085	217	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1243506228 CA413814961	222	N>S		No	ClinGen TOPMed
rs750951386 COSM1112694 CA10484083	224	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10484082 rs201028568	224	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	228	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs923885248 CA333020756	230	K>R		No	ClinGen TOPMed
rs200553710 CA333020755	237	T>A		No	ClinGen Ensembl
rs1289419139 CA413813473	238	D>N		No	ClinGen gnomAD
rs780310889 CA413813410	239	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs756198498 CA10484062	240	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs375934444 CA10484060	246	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1415184286 CA413812963	251	E>G		No	ClinGen TOPMed
rs769361272 CA10484059	253	M>V		No	ClinGen ExAC TOPMed gnomAD
rs371544849 CA413812838	256	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs371544849 CA10484058	256	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs752338272 CA10484055	257	V>I		No	ClinGen ExAC gnomAD
TCGA novel	260	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745438076 CA10484053	262	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	270	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	271	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413812189 rs1340711447	272	C>Y		No	ClinGen gnomAD
CA413812071 rs1260015530	276	Y>H		No	ClinGen gnomAD
rs148426245 CA333020555	280	R>C		No	ClinGen ESP gnomAD
CA413811966 COSM1112690 rs1366297708	280	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1366297708 CA413811968	280	R>L		No	ClinGen TOPMed gnomAD
CA10484037 rs758727540	281	M>R		No	ClinGen ExAC gnomAD
CA10484038 rs772694245	281	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	283	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413811805 rs1327984355	286	R>C		No	ClinGen TOPMed gnomAD
CA413811748 rs1377261133	288	K>T		No	ClinGen gnomAD
CA10484034 rs754668553	290	V>L		No	ClinGen ExAC gnomAD
rs200387180 CA10484033	292	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	294	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760164998 CA10484031	295	I>T		No	ClinGen ExAC
CA413811361 rs1181985045	300	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	301	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10484028 rs761617610	304	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1482287650 CA413811257	304	Y>H		No	ClinGen gnomAD
rs1301147645 CA413811182	306	T>A		No	ClinGen TOPMed
CA10484027 rs374513815	307	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA10484026 rs374513815	307	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA413810391 rs1191324790	315	Q>H		No	ClinGen gnomAD
CA413810400 rs1270665455	315	Q>L		No	ClinGen TOPMed
rs764018747 COSM1315096 CA10484009	317	R>K	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA413810340 rs764018747	317	R>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	318	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	322	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778848235 CA10484008	325	K>N		No	ClinGen 1000Genomes ExAC
rs41304048 CA10484007	326	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10484005 rs771305678	327	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM325839 rs1431303713 CA413809930	328	N>K	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	339	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	342	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA333019388 rs961640852	343	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA10484002 rs138558505	347	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	348	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	349	C>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	351	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767691764 CA10483982	355	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10483981 rs147526562	355	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1555987438 CA413807495	358	G>D		No	ClinGen Ensembl
