AiPD: Autoinhibited Protein Database

Q8NF37

Gene name	LPCAT1 (AYTL2, PFAAP3)
Protein name	Lysophosphatidylcholine acyltransferase 1
Names	LPC acyltransferase 1, LPCAT-1, LysoPC acyltransferase 1, 1-acylglycerol-3-phosphate O-acyltransferase, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 2, Phosphonoformate immuno-associated protein 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79888
EC number	2.3.1.23: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-53 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NF37

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NF37-F1	Predicted				AlphaFoldDB

426 variants for Q8NF37

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA112985221 rs1053126084	8	P>H		No	ClinGen TOPMed gnomAD
CA359072995 rs1053126084	8	P>R		No	ClinGen TOPMed gnomAD
CA359072996 rs1579824516	8	P>S		No	ClinGen Ensembl
rs1377092738 CA359072977	10	A>V		No	ClinGen TOPMed gnomAD
CA359072970 rs1450229397	11	A>D		No	ClinGen TOPMed
rs1450229397 CA359072967	11	A>V		No	ClinGen TOPMed
CA359072959 rs1282531275	12	P>R		No	ClinGen TOPMed
CA112985214 rs979437124	13	A>V		No	ClinGen TOPMed
CA112985210 rs948126928	18	A>V		No	ClinGen TOPMed
rs916682617 CA112985208	21	A>S		No	ClinGen TOPMed gnomAD
CA359072850 rs1224765854	22	R>W		No	ClinGen gnomAD
CA359072837 rs1490004527	23	L>P		No	ClinGen gnomAD
CA359072821 rs1289721390	25	A>V		No	ClinGen TOPMed gnomAD
CA359072815 rs1341995231	26	P>H		No	ClinGen TOPMed gnomAD
CA359072813 rs1341995231	26	P>L		No	ClinGen TOPMed gnomAD
rs1329019786 CA359072804	27	P>R		No	ClinGen gnomAD
CA359072793 rs1249947367	28	G>W		No	ClinGen gnomAD
CA359072756 rs1184734531	31	P>L		No	ClinGen TOPMed
rs1439902604 CA359072743	32	F>L		No	ClinGen TOPMed
CA359072728 rs1180169270	34	H>R		No	ClinGen TOPMed
rs1216469134 CA359072700	37	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA112985200 rs991976777	37	R>H		No	ClinGen TOPMed gnomAD
rs960829164 CA112985189	39	S>G		No	ClinGen TOPMed
CA359072543 rs1339396281	45	Q>*		No	ClinGen gnomAD
rs780293144 CA3187206	46	V>M		No	ClinGen ExAC TOPMed gnomAD
CA3187204 rs570991069	51	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767638683 CA3187203	52	T>M		No	ClinGen ExAC TOPMed gnomAD
CA359066568 rs1462088213	54	F>I		No	ClinGen gnomAD
CA359066529 rs1440315285	55	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3187198 rs776025222	55	P>S		No	ClinGen ExAC gnomAD
COSM1619857 rs1307070775 CA359066480	57	R>Q	liver Variant assessed as Somatic; 4.632e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA359066484 rs1352768085	57	R>W		No	ClinGen gnomAD
rs747598435 CA3187193	59	L>V		No	ClinGen ExAC gnomAD
rs768548139 CA3187191	62	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	63	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368855942 CA3187190	64	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA359066360 rs1319066169 CA359066362	65	M>I		No	ClinGen gnomAD
rs150608796 CA359066346	67	L>V		No	ClinGen ESP ExAC gnomAD
TCGA novel	69	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	69	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778992691 CA3187186	72	A>T		No	ClinGen ExAC TOPMed
CA359066255 rs1445731870	73	L>F		No	ClinGen gnomAD
CA3187184 rs753834210	75	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA359066225 rs1231859689	75	A>V		No	ClinGen TOPMed
TCGA novel	76	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs961668552 CA112970162	76	S>T		No	ClinGen TOPMed
rs559046387 CA112970159	76	S>Y		No	ClinGen 1000Genomes
CA3187181 rs753194354	79	S>F		No	ClinGen ExAC TOPMed gnomAD
CA3187180 rs201810874	80	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA3187177 rs764774088	83	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1242623674 CA359066098	84	P>T		No	ClinGen gnomAD
CA3187175 rs138116906	85	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138116906 CA3187174	85	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359066047 rs1384897370	86	Q>H		No	ClinGen TOPMed gnomAD
rs775402244 CA3187173	87	P>S		No	ClinGen ExAC gnomAD
