AiPD: Autoinhibited Protein Database

Q8NE63

Gene name	HIPK4
Protein name	Homeodomain-interacting protein kinase 4
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:147746
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

314-616 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

314-616 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NE63

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NE63-F1	Predicted				AlphaFoldDB

240 variants for Q8NE63

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000149343 rs193920880	427	D>N	Malignant tumor of prostate [ClinVar]	Yes	ClinVar dbSNP
rs1599646939 CA405888212	2	S>P		No	ClinGen Ensembl
rs1599646935 CA405888194	3	T>P		No	ClinGen Ensembl
rs760319453 CA9443597	5	Q>*		No	ClinGen ExAC gnomAD
CA308410582 rs370355041	5	Q>H		No	ClinGen Ensembl
rs1445338664 CA405888141	5	Q>P		No	ClinGen gnomAD
rs1445338664 CA405888145	5	Q>R		No	ClinGen gnomAD
rs760883836 CA9443596	6	S>L		No	ClinGen ExAC TOPMed gnomAD
rs773646336 CA9443593	8	T>I		No	ClinGen ExAC TOPMed gnomAD
rs769993499 CA9443592	9	D>N		No	ClinGen ExAC TOPMed gnomAD
rs374592673 CA9443591	10	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9443590 rs558660995	10	C>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405887987 rs1364058769	12	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9443586 rs377107606	15	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9443584 rs570114842	17	L>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	18	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	22	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760368671 CA9443580	30	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9443581 rs763886506	30	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs199527408 CA9443578 COSM175980	31	R>Q	large_intestine central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA9443579 rs775166307	31	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA405887551 rs1599646852	32	S>G		No	ClinGen Ensembl
rs1599646848 CA405887538	32	S>R		No	ClinGen Ensembl
CA9443577 rs763526891	33	T>M		No	ClinGen ExAC gnomAD
rs1162398046 CA405887521	34	G>S		No	ClinGen gnomAD
rs748573312 CA9443574	35	E>K		No	ClinGen ExAC TOPMed gnomAD
rs776961937 CA9443573	36	M>I		No	ClinGen ExAC gnomAD
rs1599646827 CA405887479	37	V>G		No	ClinGen Ensembl
CA405887474 rs1599646824	38	A>G		No	ClinGen Ensembl
CA405887471 rs1477498433	39	I>L		No	ClinGen gnomAD
CA308410408 rs1030104437	40	K>R		No	ClinGen TOPMed
CA9443572 rs768907639	41	I>L		No	ClinGen ExAC gnomAD
rs747192970 CA9443571	41	I>M		No	ClinGen ExAC TOPMed gnomAD
rs758353813 CA9443569	46	A>T		No	ClinGen ExAC TOPMed gnomAD
rs745953817 CA9443568	48	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9443567 COSM3378936 rs778771912	48	R>H	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs190827341 CA9443566	50	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs146668696 CA9443565	50	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9443564 rs146668696	50	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1284625104 CA405887292	51	I>N		No	ClinGen gnomAD
rs1169524144 CA405887296	51	I>V		No	ClinGen gnomAD
CA9443563 rs755849000	52	I>V		No	ClinGen ExAC gnomAD
COSM996672 CA9443562 rs17853310	53	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1227295944 CA405887260	53	K>R		No	ClinGen TOPMed
rs1568698585 CA405887230	55	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	59	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9443558 rs765716221	60	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA9443559 rs751069591	60	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1465278181 CA405887132	61	C>Y		No	ClinGen gnomAD
CA405887122 rs1421809889	62	M>L		No	ClinGen gnomAD
rs1266566496 CA405887116	62	M>T		No	ClinGen TOPMed
rs1328912809 CA405887104	63	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9443557 rs762281156	63	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1568698555 CA405887094	64	G>S		No	ClinGen Ensembl
CA9443556 rs777010991	65	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1181395686 CA405887052	67	P>H		No	ClinGen TOPMed
rs1189984591 CA405887043	68	E>D		No	ClinGen gnomAD
rs1041408921 CA308410337	68	E>K		No	ClinGen Ensembl
rs1185228571 COSM1638049 CA405887039	69	E>V	bone [Cosmic]	No	ClinGen cosmic curated gnomAD
CA9443554 rs760901221	70	A>T		No	ClinGen ExAC TOPMed
TCGA novel	71	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9443553 rs775509708	72	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1160820347 CA405887011	73	I>S		No	ClinGen TOPMed
rs1160820347 CA405887012	73	I>T		No	ClinGen TOPMed
rs369248074 CA9443551	74	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1057246320 CA308410330	74	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	75	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9443550 rs779019561	76	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1356834381 CA405886990	77	E>Q		No	ClinGen TOPMed
COSM711399 CA405886978 rs1350242537	78	F>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs914216707 CA308410307	78	F>V		No	ClinGen TOPMed gnomAD
rs1225389809 CA405886965	80	H>R		No	ClinGen TOPMed gnomAD
rs777721110 CA405886953	82	A>P		No	ClinGen ExAC gnomAD
