Q8QZV4

PR
Gene name
Stk32c
Protein name
Serine/threonine-protein kinase 32C
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:57740
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

234-256 (Activation loop from InterPro)

Target domain

94-354 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8QZV4

Entry ID Method Resolution Chain Position Source
AF-Q8QZV4-F1 Predicted AlphaFoldDB

21 variants for Q8QZV4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388954193 96 I>N No EVA
rs3388955454 116 T>I No EVA
rs3388951611 150 E>K No EVA
rs3388954254 197 Y>F No EVA
rs3398612156 213 I>L No EVA
rs3398190694 214 I>S No EVA
rs3388912892 217 D>Y No EVA
rs3388951606 222 N>K No EVA
rs3388936158 258 M>L No EVA
rs3388959378 263 F>S No EVA
rs250627423 267 V>I No EVA
rs3388950269 268 N>D No EVA
rs3388954268 271 T>I No EVA
rs3388959521 273 Y>F No EVA
rs3388936166 325 E>D No EVA
rs3388960351 343 S>Y No EVA
rs3388959058 351 A>S No EVA
rs3388946073 383 T>S No EVA
rs3388951602 395 P>H No EVA
rs3388946121 400 K>I No EVA
rs3388960364 443 K>M No EVA

No associated diseases with Q8QZV4

6 regional properties for Q8QZV4

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 181 - 189 IPR000629
domain Helicase, C-terminal 246 - 407 IPR001650
domain DEAD/DEAH box helicase domain 58 - 222 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 52 - 250 IPR014001
domain RNA helicase, DEAD-box type, Q motif 33 - 61 IPR014014
domain ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain 35 - 236 IPR044728

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

29 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6TJY3 RPS6KB1 Ribosomal protein S6 kinase beta-1 Bos taurus (Bovine) SS
P23443 RPS6KB1 Ribosomal protein S6 kinase beta-1 Homo sapiens (Human) EV SS
Q9UBS0 RPS6KB2 Ribosomal protein S6 kinase beta-2 Homo sapiens (Human) PR
Q9HBY8 SGK2 Serine/threonine-protein kinase Sgk2 Homo sapiens (Human) SS
O00141 SGK1 Serine/threonine-protein kinase Sgk1 Homo sapiens (Human) PR
Q96BR1 SGK3 Serine/threonine-protein kinase Sgk3 Homo sapiens (Human) SS
Q9Z1M4 Rps6kb2 Ribosomal protein S6 kinase beta-2 Mus musculus (Mouse) SS
Q8BSK8 Rps6kb1 Ribosomal protein S6 kinase beta-1 Mus musculus (Mouse) SS
Q9ERE3 Sgk3 Serine/threonine-protein kinase Sgk3 Mus musculus (Mouse) PR
Q9Z2A0 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Mus musculus (Mouse) SS
Q02956 Prkcz Protein kinase C zeta type Mus musculus (Mouse) SS
Q62074 Prkci Protein kinase C iota type Mus musculus (Mouse) SS
P70268 Pkn1 Serine/threonine-protein kinase N1 Mus musculus (Mouse) SS
Q8K045 Pkn3 Serine/threonine-protein kinase N3 Mus musculus (Mouse) SS
Q8BWW9 Pkn2 Serine/threonine-protein kinase N2 Mus musculus (Mouse) SS
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
Q02111 Prkcq Protein kinase C theta type Mus musculus (Mouse) PR
P28867 Prkcd Protein kinase C delta type Mus musculus (Mouse) PR
P20444 Prkca Protein kinase C alpha type Mus musculus (Mouse) SS
P63318 Prkcg Protein kinase C gamma type Mus musculus (Mouse) SS
P68404 Prkcb Protein kinase C beta type Mus musculus (Mouse) SS
Q60823 Akt2 RAC-beta serine/threonine-protein kinase Mus musculus (Mouse) PR
P31750 Akt1 RAC-alpha serine/threonine-protein kinase Mus musculus (Mouse) PR
Q9WUA6 Akt3 RAC-gamma serine/threonine-protein kinase Mus musculus (Mouse) PR
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
P67999 Rps6kb1 Ribosomal protein S6 kinase beta-1 Rattus norvegicus (Rat) EV SS
Q5BKK4 sgk1 Serine/threonine-protein kinase Sgk1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MRSGAERRGS SAAAPPSSPP PGRARPAGSD VSPALPPPAA SQPRARDAGD ARAQPRPLFQ
70 80 90 100 110 120
WSKWKKRMSM SSISSGSARR PVFDDKEDVN FDHFQILRAI GKGSFGKVCI VQKRDTEKMY
130 140 150 160 170 180
AMKYMNKQQC IERDEVRNVF RELEILQEIE HVFLVNLWYS FQDEEDMFMV VDLLLGGDLR
190 200 210 220 230 240
YHLQQNVQFS EDTVRLYICE MALALDYLRS QHIIHRDVKP DNILLDEQGH AHLTDFNIAT
250 260 270 280 290 300
IIKDGERATA LAGTKPYMAP EIFHSFVNGG TGYSFEVDWW SVGVMAYELL RGWRPYDIHS
310 320 330 340 350 360
SNAVESLVQL FSTVSVQYVP TWSKEMVALL RKLLTVNPEH RFSSLQDMQT APSLAHVLWD
370 380 390 400 410 420
DLSEKKVEPG FVPNKGRLHC DPTFELEEMI LESRPLHKKK KRLAKNKSRD SSRDSSQSEN
430 440 450 460 470 480
DYLQDCLDAI QQDFVIFNRE KLKRSQELMS EPPPGPETSD MTDSTADSEA EPTALPMCGS
ICPSSGSS