rs775402244 CA3187172	87	P>T		No	ClinGen ExAC gnomAD
CA3187171 rs771913207	88	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771913207 CA359066025	88	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1414601281 CA359066007	89	A>V		No	ClinGen TOPMed
CA359065997 rs1297631704	90	L>P		No	ClinGen TOPMed gnomAD
rs1297631704 CA359065994	90	L>Q		No	ClinGen TOPMed gnomAD
CA359066001 rs1314117656	90	L>V		No	ClinGen TOPMed
rs779237434 CA3187169	91	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA359064504 rs1327589466	96	D>E		No	ClinGen TOPMed
rs1204600267 CA359064502	97	F>L		No	ClinGen TOPMed gnomAD
rs766937927 CA3187110	101	A>V		No	ClinGen ExAC gnomAD
CA359064384 rs1312165729	102	I>T		No	ClinGen gnomAD
TCGA novel	103	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359064374 rs1234155126	103	M>V		No	ClinGen TOPMed
rs1337780098 CA359064324	105	T>I		No	ClinGen gnomAD
CA3187106 rs140317722	109	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA359064231 rs1300573368	109	A>V		No	ClinGen gnomAD
TCGA novel	110	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369052835 CA3187104	110	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA3187102 rs776989506	111	G>S		No	ClinGen ExAC gnomAD
CA3187100 rs747091378	113	H>L		No	ClinGen ExAC TOPMed gnomAD
rs768676081 CA3187101	113	H>Y		No	ClinGen ExAC gnomAD
rs772669639 CA359064140	114	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772669639 CA3187098	114	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs775903785 CA3187099	114	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs926337665 CA359064132	115	V>L		No	ClinGen TOPMed gnomAD
rs926337665 CA112966382	115	V>M		No	ClinGen TOPMed gnomAD
rs1337223872 CA359064099	116	A>V		No	ClinGen Ensembl
CA3187095 rs199809414	117	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs149039406 CA3187093	120	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3187094 rs747860604	120	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1047455382 CA112966376	124	P>S		No	ClinGen Ensembl
rs28715640 CA3187092	125	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359063919 rs1395059469	126	E>A		No	ClinGen gnomAD
rs765765060 CA3187090	126	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758431577 CA3187089	127	A>V		No	ClinGen ExAC TOPMed gnomAD
CA112966352 rs67276504	128	A>G		No	ClinGen Ensembl
CA3187086 rs761687464	128	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM270942 rs764346932 CA3187084	131	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA3187082 rs775664260	132	L>F		No	ClinGen ExAC gnomAD
rs746382072 COSM1064285 CA3187080	133	A>V	Variant assessed as Somatic; 0.0 impact. liver pancreas endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs560716607 CA112966323	138	Y>C		No	ClinGen 1000Genomes
rs369309184 CA3187076	139	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1354769326 CA359063721	142	I>L		No	ClinGen gnomAD
CA3187073 rs376037728	143	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs913478692 CA112966306	145	T>A		No	ClinGen Ensembl
CA359063699 rs370820131	145	T>I		No	ClinGen TOPMed gnomAD
rs370820131 CA112966304	145	T>S		No	ClinGen TOPMed gnomAD
rs750444468 CA3187071	147	T>A		No	ClinGen ExAC gnomAD
CA359063666 rs1339369321	147	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs367806579 CA3187069	148	M>T		No	ClinGen ESP ExAC gnomAD
TCGA novel	149	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753699994 CA3187068	150	S>F		No	ClinGen ExAC gnomAD
CA359063585 rs1376977307	152	V>M		No	ClinGen TOPMed
CA3187066 rs760967986	156	E>D		No	ClinGen ExAC
TCGA novel	156	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752800082 CA3187065	158	R>G		No	ClinGen ExAC gnomAD
CA3187062 rs374772443	161	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs773646628 CA3187059	163	W>C		No	ClinGen ExAC gnomAD
rs913250358 CA113022040	165	T>I		No	ClinGen Ensembl
rs770282686 CA359084607	166	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs200423327 CA3187033	168	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA359084579 rs1579785587	170	I>L		No	ClinGen Ensembl