CA9443546 rs777721110 COSM244906	82	A>T	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA308410300 rs377377843	82	A>V		No	ClinGen ESP gnomAD
rs1466554928 CA405886947	83	L>F		No	ClinGen gnomAD
CA308410294 rs926825676	84	K>R		No	ClinGen TOPMed gnomAD
rs780768411 CA405886919	87	L>V		No	ClinGen ExAC TOPMed gnomAD
rs374640365 CA308410282	91	L>M		No	ClinGen ESP TOPMed
CA9443542 rs754639958	92	L>M		No	ClinGen ExAC gnomAD
TCGA novel	95	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1251058698 CA405886859	96	L>F		No	ClinGen TOPMed
CA9443540 rs200286326	98	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1244539445 CA405886846	98	E>Q		No	ClinGen TOPMed gnomAD
rs754287958 CA9443538	102	E>D		No	ClinGen ExAC gnomAD
rs762330541 CA9443539	102	E>G		No	ClinGen ExAC
CA405886798 rs1253729226	104	N>T		No	ClinGen gnomAD
CA405886789 rs1599646646	105	F>S		No	ClinGen Ensembl
CA9443535 rs34434715	106	A>P		No	ClinGen ExAC TOPMed gnomAD
CA9443536 rs34434715 VAR_040554	106	A>T		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs79236726 CA9443534	106	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9443530 rs75999496	108	L>P		No	ClinGen ExAC gnomAD
rs747946015 CA9443527	110	A>P		No	ClinGen ExAC TOPMed gnomAD
rs747946015 CA9443528	110	A>T		No	ClinGen ExAC TOPMed gnomAD
CA308410167 rs1030401738	111	R>C		No	ClinGen TOPMed gnomAD
CA308410163 rs1026949470	111	R>H		No	ClinGen TOPMed gnomAD
rs781013832 CA9443526	114	R>C		No	ClinGen ExAC TOPMed gnomAD
rs962058548 CA308410133	114	R>H		No	ClinGen TOPMed
CA308410120 rs996806991	115	T>R		No	ClinGen Ensembl
rs751175620 CA9443524	117	T>I		No	ClinGen ExAC gnomAD
TCGA novel	117	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	119	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757837797 CA9443522	122	T>A		No	ClinGen ExAC gnomAD
CA308410092 rs142915464	123	A>V		No	ClinGen ESP TOPMed gnomAD
TCGA novel	124	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9443518 rs753035027	126	R>Q		No	ClinGen ExAC gnomAD
CA9443519 rs144825243	126	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs767870024 CA9443517	127	L>F		No	ClinGen ExAC gnomAD
CA9443515 rs371633633	129	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA405886649 rs1477615632	131	A>S		No	ClinGen TOPMed
rs1246292512 CA405886635	133	I>V		No	ClinGen Ensembl
TCGA novel	134	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468373327 CA405886520	142	I>T		No	ClinGen TOPMed gnomAD
CA308409995 rs903243596	145	V>A		No	ClinGen TOPMed
rs769896103 CA405886414	148	T>I		No	ClinGen ExAC TOPMed gnomAD
rs769896103 CA9443508	148	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1599646534 CA405886421	148	T>P		No	ClinGen Ensembl
rs748082189 CA9443507	149	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9443506 rs776313176	149	R>H		No	ClinGen ExAC TOPMed gnomAD
CA405886401 rs776313176	149	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1172093641 CA405886388	150	C>Y		No	ClinGen gnomAD
CA405886366 rs1348494874	151	P>L		No	ClinGen TOPMed
TCGA novel	156	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1599643843 CA405884815	156	V>G		No	ClinGen Ensembl
CA405884813 rs1325764906	157	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs756715560 CA9443481	162	A>P		No	ClinGen ExAC TOPMed gnomAD
CA405884773 rs1483890261	163	S>R		No	ClinGen TOPMed
rs755420431 CA9443479	164	I>S		No	ClinGen ExAC TOPMed gnomAD
rs755420431 CA9443478	164	I>T		No	ClinGen ExAC TOPMed gnomAD
CA9443480 rs200937693	164	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405884752 rs1328891678	166	S>C		No	ClinGen TOPMed gnomAD
CA405884754 rs1328891678	166	S>R		No	ClinGen TOPMed gnomAD
CA9443476 rs780526664	167	E>*		No	ClinGen ExAC gnomAD
CA405884734 rs1599643814	168	V>G		No	ClinGen Ensembl
CA405884731 rs1171547119	169	R>C		No	ClinGen gnomAD
rs201085696 CA308405892	169	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA405884727 rs1474702512	170	Y>H		No	ClinGen TOPMed
CA9443473 rs765240481	171	V>A		No	ClinGen ExAC gnomAD
CA405884718 rs765240481	171	V>G		No	ClinGen ExAC gnomAD
VAR_040555 rs55964225 CA9443474	171	V>M		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
rs762023461 CA9443472	172	K>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	178	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764129980 CA9443470	179	R>H		No	ClinGen ExAC gnomAD
CA405884662 rs764129980	179	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767356290 CA308405856	182	R>W		No	ClinGen TOPMed gnomAD
CA405884631 rs1387617697	184	P>R		No	ClinGen TOPMed
CA405884602 rs1241260301	189	G>W		No	ClinGen gnomAD
CA405884595 rs1324801852	190	L>P		No	ClinGen TOPMed
rs771792535 CA9443467	192	F>V		No	ClinGen ExAC gnomAD
CA9443466 rs759191946	193	C>R		No	ClinGen ExAC gnomAD
CA9443463 rs748876993	198	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1240189178 CA405884524	200	S>F		No	ClinGen gnomAD
rs777117806 CA9443462	201	L>P		No	ClinGen ExAC TOPMed gnomAD
rs143873993 CA9443461	203	C>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9443460 rs757043623	204	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9443459 rs780579566	206	A>V		No	ClinGen ExAC gnomAD
CA405884471 rs1599643728	209	H>P		No	ClinGen Ensembl
TCGA novel	210	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1473878008 CA405884441	213	P>L		No	ClinGen gnomAD
