Q8RWW0
Gene name |
ALE2 (At2g20300, F11A3.15) |
Protein name |
Receptor-like serine/threonine-protein kinase ALE2 |
Names |
Protein ABNORMAL LEAF SHAPE 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G20300 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
487-511 (Activation loop from InterPro)
Target domain |
349-619 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8RWW0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RWW0-F1 | Predicted | AlphaFoldDB |
35 variants for Q8RWW0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_8759833_C_A | 5 | A>S | No | 1000Genomes | |
| tmp_2_8759154_G_T | 49 | L>I | No | 1000Genomes | |
| ENSVATH05540506 | 80 | R>H | No | 1000Genomes | |
| tmp_2_8758567_T_C | 164 | D>G | No | 1000Genomes | |
| tmp_2_8758564_C_T | 165 | S>N | No | 1000Genomes | |
| ENSVATH01850867 | 165 | S>R | No | 1000Genomes | |
| ENSVATH14524208 | 248 | A>P | No | 1000Genomes | |
| ENSVATH14524207 | 263 | A>V | No | 1000Genomes | |
| tmp_2_8758121_T_A | 286 | I>F | No | 1000Genomes | |
| tmp_2_8758108_G_C | 290 | S>C | No | 1000Genomes | |
| tmp_2_8758082_G_T | 299 | P>T | No | 1000Genomes | |
| ENSVATH13296367 | 301 | I>F | No | 1000Genomes | |
| tmp_2_8758071_G_T | 302 | N>K | No | 1000Genomes | |
| tmp_2_8757894_T_A | 335 | K>M | No | 1000Genomes | |
| tmp_2_8757888_A_T | 337 | F>Y | No | 1000Genomes | |
| ENSVATH13296354 | 339 | L>I | No | 1000Genomes | |
| ENSVATH14524206 | 416 | R>L | No | 1000Genomes | |
| tmp_2_8757599_G_C | 433 | H>Q | No | 1000Genomes | |
| ENSVATH13296351 | 438 | T>A | No | 1000Genomes | |
| ENSVATH05540491 | 455 | L>M | No | 1000Genomes | |
| tmp_2_8757352_T_C | 479 | E>G | No | 1000Genomes | |
| ENSVATH05540490 | 480 | D>G | No | 1000Genomes | |
| tmp_2_8757301_G_C | 496 | T>S | No | 1000Genomes | |
| tmp_2_8757115_T_A | 532 | Y>F | No | 1000Genomes | |
| tmp_2_8757031_C_G | 560 | W>S | No | 1000Genomes | |
| tmp_2_8756981_G_A | 577 | P>S | No | 1000Genomes | |
| ENSVATH13296346 | 584 | N>I | No | 1000Genomes | |
| tmp_2_8756765_C_A | 649 | A>S | No | 1000Genomes | |
| ENSVATH14524203 | 669 | S>L | No | 1000Genomes | |
| ENSVATH14524202 | 680 | L>Q | No | 1000Genomes | |
| ENSVATH00239980 | 683 | M>I | No | 1000Genomes | |
| ENSVATH14524200 | 710 | P>S | No | 1000Genomes | |
| tmp_2_8756528_C_G | 728 | G>R | No | 1000Genomes | |
| ENSVATH05540485 | 736 | L>R | No | 1000Genomes | |
| tmp_2_8756484_G_T | 742 | D>E | No | 1000Genomes |
No associated diseases with Q8RWW0
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| plant epidermis development | The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure. |
| plant organ formation | The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protoderm histogenesis | The formation of the primary meristem or meristematic tissue that gives rise to the epidermis. |
47 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O97799 | KIT | Mast/stem cell growth factor receptor Kit | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q6QNF3 | PDGFRB | Platelet-derived growth factor receptor beta | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q96S53 | TESK2 | Dual specificity testis-specific protein kinase 2 | Homo sapiens (Human) | PR |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q8VCT9 | Tesk2 | Dual specificity testis-specific protein kinase 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q924U5 | Tesk2 | Dual specificity testis-specific protein kinase 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRNFAMLLLL | ILLLHSLASF | PICFARLFPM | SLPFTRSKAH | QMHFFHPYLN | PSVAPTPSPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSPNPSRIPP | LRHKGHHRHR | RWHLRRNATA | VSPSSHDCQQ | TCVEPLTSTP | FGSPCGCVFP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MKVQLLLSVA | PFSIFPVTNE | LEIEVAAGTY | LEQSQVKIMG | ASADSENQGK | TVVDINLVPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEKFDNTTAT | LIYQRFRHKK | VPLNETVFGD | YEVTHISYPG | IPSSSPNGDV | TGDAPGGLPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PINATTFANK | SQGIGFRTIA | IIALSGFVLI | LVLVGAISII | VKWKKIGKSS | NAVGPALAPS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| INKRPGAGSM | FSSSARSSGS | DSLMSSMATC | ALSVKTFTLS | ELEKATDRFS | AKRVLGEGGF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GRVYQGSMED | GTEVAVKLLT | RDNQNRDREF | IAEVEMLSRL | HHRNLVKLIG | ICIEGRTRCL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IYELVHNGSV | ESHLHEGTLD | WDARLKIALG | AARGLAYLHE | DSNPRVIHRD | FKASNVLLED |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DFTPKVSDFG | LAREATEGSQ | HISTRVMGTF | GYVAPEYAMT | GHLLVKSDVY | SYGVVLLELL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TGRRPVDMSQ | PSGEENLVTW | ARPLLANREG | LEQLVDPALA | GTYNFDDMAK | VAAIASMCVH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QEVSHRPFMG | EVVQALKLIY | NDADETCGDY | CSQKDSSVPD | SADFKGDLAP | SDSSWWNLTP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RLRYGQASSF | ITMDYSSGPL | EDMENRPHSA | SSIPRVGGLI | LPNRSGPLRP | MRSRRNFFRL |
| 730 | 740 | ||||
| RGSMSEHGGP | SSSRHLWSGN | GDWL |