AiPD: Autoinhibited Protein Database

Q8TD08

Gene name	MAPK15 (ERK7, ERK8)
Protein name	Mitogen-activated protein kinase 15
Names	MAP kinase 15 , MAPK 15 , EC 2.7.11.24 , Extracellular signal-regulated kinase 7 , ERK-7 , Extracellular signal-regulated kinase 8 , ERK-8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:225689
EC number	2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.

Autoinhibitory domains (AIDs)

62-139 (Autoinhibitory region) SS

Target domain	13-304 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

62-139 (Autoinhibitory region)

Target domain

13-304 (Protein kinase domain)

Relief mechanism

PTM (Autophosphorylation at Thr-186 and Tyr-193)

Assay

Accessory elements

154-182 (Activation loop from InterPro)

Target domain	13-304 (Protein kinase domain)
Relief mechanism
Assay

References

Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6

Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79

Autoinhibited structure

Activated structure

1 structures for Q8TD08

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8TD08-F1	Predicted				AlphaFoldDB

773 variants for Q8TD08

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	C>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs782418120	2	C>G		No	ExAC gnomAD
rs781981331	2	C>Y		No	ExAC TOPMed gnomAD
rs1817808688	3	T>A		No	TOPMed
rs782125539	3	T>N		No	ExAC gnomAD
rs1554618339	4	V>I		No	TOPMed gnomAD
rs1554618339	4	V>L		No	TOPMed gnomAD
rs781838103	5	V>A		No	ExAC gnomAD
rs1817809105	5	V>M		No	TOPMed
rs1817809268	6	D>N		No	Ensembl
rs1554618342	7	P>L		No	TOPMed gnomAD
rs566655293	7	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs782796586	8	R>H		No	ExAC TOPMed gnomAD
rs782796586	8	R>P		No	ExAC TOPMed gnomAD
rs781910262	10	V>A		No	ExAC gnomAD
rs1466321532	10	V>L		No	TOPMed gnomAD
rs782506286	11	R>G		No	ExAC TOPMed gnomAD
rs782665000	11	R>L		No	ExAC TOPMed gnomAD
rs782665000	11	R>Q		No	ExAC TOPMed gnomAD
rs782506286	11	R>W		No	ExAC TOPMed gnomAD
rs1554618349	14	L>V		No	gnomAD
rs1554618350	15	L>V		No	gnomAD
rs1229849959	16	R>K		No	TOPMed gnomAD
rs1229849959	16	R>M		No	TOPMed gnomAD
rs1817810963	17	R>Q		No	Ensembl
rs1817811133	18	Q>*		No	gnomAD
rs1554618355	19	L>F		No	gnomAD
rs782185635	20	G>E		No	ExAC TOPMed gnomAD
rs372568132	22	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs372568132	22	G>W		No	1000Genomes ExAC TOPMed gnomAD
rs1422448305	24	Y>C		No	TOPMed
rs1554618624	24	Y>H		No	TOPMed gnomAD
rs1387050462	25	G>V		No	Ensembl
rs1817864110	27	V>A		No	Ensembl
rs1554618630	28	W>R		No	gnomAD
rs368510105	30	A>S		No	ESP ExAC TOPMed gnomAD
rs368510105	30	A>T		No	ESP ExAC TOPMed gnomAD
rs1817864719	31	V>A		No	Ensembl
rs201487703	33	R>P		No	1000Genomes ExAC TOPMed gnomAD
COSM5154214 rs201487703 COSM5154215 COSM1455378	33	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs782266146	33	R>W		No	ExAC TOPMed gnomAD
rs369747564	35	T>I		No	ESP ExAC TOPMed gnomAD
rs369747564	35	T>N		No	ESP ExAC TOPMed gnomAD
rs1554618638	36	G>D		No	gnomAD
rs45495391	36	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782155652	37	E>K		No	ExAC gnomAD
TCGA novel	38	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs141770552	39	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141770552	39	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1554618647	40	A>S		No	TOPMed gnomAD
rs1554618647	40	A>T		No	TOPMed gnomAD
rs1330750361	40	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs782744203	41	I>V		No	ExAC gnomAD
rs1402900498	42	K>N		No	gnomAD
rs1554618654	42	K>R		No	gnomAD
rs200988940	43	K>E		No	ESP ExAC TOPMed gnomAD
rs1554618658	43	K>N		No	gnomAD
rs1554618659	44	I>T		No	TOPMed gnomAD
rs1563747801	44	I>V		No	Ensembl
rs782692408	47	A>G		No	ExAC gnomAD
rs1303501721	48	F>I		No	TOPMed gnomAD
rs781856933	48	F>L		No	ExAC gnomAD
rs1554618666	48	F>S		No	gnomAD
rs782534074	49	R>K		No	ExAC gnomAD
rs1817868043	49	R>W		No	TOPMed gnomAD
rs1554618672	50	D>G		No	gnomAD
rs1554618672	50	D>V		No	gnomAD
rs62639973	50	D>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs963384644	52	T>I		No	Ensembl
rs963384644	52	T>K		No	Ensembl
rs1417282610	52	T>S		No	TOPMed
rs1554618674	53	D>N		No	gnomAD
rs61999265	54	A>P		No	Ensembl
rs534219216	55	Q>*		No	1000Genomes ExAC TOPMed gnomAD
rs199893934	58	F>S		No	1000Genomes ExAC gnomAD
rs199893934	58	F>Y		No	1000Genomes ExAC gnomAD
rs139756179	59	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs139756179	59	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs139756179	59	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1472791961	59	R>W		No	TOPMed gnomAD
rs781795310	60	E>D		No	ExAC TOPMed gnomAD
rs782072550	61	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs35285081	62	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs140665680	63	L>I		No	ESP ExAC TOPMed gnomAD
COSM5156906 COSM5156907 COSM3698880	64	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs782476914	65	Q>R		No	ExAC gnomAD
rs1817887894	66	E>G		No	Ensembl
rs782229599	69	D>A		No	ExAC TOPMed gnomAD
COSM3924796 COSM3924795 rs368587017	69	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1817888341	71	P>T		No	TOPMed
rs1554618795	72	N>Y		No	gnomAD
rs1817888529	73	I>V		No	TOPMed gnomAD
rs1554618798	74	I>S		No	TOPMed gnomAD
rs1554618798	74	I>T		No	TOPMed gnomAD
rs1007823961	75	S>G		No	gnomAD
rs371919512	75	S>N		No	gnomAD
rs150084866	77	L>F		No	ESP ExAC TOPMed gnomAD
rs782589792	77	L>P		No	ExAC gnomAD
rs782589792	77	L>R		No	ExAC gnomAD
rs140275267	79	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140275267	79	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1554618804	80	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs202055248	81	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs145380962	81	R>Q		No	ESP ExAC TOPMed gnomAD
rs202055248	81	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1554618810	82	A>T		No	gnomAD
rs372576345	83	E>D		No	ESP ExAC TOPMed
rs782709774	83	E>G		No	ExAC gnomAD