CA359084572 rs755982495	171	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1256630 CA3187031 rs755982495	171	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs777562656 CA3187032	171	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA359084568 rs1306745878	172	P>L		No	ClinGen gnomAD
TCGA novel	174	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs926066773 CA113022004	175	V>M		No	ClinGen Ensembl
CA359084536 rs1336260167	177	R>Q		No	ClinGen TOPMed gnomAD
CA359084539 rs1560973042	177	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA3187029 rs138753883	180	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	181	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755213539 CA3187028	181	D>N		No	ClinGen ExAC gnomAD
CA359084513 rs755213539	181	D>Y		No	ClinGen ExAC gnomAD
CA3187027 rs751721441	182	S>T		No	ClinGen ExAC gnomAD
rs1442061109 CA359084500	183	R>C		No	ClinGen gnomAD
CA359084499 rs1308150369	183	R>H		No	ClinGen gnomAD
rs1178374759 CA359084464	187	V>A		No	ClinGen TOPMed gnomAD
rs1178374759 CA359084463	187	V>G		No	ClinGen TOPMed gnomAD
TCGA novel	187	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237639226 CA359084443	189	E>G		No	ClinGen gnomAD
TCGA novel	189	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3187024 rs758403396	192	R>K		No	ClinGen ExAC gnomAD
rs780038428 CA359084405	193	R>P		No	ClinGen gnomAD
rs780038428 CA113021942 COSM1435461	193	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA3187023 rs546554770	193	R>W		No	ClinGen ExAC gnomAD
CA359084399 rs765632248	194	A>S		No	ClinGen ExAC TOPMed gnomAD
CA3187022 rs765632248	194	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3187021 rs147744743 COSM590623	194	A>V	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1390713034 CA359084385	195	Q>L		No	ClinGen TOPMed gnomAD
rs777160832 CA3187020	197	N>S		No	ClinGen ExAC gnomAD
rs759270315 CA3187018	198	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1446048728 CA359084322	200	W>C		No	ClinGen gnomAD
CA359084107 rs1294918726	203	I>M		No	ClinGen gnomAD
rs985296177 CA113020969	203	I>V		No	ClinGen Ensembl
CA359084095 rs1220339034	204	M>T		No	ClinGen gnomAD
TCGA novel	207	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3186990 rs758572285	215	T>I		No	ClinGen ExAC gnomAD
CA113020956 rs952545037	219	T>I		No	ClinGen Ensembl
rs1335535148 CA359082423	223	G>V		No	ClinGen gnomAD
rs753367940 CA3186959	224	A>G		No	ClinGen ExAC gnomAD
TCGA novel	224	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3186957 rs760608812	225	F>I		No	ClinGen ExAC
CA3186954 rs759350411	229	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3186952 rs370580216	230	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs140048874 COSM1580118 CA3186950	231	V>I	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA359082329 rs1425727632	233	P>H		No	ClinGen gnomAD
rs200841903 CA3186948	237	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1266051075 CA359082249	241	K>*		No	ClinGen TOPMed gnomAD
CA359082236 rs1215084181	242	L>V		No	ClinGen gnomAD
rs1457899085 CA359081414	243	D>G		No	ClinGen gnomAD
rs1193508180 CA359081354	245	I>V		No	ClinGen gnomAD
rs1235287188 CA359081181	251	G>A		No	ClinGen gnomAD
rs773618902 CA3186915	252	P>R		No	ClinGen ExAC TOPMed gnomAD
rs762830445 CA3186916	252	P>S		No	ClinGen ExAC gnomAD
CA3186914 rs765468332	253	G>R		No	ClinGen ExAC gnomAD
rs761901606 CA3186913	254	A>V		No	ClinGen ExAC gnomAD
CA3186885 rs142364979	255	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs148739098 CA113013779	255	L>Q		No	ClinGen ESP
rs142364979 CA359080645	255	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs866086697 CA113013769	258	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA113013763 rs959292312	261	T>M		No	ClinGen Ensembl
rs779671695 CA3186880	266	H>L		No	ClinGen ExAC gnomAD
