Q8R001
PR
Gene name |
Mapre2 |
Protein name |
Microtubule-associated protein RP/EB family member 2 |
Names |
APC-binding protein EB2, End-binding protein 2, EB2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:212307 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R001
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R001-F1 | Predicted | AlphaFoldDB |
17 variants for Q8R001
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389401130 | 58 | S>C | No | EVA | |
| rs3389483085 | 73 | N>I | No | EVA | |
| rs3389486098 | 127 | M>I | No | EVA | |
| rs3389490422 | 134 | P>R | No | EVA | |
| rs3389505911 | 145 | D>E | No | EVA | |
| rs3389438440 | 147 | L>M | No | EVA | |
| rs3389401082 | 159 | A>D | No | EVA | |
| rs3389487360 | 185 | E>G | No | EVA | |
| rs3389498182 | 193 | K>N | No | EVA | |
| rs3389448773 | 198 | N>H | No | EVA | |
| rs3389493740 | 208 | S>N | No | EVA | |
| rs3389487298 | 226 | A>V | No | EVA | |
| rs3389401104 | 254 | K>* | No | EVA | |
| rs3389469624 | 273 | E>A | No | EVA | |
| rs3389401109 | 291 | R>* | No | EVA | |
| rs249788518 | 301 | E>D | No | EVA | |
| rs3389502325 | 318 | Q>L | No | EVA |
No associated diseases with Q8R001
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| microtubule plus-end | The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. |
| spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| microtubule plus-end binding | Binding to the plus end of a microtubule. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| positive regulation of ARF protein signal transduction | Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction. |
| positive regulation of focal adhesion disassembly | Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of keratinocyte migration | Any process that activates or increases the frequency, rate or extent of keratinocyte migration. |
| protein localization to microtubule plus-end | A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end. |
| regulation of microtubule polymerization or depolymerization | Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. |
| spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZBD9 | MAPRE1 | Microtubule-associated protein RP/EB family member 1 | Bos taurus (Bovine) | SS |
| Q5ZLC7 | MAPRE1 | Microtubule-associated protein RP/EB family member 1 | Gallus gallus (Chicken) | SS |
| Q15691 | MAPRE1 | Microtubule-associated protein RP/EB family member 1 | Homo sapiens (Human) | EV |
| Q9UPY8 | MAPRE3 | Microtubule-associated protein RP/EB family member 3 | Homo sapiens (Human) | SS |
| Q15555 | MAPRE2 | Microtubule-associated protein RP/EB family member 2 | Homo sapiens (Human) | PR |
| Q61166 | Mapre1 | Microtubule-associated protein RP/EB family member 1 | Mus musculus (Mouse) | SS |
| Q6PER3 | Mapre3 | Microtubule-associated protein RP/EB family member 3 | Mus musculus (Mouse) | SS |
| Q5XIT1 | Mapre3 | Microtubule-associated protein RP/EB family member 3 | Rattus norvegicus (Rat) | SS |
| Q66HR2 | Mapre1 | Microtubule-associated protein RP/EB family member 1 | Rattus norvegicus (Rat) | SS |
| Q9FJJ5 | EB1B | Microtubule-associated protein RP/EB family member 1B | Arabidopsis thaliana (Mouse-ear cress) | EV |
| Q7XJ60 | EB1A | Microtubule-associated protein RP/EB family member 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6P848 | mapre1 | Microtubule-associated protein RP/EB family member 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGPTQTLSP | NGENNNDIIQ | DNGTIIPFRK | HTVRGERSYS | WGMAVNVYST | SITQETMSRH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DIIAWVNDIV | SLNYTKVEQL | CSGAAYCQFM | DMLFPGCISL | KKVKFQAKLE | HEYIHNFKLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QASFKRMNVD | KVIPVEKLVK | GRFQDNLDFI | QWFKKFYDAN | YDGKEYDPVE | ARQGQDAIPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PDPGEQIFNL | PKKSHHANSP | TAGAAKSSPA | SKPGSTPSRP | SSAKRASSSG | SASRSDKDLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQVIQLNEQV | HSLKLALEGV | EKERDFYFGK | LREIELLCQE | HGQENDDLVQ | RLMEVLYASD |
| 310 | 320 | ||||
| EQEGQTEEPE | AEEQAHDQQP | QQQEEY |