TCGA novel	358	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413807484 rs1555987438	358	G>V		No	ClinGen Ensembl
CA413807473 rs1286152454	359	V>I		No	ClinGen TOPMed
CA413807225 rs1417064222	365	I>M		No	ClinGen gnomAD
TCGA novel	367	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774960888 CA10483980	368	N>D		No	ClinGen ExAC gnomAD
TCGA novel	372	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1569304470 CA413806800	373	A>T		No	ClinGen Ensembl
rs796076640 CA333018927	380	E>D		No	ClinGen Ensembl
rs775847903 CA10483977	381	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	382	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413806149 rs1208905259	383	K>T		No	ClinGen gnomAD
CA333018920 rs368696490	384	E>K		No	ClinGen ESP
CA413806062 rs1204923525	386	R>Q		No	ClinGen gnomAD
rs770079478 CA10483976	386	R>W		No	ClinGen ExAC gnomAD
rs1437082414 CA413801861	389	I>K		No	ClinGen gnomAD
rs769101240 CA10483966	389	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1377720151 CA413801844	390	N>H		No	ClinGen TOPMed gnomAD
rs922146019 CA333014616	390	N>S		No	ClinGen gnomAD
CA10483965 rs767604089	391	A>T		No	ClinGen ExAC gnomAD
CA10483964 rs762054423	394	Q>E		No	ClinGen ExAC gnomAD
rs878920098 CA333014614	397	N>S		No	ClinGen gnomAD
TCGA novel	399	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA333014610 rs1002826564	403	K>Q		No	ClinGen TOPMed
CA413801306 rs1569299980	404	T>K		No	ClinGen Ensembl
TCGA novel	404	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1569299970 CA413801040	411	T>N		No	ClinGen Ensembl
CA413801027 rs1161160840	412	S>A		No	ClinGen TOPMed
CA10483959 rs200458251	418	I>T		No	ClinGen ExAC gnomAD
CA413800858 rs1256711768	418	I>V		No	ClinGen gnomAD
CA10483957 rs182603689	419	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs770204274 CA10483958	419	P>S		No	ClinGen ExAC TOPMed gnomAD
rs754842058 CA10483949	420	K>R		No	ClinGen ExAC gnomAD
rs977037318 CA333013735	422	P>R		No	ClinGen TOPMed
rs753605913 CA10483948	423	D>G		No	ClinGen ExAC gnomAD
rs779850091 CA10483947	424	Q>E		No	ClinGen ExAC
TCGA novel	437	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1286891358 CA413797552	438	L>I		No	ClinGen gnomAD
rs751715446 CA10483945	439	P>L		No	ClinGen ExAC gnomAD
CA413797486 rs1255229176	441	K>N		No	ClinGen gnomAD
CA10483944 rs764227066	442	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763010461 CA10483943	446	M>L		No	ClinGen ExAC gnomAD
TCGA novel	447	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320578188 CA413797069	454	Y>C		No	ClinGen TOPMed gnomAD
rs1047010299 CA333013721	457	S>F		No	ClinGen Ensembl
CA333013718 rs867578297	458	H>Y		No	ClinGen Ensembl
rs1257220742 CA413796856	459	P>R		No	ClinGen TOPMed
rs760051460 CA10483940	461	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	462	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	464	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1161220719 CA413837866	464	C>S		No	ClinGen gnomAD
rs765907166 CA10483930	465	S>C		No	ClinGen ExAC gnomAD
rs779719638 CA10483929	466	V>L		No	ClinGen ExAC gnomAD
rs1189361882 CA413837793	467	P>Q		No	ClinGen gnomAD
TCGA novel	471	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413837646 rs1448956118	472	L>F		No	ClinGen TOPMed gnomAD
CA413837638 rs1251803437	472	L>P		No	ClinGen TOPMed
rs6622126 CA10483928 VAR_051197	473	T>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	480	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413837383 rs1326913813	483	K>N		No	ClinGen gnomAD
CA413837380 rs1452349148	484	K>E		No	ClinGen gnomAD
rs1289673236 CA413837371	484	K>R		No	ClinGen gnomAD
CA10483926 rs777953037	485	Q>*		No	ClinGen ExAC gnomAD
rs1484247673 CA413837231	486	E>Q		No	ClinGen TOPMed gnomAD
rs148107538 CA10483915	489	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413837139 rs1267875589	490	E>K		No	ClinGen Ensembl
