Q8RWZ5
Gene name |
SD25 (At4g32300, F10M6.60, F8B4.10) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 |
Names |
S-domain-2 (SD2) receptor kinase 5, SD2-5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G32300 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
635-659 (Activation loop from InterPro)
Target domain |
493-768 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8RWZ5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RWZ5-F1 | Predicted | AlphaFoldDB |
14 variants for Q8RWZ5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_15600205_C_G | 79 | T>R | No | 1000Genomes | |
| tmp_4_15600261_G_A | 98 | V>M | No | 1000Genomes | |
| tmp_4_15600387_G_A | 140 | G>R | No | 1000Genomes | |
| tmp_4_15600542_C_A | 191 | N>K | No | 1000Genomes | |
| ENSVATH06811860 | 217 | T>I | No | 1000Genomes | |
| ENSVATH12349238 | 337 | V>L | No | 1000Genomes | |
| tmp_4_15601041_A_G | 358 | T>A | No | 1000Genomes | |
| tmp_4_15601074_A_T | 369 | N>Y | No | 1000Genomes | |
| tmp_4_15601095_C_T | 376 | L>F | No | 1000Genomes | |
| ENSVATH12349239 | 412 | S>I | No | 1000Genomes | |
| tmp_4_15601297_C_T | 443 | A>V | No | 1000Genomes | |
| ENSVATH12349240 | 462 | A>T | No | 1000Genomes | |
| tmp_4_15601507_C_A | 513 | P>Q | No | 1000Genomes | |
| tmp_4_15601644_G_C | 559 | A>P | No | 1000Genomes |
No associated diseases with Q8RWZ5
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
50 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRGVFIVIVT | CLVFLPDPLR | AGVASIGSIT | PGFGGSQMNY | INNDGIFLES | NNSAFGFGFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTQDSVTLFT | LSIIHKSSTK | LIWSANRASP | VSNSDKFVFD | DNGNVVMEGT | EVWRLDNSGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NASRIELRDS | GNLVVVSVDG | TSIWESFDHP | TDTLITNQAF | KEGMKLTSSP | SSSNMTYALE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKSGDMVLSV | NSLTPQVYWS | MANARERIIN | KDGGVVTSSS | LLGNSWRFFD | QKQVLLWQFV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSDNKDDNTT | WIAVLGNNGV | ISFSNLGSGA | SAADSSTKIP | SDLCGTPEPC | GPYYVCSGSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VCGCVSGLSR | ARSDCKTGIT | SPCKKTKDNA | TLPLQLVSAG | DGVDYFALGY | APPFSKKTDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DSCKEFCHNN | CSCLGLFFQN | SSGNCFLFDY | IGSFKTSGNG | GSGFVSYIKI | ASTGSGGGDN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GEDDGKHFPY | VVIIVVVTVF | IIAVLIFVAF | RIHKRKKMIL | EAPQESSEED | NFLENLSGMP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRFAYKDLQS | ATNNFSVKLG | QGGFGSVYEG | TLPDGSRLAV | KKLEGIGQGK | KEFRAEVSII |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GSIHHLHLVR | LRGFCAEGAH | RLLAYEFLSK | GSLERWIFRK | KDGDVLLDWD | TRFNIALGTA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KGLAYLHEDC | DARIVHCDIK | PENILLDDNF | NAKVSDFGLA | KLMTREQSHV | FTTMRGTRGY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LAPEWITNYA | ISEKSDVYSY | GMVLLELIGG | RKNYDPSETS | EKCHFPSFAF | KKMEEGKLMD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IVDGKMKNVD | VTDERVQRAM | KTALWCIQED | MQTRPSMSKV | VQMLEGVFPV | VQPPSSSTMG |
| 790 | 800 | 810 | 820 | ||
| SRLYSSFFKS | ISEDGGATTS | SGPSDCNSEN | YLSAVRLSGP | R |