Q8R3B1
SS
Gene name |
Plcd1 (Plcd) |
Protein name |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
Names |
EC 3.1.4.11 , Phosphoinositide phospholipase C-delta-1 , Phospholipase C-delta-1 , PLC-delta-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18799 |
EC number |
3.1.4.11: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
PLCD1 functions the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Autoinhibitory region is a portion of the linker that separates the conserved X and Y boxes comprising the catalytic TIM barrel. The disordered X/Y linker is capable of autoinhibition by hindering productive binding of PLC-δ1 to membranes and thereby restricting access of PtdIns(4,5)P2 to the active site. The active site of a PLC isozyme toward phospholipid membranes should force the negatively charged X/Y linker away from the active site, therein relieving autoinhibition of the enzyme.
Autoinhibitory domains (AIDs)
Target domain |
316-656 (TIM barrel) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R3B1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R3B1-F1 | Predicted | AlphaFoldDB |
52 variants for Q8R3B1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400407573 | 6 | D>G | No | EVA | |
| rs254615756 | 17 | P>L | No | EVA | |
| rs3389087294 | 37 | R>H | No | EVA | |
| rs3389090838 | 92 | P>L | No | EVA | |
| rs3389049607 | 92 | P>S | No | EVA | |
| rs3389049588 | 98 | S>F | No | EVA | |
| rs3389076916 | 101 | F>V | No | EVA | |
| rs3389049585 | 130 | D>N | No | EVA | |
| rs3389074722 | 145 | I>F | No | EVA | |
| rs3547795131 | 146 | H>Y | No | EVA | |
| rs3399645048 | 149 | L>W | No | EVA | |
| rs3389083481 | 177 | D>N | No | EVA | |
| rs1132316980 | 212 | A>V | No | EVA | |
| rs3400743108 | 223 | G>D | No | EVA | |
| rs3400740464 | 224 | S>P | No | EVA | |
| rs3389068813 | 253 | S>T | No | EVA | |
| rs3389049604 | 263 | T>N | No | EVA | |
| rs3389083418 | 263 | T>P | No | EVA | |
| rs3389056022 | 285 | N>S | No | EVA | |
| rs3547643746 | 306 | L>F | No | EVA | |
| rs3389091676 | 316 | L>P | No | EVA | |
| rs3547630856 | 320 | L>F | No | EVA | |
| rs3389083444 | 323 | P>S | No | EVA | |
| rs3389090794 | 339 | C>* | No | EVA | |
| rs3389068820 | 340 | L>V | No | EVA | |
| rs3389056009 | 344 | C>W | No | EVA | |
| rs3389074743 | 353 | I>F | No | EVA | |
| rs247141402 | 357 | G>C | No | EVA | |
| rs247141402 | 357 | G>S | No | EVA | |
| rs3389068892 | 358 | Y>C | No | EVA | |
| rs3389060911 | 365 | L>P | No | EVA | |
| rs3547587355 | 381 | S>T | No | EVA | |
| rs3389083649 | 396 | E>G | No | EVA | |
| rs3547622090 | 408 | I>N | No | EVA | |
| rs3389074705 | 421 | V>A | No | EVA | |
| rs3389076858 | 424 | S>R | No | EVA | |
| rs3389074797 | 433 | E>G | No | EVA | |
| rs250719358 | 435 | I>V | No | EVA | |
| rs3410685010 | 438 | K>T | No | EVA | |
| rs3389087372 | 452 | N>D | No | EVA | |
| rs3547733636 | 494 | D>N | No | EVA | |
| rs3547631004 | 501 | S>G | No | EVA | |
| rs3389090870 | 565 | V>L | No | EVA | |
| rs3389082636 | 593 | F>S | No | EVA | |
| rs3389081108 | 596 | N>I | No | EVA | |
| rs3400834985 | 622 | Q>* | No | EVA | |
| rs3389074755 | 622 | Q>L | No | EVA | |
| rs3389087333 | 691 | V>L | No | EVA | |
| rs3389056018 | 696 | D>N | No | EVA | |
| rs3389083701 | 710 | S>Y | No | EVA | |
| rs3400821529 | 727 | K>N | No | EVA | |
| rs3547686442 | 749 | F>I | No | EVA |
No associated diseases with Q8R3B1
10 regional properties for Q8R3B1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 609 - 737 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 296 - 441 | IPR000909 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 492 - 609 | IPR001711 |
| domain | Pleckstrin homology domain | 19 - 132 | IPR001849 |
| domain | EF-hand domain | 140 - 175 | IPR002048 |
| domain | Phosphoinositide-specific phospholipase C, EF-hand-like domain | 204 - 288 | IPR015359 |
| binding_site | EF-Hand 1, calcium-binding site | 153 - 165 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 189 - 201 | IPR018247-2 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain | 295 - 596 | IPR028391 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain | 144 - 283 | IPR046975 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.11 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| labyrinthine layer blood vessel development | The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. |
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidylinositol metabolic process | The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of inositol trisphosphate biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. |