COSM3834193 COSM3834194 rs1817890476 COSM5223281	83	E>Q	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1817890905	85	D>N		No	TOPMed
rs782791906	86	R>G		No	ExAC gnomAD
rs1554618814	86	R>K		No	gnomAD
rs781819421	87	D>E		No	ExAC TOPMed gnomAD
rs782695220	88	I>T		No	ExAC gnomAD
rs782097030	88	I>V		No	ExAC gnomAD
rs781805477	89	Y>*		No	ExAC TOPMed gnomAD
COSM1137833	89	Y>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM6112666 COSM6112667 COSM6112665	90	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1554618823	92	F>C		No	gnomAD
rs376608201	93	E>K		No	ESP ExAC TOPMed gnomAD
rs376608201	93	E>Q		No	ESP ExAC TOPMed gnomAD
rs1817893069	94	F>Y		No	TOPMed
rs202182231	95	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs782666661	95	M>K		No	ExAC gnomAD
rs1817893209	95	M>L		No	TOPMed gnomAD
rs782017320	97	T>N		No	ExAC gnomAD
rs1221490409	97	T>S		No	gnomAD
rs368459044	99	L>P		No	ESP ExAC TOPMed gnomAD
rs1554619009	99	L>V		No	gnomAD
rs137986185	100	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200374933	101	A>T		No	1000Genomes ExAC gnomAD
rs782745530	101	A>V		No	ExAC TOPMed gnomAD
rs1330321676	102	V>I		No	TOPMed gnomAD
rs1446788544	103	I>T		No	TOPMed
rs782069530	104	R>P		No	ExAC TOPMed gnomAD
rs782069530	104	R>Q		No	ExAC TOPMed gnomAD
rs781924461	104	R>W		No	ExAC TOPMed gnomAD
rs1817915989	105	K>T		No	TOPMed
rs375622398	107	G>C		No	ESP ExAC TOPMed gnomAD
TCGA novel	107	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs375622398	107	G>S		No	ESP ExAC TOPMed gnomAD
rs142584947	110	Q>*		No	ESP ExAC TOPMed gnomAD
rs1587435496	111	D>A		No	TOPMed
COSM4886894 COSM4886892 COSM4886893 rs371795375	112	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs371795375	112	V>L		No	ESP ExAC TOPMed gnomAD
rs1563749075	113	H>L		No	Ensembl
rs1587435523	113	H>N		No	Ensembl
rs143159328	113	H>Q		No	ESP ExAC TOPMed gnomAD
rs375351575	114	V>L		No	ESP ExAC TOPMed gnomAD
rs375351575	114	V>M		No	ESP ExAC TOPMed gnomAD
rs782627573	115	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs782627573	115	R>G		No	ExAC TOPMed gnomAD
rs782256408	115	R>H		No	ExAC TOPMed gnomAD
rs782256408	115	R>P		No	ExAC TOPMed gnomAD
rs781979662	116	S>A		No	ExAC gnomAD
rs1817918084	116	S>F		No	1000Genomes
rs1817918084	116	S>Y		No	1000Genomes
rs1817918248	118	F>C		No	Ensembl
rs1446908975	119	Y>*		No	TOPMed gnomAD
rs1381466575	121	L>V		No	TOPMed
rs782330605	122	L>P		No	ExAC gnomAD
rs1359322005	123	R>Q		No	gnomAD
rs782018613	123	R>W		No	ExAC TOPMed gnomAD
rs1817919230	124	A>T		No	Ensembl
rs1587435642	124	A>V		No	TOPMed
rs1554619045	125	T>I		No	TOPMed gnomAD
rs1554619045	125	T>N		No	TOPMed gnomAD
rs1554619045	125	T>S		No	TOPMed gnomAD
rs200419870	126	R>G		No	ExAC gnomAD
rs782765700	126	R>P		No	ExAC TOPMed gnomAD
rs782765700	126	R>Q		No	ExAC TOPMed gnomAD
rs200419870	126	R>W		No	ExAC gnomAD
rs148275086	128	L>V		No	ESP ExAC TOPMed gnomAD
rs1159840336	129	H>R		No	TOPMed
rs1817920145	129	H>Y		No	Ensembl
rs376624672	130	S>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1817920434	130	S>A		No	Ensembl
rs376624672	130	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs376624672	130	S>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs369347726	131	G>E		No	ESP ExAC
rs1241673004	132	H>N		No	TOPMed gnomAD
rs781085667	132	H>Q		No	ExAC TOPMed gnomAD
rs1445014452	133	V>A		No	TOPMed gnomAD
rs782816703	133	V>F		No	ExAC TOPMed gnomAD
rs782816703	133	V>I		No	ExAC TOPMed gnomAD
rs781847113	134	V>M		No	ExAC TOPMed gnomAD
rs1817922265	135	H>P		No	Ensembl
rs577107750	136	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs782239626	136	R>P		No	ExAC TOPMed gnomAD
rs782239626	136	R>Q		No	ExAC TOPMed gnomAD
rs577107750	136	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1379485239	137	D>N		No	TOPMed gnomAD
rs1817923018	138	Q>P		No	Ensembl
rs1554619062	139	K>N		No	gnomAD
rs201842849	140	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201842849	140	P>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141386839	142	N>S		No	ESP ExAC TOPMed gnomAD
rs1554619103	144	L>P		No	gnomAD
rs1258256206	146	D>G		No	TOPMed
rs782303554	146	D>N		No	ExAC TOPMed gnomAD
rs782007334	147	A>T		No	ExAC TOPMed gnomAD
rs1554619112	147	A>V		No	gnomAD
rs1554619115	149	C>R		No	gnomAD
rs1387927057	149	C>Y		No	TOPMed gnomAD
rs1373230950	150	T>I		No	TOPMed gnomAD
rs1449038197	151	V>G		No	TOPMed
rs782084585	151	V>M		No	ExAC TOPMed gnomAD
rs1817930351	154	C>G		No	TOPMed gnomAD
rs1817930351	154	C>R		No	TOPMed gnomAD
rs939199478	154	C>Y		No	TOPMed gnomAD
rs1554619124	156	F>S		No	gnomAD
rs782761300	159	A>V		No	ExAC gnomAD
rs781932698	160	R>C		No	ExAC TOPMed gnomAD
rs782145185	160	R>H		No	ExAC gnomAD
rs782145185	160	R>P		No	ExAC gnomAD
rs990589322	161	S>Y		No	Ensembl
rs139710965	162	L>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1817931855	163	G>D		No	TOPMed
rs1817932208	164	D>G		No	gnomAD
rs200023367	164	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs200023367	164	D>Y		No	1000Genomes ExAC TOPMed gnomAD
rs1202680423	166	P>A		No	TOPMed gnomAD
rs782281793	166	P>H		No	ExAC TOPMed gnomAD
rs782281793	166	P>L		No	ExAC TOPMed gnomAD
rs1202680423	166	P>S		No	TOPMed gnomAD
rs1817932760	167	E>A		No	Ensembl
rs2131576498	167	E>D		No	Ensembl
rs147489825	167	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1554619144	168	G>E		No	TOPMed gnomAD
rs1554619142	168	G>R		No	gnomAD
rs1554619149	169	P>R		No	gnomAD
rs1554619148	169	P>S		No	gnomAD
rs1305431321	170	E>K		No	TOPMed
COSM1097004	171	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1817933793	171	D>V		No	Ensembl
rs868943271	172	Q>H		No	Ensembl
rs1242926386	173	A>T		No	TOPMed gnomAD
rs782347920	174	V>L		No	ExAC TOPMed gnomAD
rs782347920	174	V>M		No	ExAC TOPMed gnomAD
rs781973633	176	E>D		No	ExAC TOPMed gnomAD
rs1817934823	177	Y>C		No	TOPMed gnomAD
rs1554619163	177	Y>H		No	gnomAD
rs1817935263	178	V>A		No	gnomAD
rs782401024	178	V>M		No	ExAC TOPMed gnomAD
rs1040261746	179	A>T		No	TOPMed gnomAD
rs898611815	180	T>I		No	TOPMed gnomAD
rs1441429589	180	T>P		No	TOPMed gnomAD
