Q8R3L8
Gene name |
Cdk8 |
Protein name |
Cyclin-dependent kinase 8 |
Names |
Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:264064 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
172-198 (Activation loop from InterPro)
Target domain |
21-335 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8R3L8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R3L8-F1 | Predicted | AlphaFoldDB |
21 variants for Q8R3L8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388810929 | 46 | D>N | No | EVA | |
| rs3395961799 | 51 | L>* | No | EVA | |
| rs3388804188 | 100 | A>G | No | EVA | |
| rs3388780037 | 120 | P>S | No | EVA | |
| rs3388807248 | 173 | D>V | No | EVA | |
| rs3388811322 | 182 | S>* | No | EVA | |
| rs3388810952 | 183 | P>H | No | EVA | |
| rs3388813898 | 183 | P>S | No | EVA | |
| rs3388807210 | 199 | Y>F | No | EVA | |
| rs3388810783 | 226 | E>Q | No | EVA | |
| rs3388791319 | 259 | M>K | No | EVA | |
| rs3396400658 | 260 | G>E | No | EVA | |
| rs3388817598 | 266 | D>E | No | EVA | |
| rs3388817681 | 266 | D>N | No | EVA | |
| rs3395961905 | 294 | I>KLHETSENKHPH* | No | EVA | |
| rs3388780039 | 299 | K>N | No | EVA | |
| rs3388807207 | 309 | F>I | No | EVA | |
| rs3388817635 | 340 | L>R | No | EVA | |
| rs3388780020 | 348 | G>C | No | EVA | |
| rs3388810397 | 359 | L>* | No | EVA | |
| rs3388804253 | 365 | D>E | No | EVA |
No associated diseases with Q8R3L8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39073 | SSN3 | Meiotic mRNA stability protein kinase SSN3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9VT57 | Cdk8 | Cyclin-dependent kinase 8 | Drosophila melanogaster (Fruit fly) | PR |
| Q9BWU1 | CDK19 | Cyclin-dependent kinase 19 | Homo sapiens (Human) | PR |
| P49336 | CDK8 | Cyclin-dependent kinase 8 | Homo sapiens (Human) | PR |
| Q3UMM4 | Cdk10 | Cyclin-dependent kinase 10 | Mus musculus (Mouse) | PR |
| O35495 | Cdk14 | Cyclin-dependent kinase 14 | Mus musculus (Mouse) | PR |
| Q8K0D0 | Cdk17 | Cyclin-dependent kinase 17 | Mus musculus (Mouse) | PR |
| Q8BWD8 | Cdk19 | Cyclin-dependent kinase 19 | Mus musculus (Mouse) | PR |
| Q99J95 | Cdk9 | Cyclin-dependent kinase 9 | Mus musculus (Mouse) | PR |
| Q3TZA2 | Cdkl4 | Cyclin-dependent kinase-like 4 | Mus musculus (Mouse) | PR |
| Q8CEQ0 | Cdkl1 | Cyclin-dependent kinase-like 1 | Mus musculus (Mouse) | PR |
| Q8BLF2 | Cdkl3 | Cyclin-dependent kinase-like 3 | Mus musculus (Mouse) | PR |
| Q9QUK0 | Cdkl2 | Cyclin-dependent kinase-like 2 | Mus musculus (Mouse) | PR |
| Q9JHU3 | Cdk20 | Cyclin-dependent kinase 20 | Mus musculus (Mouse) | PR |
| Q6P3N6 | cdk8 | Cyclin-dependent kinase 8 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q8JH47 | cdk8 | Cyclin-dependent kinase 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDYDFKVKLS | SERERVEDLF | EYEGCKVGRG | TYGHVYKAKR | KDGKDDKDYA | LKQIEGTGIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MSACREIALL | RELKHPNVIS | LLKVFLSHAD | RKVWLLFDYA | EHDLWHIIKF | HRASKANKKP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VQLPRGMVKS | LLYQILDGIH | YLHANWVLHR | DLKPANILVM | GEGPERGRVK | IADMGFARLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSPLKPLADL | DPVVVTFWYR | APELLLGARH | YTKAIDIWAI | GCIFAELLTS | EPIFHCRQED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKTSNPYHHD | QLDRIFNVMG | FPADKDWEDI | KKMPEHSTLM | KDFRRNTYTN | CSLIKYMEKH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KVKPDSKAFH | LLQKLLTMDP | IKRITSEQAM | QDPYFLEDPL | PTSDVFAGCQ | IPYPKREFLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEEPDEKGDK | KTQQQQQGNN | HTNGTGHPGN | QDSGHAQGPP | LKKVRVVPPT | TTSGGLIMTS |
| 430 | 440 | 450 | 460 | ||
| DYQRSNPHAA | YPNPGPSTSQ | PQSSMGYSAT | SQQPPQYSHQ | THRY |