rs1340599081 CA413837106	491	E>K		No	ClinGen gnomAD
rs1219301419 CA413837027	493	K>R		No	ClinGen TOPMed gnomAD
CA413836931 rs1234579325	497	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA333037473 rs1007015574	499	N>S		No	ClinGen TOPMed
rs1179028378 CA413836820	500	E>D		No	ClinGen TOPMed gnomAD
CA10483912 rs746224109	500	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413836794 rs768146179	501	N>K		No	ClinGen ExAC TOPMed gnomAD
rs756647130 CA10483898	506	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1329400761 CA413836481	506	S>N		No	ClinGen gnomAD
CA413836457 rs1287530460	507	N>K		No	ClinGen gnomAD
CA413836433 rs1376156100	509	P>T		No	ClinGen gnomAD
rs145964427 CA10483897	510	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA413836358 rs1250096876	512	L>F		No	ClinGen TOPMed
CA333036943 rs1006166350	514	V>I		No	ClinGen Ensembl
CA413836247 CA413836250 rs1381320290	517	M>I		No	ClinGen TOPMed gnomAD
CA413836244 rs775673203	518	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10483896 rs775673203	518	A>T		No	ClinGen ExAC TOPMed gnomAD
CA333036921 rs961751082	519	G>E		No	ClinGen TOPMed gnomAD
rs774049936 CA10483894	523	K>N		No	ClinGen ExAC TOPMed gnomAD
CA10483895 rs761562654	523	K>R		No	ClinGen ExAC TOPMed gnomAD
rs992380886 CA333036879	525	I>N		No	ClinGen TOPMed gnomAD
rs992380886 CA413836093	525	I>T		No	ClinGen TOPMed gnomAD
rs762505495 CA10483892	534	S>I		No	ClinGen ExAC
rs1472730697 CA413835860	536	L>F		No	ClinGen gnomAD
rs769758497 CA10483890	537	P>A		No	ClinGen ExAC gnomAD
CA413835812 rs1569297657	538	S>F		No	ClinGen Ensembl
rs1210027263 CA413835779	540	G>V		No	ClinGen gnomAD
CA10483889 rs745761067	541	E>Q		No	ClinGen ExAC gnomAD
CA333036845 rs968776176	543	S>C		No	ClinGen Ensembl
CA413835700 rs1206372705	544	R>G		No	ClinGen gnomAD
CA413835683 rs1323288616	544	R>S		No	ClinGen gnomAD
CA10483887 rs201996274	548	L>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413835618 rs201996274	548	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1001835653 CA333036841	552	P>L		No	ClinGen TOPMed
CA10483886 rs748424034	552	P>T		No	ClinGen ExAC gnomAD
rs868172752 CA333036837	554	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1313092831 CA413835503	555	S>F		No	ClinGen gnomAD
rs866010532 CA333036825	559	Q>*		No	ClinGen Ensembl
rs779171684 CA10483885	559	Q>L		No	ClinGen ExAC gnomAD
CA413835413 rs1225765945	560	F>L		No	ClinGen TOPMed
CA10483884 rs140475018	561	S>F		No	ClinGen ESP ExAC TOPMed
CA10483882 rs779948361	562	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10483867 rs368894756	564	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs766797993 CA10483866	565	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413833552 rs1602470725	567	I>T		No	ClinGen Ensembl
CA10483863 rs763475705	580	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1028799843 CA333030933	583	M>V		No	ClinGen Ensembl
rs746436169 CA413833215	585	T>A		No	ClinGen ExAC TOPMed gnomAD
rs746436169 CA10483862	585	T>P		No	ClinGen ExAC TOPMed gnomAD
rs373175644 CA333030915	586	P>R		No	ClinGen ESP TOPMed gnomAD
CA10483861 rs781759399	586	P>S		No	ClinGen ExAC gnomAD
rs773185595 CA10483860	588	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs751987859 CA10483859	589	D>G		No	ClinGen ExAC gnomAD
COSM3843136 rs777953821 CA10483858	591	S>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA413833048 rs1305677524	592	M>I		No	ClinGen gnomAD
CA10483857 rs758086567	592	M>V		No	ClinGen ExAC gnomAD
CA10483856 rs752283079	594	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1274059994 CA413832993	595	P>S		No	ClinGen TOPMed gnomAD
rs1225323672 CA413832927	598	R>M		No	ClinGen gnomAD
rs997684975 CA333030878	601	A>S		No	ClinGen gnomAD
TCGA novel	601	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769964255 CA10483854	603	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs769964255 CA10483853	603	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA413832825 rs1386366383	604	A>S		No	ClinGen gnomAD