rs782030603	181	R>C		No	ExAC TOPMed gnomAD
rs569840820	181	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs1587436762	182	W>*		No	Ensembl
rs1554619175	182	W>*		No	gnomAD
rs868953006	183	Y>*		No	TOPMed gnomAD
rs782787552	184	R>*		No	ExAC TOPMed gnomAD
rs781945350	184	R>Q		No	ExAC TOPMed gnomAD
COSM4833484 COSM4833483 COSM4833482	185	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1355038243	185	A>T		No	TOPMed
COSM4833194 rs1314484085 COSM4833195 COSM4833196	185	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs145373239	186	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1554619188	187	E>*		No	gnomAD
TCGA novel	187	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3412806	188	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1313643632	188	V>M		No	TOPMed gnomAD
rs1817939213	190	L>F		No	gnomAD
rs1817939541	191	S>C		No	Ensembl
RCV000970192 rs151138393	192	S>*		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs151138393	192	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs142470971	192	S>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140242632	193	H>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140242632	193	H>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782604678	194	R>*		No	1000Genomes ExAC TOPMed gnomAD
rs782604678	194	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs371133489	194	R>L		No	ESP ExAC TOPMed gnomAD
rs371133489	194	R>Q		No	ESP ExAC TOPMed gnomAD
rs1817952898	196	T>N		No	Ensembl
rs1554619239	197	L>F		No	gnomAD
rs1817953303	198	G>A		No	Ensembl
rs1181216964	198	G>R		No	Ensembl
rs1199581734	200	D>N		No	TOPMed gnomAD
rs1199581734	200	D>Y		No	TOPMed gnomAD
rs145318696	201	M>L		No	ESP ExAC TOPMed gnomAD
rs1817953744	201	M>T		No	TOPMed
rs1277674170	202	W>*		No	TOPMed gnomAD
rs376558180	203	S>I		No	ESP ExAC TOPMed gnomAD
rs376558180	203	S>N		No	ESP ExAC TOPMed gnomAD
rs1817953985	203	S>R		No	Ensembl
rs546536937	204	L>P		No	1000Genomes ExAC TOPMed gnomAD
rs1554619245	205	G>V		No	gnomAD
rs782083079	206	C>R		No	ExAC TOPMed gnomAD
rs782083079	206	C>S		No	ExAC TOPMed gnomAD
COSM3432191 COSM5075898 COSM5075897	207	I>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1275326332	207	I>V		No	TOPMed gnomAD
rs1554619247	208	L>P		No	gnomAD
rs1554619253	209	G>E		No	gnomAD
rs1554619252	209	G>W		No	Ensembl
rs782812161	210	E>D		No	ExAC TOPMed gnomAD
rs1447136347	210	E>K		No	gnomAD
rs1554619258	211	M>I		No	gnomAD
rs568305959	211	M>V		No	1000Genomes ExAC TOPMed gnomAD
rs782727860	213	R>G		No	ExAC TOPMed gnomAD
rs149683519	213	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs149683519	213	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs149683519	213	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM5874046 COSM5874047 COSM5874045 rs782727860	213	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs201456897	214	G>A		No	ExAC TOPMed gnomAD
rs201456897	214	G>E		No	ExAC TOPMed gnomAD
rs1554619266	214	G>R		No	gnomAD
TCGA novel	215	R>D	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs782270731	216	P>H		No	ExAC TOPMed gnomAD
rs782270731	216	P>L		No	ExAC TOPMed gnomAD
rs782627103	218	F>L		No	ExAC TOPMed gnomAD
rs1279035071	219	P>L		No	TOPMed gnomAD
rs1817957939	220	G>D		No	Ensembl
rs149319950	220	G>S		No	ESP ExAC TOPMed gnomAD
VAR_061535 rs60732298	221	T>K		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs60732298	221	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1554619284	222	S>C		No	gnomAD
rs1554619284	222	S>F		No	gnomAD
rs139010308	222	S>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs887221716	223	T>I		No	TOPMed gnomAD
rs1817958906	223	T>P		No	TOPMed
rs1554619285	225	H>Y		No	TOPMed gnomAD
rs782683762	228	E>*		No	ExAC gnomAD
rs1360149895	228	E>D		No	TOPMed gnomAD
rs781936157	229	L>V		No	ExAC TOPMed gnomAD
rs1817960310	232	E>D		No	Ensembl
rs1817960420	233	T>S		No	TOPMed
rs938761772	235	P>A		No	TOPMed gnomAD
rs537644016 COSM3646105	235	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs938761772	235	P>S		No	TOPMed gnomAD
rs1554619298	236	P>A		No	gnomAD
rs541074717	236	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1554619298	236	P>S		No	gnomAD
rs782737151	237	P>L		No	ExAC gnomAD
rs1817961497	238	S>F		No	TOPMed
rs1411697307	239	E>*		No	TOPMed gnomAD
rs781843826	239	E>D		No	ExAC gnomAD
rs1411697307	239	E>K		No	TOPMed gnomAD
rs1183861827	240	E>D		No	gnomAD
rs1554619307	240	E>G		No	gnomAD
rs553319137	240	E>K		No	1000Genomes ExAC gnomAD
rs528920791	241	D>E		No	1000Genomes ExAC TOPMed gnomAD
rs199791564	241	D>N		No	1000Genomes
rs1817992627	242	L>R		No	Ensembl
rs781867379	242	L>V		No	ExAC gnomAD
rs1817992913	243	L>R		No	Ensembl
rs1554619386	244	A>P		No	gnomAD
rs1817993105	245	L>R		No	TOPMed gnomAD
rs139970630	246	G>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs868912726	246	G>D		No	gnomAD
rs139970630	246	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs782688684	247	S>L		No	ExAC TOPMed gnomAD
rs782661800	248	G>S		No	ExAC gnomAD
rs1554619391	249	C>Y		No	gnomAD
rs997051631	250	R>C		No	TOPMed gnomAD
rs201691605	250	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs201691605	250	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs782373413	251	A>T		No	ExAC gnomAD
rs782662984	251	A>V		No	ExAC TOPMed gnomAD
rs781924012	255	H>Q		No	ExAC TOPMed gnomAD
rs1198716435	256	Q>H		No	TOPMed gnomAD
rs533253499	258	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs533253499	258	G>V		No	1000Genomes ExAC TOPMed gnomAD
rs1554619404	258	G>W		No	gnomAD
TCGA novel	259	S>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1374231584	260	R>Q		No	TOPMed gnomAD
rs35925379	260	R>W		No	ESP ExAC TOPMed gnomAD
rs1818019661	261	P>L		No	Ensembl
rs1307409405	261	P>T		No	Ensembl
rs781788165	262	R>*		No	ExAC TOPMed gnomAD
rs200749268	262	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200749268	262	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200749268	262	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782674568	263	Q>*		No	ExAC gnomAD
rs782674568	263	Q>E		No	ExAC gnomAD