rs1186866702 CA405884424	216	P>S		No	ClinGen gnomAD
rs750816448 CA9443457	217	G>R		No	ClinGen ExAC
rs779255747 CA9443456	218	N>K		No	ClinGen ExAC TOPMed gnomAD
rs150436293 CA405884401	219	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs753979656 CA9443452	220	E>D		No	ClinGen ExAC gnomAD
CA9443453 rs1034023576	220	E>K		No	ClinGen Ensembl
rs1353697202 CA405884396	220	E>V		No	ClinGen gnomAD
rs1003425015 CA405884386	222	D>H		No	ClinGen TOPMed gnomAD
rs1003425015 CA308405762	222	D>N		No	ClinGen TOPMed gnomAD
rs752564037 CA9443449	225	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM1162493 CA9443448 rs767437240	225	R>H	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1298339321 CA405884361	226	Y>N		No	ClinGen gnomAD
CA9443447 rs759382507	228	C>Y		No	ClinGen ExAC gnomAD
CA405884322 rs1599643644	230	T>P		No	ClinGen Ensembl
rs1017465649 CA308405740	232	G>S		No	ClinGen TOPMed
CA9443445 rs770659093	235	K>*		No	ClinGen ExAC gnomAD
rs762474104 CA9443444	236	P>T		No	ClinGen ExAC gnomAD
CA9443443 rs772802613	237	H>Y		No	ClinGen ExAC gnomAD
rs747527574 CA9443441	238	L>V		No	ClinGen ExAC TOPMed gnomAD
rs780777730 CA9443440	241	A>T		No	ClinGen ExAC TOPMed gnomAD
rs746295654 CA9443438	242	A>D		No	ClinGen ExAC TOPMed gnomAD
rs888213578 CA308405666	242	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs749410438 CA9443435	246	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA405883971 rs1349505835	250	K>R		No	ClinGen TOPMed
rs756252191 CA9443433	251	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9443432 rs752760077	251	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756252191 CA9443434	251	R>S		No	ClinGen ExAC TOPMed gnomAD
rs199630536 CA9443431 CA405883935	252	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs75602333 CA308405600	252	N>T		No	ClinGen Ensembl
CA308405598 rs920899826	253	P>L		No	ClinGen TOPMed gnomAD
CA405883914 rs1466619079	254	H>N		No	ClinGen TOPMed
CA405883908 rs1599643584	254	H>P		No	ClinGen Ensembl
rs1298739960 CA405883851	257	A>D		No	ClinGen gnomAD
CA9443427 rs200561773	257	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1171426008 CA405883837	258	A>V		No	ClinGen gnomAD
rs1477550015 CA405883817	259	N>K		No	ClinGen gnomAD
CA405883805 COSM1712300 rs1422037767	260	P>L	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA308405568 rs944975576	264	K>E		No	ClinGen Ensembl
CA405883726 rs1193420779	265	S>F		No	ClinGen gnomAD
CA9443425 rs571026735	266	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9443426 rs772674739	266	S>T		No	ClinGen ExAC gnomAD
rs746309036 CA9443421	269	Y>H		No	ClinGen ExAC gnomAD
rs148038861 CA9443420	271	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148038861 CA405883643	271	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373462941 COSM996662 CA9443418	272	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs200281362 CA9443417	273	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773591468	280	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs145519209	287	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs144600040	299	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs11670988 VAR_030578	302	R>Q		No	UniProt dbSNP
RCV000881666 rs79330270	304	T>I		No	ClinVar dbSNP
rs374741709	316	D>N	Variant assessed as Somatic; 4.763e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs893696566	319	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	323	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326236017	334	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	348	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764500728	353	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	357	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767888140	357	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1473930178	365	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs372254628	367	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs959035795	370	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	374	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs55760165 VAR_040556	381	T>M		No	UniProt dbSNP
rs768093416	381	T>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
VAR_040557 rs56365273	386	A>T		No	UniProt dbSNP
rs56094851 RCV000959273 VAR_040558	406	S>R		No	ClinVar UniProt dbSNP
rs1555799118	415	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs769433752	417	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs56117722 RCV000966071 VAR_040559	421	G>S		No	ClinVar UniProt dbSNP
rs1347126238	441	L>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs367871526	448	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs201121603	449	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	472	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_040560 rs55801979	481	R>C		No	UniProt dbSNP
rs759855803	485	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1210868555	541	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779285376	564	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs766371069	603	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	609	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379893490	617	H>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q8NE63