rs375249372 CA3186881	266	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142758587 CA3186878	269	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3186877 rs375427371	271	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	277	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	279	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756339660 CA3186855	281	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	283	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3186853 rs767655718	284	K>E		No	ClinGen ExAC gnomAD
CA359079963 rs1417361127	286	N>H		No	ClinGen gnomAD
CA359079948 rs1453027865	287	P>H		No	ClinGen TOPMed gnomAD
rs1435157664 CA359079943	288	A>T		No	ClinGen TOPMed
CA3186850 rs199967384	288	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3186845 rs775268624	292	S>N		No	ClinGen ExAC TOPMed gnomAD
rs771755160 CA3186844	292	S>R		No	ClinGen ExAC gnomAD
rs775268624 CA359079889	292	S>T		No	ClinGen ExAC TOPMed gnomAD
CA359079880 rs1170481920	293	N>S		No	ClinGen TOPMed
CA3186842 rs773868926	294	V>M		No	ClinGen ExAC TOPMed gnomAD
CA3186841 rs770793471	295	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA359079866 rs1220288606	295	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA359079856 rs1428476035	296	R>*		No	ClinGen Ensembl
rs906599099 COSM162202 CA113011615	296	R>Q	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA3186838 rs558517257	298	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA359079839 rs371623388	298	M>L		No	ClinGen ESP ExAC gnomAD
rs777545665 CA3186839	298	M>T		No	ClinGen ExAC gnomAD
CA3186840 rs371623388	298	M>V		No	ClinGen ESP ExAC gnomAD
rs377695067 CA3186834	300	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377695067 CA3186835	300	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368297052 CA3186814	301	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs751015911 CA3186812	303	G>D		No	ClinGen ExAC gnomAD
rs758491501 CA3186813	303	G>R		No	ClinGen ExAC
rs757797347 CA3186810	305	S>C		No	ClinGen ExAC gnomAD
TCGA novel	305	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764493318 CA3186808	306	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3186807 rs749719146	308	D>E		No	ClinGen ExAC gnomAD
rs184906742 CA3186806	309	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs202218033 CA3186805	310	T>K		No	ClinGen ExAC gnomAD
rs202218033 CA3186804	310	T>M		No	ClinGen ExAC gnomAD
rs1487658112 CA359078435	310	T>S		No	ClinGen TOPMed
rs370890349 CA113008128	312	E>K		No	ClinGen ESP TOPMed gnomAD
TCGA novel	313	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3186800 rs776426210	314	C>G		No	ClinGen ExAC gnomAD
CA359078343 rs1488879883	315	Q>H		No	ClinGen gnomAD
rs1373949233 CA359078254	319	A>T		No	ClinGen gnomAD
rs1180481540 CA359078240	319	A>V		No	ClinGen TOPMed
rs1440904522 CA359078211	321	G>R		No	ClinGen TOPMed
rs141767236 CA3186798	322	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs545411507 CA3186795	324	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1165331 rs377578537 CA3186794	324	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs377578537 CA359078151	324	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1213900585 CA359078146	325	L>F		No	ClinGen gnomAD
CA359078139 rs1336379037	325	L>P		No	ClinGen gnomAD
CA3186791 rs778062419	327	A>D		No	ClinGen ExAC gnomAD
CA3186793 rs138573338	327	A>T		No	ClinGen ESP ExAC TOPMed
CA3186792 rs778062419	327	A>V		No	ClinGen ExAC gnomAD
rs574853919 CA3186790	328	D>H		No	ClinGen 1000Genomes ExAC gnomAD
CA3186789 rs751223289	329	T>A		No	ClinGen ExAC gnomAD
rs766027119 CA3186788	329	T>I		No	ClinGen ExAC gnomAD
CA113008025 TCGA novel rs201107441	333	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed gnomAD
CA3186787 rs762475985	334	F>L		No	ClinGen ExAC gnomAD
CA113008018 rs868865729	335	A>V		No	ClinGen Ensembl
CA3186786 rs749959100	337	L>V		No	ClinGen ExAC TOPMed gnomAD
rs201807269 CA113007990	338	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201807269 CA3186784	338	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1015784961 CA113007984	339	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1306985481 CA359077909	340	G>D		No	ClinGen TOPMed
rs780303802	341	L>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs367944297 CA113007977	341	L>F		No	ClinGen ESP gnomAD