rs375159276	263	Q>R		No	ESP ExAC TOPMed gnomAD
rs1554619519	264	T>A		No	gnomAD
rs146609910	264	T>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs146609910	264	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782365722	267	A>V		No	ExAC gnomAD
rs921217130	268	L>P		No	Ensembl
rs782408799	270	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs782408799	270	P>Q		No	1000Genomes ExAC TOPMed gnomAD
rs201757970	273	T>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782397609	273	T>I		No	ExAC gnomAD
rs1554619533	274	S>A		No	TOPMed gnomAD
rs782048909	276	E>D		No	ExAC
rs782714237	279	D>E		No	ExAC gnomAD
rs1563751271	280	L>F		No	Ensembl
rs782159938	283	R>*		No	ExAC TOPMed gnomAD
rs782747708	283	R>Q		No	ExAC TOPMed gnomAD
rs1554619530	284	L>H		No	gnomAD
rs781866712	284	L>P		No	ExAC gnomAD
rs369904060	285	L>P		No	ESP ExAC TOPMed gnomAD
rs782459313	285	L>V		No	ExAC TOPMed
rs782463656	288	A>T		No	ExAC gnomAD
rs141379949	289	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782674293	289	P>S		No	ExAC TOPMed gnomAD
rs1818024710	290	D>G		No	gnomAD
rs782214797	292	R>P		No	ExAC TOPMed gnomAD
rs782214797	292	R>Q		No	ExAC TOPMed gnomAD
rs185466475	292	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1554619552	293	L>S		No	gnomAD
rs1554619553	294	S>N		No	gnomAD
rs573414435 COSM2868588	295	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs56108642	295	A>V		No	ESP ExAC TOPMed gnomAD
rs1554619555	296	T>A		No	gnomAD
rs1554619555	296	T>P		No	gnomAD
rs782127092	298	A>S		No	ExAC gnomAD
rs781840822	299	L>P		No	ExAC TOPMed gnomAD
rs782055425	300	Q>R		No	ExAC gnomAD
rs782712274	301	H>Q		No	ExAC gnomAD
rs781894574	302	P>S		No	ExAC gnomAD
rs781894574	302	P>T		No	ExAC gnomAD
rs1554619566	303	Y>H		No	gnomAD
rs782636164	304	V>M		No	ExAC TOPMed gnomAD
COSM4402314 rs781873894	305	Q>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1554619571	306	R>T		No	gnomAD
rs1818036190	308	H>Q		No	TOPMed gnomAD
rs782032208	308	H>Y		No	ExAC TOPMed gnomAD
rs782250538	310	P>L		No	ExAC TOPMed gnomAD
rs1818036720	311	S>C		No	gnomAD
rs781962011	312	D>N		No	ExAC TOPMed gnomAD
rs1334413737	313	E>G		No	TOPMed gnomAD
rs782711436	313	E>K		No	ExAC gnomAD
rs782711436	313	E>Q		No	ExAC gnomAD
rs1331223887	314	W>*		No	gnomAD
rs1818037376	314	W>*		No	Ensembl
rs1006151943	315	A>P		No	Ensembl
rs1006151943	315	A>S		No	Ensembl
rs782012920	316	R>*		No	ExAC gnomAD
COSM3646106 rs370712189	316	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs374078550	317	E>K		No	ESP ExAC TOPMed gnomAD
rs1818038339	318	A>T		No	TOPMed gnomAD
rs1395734151	318	A>V		No	TOPMed gnomAD
rs1554619635	319	D>G		No	gnomAD
rs1554619640	320	V>G		No	gnomAD
rs1554619639	320	V>M		No	gnomAD
rs200452806	321	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs374324527	321	R>Q		No	ESP ExAC TOPMed gnomAD
rs200452806	321	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs62639971	323	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs550675679	323	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1280398379	324	A>G		No	TOPMed
rs781830005	324	A>P		No	ExAC TOPMed gnomAD
rs781830005	324	A>T		No	ExAC TOPMed gnomAD
rs1280398379	324	A>V		No	TOPMed
rs782666864	325	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs782213458	326	E>K		No	ExAC TOPMed gnomAD
rs782213458	326	E>Q		No	ExAC TOPMed gnomAD
rs1554619665	327	G>E		No	gnomAD
rs1563751735	327	G>R		No	Ensembl
rs1554619665	327	G>V		No	gnomAD
rs1563751762	329	Q>H		No	gnomAD
rs1554619669	329	Q>P		No	TOPMed gnomAD
rs1348014005	330	L>F		No	TOPMed gnomAD
rs1281676712	332	V>G		No	TOPMed gnomAD
rs782573653	332	V>L		No	ExAC gnomAD
rs782573653	332	V>M		No	ExAC gnomAD
rs2131581418	333	P>A		No	Ensembl
rs1818041702	334	E>K		No	gnomAD
COSM3778970	334	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs375851848	336	R>C		No	ESP ExAC TOPMed gnomAD
rs770418939	336	R>H		No	ExAC TOPMed gnomAD
rs782338338	338	R>C		No	ExAC TOPMed gnomAD
rs61736746	338	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs781894709	339	V>D		No	ExAC TOPMed gnomAD
rs375345657 COSM3715967	339	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs375345657	339	V>L		No	ESP ExAC TOPMed gnomAD
rs1159344009	341	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1159344009	341	Q>K		No	TOPMed gnomAD
rs369273867	341	Q>R		No	ESP TOPMed gnomAD
rs782644613	344	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs782644613	344	L>Q		No	ExAC gnomAD
rs994047847	345	E>D		No	TOPMed gnomAD
rs373530648	345	E>K		No	ESP TOPMed
TCGA novel	345	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781818035	346	C>G		No	ExAC TOPMed gnomAD
rs781818035	346	C>R		No	ExAC TOPMed gnomAD
rs1335880546	346	C>Y		No	TOPMed gnomAD
rs1587441537	348	G>S		No	Ensembl
rs2131581809	349	S>G		No	Ensembl
rs782192249	349	S>R		No	ExAC gnomAD
rs1270785054	351	G>D		No	TOPMed
rs374408984	351	G>S		No	ESP ExAC TOPMed gnomAD
rs782390868	352	T>I		No	ExAC TOPMed gnomAD
rs782390868	352	T>N		No	ExAC TOPMed gnomAD
rs201591856 COSM1097005	353	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1818052557	354	R>K		No	TOPMed
rs1818052755	355	E>G		No	TOPMed
rs1554619751	355	E>K		No	TOPMed gnomAD
TCGA novel	356	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs782315097	357	G>A		No	ExAC TOPMed gnomAD
rs34410761	358	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs34410761	358	P>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1097006	359	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1818053478	360	G>D		No	TOPMed
rs200752759	360	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs1818053670	362	S>A		No	gnomAD
rs1554619772	362	S>F		No	gnomAD
rs1818053670	362	S>P		No	gnomAD
rs1554619777	363	P>A		No	gnomAD
rs374153139	364	S>N		No	ESP ExAC TOPMed gnomAD
rs1554619781	366	A>V		No	gnomAD
rs1818054751	367	H>Q		No	TOPMed
rs1563752106	367	H>Y		No	Ensembl
rs782444194	369	H>Q		No	ExAC TOPMed gnomAD
rs1554619782	369	H>R		No	gnomAD
rs1818055017	370	K>I		No	TOPMed
rs140439631	373	A>P		No	1000Genomes ESP TOPMed gnomAD