rs766332990 CA10483852	604	A>V		No	ClinGen ExAC gnomAD
CA413832785 rs760479375	606	P>S		No	ClinGen ExAC TOPMed gnomAD
rs760479375 CA10483851	606	P>T		No	ClinGen ExAC TOPMed gnomAD
rs773071665 CA10483850	607	E>K		No	ClinGen ExAC gnomAD
CA10483849 rs146759137	610	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs887390217 CA333030845	612	H>R		No	ClinGen TOPMed
TCGA novel	613	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775843057 CA10483847	613	D>N		No	ClinGen ExAC gnomAD
CA413832596 rs1389070754	613	D>V		No	ClinGen TOPMed
rs745913872 CA413832544	615	S>*		No	ClinGen ExAC gnomAD
rs745913872 CA10483845	615	S>W		No	ClinGen ExAC gnomAD
TCGA novel	618	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781383076 CA10483844	621	T>I		No	ClinGen ExAC gnomAD
CA413832306 rs1249507219	626	F>S		No	ClinGen gnomAD
CA333030825 rs1049139040	627	P>S		No	ClinGen Ensembl
CA413832200 rs1289739994	632	A>S		No	ClinGen gnomAD
rs974423904 CA333030810	634	K>E		No	ClinGen TOPMed gnomAD
TCGA novel rs1425376092 CA413832149	634	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
CA10483842 rs747420751	635	N>S		No	ClinGen ExAC gnomAD
rs1415418189 CA413832126	636	T>A		No	ClinGen TOPMed
rs1175715893 CA413832104	637	G>D		No	ClinGen TOPMed
rs916072091 CA333030802	638	Q>*		No	ClinGen Ensembl
CA413832090 rs1404346181	638	Q>R		No	ClinGen TOPMed
CA333030801 CA10483841 rs778208181	639	N>K		No	ClinGen ExAC TOPMed gnomAD
CA10483840 rs143431283	642	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs938785488 CA333030797	644	I>V		No	ClinGen TOPMed
rs752392465 CA10483839	646	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	646	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778517827 CA413831917	649	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10483837 rs778517827	649	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1602470370 CA413831907	649	A>V		No	ClinGen Ensembl
CA413831854 rs1346758621	652	Q>R		No	ClinGen gnomAD
rs3827464 VAR_051198 CA10483835	653	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10483834 rs557687749	653	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10483833 rs557687749	653	R>L		No	ClinGen ExAC TOPMed gnomAD
CA413831763 rs1390374443	658	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA333030746 rs867787418	659	P>S		No	ClinGen Ensembl
CA10483831 rs201599144	664	D>N		No	ClinGen ExAC TOPMed gnomAD
CA333030693 rs768854498	664	D>V		No	ClinGen 1000Genomes
CA10483830 rs761480604	667	P>S		No	ClinGen ExAC gnomAD
TCGA novel	668	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413831551 rs1423952294	669	L>F		No	ClinGen gnomAD
CA10483828 rs765577077	671	A>T		No	ClinGen ExAC gnomAD
CA413831477 rs1200301381	674	S>C		No	ClinGen TOPMed
rs1257013454 CA413831485	674	S>P		No	ClinGen gnomAD
TCGA novel	677	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759788793 CA10483827	677	G>C		No	ClinGen ExAC gnomAD
CA10483826 rs113069970	677	G>D		No	ClinGen ExAC TOPMed gnomAD
CA413831414 rs1209524618	678	S>N		No	ClinGen TOPMed gnomAD
CA413831385 rs1427687424	680	T>A		No	ClinGen TOPMed
CA413831379 rs1328940608	680	T>I		No	ClinGen gnomAD
TCGA novel	680	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770854711 CA10483825	683	K>N		No	ClinGen ExAC gnomAD
CA413831304 rs1341560680	684	E>G		No	ClinGen TOPMed gnomAD
CA413831302 rs1341560680	684	E>V		No	ClinGen TOPMed gnomAD
rs1399025642	685	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10483823 rs747622368	686	V>F		No	ClinGen ExAC TOPMed gnomAD
CA413831257 rs1390123816	687	N>H		No	ClinGen gnomAD
CA10483821 rs772539216	687	N>S		No	ClinGen ExAC gnomAD
rs775067298 CA333030659	688	K>E		No	ClinGen Ensembl
rs375823957 CA10483820	690	P>S		No	ClinGen ESP ExAC gnomAD
CA333030624 rs1001805311	693	A>D		No	ClinGen Ensembl