CA3186782 rs763843755	342	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3186754 rs771187124	343	L>V		No	ClinGen ExAC TOPMed gnomAD
rs376035513 CA113007498	345	P>L		No	ClinGen TOPMed
rs376035513 CA113007500	345	P>R		No	ClinGen TOPMed
CA359077762 rs1287716765	346	E>Q		No	ClinGen TOPMed
CA3186752 rs773130273	349	E>A		No	ClinGen ExAC gnomAD
rs1402475964 CA359077716	349	E>K		No	ClinGen TOPMed
CA113007485 rs893677656	351	D>H		No	ClinGen Ensembl
rs1028949150 CA113007475	352	L>M		No	ClinGen TOPMed
rs113609424 CA359077600	355	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA3186750 rs199553328	356	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1176071642 CA359077235	357	E>A		No	ClinGen gnomAD
rs1176071642 CA359077228	357	E>G		No	ClinGen gnomAD
CA359077107 rs1394832147	362	K>M		No	ClinGen gnomAD
CA113007448 rs371335596	364	G>E		No	ClinGen Ensembl
TCGA novel	366	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1171661362 CA359077022	367	I>R		No	ClinGen TOPMed gnomAD
CA359077023 rs1171661362	367	I>T		No	ClinGen TOPMed gnomAD
rs1055043360 CA113007445	368	G>D		No	ClinGen Ensembl
CA359077000 rs1470285595	368	G>R		No	ClinGen TOPMed gnomAD
CA3186747 rs745579397	369	I>S		No	ClinGen ExAC gnomAD
CA3186746 rs778505363	370	A>V		No	ClinGen ExAC TOPMed gnomAD
CA113007384 rs866800585	373	A>V		No	ClinGen Ensembl
rs148005551 CA359076872	374	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs148005551 CA3186743	374	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs371978316 CA3186742	374	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1046075586 CA113007323	375	S>C		No	ClinGen Ensembl
rs1224578151 CA359076832	376	L>P		No	ClinGen gnomAD
rs752568981 CA3186741	377	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	379	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143470660 CA3186737	380	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3186736 rs763040673	382	D>Y		No	ClinGen ExAC gnomAD
CA3186735 rs773358299	385	E>K		No	ClinGen ExAC gnomAD
rs1409783773 CA359076631	386	D>E		No	ClinGen gnomAD
CA359076638 rs1400944063	386	D>N		No	ClinGen gnomAD
CA3186734 rs769696449	387	M>V		No	ClinGen ExAC gnomAD
TCGA novel	389	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359076134 rs762450253	391	F>L		No	ClinGen ExAC gnomAD
CA113007232 rs141080202	392	D>H		No	ClinGen ESP
CA113007233 rs141080202	392	D>N		No	ClinGen ESP
CA3186731 rs769059153	393	E>K		No	ClinGen ExAC gnomAD
rs1233480344 CA359075602	394	S>G		No	ClinGen gnomAD
CA3186698 rs750709106	395	G>S		No	ClinGen ExAC gnomAD
CA113003034 rs769365707	396	S>I		No	ClinGen TOPMed gnomAD
rs1350502986 CA359075560	397	G>S		No	ClinGen TOPMed gnomAD
CA3186694 rs753927160	398	E>K		No	ClinGen ExAC TOPMed
rs147749305 CA3186693	402	R>*		No	ClinGen ESP ExAC gnomAD
CA359075509 rs1366324705	402	R>Q		No	ClinGen TOPMed gnomAD
rs761234099 CA3186692	403	E>*		No	ClinGen ExAC gnomAD
rs775958276 CA3186691	403	E>A		No	ClinGen ExAC TOPMed gnomAD
CA359075495 rs775958276	403	E>V		No	ClinGen ExAC TOPMed gnomAD
CA3186690 rs767971999	404	C>S		No	ClinGen ExAC gnomAD
CA3186688 rs774740117	406	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1331073519 CA359075430	409	S>F		No	ClinGen TOPMed
rs768278241 CA3186684 COSM1695355	410	V>A	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA3186685 rs776289215	410	V>I		No	ClinGen ExAC gnomAD
rs111307365 CA3186683	411	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000144228 rs587776361 CA249827	412	C>F		No	ClinGen ClinVar Ensembl dbSNP
rs141834134 CA3186681	413	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs375661111 CA3186682	413	R>W		No	ClinGen ESP ExAC gnomAD
CA359075379 rs1278580055	414	P>L		No	ClinGen TOPMed gnomAD
rs1311189443 CA359075371	415	A>D		No	ClinGen gnomAD
CA3186678 rs180837307	416	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369833504 CA359075364	416	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs369833504 CA3186677	416	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA359075366 rs180837307	416	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1348053215 CA359075359	417	T>A		No	ClinGen gnomAD