rs375630764	373	A>V		No	Ensembl
rs371482487 COSM3897475	374	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs782652619	374	D>V		No	ExAC gnomAD
rs371482487	374	D>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM4420539	378	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	379	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs374710085	380	R>K		No	ESP ExAC TOPMed gnomAD
rs371318944	381	T>I		No	ESP ExAC TOPMed gnomAD
rs56241827	381	T>P		No	ESP ExAC TOPMed gnomAD
rs1818056542	382	P>R		No	Ensembl
rs1441915059	382	P>S		No	TOPMed gnomAD
rs782182358	383	V>A		No	ExAC gnomAD
rs1818056738	383	V>L		No	gnomAD
rs1368115277	384	Q>*		No	TOPMed gnomAD
rs34115313	385	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs781980773	385	G>C		No	ExAC TOPMed gnomAD
rs34115313	385	G>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs781980773	385	G>S		No	ExAC TOPMed gnomAD
rs367851658	386	P>R		No	ESP TOPMed gnomAD
rs1554619795	386	P>T		No	TOPMed gnomAD
rs782333110	387	R>G		No	ExAC TOPMed
TCGA novel	388	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	390	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2131582173	390	P>T		No	Ensembl
rs1563752219	391	Q>H		No	Ensembl
rs781965964	391	Q>R		No	ExAC TOPMed gnomAD
rs1554619803	392	S>G		No	gnomAD
rs1554619805	392	S>N		No	gnomAD
rs1433603158	393	S>G		No	TOPMed
rs1175188794	394	P>R		No	TOPMed gnomAD
rs1818058797	394	P>S		No	Ensembl
rs782049967	395	G>R		No	ExAC gnomAD
rs542636144	396	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs560815393	396	H>R		No	1000Genomes ExAC TOPMed gnomAD
rs782756091	397	D>E		No	ExAC TOPMed gnomAD
rs537724339	398	P>S		No	ExAC TOPMed gnomAD
rs782465429	399	A>T		No	ExAC gnomAD
rs1210761093	399	A>V		No	TOPMed gnomAD
rs782753569	400	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs782753569	400	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1818060735	401	H>R		No	Ensembl
rs1818060631	401	H>Y		No	TOPMed
rs781847069	402	E>*		No	ExAC TOPMed gnomAD
COSM749749	402	E>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1428062615	402	E>A		No	TOPMed gnomAD
rs782148391	402	E>D		No	ExAC gnomAD
rs1428062615	402	E>G		No	TOPMed gnomAD
rs781847069	402	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs200062409	403	S>F		No	1000Genomes ExAC TOPMed gnomAD
rs200062409	403	S>Y		No	1000Genomes ExAC TOPMed gnomAD
rs781783623	404	P>R		No	ExAC gnomAD
rs782739254	404	P>T		No	ExAC TOPMed gnomAD
rs201596367	405	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782786398	405	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs782786398	405	R>L		No	ExAC TOPMed gnomAD
rs782786398	405	R>P		No	ExAC TOPMed gnomAD
rs201596367	405	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs554447551	407	A>T		No	1000Genomes ExAC gnomAD
rs1325407534	408	K>E		No	TOPMed gnomAD
COSM3432192	408	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs782490052	410	V>F		No	ExAC TOPMed gnomAD
rs782490052	410	V>I		No	ExAC TOPMed gnomAD
rs375262821	411	P>L		No	ESP ExAC TOPMed gnomAD
rs782580278	411	P>S		No	ExAC TOPMed gnomAD
rs1554619853	412	R>K		No	gnomAD
rs782555019	413	Q>*		No	ExAC TOPMed gnomAD
rs782555019	413	Q>E		No	ExAC TOPMed gnomAD
rs782337392	414	N>K		No	ExAC gnomAD
rs782253946	414	N>T		No	ExAC gnomAD
rs781961337	415	S>A		No	ExAC gnomAD
rs1554619860	415	S>C		No	gnomAD
COSM3646108	415	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs782319299	416	A>T		No	ExAC TOPMed gnomAD
rs371534644	417	P>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1818070026	417	P>L		No	TOPMed
rs371534644	417	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs371534644	417	P>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1371407269	419	L>F		No	TOPMed gnomAD
rs781913233	419	L>P		No	ExAC TOPMed gnomAD
rs1554619870	420	Q>R		No	gnomAD
rs781996816	422	A>G		No	ExAC TOPMed gnomAD
rs782088366	423	L>P		No	ExAC TOPMed gnomAD
rs782088366	423	L>R		No	ExAC TOPMed gnomAD
rs35986760	424	L>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs892984473	424	L>V		No	TOPMed gnomAD
rs35834318	425	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs1554619881	425	G>R		No	gnomAD
rs1338593996	426	N>H		No	Ensembl
rs782794549	427	G>W		No	ExAC gnomAD
rs1818071680	428	E>G		No	Ensembl
rs1249150117	428	E>K		No	TOPMed gnomAD
rs1554619883	429	R>K		No	gnomAD
rs782501494	429	R>S		No	ExAC gnomAD
rs782603320	430	P>A		No	ExAC TOPMed gnomAD
rs1818072471	430	P>L		No	TOPMed gnomAD
rs782603320	430	P>S		No	ExAC TOPMed gnomAD
rs782603320	430	P>T		No	ExAC TOPMed gnomAD
rs1554619886	431	P>L		No	gnomAD
rs199585686	432	G>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1818073339	433	A>T		No	Ensembl
rs372002074	433	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3897476	434	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs376910803	435	E>A		No	ESP ExAC TOPMed gnomAD
rs781983437	435	E>D		No	ExAC TOPMed gnomAD
rs200756292	436	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1818074014	436	A>S		No	Ensembl
rs200756292	436	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782055895	437	P>L		No	ExAC TOPMed gnomAD
rs781973567	437	P>S		No	ExAC TOPMed gnomAD
rs782172273	438	P>L		No	ExAC TOPMed gnomAD
rs782172273	438	P>R		No	ExAC TOPMed gnomAD
rs782025905	438	P>T		No	ExAC gnomAD
rs781875603	439	L>M		No	ExAC gnomAD
rs1437192900	440	T>S		No	TOPMed gnomAD
rs1554619908	441	L>H		No	gnomAD
rs1207177047	442	S>A		No	TOPMed gnomAD
rs376507846	442	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1207177047	442	S>P		No	TOPMed gnomAD
rs376507846	442	S>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1204180320	444	V>G		No	TOPMed gnomAD
rs1554619958	445	K>T		No	gnomAD
rs1554619962	446	P>L		No	TOPMed gnomAD
rs1011441620	446	P>S		No	Ensembl
rs1818082323	447	S>C		No	gnomAD
rs202138250	447	S>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782780054	447	S>T		No	ExAC gnomAD
rs199611064	448	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1563752761	449	R>G		No	Ensembl
rs1554619963	449	R>S		No	gnomAD
rs1355339812	449	R>T		No	TOPMed gnomAD