rs754631888 CA10483818	701	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	703	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA333030623 rs368221432	704	S>P		No	ClinGen ESP TOPMed
rs1281582548 CA413830876	706	A>T		No	ClinGen TOPMed
rs1014615306 CA333030617	706	A>V		No	ClinGen Ensembl
CA10483817 rs748882023	717	E>G		No	ClinGen ExAC TOPMed gnomAD
CA413830473 rs1228731741	722	R>*		No	ClinGen TOPMed
rs149926328 CA10483816	722	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149926328 CA10483815	722	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000963051 CA10483813 rs139105737	724	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1282642818 CA413830259	731	V>M		No	ClinGen gnomAD
rs763911048 CA10483810	733	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA10483811 rs751428354	733	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA10483809 rs374994174	734	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371512357 CA10483808	736	A>D		No	ClinGen ESP ExAC gnomAD
CA413830152 rs1366782137	736	A>P		No	ClinGen gnomAD
CA10483806 rs150736453	737	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs766524626 CA10483807	737	S>P		No	ClinGen ExAC gnomAD
TCGA novel	737	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10483805 rs773297227	738	A>V		No	ClinGen ExAC gnomAD
CA10483804 rs772489097	739	A>V		No	ClinGen ExAC gnomAD
rs1431495462 CA413830046	741	P>L		No	ClinGen gnomAD
CA10483801 rs768995845	743	A>T		No	ClinGen ExAC gnomAD
CA10483799 rs779541314	745	I>F		No	ClinGen ExAC TOPMed gnomAD
CA10483798 rs367972076	745	I>T		No	ClinGen ESP ExAC gnomAD
CA413829904 rs1347249313	747	E>K		No	ClinGen TOPMed gnomAD
rs1602469934 CA413829839	749	A>T		No	ClinGen Ensembl
rs1452550546 CA413829816	750	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1602469912 CA413829700	754	E>Q		No	ClinGen Ensembl
CA413829607 rs1344911422	757	G>R		No	ClinGen gnomAD
CA413829575 rs1274790317	758	H>Y		No	ClinGen gnomAD
CA10483795 rs562728763	761	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1301552971 CA413829461	762	K>E		No	ClinGen TOPMed
TCGA novel	762	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413829415 rs1410214330	764	K>E		No	ClinGen TOPMed
rs758240772 CA10483793	765	N>K		No	ClinGen ExAC TOPMed gnomAD
rs373809376 CA10483791	766	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA333030454 rs140250327	767	R>G		No	ClinGen ESP
TCGA novel	769	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	769	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766534510 CA10483790	770	E>K		No	ClinGen ExAC TOPMed gnomAD
rs760914591 CA10483789	775	T>S		No	ClinGen ExAC gnomAD
CA10483787 rs767577259	781	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1409462881 CA413828979	781	R>H		No	ClinGen TOPMed gnomAD
rs1409462881 CA413828975	781	R>L		No	ClinGen TOPMed gnomAD
CA333030412 rs866132253	785	E>K		No	ClinGen Ensembl
CA413828874 rs1417383143	787	N>I		No	ClinGen gnomAD
CA413828862 rs1483215552	788	L>S		No	ClinGen TOPMed
rs765658731 CA10483775	793	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1358097824 CA413828499	804	Q>R		No	ClinGen gnomAD
rs752469091 CA10483773	806	E>D		No	ClinGen ExAC gnomAD
CA10483772 rs778704993	808	K>R		No	ClinGen ExAC gnomAD
TCGA novel	810	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413828376 rs1260877464	811	Q>L		No	ClinGen gnomAD
CA413828378 rs1260877464	811	Q>R		No	ClinGen gnomAD
CA333030117 rs1054897898	812	H>N		No	ClinGen gnomAD
rs1283240824 CA413828353	812	H>R		No	ClinGen gnomAD
CA413828359 rs1054897898	812	H>Y		No	ClinGen gnomAD
CA10483769 rs147139519	816	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA413828287 rs1222056988	816	I>T		No	ClinGen gnomAD
rs921868590 CA333030073	818	S>R		No	ClinGen Ensembl
CA413828184 rs1453458029	821	E>D		No	ClinGen gnomAD
rs975991683 CA333030066	822	A>T		No	ClinGen TOPMed
CA10483767 rs752110087	822	A>V		No	ClinGen ExAC TOPMed gnomAD
