Q8T3B9
SS
Gene name |
sem-2 (C32E12.5) |
Protein name |
Transcription factor sem-2 |
Names |
Sex muscle abnormal protein 2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C32E12.5 |
EC number |
|
Protein Class |
|
Descriptions
Sox11 acts as a transcriptional activator of TEAD2 by binding to its gene promoter. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').
Autoinhibitory domains (AIDs)
Target domain |
82-173 (HMG box domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q8T3B9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8T3B9-F1 | Predicted | AlphaFoldDB |
No variants for Q8T3B9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8T3B9 | |||||
No associated diseases with Q8T3B9
1 regional properties for Q8T3B9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 92 - 162 | IPR009071 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| mesodermal cell fate specification | The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. |
| myoblast fate specification | The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| positive regulation of egg-laying behavior | Any process that activates or increases the frequency, rate or extent of oviposition. |
| positive regulation of embryonic development | Any process that activates or increases the frequency, rate or extent of embryonic development. |
| positive regulation of mesodermal cell fate specification | Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification. |
| positive regulation of post-embryonic development | Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of vulval development | Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48435 | SOX11 | Transcription factor SOX-11 | Gallus gallus (Chicken) | SS |
| P48436 | SOX9 | Transcription factor SOX-9 | Homo sapiens (Human) | PR |
| O94993 | SOX30 | Transcription factor SOX-30 | Homo sapiens (Human) | PR |
| O15370 | SOX12 | Transcription factor SOX-12 | Homo sapiens (Human) | SS |
| P35716 | SOX11 | Transcription factor SOX-11 | Homo sapiens (Human) | EV |
| Q04888 | Sox10 | Transcription factor SOX-10 | Mus musculus (Mouse) | PR |
| Q04886 | Sox8 | Transcription factor SOX-8 | Mus musculus (Mouse) | SS |
| Q04887 | Sox9 | Transcription factor SOX-9 | Mus musculus (Mouse) | PR |
| Q04890 | Sox12 | Transcription factor SOX-12 | Mus musculus (Mouse) | SS |
| Q05738 | Sry | Sex-determining region Y protein | Mus musculus (Mouse) | SS |
| Q7M6Y2 | Sox11 | Transcription factor SOX-11 | Mus musculus (Mouse) | SS |
| P0C1G9 | Sox11 | Transcription factor SOX-11 | Rattus norvegicus (Rat) | SS |
| Q6GLH8 | sox17b.2 | Transcription factor Sox-17-beta.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q66JF1 | sox11 | Transcription factor Sox-11 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q8AWH2 | sox17b.1 | Transcription factor Sox-17-beta.1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLQKPPNFM | LDCGMAPHMM | PPINWAAAAI | AVASSTSGAT | NATSSNSVAT | SQQLQHHPYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAAGGYKHAQ | QAIPKSVTPY | SDATNCKKSS | NHIKRPMNAF | MVWSQMERRK | ICEHQPDMHN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEISKQLGSR | WRSLTDEEKA | PFVAEAERLR | VCHMQEYPDY | KYKPRKKPKK | NPDGTLQQPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPQAPQQQQA | PPRGASPQAR | QRKRPNTDQQ | SETQQFQNFK | SVKVEQDWMG | NAHMSHAQKM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PFHPSYPSPS | EFGHAPLTPE | SGFYDDYFTQ | QHHQQHFASQ | HHNSAGSPLR | MTNLGMDMGM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PPQMMGHNSG | FGAGNHPFYL | HTSPPSVDQD | DMRSLSSGSS | GYADCSASEQ | STSSPNSAGV |
| 370 | 380 | 390 | 400 | ||
| VTMATAATTT | THLDDLEQIC | PTVTTGELVN | YPWSDALGID | INFS |