rs1030460639	450	G>A		No	Ensembl
rs2131583205	450	G>R		No	Ensembl
TCGA novel	452	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1554619968	452	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs782531535	453	P>A		No	ExAC TOPMed gnomAD
rs782531535	453	P>S		No	ExAC TOPMed gnomAD
rs1554619970	454	S>F		No	gnomAD
COSM4845996	454	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs953086201	455	L>V		No	TOPMed gnomAD
rs782400329	456	T>I		No	ExAC TOPMed gnomAD
rs782253531	456	T>P		No	ExAC gnomAD
rs1818085455	457	S>F		No	Ensembl
rs1818085747	458	Q>E		No	TOPMed
rs11783450	459	A>D		No	Ensembl
rs782606854	460	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs782318578	461	A>V		No	ExAC gnomAD
rs782010546	462	Q>R		No	ExAC TOPMed gnomAD
rs1185669899	463	V>M		No	TOPMed gnomAD
rs200892039	464	A>V		No	1000Genomes ExAC gnomAD
rs1818087252	467	A>G		No	Ensembl
rs782371903	467	A>T		No	ExAC TOPMed gnomAD
rs781996286	469	I>V		No	ExAC
rs536928468	470	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs576245505	470	R>Q		No	1000Genomes ExAC TOPMed gnomAD
COSM3646109 rs536928468	470	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1554619996	471	G>S		No	gnomAD
rs1209697851	471	G>V		No	TOPMed gnomAD
rs1818088822	472	D>A		No	gnomAD
rs200370966	475	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200370966	475	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199544510	475	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1818089611	476	G>C		No	Ensembl
rs371062521	476	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs376274608	477	G>R		No	ESP ExAC TOPMed gnomAD
rs376274608	477	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	481	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1818090346	481	V>M		No	Ensembl
rs782432572	482	A>T		No	ExAC gnomAD
rs782577773	482	A>V		No	ExAC gnomAD
rs782269871	483	S>I		No	ExAC gnomAD
rs782269871	483	S>N		No	ExAC gnomAD
rs370180308	483	S>R		No	ESP ExAC TOPMed gnomAD
rs374901309	484	V>I		No	ESP ExAC TOPMed gnomAD
rs1162775778	486	Q>*		No	TOPMed gnomAD
rs1554620119	487	V>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs1312621650	487	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1818104209	488	P>R		No	TOPMed
rs1554620120	488	P>S		No	gnomAD
rs781819025	489	P>L		No	ExAC gnomAD
rs782766429	489	P>S		No	ExAC TOPMed gnomAD
rs781807931	490	R>Q		No	ExAC gnomAD
rs782706794	490	R>W		No	ExAC TOPMed gnomAD
rs982290489	492	P>S		No	Ensembl
rs376709769	493	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2131584081	493	P>S		No	Ensembl
rs781862344	494	E>D		No	ExAC gnomAD
rs199510165	496	R>L		No	ESP ExAC TOPMed gnomAD
rs199510165	496	R>Q		No	ESP ExAC TOPMed gnomAD
rs200198011	496	R>W		No	ESP ExAC TOPMed gnomAD
rs782313901	497	P>R		No	ExAC gnomAD
rs1554620144	497	P>S		No	gnomAD
rs782370563	498	G>C		No	ExAC TOPMed gnomAD
rs782370563	498	G>R		No	ExAC TOPMed gnomAD
rs782370563	498	G>S		No	ExAC TOPMed gnomAD
rs924630192	499	R>Q		No	TOPMed gnomAD
rs782354890	499	R>W		No	ExAC TOPMed gnomAD
rs1485628843	500	R>K		No	TOPMed
rs371281381	500	R>S		No	ESP ExAC TOPMed gnomAD
rs1554620157	501	M>I		No	gnomAD
rs1818107395	502	F>I		No	Ensembl
rs782786763	502	F>S		No	ExAC
rs1554620162	504	T>A		No	TOPMed gnomAD
rs1554620167	504	T>I		No	gnomAD
rs1330909148	505	S>C		No	TOPMed gnomAD
rs1330909148	505	S>F		No	TOPMed gnomAD
VAR_061536 rs56038219	505	S>P		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs377092619	507	L>S		No	ESP ExAC TOPMed gnomAD
rs1672788674	508	Q>*		No	TOPMed
rs1818108448	508	Q>P		No	TOPMed
rs782784031	509	G>C		No	ExAC TOPMed gnomAD
rs781831384	509	G>D		No	ExAC TOPMed gnomAD
rs782784031	509	G>R		No	ExAC TOPMed gnomAD
rs781831384	509	G>V		No	ExAC TOPMed gnomAD
rs1554620177	510	A>D		No	gnomAD
rs1314162119	511	Q>missing	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1360782487	511	Q>H		No	TOPMed gnomAD
rs1818109323	512	G>A		No	gnomAD
rs782585619	512	G>R		No	ExAC gnomAD
rs782585619	512	G>W		No	ExAC gnomAD
rs782558070 COSM2868615	513	G>missing	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs782557993	513	G>D		No	ExAC TOPMed gnomAD
rs1554620184	513	G>R		No	gnomAD
rs782627890	514	A>T		No	ExAC TOPMed gnomAD
rs782259792	516	A>P		No	ExAC gnomAD
rs2131584309	519	G>R		No	1000Genomes
rs1554620189	523	Q>*		No	TOPMed gnomAD
rs1554620189	523	Q>E		No	TOPMed gnomAD
rs782470219	524	A>V		No	ExAC TOPMed gnomAD
rs200082081	525	Y>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs782614890	525	Y>F		No	ExAC TOPMed gnomAD
rs1818110262	525	Y>H		No	TOPMed
rs1554620196	526	G>E		No	gnomAD
rs202144789	526	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1554620196	526	G>V		No	gnomAD
rs1033852459	528	V>A		No	TOPMed gnomAD
rs1003263169	528	V>I		No	TOPMed gnomAD
COSM3924797	528	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1190746711	529	C>*		No	Ensembl
rs959193009	529	C>S		No	TOPMed gnomAD
rs1554620202	529	C>S		No	gnomAD
rs782292523	530	H>P		No	ExAC TOPMed gnomAD
rs782292523	530	H>R		No	ExAC TOPMed gnomAD
rs782382234	531	S>L		No	ExAC TOPMed gnomAD
rs782090096	532	A>S		No	ExAC gnomAD
rs782090096	532	A>T		No	ExAC gnomAD
rs1818111824	532	A>V		No	Ensembl
rs577018458	534	G>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA gnomAD
rs577018458	534	G>D		No	1000Genomes ExAC gnomAD
rs1554620213	534	G>R		No	gnomAD
rs1554620218	535	H>Q		No	gnomAD
rs781927819	535	H>R		No	ExAC gnomAD
rs1266721113	535	H>Y		No	TOPMed
rs782072708	536	L>Q		No	ExAC TOPMed gnomAD
rs1818112830	537	P>L		No	TOPMed
rs1554620227	537	P>S		No	gnomAD
rs782507603	540	E>*		No	ExAC TOPMed gnomAD
TCGA novel	540	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs782507603	540	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs781835294	541	G>E		No	ExAC TOPMed gnomAD
rs782725725	541	G>R		No	ExAC TOPMed gnomAD
rs781835294	541	G>V		No	ExAC TOPMed gnomAD
rs371852180	542	H>Y		No	ESP ExAC TOPMed gnomAD
rs1587444282	543	H>R		No	TOPMed gnomAD
rs199891092	544	V>E		No	1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with Q8TD08