3 regional properties for Q8NE63

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	11 - 347	IPR000719
active_site	Serine/threonine-protein kinase, active site	132 - 144	IPR008271
binding_site	Protein kinase, ATP binding site	17 - 40	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity	Catalysis of the transfer of a phosphate group to a histone.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

5 GO annotations of biological process

Name	Definition
histone modification	The covalent alteration of one or more amino acid residues within a histone protein.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of signal transduction by p53 class mediator	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (Human)	PR
Q9H422	HIPK3	Homeodomain-interacting protein kinase 3	Homo sapiens (Human)	SS
Q9H2X6	HIPK2	Homeodomain-interacting protein kinase 2	Homo sapiens (Human)	EV
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (Human)	PR
Q9NR20	DYRK4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens (Human)	PR
Q8BI55	Dyrk4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Mus musculus (Mouse)	PR
Q61214	Dyrk1a	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Mus musculus (Mouse)	PR
Q9QZR5	Hipk2	Homeodomain-interacting protein kinase 2	Mus musculus (Mouse)	SS
Q3V016	Hipk4	Homeodomain-interacting protein kinase 4	Mus musculus (Mouse)	PR
Q4V793	Hipk4	Homeodomain-interacting protein kinase 4	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSTIQSETDC	YDIIEVLGKG	TFGEVAKGWR	RSTGEMVAIK	ILKNDAYRNR	IIKNELKLLH
70	80	90	100	110	120
CMRGLDPEEA	HVIRFLEFFH	DALKFYLVFE	LLEQNLFEFQ	KENNFAPLPA	RHIRTVTLQV
130	140	150	160	170	180
LTALARLKEL	AIIHADLKPE	NIMLVDQTRC	PFRVKVIDFG	SASIFSEVRY	VKEPYIQSRF
190	200	210	220	230	240
YRAPEILLGL	PFCEKVDVWS	LGCVMAELHL	GWPLYPGNNE	YDQVRYICET	QGLPKPHLLH
250	260	270	280	290	300
AACKAHHFFK	RNPHPDAANP	WQLKSSADYL	AETKVRPLER	RKYMLKSLDQ	IETVNGGSVA
310	320	330	340	350	360
SRLTFPDREA	LAEHADLKSM	VELIKRMLTW	ESHERISPSA	ALRHPFVSMQ	QLRSAHETTH
370	380	390	400	410	420
YYQLSLRSYR	LSLQVEGKPP	TPVVAAEDGT	PYYCLAEEKE	AAGMGSVAGS	SPFFREEKAP
430	440	450	460	470	480
GMQRAIDQLD	DLSLQEAGHG	LWGETCTNAV	SDMMVPLKAA	ITGHHVPDSG	PEPILAFYSS
490	500	510	520	530	540
RLAGRHKARK	PPAGSKSDSN	FSNLIRLSQV	SPEDDRPCRG	SSWEEGEHLG	ASAEPLAILQ
550	560	570	580	590	600
RDEDGPNIDN	MTMEAERPDP	ELFDPSSCPG	EWLSEPDCTL	ESVRGPRAQG	LPPRRSHQHG
610
PPRGATSFLQ	HVTGHH