TCGA novel	419	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359075326 rs1156971663	420	T>A		No	ClinGen TOPMed
rs781628867 CA113002848	420	T>S		No	ClinGen Ensembl
CA359075270 rs1384331841	422	Q>H		No	ClinGen TOPMed
rs1377078487 CA359075222	426	K>E		No	ClinGen gnomAD
rs149822046 CA3186675	426	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3186652 rs766712143 CA3186651	427	M>I		No	ClinGen ExAC TOPMed gnomAD
CA112998117 rs35452723	427	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3186654 rs748135748	427	M>L		No	ClinGen ExAC TOPMed gnomAD
CA3186653 rs35452723	427	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1425873873 CA359073639	429	G>E		No	ClinGen TOPMed
rs942008585 CA112998088	429	G>R		No	ClinGen Ensembl
rs1305453663 CA359073628	430	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA359073575 rs954777354	433	D>E		No	ClinGen TOPMed gnomAD
CA112998062 rs986179103	433	D>N		No	ClinGen Ensembl
rs535425512 CA3186646	434	G>C		No	ClinGen ExAC gnomAD
rs143106036 CA3186644 COSM3661578	434	G>D	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA3186645 rs535425512	434	G>S		No	ClinGen ExAC gnomAD
CA359073535 rs1328418465	436	V>F		No	ClinGen TOPMed
rs1225430434 CA359072490	438	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA359072459 rs1339492979	439	G>S		No	ClinGen TOPMed gnomAD
rs955924676 CA112998026	440	D>E		No	ClinGen TOPMed gnomAD
rs1044903820 CA112998040	440	D>G		No	ClinGen TOPMed
CA359072374 rs1579751478	442	S>F		No	ClinGen Ensembl
CA3186641 rs749109602	444	I>F		No	ClinGen ExAC gnomAD
CA359072223 rs1264601328	447	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1263141946 CA359072214	448	A>P		No	ClinGen TOPMed
CA359072196 rs1032005944	449	L>V		No	ClinGen gnomAD
rs113155822 CA112997994	451	V>A		No	ClinGen TOPMed gnomAD
CA3186637 rs781199821	453	E>K		No	ClinGen ExAC gnomAD
rs780580539 CA3186634	455	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1367219101 CA359072065	455	T>I		No	ClinGen TOPMed
rs780580539 CA3186635	455	T>P		No	ClinGen ExAC TOPMed gnomAD
CA3186631 rs765629260	456	V>L		No	ClinGen ExAC TOPMed gnomAD
rs752381395 CA3186629	457	T>A		No	ClinGen ExAC gnomAD
CA359072042 rs1306717256	457	T>S		No	ClinGen gnomAD
CA3186623 CA359071956 rs543894552	460	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA112997894 rs376760316	460	F>V		No	ClinGen ESP gnomAD
CA359071926 rs1383309700	461	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1454355406 CA359071911	461	R>L		No	ClinGen TOPMed
rs769575480 CA3186622	462	A>V		No	ClinGen ExAC gnomAD
TCGA novel	463	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359071875 rs1253937346	463	I>V		No	ClinGen gnomAD
CA3186620 rs776889940	464	D>G		No	ClinGen ExAC TOPMed gnomAD
rs768659423 CA3186619	465	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs747144587 CA3186618	467	E>D		No	ClinGen ExAC gnomAD
CA359071734 rs1368058605	468	K>T		No	ClinGen gnomAD
rs1262000361 CA359071705	469	G>R		No	ClinGen TOPMed
rs146280460 CA3186616	470	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3186615 rs758976923	470	K>R		No	ClinGen ExAC gnomAD
rs779476967 CA3186614	471	I>M		No	ClinGen ExAC TOPMed gnomAD
rs757618527 CA3186612	472	T>I		No	ClinGen ExAC TOPMed gnomAD
CA112997778 rs148686721	473	F>L		No	ClinGen ESP TOPMed gnomAD
CA3186611 rs141884703	473	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3186610 rs767227485	474	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1271068661 CA359070449	475	D>E		No	ClinGen gnomAD
CA3186583 rs375617054	476	F>L		No	ClinGen ESP ExAC gnomAD
CA3186582 rs761012101	477	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs144081179 CA3186581	480	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144081179 CA359070320	480	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs919674807 CA112992651	481	E>D		No	ClinGen Ensembl
rs774522469 CA3186578	482	M>I		No	ClinGen ExAC gnomAD
rs759720072 CA3186579	482	M>T		No	ClinGen ExAC gnomAD