3 regional properties for Q8TD08

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	13 - 304	IPR000719
conserved_site	Mitogen-activated protein (MAP) kinase, conserved site	48 - 149	IPR003527
binding_site	Protein kinase, ATP binding site	19 - 43	IPR017441

Functions

		Description
EC Number	2.7.11.24	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm, cytoskeleton, cilium basal body Cell junction, tight junction Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasmic vesicle, autophagosome Golgi apparatus Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle	Co-localizes to the cytoplasm only in presence of ESRRA (PubMed:21190936) Translocates to the nucleus upon activation (PubMed:20638370) At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
autophagosome	A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
bicellular tight junction	An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
meiotic spindle	A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
MAP kinase activity	Catalysis of the reaction
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions
SH3 domain binding	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

16 GO annotations of biological process

Name	Definition
DNA damage response	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
dopamine uptake	The directed movement of dopamine into a cell.
endoplasmic reticulum organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of metaphase/anaphase transition of meiosis I	Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I.
positive regulation of spindle assembly	Any process that activates or increases the frequency, rate or extent of spindle assembly.
positive regulation of telomerase activity	Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction
positive regulation of telomere capping	Any process that activates or increases the frequency, rate or extent of telomere capping.
positive regulation of telomere maintenance via telomerase	Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein localization to ciliary transition zone	A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone.
regulation of autophagy	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
regulation of cilium assembly	Any process that modulates the frequency, rate or extent of cilium assembly.
regulation of COPII vesicle coating	Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.