| positive regulation of norepinephrine secretion | Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| release of sequestered calcium ion into cytosol | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| response to peptide hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32383 | PLC1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q1RML2 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Bos taurus (Bovine) | PR |
| P10895 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Bos taurus (Bovine) | SS |
| Q2VRL0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Gallus gallus (Chicken) | PR |
| Q86YW0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Homo sapiens (Human) | PR |
| Q9P212 | PLCE1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Homo sapiens (Human) | SS |
| Q9BRC7 | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | Homo sapiens (Human) | SS |
| Q15111 | PLCL1 | Inactive phospholipase C-like protein 1 | Homo sapiens (Human) | PR |
| Q9UPR0 | PLCL2 | Inactive phospholipase C-like protein 2 | Homo sapiens (Human) | PR |
| Q8N3E9 | PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Homo sapiens (Human) | SS |
| P51178 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Homo sapiens (Human) | EV |
| Q8K2J0 | Plcd3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Mus musculus (Mouse) | PR |
| Q8K394 | Plcl2 | Inactive phospholipase C-like protein 2 | Mus musculus (Mouse) | PR |
| Q8K4S1 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Mus musculus (Mouse) | SS |
| P51432 | Plcb3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | Mus musculus (Mouse) | SS |
| Q62077 | Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Mus musculus (Mouse) | SS |
| A3KGF7 | Plcb2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | Mus musculus (Mouse) | PR |
| Q9Z1B3 | Plcb1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | Mus musculus (Mouse) | SS |
| Q7YRU3 | PLCZ | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Sus scrofa (Pig) | PR |
| Q99P84 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Rattus norvegicus (Rat) | EV |
| P10688 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Rattus norvegicus (Rat) | SS |
| Q39032 | PLC1 | Phosphoinositide phospholipase C 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56W08 | PLC3 | Phosphoinositide phospholipase C 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NMA7 | PLC9 | Phosphoinositide phospholipase C 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GV43 | PLC6 | Phosphoinositide phospholipase C 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C2 | PLC5 | Phosphoinositide phospholipase C 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STZ3 | PLC8 | Phosphoinositide phospholipase C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C1 | PLC4 | Phosphoinositide phospholipase C 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A5D6R3 | plcd3a | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSGRDFLTL | HGLQDDPDLQ | ALLKGSQLLK | VKSSSWRRER | FYKLQEDCKT | IWQESRKVMR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SPESQLFSIE | DIQEVRMGHR | TEGLEKFARD | IPEDRCFSIV | FKDQRNTLDL | IAPSPADVQH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WVQGLRKIID | RSGSMDQRQK | LQHWIHSCLR | KADKNKDNKM | NFKEVKDFLK | ELNVQVDDSY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARKIFRECDH | SQTDSLEDEE | IETFYRMLTQ | RAEIDRAFAE | AAGSAETLSV | EKLVTFLQHQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QREEEAGPAL | ALSLIERYEP | SETAKAQRQM | TKDGFLMYLL | SADGNAFSLA | HRRVYQDMNQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLSHYLVSSS | HNTYLLEDQL | TGPSSTEAYI | RALCKGCRCL | ELDCWDGPNQ | EPIIYHGYTF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSKILFCDVL | RAIRDYAFKA | SPYPVILSLE | NHCSLEQQRV | MAHHLRAILG | PMLLDQPLDG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTTSLPSPEQ | LKEKILLKGK | KLGGLLPAGG | ENGPEATDVS | DEDEAAEMED | EAVRSQVQHK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PKEDKLKLVP | ELSDMVIYCK | SVHFGGFSSP | STSGQAFYEM | ASFSESRALR | LLQESGNSFV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RHNVGHLSRI | YPAGWRTDSS | NYSPVEMWNG | GCQIVALNFQ | TPGPEMDVYL | GCFQDNGGCG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YVLKPAFLRD | PDTTFNSRAL | TQGPWWAPKK | LRVWIISGQQ | LPKVNKNKNS | IVDPKVIVEI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HGVGQDVASR | QTAVITNNGF | NPRWDTEFEF | VVAVPDLALV | RFMVEDYDSS | SKNDFIGQST |
| 730 | 740 | 750 | |||
| IPWNSLKQGY | RHVHLLSKNG | DLHPSATLFV | KISIQD |