Q8RXK7
SS
Gene name |
PME41 (ARATH41, At4g02330, T14P8.14) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 41 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G02330 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
259-557 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q8RXK7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RXK7-F1 | Predicted | AlphaFoldDB |
46 variants for Q8RXK7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06423756 | 6 | L>V | No | 1000Genomes | |
| ENSVATH06423758 | 30 | S>T | No | 1000Genomes | |
| tmp_4_1032628_A_C | 50 | Q>H | No | 1000Genomes | |
| ENSVATH00454806 | 80 | R>K | No | 1000Genomes | |
| tmp_4_1032723_T_A | 82 | L>H | No | 1000Genomes | |
| ENSVATH06423764 | 113 | T>A | No | 1000Genomes | |
| tmp_4_1032826_G_T | 116 | E>D | No | 1000Genomes | |
| ENSVATH06423765 | 127 | L>M | No | 1000Genomes | |
| ENSVATH06423766 | 129 | F>L | No | 1000Genomes | |
| tmp_4_1032921_C_A | 148 | T>K | No | 1000Genomes | |
| ENSVATH06423770 | 158 | S>T | No | 1000Genomes | |
| ENSVATH06423771 | 159 | S>T | No | 1000Genomes | |
| ENSVATH06423773 | 188 | G>S | No | 1000Genomes | |
| ENSVATH06423775 | 209 | H>Q | No | 1000Genomes | |
| tmp_4_1033147_A_T | 223 | L>F | No | 1000Genomes | |
| ENSVATH10533257 | 232 | R>C | No | 1000Genomes | |
| ENSVATH13881839 | 236 | E>K | No | 1000Genomes | |
| ENSVATH06423777 | 240 | R>K | No | 1000Genomes | |
| ENSVATH06423778 | 244 | A>D | No | 1000Genomes | |
| tmp_4_1033216_C_A | 246 | D>E | No | 1000Genomes | |
| tmp_4_1033214_G_A | 246 | D>N | No | 1000Genomes | |
| tmp_4_1033224_A_G | 249 | D>G | No | 1000Genomes | |
| tmp_4_1033265_C_G | 263 | Q>E | No | 1000Genomes | |
| ENSVATH06423779 | 277 | N>I | No | 1000Genomes | |
| ENSVATH06423779 | 277 | N>S | No | 1000Genomes | |
| ENSVATH06423780 | 278 | S>W | No | 1000Genomes | |
| ENSVATH02621717 | 286 | T>A | No | 1000Genomes | |
| ENSVATH02621718 | 287 | A>G | No | 1000Genomes | |
| tmp_4_1033401_A_G | 308 | N>S | No | 1000Genomes | |
| tmp_4_1033407_G_A | 310 | R>K | No | 1000Genomes | |
| tmp_4_1033415_A_C | 313 | M>L | No | 1000Genomes | |
| tmp_4_1033475_G_A | 333 | G>S | No | 1000Genomes | |
| ENSVATH00454819 | 359 | T>N | No | 1000Genomes | |
| ENSVATH10533392 | 363 | E>D | No | 1000Genomes | |
| tmp_4_1034294_A_G | 363 | E>G | No | 1000Genomes | |
| tmp_4_1034440_A_G | 412 | I>V | No | 1000Genomes | |
| tmp_4_1034470_G_A | 422 | D>N | No | 1000Genomes | |
| ENSVATH06423818 | 460 | K>R | No | 1000Genomes | |
| ENSVATH06423819 | 461 | P>A | No | 1000Genomes | |
| tmp_4_1034610_T_G | 468 | S>R | No | 1000Genomes | |
| tmp_4_1034624_A_G | 473 | K>R | No | 1000Genomes | |
| tmp_4_1034741_G_A | 512 | S>N | No | 1000Genomes | |
| ENSVATH02621791 | 517 | A>G | No | 1000Genomes | |
| ENSVATH00454825 | 527 | S>N | No | 1000Genomes | |
| ENSVATH06423822 | 535 | P>S | No | 1000Genomes | |
| ENSVATH02621797 | 572 | L>I | No | 1000Genomes |
No associated diseases with Q8RXK7
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
| response to brassinosteroid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSLKLFLVT | LFLSLQTLFI | ASQTLLPSNS | SSTICKTTPD | PKFCKSVFPQ | TSQGDVREYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFSLRKSLTQ | SRKFTRTIDR | YLKRNNALLS | QSAVGALQDC | RYLASLTTDY | LITSFETVNI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTSSKTLSFS | KADEIQTLLS | AALTNEQTCL | DGINTAASSS | WTIRNGVALP | LINDTKLFSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLALFTKGWV | PKKKKQVASY | SWAHPKNTHS | HTKPFRHFRN | GALPLKMTEH | TRAVYESLSR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKLADDDNDV | NTVLVSDIVT | VNQNGTGNFT | TITEAVNSAP | NKTDGTAGYF | VIYVTSGVYE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENVVIAKNKR | YLMMIGDGIN | RTVVTGNRNV | VDGWTTFNSA | TFAVTSPNFV | AVNMTFRNTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GPEKHQAVAM | RSSADLSIFY | SCSFEAYQDT | LYTHSLRQFY | RECDIYGTVD | FIFGNAAVVF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QDCNLYPRQP | MQNQFNAITA | QGRTDPNQNT | GISIHNCTIK | PADDLVSSNY | TVKTYLGRPW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KEYSRTVFMQ | SYIDEVVEPV | GWREWNGDFA | LSTLYYAEYN | NTGSGSSTTD | RVVWPGYHVI |
| 550 | 560 | 570 | |||
| NSTDANNFTV | ENFLLGDGWM | VQSGVPYISG | LLS |