CA3186580 rs138685440	482	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359070246 rs1403499905	483	Y>H		No	ClinGen TOPMed gnomAD
CA359070189 rs1168336545	485	A>S		No	ClinGen TOPMed gnomAD
rs1168336545 CA359070200	485	A>T		No	ClinGen TOPMed gnomAD
rs749688837 CA3186576	485	A>V		No	ClinGen ExAC gnomAD
rs772635191 CA359070143	486	F>L		No	ClinGen ExAC TOPMed gnomAD
CA359070147 rs1246461658	486	F>S		No	ClinGen gnomAD
CA3186574 rs770042906	488	E>K		No	ClinGen ExAC TOPMed gnomAD
CA359070099 rs1248487431	489	E>K		No	ClinGen gnomAD
rs559330897 CA112992627	490	Y>F		No	ClinGen 1000Genomes gnomAD
CA359070033 rs1331476848	491	L>P		No	ClinGen TOPMed gnomAD
rs746713358 CA3186573	493	P>L		No	ClinGen ExAC gnomAD
CA359069952 rs1340442862	495	Q>*		No	ClinGen TOPMed gnomAD
rs1340442862 CA359069964	495	Q>K		No	ClinGen TOPMed gnomAD
CA359069944 rs1416731706	495	Q>R		No	ClinGen TOPMed
rs137984614 CA3186570	499	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1377761661 CA359069862	500	S>C		No	ClinGen TOPMed
CA3186568 rs537723576	502	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1161855709 CA359069767	504	T>I		No	ClinGen TOPMed gnomAD
CA3186566 rs763995971	505	S>L		No	ClinGen ExAC gnomAD
CA3186564 rs752496909	506	P>L		No	ClinGen ExAC gnomAD
CA3186565 rs146947988	506	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
COSM75265 CA359069686 rs1469632956	507	A>V	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA3186562 rs142709570	508	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3186560 rs770913919	509	I>V		No	ClinGen ExAC TOPMed gnomAD
CA3186559 rs763574216	510	P>A		No	ClinGen ExAC gnomAD
CA3186557 rs368316464	510	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3186558 rs368316464	510	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359069636 rs763574216	510	P>S		No	ClinGen ExAC gnomAD
CA359069646 rs763574216	510	P>T		No	ClinGen ExAC gnomAD
CA359069370 rs865822780	514	C>F		No	ClinGen gnomAD
CA112992510 rs865822780	514	C>Y		No	ClinGen gnomAD
rs529710476 CA3186554	516	D>N		No	ClinGen ExAC gnomAD
rs1479449868 CA359069306	518	S>N		No	ClinGen TOPMed
CA359069295 rs1302920160	518	S>R		No	ClinGen gnomAD
CA359069286 rs1217040611	519	P>L		No	ClinGen gnomAD
rs112539594 CA3186552	522	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3186551 rs547466871	523	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA359069229 rs1224122346	524	A>T		No	ClinGen gnomAD
rs756067328 CA3186548	525	G>E		No	ClinGen ExAC gnomAD
rs1174214239 CA359069210	526	R>Q		No	ClinGen gnomAD
rs140641175 CA3186546	526	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs751718602 CA3186544	528	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1408735162 CA359069175	529	V>F		No	ClinGen gnomAD
rs1184972718 CA359069168	530	R>G		No	ClinGen gnomAD
CA3186543 rs766530725	530	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA112992418 rs766530725	530	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1184972718 CA359069170	530	R>S		No	ClinGen gnomAD
CA359069137 rs566361131	533	L>M		No	ClinGen gnomAD
CA3186542 rs762911281	534	D>G		No	ClinGen ExAC gnomAD

No associated diseases with Q8NF37

4 regional properties for Q8NF37

Type	Name	Position	InterPro Accession
domain	EF-hand domain	379 - 414	IPR002048-1
domain	EF-hand domain	432 - 486	IPR002048-2
domain	Phospholipid/glycerol acyltransferase	114 - 239	IPR002123
domain	Lysophosphatidylcholine acyltransferase LPCAT1-like	103 - 314	IPR045252

Functions

		Description
EC Number	2.3.1.23	Transferring groups other than amino-acyl groups
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Cell membrane ; Single-pass type II membrane protein Lipid droplet	May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
azurophil granule membrane	The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lipid droplet	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name	Definition
1-acylglycerol-3-phosphate O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
1-acylglycerophosphocholine O-acyltransferase activity	Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.