90 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A5PKJ4	MAPK7	Mitogen-activated protein kinase 7	Bos taurus (Bovine)	SS
Q3T0N5	MAPK13	Mitogen-activated protein kinase 13	Bos taurus (Bovine)	SS
P46196	MAPK1	Mitogen-activated protein kinase 1	Bos taurus (Bovine)	SS
Q5F3W3	MAPK6	Mitogen-activated protein kinase 6	Gallus gallus (Chicken)	SS
Q95NE7	MAPK14	Mitogen-activated protein kinase 14	Pan troglodytes (Chimpanzee)	SS
Q9N272	MAPK13	Mitogen-activated protein kinase 13	Pan troglodytes (Chimpanzee)	SS
O61443	p38b	Mitogen-activated protein kinase p38b	Drosophila melanogaster (Fruit fly)	SS
O62618	p38a	Mitogen-activated protein kinase p38a	Drosophila melanogaster (Fruit fly)	SS
P83100	p38c	Putative mitogen-activated protein kinase 14C	Drosophila melanogaster (Fruit fly)	SS
P40417	rl	Mitogen-activated protein kinase ERK-A	Drosophila melanogaster (Fruit fly)	SS
Q9W354	Erk7	Extracellular signal-regulated kinase 7	Drosophila melanogaster (Fruit fly)	SS
P20794	MAK	Serine/threonine-protein kinase MAK	Homo sapiens (Human)	PR
Q9UQ07	MOK	MAPK/MAK/MRK overlapping kinase	Homo sapiens (Human)	PR
P45984	MAPK9	Mitogen-activated protein kinase 9	Homo sapiens (Human)	SS
P45983	MAPK8	Mitogen-activated protein kinase 8	Homo sapiens (Human)	EV
P53779	MAPK10	Mitogen-activated protein kinase 10	Homo sapiens (Human)	EV
Q9UBE8	NLK	Serine/threonine-protein kinase NLK	Homo sapiens (Human)	SS
P27361	MAPK3	Mitogen-activated protein kinase 3	Homo sapiens (Human)	SS
P28482	MAPK1	Mitogen-activated protein kinase 1	Homo sapiens (Human)	EV
P31152	MAPK4	Mitogen-activated protein kinase 4	Homo sapiens (Human)	SS
Q16659	MAPK6	Mitogen-activated protein kinase 6	Homo sapiens (Human)	SS
Q13164	MAPK7	Mitogen-activated protein kinase 7	Homo sapiens (Human)	SS
P53778	MAPK12	Mitogen-activated protein kinase 12	Homo sapiens (Human)	SS
O15264	MAPK13	Mitogen-activated protein kinase 13	Homo sapiens (Human)	SS
Q15759	MAPK11	Mitogen-activated protein kinase 11	Homo sapiens (Human)	SS
Q16539	MAPK14	Mitogen-activated protein kinase 14	Homo sapiens (Human)	SS
Q9Z1B7	Mapk13	Mitogen-activated protein kinase 13	Mus musculus (Mouse)	SS
P47811	Mapk14	Mitogen-activated protein kinase 14	Mus musculus (Mouse)	SS
Q61532	Mapk6	Mitogen-activated protein kinase 6	Mus musculus (Mouse)	SS
Q63844	Mapk3	Mitogen-activated protein kinase 3	Mus musculus (Mouse)	SS
P63085	Mapk1	Mitogen-activated protein kinase 1	Mus musculus (Mouse)	SS
Q9WVS8	Mapk7	Mitogen-activated protein kinase 7	Mus musculus (Mouse)	SS
Q9WUI1	Mapk11	Mitogen-activated protein kinase 11	Mus musculus (Mouse)	SS
O08911	Mapk12	Mitogen-activated protein kinase 12	Mus musculus (Mouse)	SS
Q6P5G0	Mapk4	Mitogen-activated protein kinase 4	Mus musculus (Mouse)	SS
Q80Y86	Mapk15	Mitogen-activated protein kinase 15	Mus musculus (Mouse)	SS
P70618	Mapk14	Mitogen-activated protein kinase 14	Rattus norvegicus (Rat)	SS
Q9WTY9	Mapk13	Mitogen-activated protein kinase 13	Rattus norvegicus (Rat)	SS
P63086	Mapk1	Mitogen-activated protein kinase 1	Rattus norvegicus (Rat)	SS
P27704	Mapk6	Mitogen-activated protein kinase 6	Rattus norvegicus (Rat)	SS
P21708	Mapk3	Mitogen-activated protein kinase 3	Rattus norvegicus (Rat)	SS
Q63538	Mapk12	Mitogen-activated protein kinase 12	Rattus norvegicus (Rat)	SS
Q63454	Mapk4	Mitogen-activated protein kinase 4	Rattus norvegicus (Rat)	SS
P0C865	Mapk7	Mitogen-activated protein kinase 7	Rattus norvegicus (Rat)	SS
Q9Z2A6	Mapk15	Mitogen-activated protein kinase 15	Rattus norvegicus (Rat)	SS
Q5ZCI1	MPK10	Mitogen-activated protein kinase 10	Oryza sativa subsp. japonica (Rice)	SS
Q5VP69	MPK16	Mitogen-activated protein kinase 16	Oryza sativa subsp. japonica (Rice)	SS
Q5SN53	MPK8	Mitogen-activated protein kinase 8	Oryza sativa subsp. japonica (Rice)	SS
Q0E459	MPK13	Mitogen-activated protein kinase 13	Oryza sativa subsp. japonica (Rice)	SS
Q6Z437	MPK3	Mitogen-activated protein kinase 3	Oryza sativa subsp. japonica (Rice)	SS
Q10N20	MPK5	Mitogen-activated protein kinase 5	Oryza sativa subsp. japonica (Rice)	SS
Q75KK8	MPK14	Mitogen-activated protein kinase 14	Oryza sativa subsp. japonica (Rice)	SS
Q67C40	MPK7	Mitogen-activated protein kinase 7	Oryza sativa subsp. japonica (Rice)	SS
Q6L5F7	MPK17	Mitogen-activated protein kinase 17	Oryza sativa subsp. japonica (Rice)	SS
Q84UI5	MPK1	Mitogen-activated protein kinase 1	Oryza sativa subsp. japonica (Rice)	SS
Q5VN19	MPK11	Mitogen-activated protein kinase 11	Oryza sativa subsp. japonica (Rice)	SS
Q5Z859	MPK4	Mitogen-activated protein kinase 4	Oryza sativa subsp. japonica (Rice)	SS
Q5Z9J0	MPK12	Mitogen-activated protein kinase 12	Oryza sativa subsp. japonica (Rice)	SS
Q5J4W4	MPK2	Mitogen-activated protein kinase 2	Oryza sativa subsp. japonica (Rice)	SS
Q336X9	MPK6	Mitogen-activated protein kinase 6	Oryza sativa subsp. japonica (Rice)	SS
Q53N72	MPK15	Mitogen-activated protein kinase 15	Oryza sativa subsp. japonica (Rice)	SS
Q17446	pmk-1	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	SS
Q8MXI4	pmk-2	Mitogen-activated protein kinase pmk-2	Caenorhabditis elegans	SS
O44514	pmk-3	Mitogen-activated protein kinase pmk-3	Caenorhabditis elegans	PR
P39745	mpk-1	Mitogen-activated protein kinase mpk-1	Caenorhabditis elegans	SS
G5EBT1	sma-5	Mitogen-activated protein kinase sma-5	Caenorhabditis elegans	SS
Q11179	mapk-15	Mitogen-activated protein kinase 15	Caenorhabditis elegans	SS
Q9LMM5	MPK11	Mitogen-activated protein kinase 11	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LQQ9	MPK13	Mitogen-activated protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39021	MPK1	Mitogen-activated protein kinase 1	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LM33	MPK8	Mitogen-activated protein kinase 8	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9C5C0	MPK18	Mitogen-activated protein kinase 18	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39022	MPK2	Mitogen-activated protein kinase 2	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9C9U4	MPK15	Mitogen-activated protein kinase 15	Arabidopsis thaliana (Mouse-ear cress)	SS
Q84M93	MPK17	Mitogen-activated protein kinase 17	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39027	MPK7	Mitogen-activated protein kinase 7	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9SJG9	MPK20	Mitogen-activated protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39026	MPK6	Mitogen-activated protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	SS
Q8GYQ5	MPK12	Mitogen-activated protein kinase 12	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LUC3	MPK19	Mitogen-activated protein kinase 19	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9LV37	MPK9	Mitogen-activated protein kinase 9	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39023	MPK3	Mitogen-activated protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9M1Z5	MPK10	Mitogen-activated protein kinase 10	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39024	MPK4	Mitogen-activated protein kinase 4	Arabidopsis thaliana (Mouse-ear cress)	SS
Q39025	MPK5	Mitogen-activated protein kinase 5	Arabidopsis thaliana (Mouse-ear cress)	SS
O23236	MPK14	Mitogen-activated protein kinase 14	Arabidopsis thaliana (Mouse-ear cress)	SS
Q8W4J2	MPK16	Mitogen-activated protein kinase 16	Arabidopsis thaliana (Mouse-ear cress)	SS
O42376	mapk12	Mitogen-activated protein kinase 12	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q9DGE1	mapk14b	Mitogen-activated protein kinase 14B	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q9DGE2	mapk14a	Mitogen-activated protein kinase 14A	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MCTVVDPRIV	RRYLLRRQLG	QGAYGIVWKA	VDRRTGEVVA	IKKIFDAFRD	KTDAQRTFRE
70	80	90	100	110	120
ITLLQEFGDH	PNIISLLDVI	RAENDRDIYL	VFEFMDTDLN	AVIRKGGLLQ	DVHVRSIFYQ
130	140	150	160	170	180
LLRATRFLHS	GHVVHRDQKP	SNVLLDANCT	VKLCDFGLAR	SLGDLPEGPE	DQAVTEYVAT
190	200	210	220	230	240
RWYRAPEVLL	SSHRYTLGVD	MWSLGCILGE	MLRGRPLFPG	TSTLHQLELI	LETIPPPSEE
250	260	270	280	290	300
DLLALGSGCR	ASVLHQLGSR	PRQTLDALLP	PDTSPEALDL	LRRLLVFAPD	KRLSATQALQ
310	320	330	340	350	360
HPYVQRFHCP	SDEWAREADV	RPRAHEGVQL	SVPEYRSRVY	QMILECGGSS	GTSREKGPEG
370	380	390	400	410	420
VSPSQAHLHK	PRADPQLPSR	TPVQGPRPRP	QSSPGHDPAE	HESPRAAKNV	PRQNSAPLLQ
430	440	450	460	470	480
TALLGNGERP	PGAKEAPPLT	LSLVKPSGRG	AAPSLTSQAA	AQVANQALIR	GDWNRGGGVR
490	500	510	520	530	540
VASVQQVPPR	LPPEARPGRR	MFSTSALQGA	QGGARALLGG	YSQAYGTVCH	SALGHLPLLE

GHHV