Q8R554
Gene name |
Otud7a (Cezanne2, Otud7) |
Protein name |
OTU domain-containing protein 7A |
Names |
EC 3.4.19.12 , Zinc finger protein Cezanne 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:170711 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
201-377 (OTU domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R554
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R554-F1 | Predicted | AlphaFoldDB |
21 variants for Q8R554
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388910162 | 13 | E>K | No | EVA | |
| rs3388917870 | 60 | L>I | No | EVA | |
| rs3388915701 | 89 | R>L | No | EVA | |
| rs3545828447 | 92 | P>L | No | EVA | |
| rs3388918429 | 120 | I>V | No | EVA | |
| rs3388912864 | 158 | L>V | No | EVA | |
| rs3388893911 | 193 | T>S | No | EVA | |
| rs3388917882 | 238 | M>T | No | EVA | |
| rs3388918397 | 274 | K>I | No | EVA | |
| rs3388907157 | 281 | R>H | No | EVA | |
| rs3398000835 | 322 | I>N | No | EVA | |
| rs3388874474 | 416 | D>E | No | EVA | |
| rs3388913055 | 424 | A>V | No | EVA | |
| rs3398002242 | 456 | L>V | No | EVA | |
| rs3397611560 | 470 | V>A | No | EVA | |
| rs240724355 | 692 | V>A | No | EVA | |
| rs3545982233 | 704 | A>S | No | EVA | |
| rs223952183 | 739 | R>W | No | EVA | |
| rs3545809238 | 867 | A>S | No | EVA | |
| rs259650498 | 874 | S>L | No | EVA | |
| rs3398020267 | 927 | P>W | No | EVA |
No associated diseases with Q8R554
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| K63-linked polyubiquitin modification-dependent protein binding | Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein K11-linked deubiquitination | A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21580 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | Homo sapiens (Human) | SS |
| Q6GQQ9 | OTUD7B | OTU domain-containing protein 7B | Homo sapiens (Human) | EV |
| Q8TE49 | OTUD7A | OTU domain-containing protein 7A | Homo sapiens (Human) | SS |
| B2RUR8 | Otud7b | OTU domain-containing protein 7B | Mus musculus (Mouse) | SS |
| Q60769 | Tnfaip3 | Tumor necrosis factor alpha-induced protein 3 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSSLLPNPP | SAECWAALLH | DPMTLDMDAV | LSDFVRSTGA | EPGLARDLLE | GKNWDLTAAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDYEQLRQVH | TANLPHVFNE | GRCAKQAERE | LPQPGHKVER | PCLQRQDDIA | QAEKRLSRGI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SHASSAIVSL | ARSHVANECN | NEQFPLEMPI | YTFQLPDLSV | YSEDFRSFIE | RDLIEQATMV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALEQAGRLNW | WSTVCTSCKR | LLPLATTGDG | NCLLHAASLG | MWGFHDRDLV | LRKALYTMMR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGAEREALKR | RWRWQQTQQN | KEEEWEREWT | ELLKLASSEP | RTHFSKNGSG | TGGGVDNSED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PVYESLEEFH | VFVLAHILRR | PIVVVADTML | RDSGGEAFAP | IPFGGIYLPL | EVPPNRCHCS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PLVLAYDQAH | FSALVSMEQR | DQQREQAVIP | LTDSEHKLLP | LHFAVDPGKD | WEWGKDDNDN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ARLANLILSL | EAKLNLLHSY | MNVTWIRIPS | ETRAPLAQPE | SPTASAGEDV | QSLAESLDSD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RDSVCSNSNS | NNGKNGKDKE | KEKQRKDKDK | TRADSVANKL | GSFSKTLGIK | LKKNMGGLGG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVHGKMGRAN | SANGKNGDSA | ERNKEKKSKS | RKGSKEESGA | SASTSPSEKT | TPSPTDKASG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ASPADKGSGS | RGDAWKYSTD | VKLSLNILRA | AMQGERKFIF | AGLLLTSHRH | QFHEEMIGYY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LTSAQERFSA | EQEQRRRDAA | AAAAAATATA | TVKRPARRPE | AEGAPGPERA | SPGPTAAQPT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QLVLKLKERP | SPGTGASARA | ARAAGGAASP | GPGGGARRAA | PGTGGPTPGR | SPPAPARQSV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IHVQAAARDE | ACAPTVGALR | PCATYPQQNR | SLWSQSYSPA | RSALRTVNTV | ESLAPGGADA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PGPAEHKSQT | YSNGFGAARD | GLEFADADAP | AARSNAECGR | GGPGPAQRRC | QRENCAFYGR |
| 910 | 920 | ||||
| AETEHFCSYC | YREELRRRRE | ARAARP |