1-alkenylglycerophosphocholine O-acyltransferase activity	Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA.
1-alkylglycerophosphocholine O-acetyltransferase activity	Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA.
1-alkylglycerophosphocholine O-acyltransferase activity	Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA.
2-acylglycerol-3-phosphate O-acyltransferase activity	Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA.
calcium ion binding	Binding to a calcium ion (Ca2+).
plasmalogen synthase activity	Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine.

10 GO annotations of biological process

Name	Definition
negative regulation of phosphatidylcholine biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process.
phosphatidic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidylcholine acyl-chain remodeling	Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.
phosphatidylcholine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylglycerol acyl-chain remodeling	Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains.
phospholipid biosynthetic process	The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
positive regulation of protein catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
retina development in camera-type eye	The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
surfactant homeostasis	Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A3FPG8	GPAT4	Glycerol-3-phosphate acyltransferase 4	Bos taurus (Bovine)	PR
Q5ZLL8	GPAT3	Glycerol-3-phosphate acyltransferase 3	Gallus gallus (Chicken)	PR
Q86UL3	GPAT4	Glycerol-3-phosphate acyltransferase 4	Homo sapiens (Human)	PR
Q8C0N2	Gpat3	Glycerol-3-phosphate acyltransferase 3	Mus musculus (Mouse)	PR
Q8K2C8	Gpat4	Glycerol-3-phosphate acyltransferase 4	Mus musculus (Mouse)	PR
Q6NVG1	Lpcat4	Lysophospholipid acyltransferase LPCAT4	Mus musculus (Mouse)	PR
Q3TFD2	Lpcat1	Lysophosphatidylcholine acyltransferase 1	Mus musculus (Mouse)	PR
Q1HAQ0	Lpcat1	Lysophosphatidylcholine acyltransferase 1	Rattus norvegicus (Rat)	PR
Q8L7R3	LPEAT1	Lysophospholipid acyltransferase LPEAT1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8S8S2	LPEAT2	Lysophospholipid acyltransferase LPEAT2	Arabidopsis thaliana (Mouse-ear cress)	PR
A3KGT9	agpat9l	Glycerol-3-phosphate acyltransferase 3-like	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q6PBN5	aup1	Lipid droplet-regulating VLDL assembly factor AUP1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q1LWG4	lpcat1	Lysophosphatidylcholine acyltransferase 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MRLRGCGPRA	APASSAGASD	ARLLAPPGRN	PFVHELRLSA	LQKAQVALMT	LTLFPVRLLV
70	80	90	100	110	120
AAAMMLLAWP	LALVASLGSA	EKEPEQPPAL	WRKVVDFLLK	AIMRTMWFAG	GFHRVAVKGR
130	140	150	160	170	180
QALPTEAAIL	TLAPHSSYFD	AIPVTMTMSS	IVMKAESRDI	PIWGTLIQYI	RPVFVSRSDQ
190	200	210	220	230	240
DSRRKTVEEI	KRRAQSNGKW	PQIMIFPEGT	CTNRTCLITF	KPGAFIPGAP	VQPVVLRYPN
250	260	270	280	290	300
KLDTITWTWQ	GPGALEILWL	TLCQFHNQVE	IEFLPVYSPS	EEEKRNPALY	ASNVRRVMAE
310	320	330	340	350	360
ALGVSVTDYT	FEDCQLALAE	GQLRLPADTC	LLEFARLVRG	LGLKPEKLEK	DLDRYSERAR
370	380	390	400	410	420
MKGGEKIGIA	EFAASLEVPV	SDLLEDMFSL	FDESGSGEVD	LRECVVALSV	VCRPARTLDT
430	440	450	460	470	480
IQLAFKMYGA	QEDGSVGEGD	LSCILKTALG	VAELTVTDLF	RAIDQEEKGK	ITFADFHRFA
490	500	510	520	530
EMYPAFAEEY	LYPDQTHFES	CAETSPAPIP	NGFCADFSPE	NSDAGRKPVR	KKLD