Descriptions
(Annotation based on sequence homology with P15336)
ATF-2 is a cellular basic region-leucine zipper (bZIP) transcription factor that can mediate diverse transcriptional responses, including activation by the adenovirus Ela protein. ATF-2 contains an activation domain, required for transcriptional activity, but in the absence of an appropriate inducer, full-length ATF-2 is transcriptionally inactive. The ATF-2 bZIP (residues 350-415) suppresses the ATF-2 and the related Ela activation domains but not acidic- and glutamine-rich activation domains. The ATF-2 bZIP and activation domain are engaged in an inhibitory intramolecular interaction and the inducers of ATF-2 disrupt this interaction to activate transcription.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R0S1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R0S1-F1 | Predicted | AlphaFoldDB |
13 variants for Q8R0S1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389403936 | 16 | Q>R | No | EVA | |
| rs3389403972 | 28 | K>N | No | EVA | |
| rs3389390201 | 63 | E>* | No | EVA | |
| rs3389394909 | 63 | E>D | No | EVA | |
| rs264525791 | 80 | K>R | No | EVA | |
| rs3389396873 | 93 | P>H | No | EVA | |
| rs3389394966 | 95 | D>E | No | EVA | |
| rs3405632510 | 213 | V>I | No | EVA | |
| rs3406251680 | 215 | M>K | No | EVA | |
| rs3406508746 | 216 | P>A | No | EVA | |
| rs3389356526 | 258 | M>L | No | EVA | |
| rs3413014953 | 316 | T>P | No | EVA | |
| rs3389374195 | 413 | K>R | No | EVA |
No associated diseases with Q8R0S1
No regional properties for Q8R0S1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8R0S1 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP response element binding | Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| metal ion binding | Binding to a metal ion. |
| mitogen-activated protein kinase binding | Binding to a mitogen-activated protein kinase. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| transcription coactivator binding | Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| hematopoietic progenitor cell differentiation | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
| hepatocyte apoptotic process | Any apoptotic process in a hepatocyte, the main structural component of the liver. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| liver development | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| p38MAPK cascade | An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O93602 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | Gallus gallus (Chicken) | SS |
| P15336 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | Homo sapiens (Human) | EV |
| P15408 | FOSL2 | Fos-related antigen 2 | Homo sapiens (Human) | PR |
| Q02930 | CREB5 | Cyclic AMP-responsive element-binding protein 5 | Homo sapiens (Human) | SS |
| P17544 | ATF7 | Cyclic AMP-dependent transcription factor ATF-7 | Homo sapiens (Human) | PR |
| P47930 | Fosl2 | Fos-related antigen 2 | Mus musculus (Mouse) | PR |
| P16951 | Atf2 | Cyclic AMP-dependent transcription factor ATF-2 | Mus musculus (Mouse) | SS |
| Q00969 | Atf2 | Cyclic AMP-dependent transcription factor ATF-2 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDDRPFVCS | APGCGQRFTN | EDHLAVHKHK | HEMTLKFGPA | RTDSVIIADQ | TPTPTRFLKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CEEVGLFNEL | ASSFEHEFKK | ASDDDEKKGA | AGPLDMSLPS | TPDIKIKEEE | PVEVDSSPPD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPASSPCSPP | LKEKEVTTKP | VVISTPTPTI | VRPGSLPLHL | GYDPLHPTLP | SPTSVITQAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSNRQIGSPT | GSLPLVMHLA | NGQTMPMLPG | PPVQMPSVIS | LARPVSMVPN | IPGIPGPPVN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NSGSISPSGH | PMPSEAKMRL | KATLTHQVSS | INGGCGMVVG | TASTMVTARP | EQNQILIQHP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAPSPAQPQV | SPAQPTPSTG | GRRRRTVDED | PDERRQRFLE | RNRAAASRCR | QKRKLWVSSL |
| 370 | 380 | 390 | 400 | 410 | |
| EKKAEELTSQ | NIQLSNEVTL | LRNEVAQLKQ | LLLAHKDCPV | TALQKKTQGY | LGK |