rs764607177 CA10483766	824	G>S		No	ClinGen ExAC gnomAD
CA413828135 rs1389902102	824	G>V		No	ClinGen gnomAD
CA10483765 rs763409410	831	H>D		No	ClinGen ExAC gnomAD
rs944590601 CA333030024	832	M>I		No	ClinGen gnomAD
CA10483764 rs371210479	832	M>L		No	ClinGen ESP ExAC gnomAD
CA10483763 rs199503317	834	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413827940 rs1202359493	835	R>C		No	ClinGen TOPMed
rs759166614 CA10483762	835	R>H		No	ClinGen ExAC gnomAD
rs1190132829 CA413827916	836	Q>H		No	ClinGen gnomAD
rs1465053937 CA413827911	837	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10483761 rs776338713	839	F>C		No	ClinGen ExAC gnomAD
CA413827727 rs1270520427	848	R>G		No	ClinGen TOPMed
CA413827722 rs1465408882	848	R>K		No	ClinGen TOPMed
CA413827696 rs1569293200	849	T>I		No	ClinGen Ensembl
CA10483758 rs777380445	852	E>G		No	ClinGen ExAC gnomAD
CA413827618 rs1475776367	854	Q>E		No	ClinGen gnomAD
CA333030002 rs983245129	854	Q>R		No	ClinGen gnomAD
TCGA novel	855	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259737947 CA413827507	860	L>V		No	ClinGen TOPMed
rs1437597311 CA413827477	862	E>K		No	ClinGen TOPMed gnomAD
CA413827457 rs1362914073	863	T>A		No	ClinGen gnomAD
rs1199822347 CA413827431	864	E>D		No	ClinGen TOPMed
CA10483757 rs772143288	865	T>A		No	ClinGen ExAC gnomAD
CA413827416 rs1351911254	866	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	873	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	874	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413827223 rs1169909272	877	Y>H		No	ClinGen gnomAD
CA333029984 rs1027390567	878	R>Q		No	ClinGen TOPMed gnomAD
rs183174102 CA10483755	878	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA413827169 rs1184346481	880	P>L		No	ClinGen TOPMed gnomAD
CA413827155 rs1247027303	881	E>G		No	ClinGen gnomAD
CA413826792 rs1253905220	893	T>M		No	ClinGen TOPMed gnomAD
CA10483736 rs760339925	894	R>Q		No	ClinGen ExAC gnomAD
rs747662628 CA10483737	894	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1202750739 CA413826728	896	R>C		No	ClinGen gnomAD
rs772865513 COSM1112644 CA10483735	896	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA413826694 rs1284406230	897	I>V		No	ClinGen gnomAD
rs139334870 CA10483733	899	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	905	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10483731 rs774315028	906	V>I		No	ClinGen ExAC
rs768385656 CA10483730	907	L>P		No	ClinGen ExAC gnomAD
TCGA novel	910	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780806565 CA10483728	913	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs996642540 CA333029799	915	I>T		No	ClinGen Ensembl
rs201132616 CA10483727	915	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10483725 rs777885263	917	Y>F		No	ClinGen ExAC
rs1423891899 CA413825972	918	D>G		No	ClinGen TOPMed
CA333029766 rs112419924	918	D>Y		No	ClinGen Ensembl
CA10483724 rs758497821	919	S>L		No	ClinGen ExAC gnomAD
CA413825770 rs1382835285	927	Y>C		No	ClinGen TOPMed
TCGA novel	927	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10483723 rs753180310	928	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1182460757 CA413825730	929	V>A		No	ClinGen gnomAD
CA413825736 rs1371591842	929	V>L		No	ClinGen TOPMed
rs755404195 CA10483721	931	E>A		No	ClinGen ExAC
rs754261305 CA10483720	933	N>D		No	ClinGen ExAC gnomAD
TCGA novel	933	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413825613 rs1175555676	935	I>V		No	ClinGen TOPMed gnomAD

No associated diseases with Q8TE76

4 regional properties for Q8TE76

Type	Name	Position	InterPro Accession
domain	CLASP N-terminal domain	94 - 311	IPR024395
domain	TOG domain	90 - 323	IPR034085-1
domain	TOG domain	640 - 877	IPR034085-2
domain	TOG domain	1043 - 1274	IPR034085-3

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
ATP hydrolysis activity	Catalysis of the reaction
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.
zinc ion binding	Binding to a zinc ion (Zn).

