Q8RWY3
PR
Gene name |
CHR11 |
Protein name |
ISWI chromatin-remodeling complex ATPase CHR11 |
Names |
ISW2-like, Protein CHROMATIN REMODELING 11, Sucrose nonfermenting protein 2 homolog |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G06400 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RWY3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RWY3-F1 | Predicted | AlphaFoldDB |
23 variants for Q8RWY3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_1941118_A_G | 18 | E>G | No | 1000Genomes | |
| tmp_3_1941162_G_A | 33 | A>T | No | 1000Genomes | |
| ENSVATH00309274 | 38 | S>F | No | 1000Genomes | |
| ENSVATH10523317 | 56 | G>E | No | 1000Genomes | |
| ENSVATH02118355 | 56 | G>R | No | 1000Genomes | |
| tmp_3_1941237_G_A,C | 58 | A>P | No | 1000Genomes | |
| tmp_3_1941237_G_A,C | 58 | A>T | No | 1000Genomes | |
| tmp_3_1941258_T_G | 65 | Y>D | No | 1000Genomes | |
| tmp_3_1941932_A_G | 152 | K>E | No | 1000Genomes | |
| tmp_3_1942465_C_A | 232 | H>N | No | 1000Genomes | |
| ENSVATH10523320 | 286 | A>T | No | 1000Genomes | |
| tmp_3_1943570_C_T | 480 | T>I | No | 1000Genomes | |
| ENSVATH10523357 | 506 | D>A | No | 1000Genomes | |
| tmp_3_1945123_C_T | 761 | R>W | No | 1000Genomes | |
| tmp_3_1945875_A_C | 885 | K>Q | No | 1000Genomes | |
| ENSVATH10523387 | 928 | Y>C | No | 1000Genomes | |
| tmp_3_1946481_G_C | 1016 | E>Q | No | 1000Genomes | |
| tmp_3_1946511_G_A | 1026 | A>T | No | 1000Genomes | |
| tmp_3_1946612_G_A | 1028 | S>N | No | 1000Genomes | |
| ENSVATH05783251 | 1037 | G>V | No | 1000Genomes | |
| ENSVATH05783252 | 1047 | T>M | No | 1000Genomes | |
| ENSVATH05783253 | 1053 | L>M | No | 1000Genomes | |
| ENSVATH05783254 | 1053 | L>Q | No | 1000Genomes |
No associated diseases with Q8RWY3
5 regional properties for Q8RWY3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 424 - 528 | IPR002048 |
| domain | Phospholipid/glycerol acyltransferase | 171 - 282 | IPR002123 |
| binding_site | EF-Hand 1, calcium-binding site | 470 - 482 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 506 - 518 | IPR018247-2 |
| domain | Lysophosphatidylcholine acyltransferase LPCAT1-like | 148 - 356 | IPR045252 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| nucleosome array spacer activity | A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair. |
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| flower development | The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. |
| megagametogenesis | The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. |
| positive regulation of cellular response to heat | Any process that activates or increases the frequency, rate or extent of cellular response to heat. |
| regulation of timing of transition from vegetative to reproductive phase | The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38144 | ISW1 | ISWI chromatin-remodeling complex ATPase ISW1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3B7N1 | CHD1L | Chromodomain-helicase-DNA-binding protein 1-like | Bos taurus (Bovine) | SS |
| Q24368 | Iswi | Chromatin-remodeling complex ATPase chain Iswi | Drosophila melanogaster (Fruit fly) | SS |
| Q86WJ1 | CHD1L | Chromodomain-helicase-DNA-binding protein 1-like | Homo sapiens (Human) | EV |
| Q9NRZ9 | HELLS | Lymphoid-specific helicase | Homo sapiens (Human) | PR |
| O60264 | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Homo sapiens (Human) | EV |
| P28370 | SMARCA1 | Probable global transcription activator SNF2L1 | Homo sapiens (Human) | SS |
| Q60848 | Hells | Lymphocyte-specific helicase | Mus musculus (Mouse) | PR |
| Q9CXF7 | Chd1l | Chromodomain-helicase-DNA-binding protein 1-like | Mus musculus (Mouse) | SS |
| Q91ZW3 | Smarca5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Mus musculus (Mouse) | SS |
| Q6PGB8 | Smarca1 | Probable global transcription activator SNF2L1 | Mus musculus (Mouse) | SS |
| Q7G8Y3 | Os01g0367900 | Probable chromatin-remodeling complex ATPase chain | Oryza sativa subsp japonica (Rice) | PR |
| P41877 | isw-1 | Chromatin-remodeling complex ATPase chain isw-1 | Caenorhabditis elegans | SS |
| Q9XFH4 | DDM1 | ATP-dependent DNA helicase DDM1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4J9M5 | CHR12 | Probable ATP-dependent DNA helicase CHR12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4K128 | CHR23 | Probable ATP-dependent DNA helicase CHR23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARNSNSDEA | FSSEEEEERV | KDNEEEDEEE | LEAVARSSGS | DDDEVAAADE | SPVSDGEAAP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VEDDYEDEED | EEKAEISKRE | KARLKEMQKL | KKQKIQEMLE | SQNASIDADM | NNKGKGRLKY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLQQTELFAH | FAKSDGSSSQ | KKAKGRGRHA | SKITEEEEDE | EYLKEEEDGL | TGSGNTRLLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPSCIQGKMR | DYQLAGLNWL | IRLYENGING | ILADEMGLGK | TLQTISLLAY | LHEYRGINGP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HMVVAPKSTL | GNWMNEIRRF | CPVLRAVKFL | GNPEERRHIR | EDLLVAGKFD | ICVTSFEMAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KEKTALRRFS | WRYIIIDEAH | RIKNENSLLS | KTMRLFSTNY | RLLITGTPLQ | NNLHELWALL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NFLLPEIFSS | AETFDEWFQI | SGENDQQEVV | QQLHKVLRPF | LLRRLKSDVE | KGLPPKKETI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKVGMSQMQK | QYYKALLQKD | LEAVNAGGER | KRLLNIAMQL | RKCCNHPYLF | QGAEPGPPYT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TGDHLITNAG | KMVLLDKLLP | KLKERDSRVL | IFSQMTRLLD | ILEDYLMYRG | YLYCRIDGNT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GGDERDASIE | AYNKPGSEKF | VFLLSTRAGG | LGINLATADV | VILYDSDWNP | QVDLQAQDRA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HRIGQKKEVQ | VFRFCTESAI | EEKVIERAYK | KLALDALVIQ | QGRLAEQKTV | NKDELLQMVR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YGAEMVFSSK | DSTITDEDID | RIIAKGEEAT | AELDAKMKKF | TEDAIQFKMD | DSADFYDFDD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DNKDENKLDF | KKIVSDNWND | PPKRERKRNY | SESEYFKQTL | RQGAPAKPKE | PRIPRMPQLH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DFQFFNIQRL | TELYEKEVRY | LMQTHQKNQL | KDTIDVEEPE | EGGDPLTTEE | VEEKEGLLEE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GFSTWSRRDF | NTFLRACEKY | GRNDIKSIAS | EMEGKTEEEV | ERYAKVFKER | YKELNDYDRI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IKNIERGEAR | ISRKDEIMKA | IGKKLDRYRN | PWLELKIQYG | QNKGKLYNEE | CDRFMICMIH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KLGYGNWDEL | KAAFRTSSVF | RFDWFVKSRT | SQELARRCDT | LIRLIEKENQ | EFDERERQAR |
| 1030 | 1040 | 1050 | |||
| KEKKLAKSAT | PSKRPLGRQA | SESPSSTKKR | KHLSMR |