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y6X9	MORC2	ATPase MORC2	Homo sapiens (Human)	PR
Q14149	MORC3	MORC family CW-type zinc finger protein 3	Homo sapiens (Human)	EV
F7BJB9	Morc3	MORC family CW-type zinc finger protein 3	Mus musculus (Mouse)	SS
Q69ZX6	Morc2a	ATPase MORC2A	Mus musculus (Mouse)	PR
Q8C5W4	Morc2b	ATPase MORC2B	Mus musculus (Mouse)	PR
Q8BMD7	Morc4	MORC family CW-type zinc finger protein 4	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MLLYRGAPAG	PGAPGCGLAR	PGGGPQAFGI	RLSTMSPRYL	QSNSSSHTRP	FSAIAELLDN
70	80	90	100	110	120
AVDPDVSART	VFIDVEEVKN	KSCLTFTDDG	CGMTPHKLHR	MLSFGFTDKV	IKKSQCPIGV
130	140	150	160	170	180
FGNGFKSGSM	RLGKDALVFT	KNGGTLTVGL	LSQTYLECVQ	AQAVIVPIVP	FNQQNKKMII
190	200	210	220	230	240
TEDSLPSLEA	ILNYSIFNRE	NDLLAQFDAI	PGKKGTRVLI	WNIRRNKNGK	SELDFDTDQY
250	260	270	280	290	300
DILVSDFDTE	EKMTGGVTSE	LPETEYSLRA	FCGILYMKPR	MKIFLRQKKV	TTQMIAKSLA
310	320	330	340	350	360
NVEYDTYKPT	FTNKQVRITF	GFSCKNSNQF	GIMMYHNNRL	IKSFEKVGCQ	VKPTRGEGVG
370	380	390	400	410	420
VIGVIECNFL	KPAYNKQDFE	YTKEYRLTIN	ALAQKLNAYW	KEKTSQDNFE	TSTVARPIPK
430	440	450	460	470	480
VPDQTWVQCD	ECLKWRKLPG	KIDPSMLPAR	WFCYYNSHPK	YRRCSVPEEQ	ELTDEDLCLS
490	500	510	520	530	540
KAKKQEQTVE	EKKKMPMENE	NHQVFSNPPK	ILTVQEMAGL	NNKTIGYEGI	HSPSVLPSGG
550	560	570	580	590	600
EESRSPSLQL	KPLDSSVLQF	SSKYKWILGE	EPVEKRRRLQ	NEMTTPSLDY	SMPAPYRRVE
610	620	630	640	650	660
APVAYPEGEN	SHDKSSSERS	TPPYLFPEYP	EASKNTGQNR	EVSILYPGAK	DQRQGSLLPE
670	680	690	700	710	720
ELEDQMPRLV	AEESNRGSTT	INKEEVNKGP	FVAVVGVAKG	VRDSGAPIQL	IPFNREELAE
730	740	750	760	770	780
RRKAVESWNP	VPYSVASAAI	PAAAIGEKAR	GYEESEGHNT	PKLKNQRELE	ELKRTTEKLE
790	800	810	820	830	840
RVLAERNLFQ	QKVEELEQER	NHWQSEFKKV	QHELVIYSTQ	EAEGLYWSKK	HMGYRQAEFQ
850	860	870	880	890	900
ILKAELERTK	EEKQELKEKL	KETETHLEML	QKAQVSYRTP	EGDDLERALA	KLTRLRIHVS
910	920	930
YLLTSVLPHL	ELREIGYDSE	QVDGILYTVL	EANHILD