AiPD: Autoinhibited Protein Database

Q8ND24

Gene name	RNF214
Protein name	RING finger protein 214
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:257160
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-87 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

17-87 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8ND24

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8ND24-F1	Predicted				AlphaFoldDB

499 variants for Q8ND24

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs761403728 CA6293288	3	A>T		No	ClinGen ExAC gnomAD
CA6293289 rs764897950	5	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	6	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6293290 rs147353011	6	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6293292 rs766088933	7	A>V		No	ClinGen ExAC gnomAD
CA229375131 rs935515965	8	G>D		No	ClinGen TOPMed
CA229375126 rs903624605	8	G>R		No	ClinGen TOPMed
CA229375133 rs1000643333	9	V>G		No	ClinGen TOPMed
CA6293294 rs755386792	10	V>L		No	ClinGen ExAC gnomAD
CA229375140 rs895608798	11	A>G		No	ClinGen TOPMed gnomAD
CA6293296 rs748724641	12	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6293298 rs191545890	14	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA382755394 rs1242208108	15	S>C		No	ClinGen gnomAD
CA382755388 rs1242208108	15	S>R		No	ClinGen gnomAD
TCGA novel	15	S>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382755412 rs139503238	16	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA382755415 rs1289020102	16	P>L		No	ClinGen TOPMed gnomAD
CA382755416 rs1289020102	16	P>R		No	ClinGen TOPMed gnomAD
CA6293299 rs139503238	16	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774643831 CA6293301	17	P>L		No	ClinGen ExAC TOPMed gnomAD
rs771091142 CA6293300	17	P>S		No	ClinGen ExAC gnomAD
rs369245505 CA382755526	22	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6293303 rs768560943	22	L>I		No	ClinGen ExAC gnomAD
CA229375179 rs184163025	24	A>V		No	ClinGen 1000Genomes gnomAD
CA229375185 rs1002009202	25	S>T		No	ClinGen Ensembl
rs761891854 CA6293305	27	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6293306 rs764809941	28	D>E		No	ClinGen ExAC gnomAD
rs1158252620 CA382755667	29	E>G		No	ClinGen gnomAD
CA6293307 rs373008488 COSM1297674	29	E>K	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs527693273 CA382755688	30	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs527693273 CA6293308	30	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1158895987 CA382755746	33	D>G		No	ClinGen TOPMed gnomAD
TCGA novel	34	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371085366 CA229375199	36	S>T		No	ClinGen ESP TOPMed
CA382756512 rs1447589083	38	K>E		No	ClinGen TOPMed
CA6293333 rs754406898	38	K>R		No	ClinGen ExAC TOPMed gnomAD
rs757268979 CA6293334	39	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	40	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382756530 rs1272554428	40	S>F		No	ClinGen gnomAD
rs370273925 CA6293335	41	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1177649799 CA382756537	42	Q>E		No	ClinGen TOPMed gnomAD
CA6293336 rs750579748	42	Q>R		No	ClinGen ExAC gnomAD
rs533703575 CA6293338	44	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs533703575 CA382756554	44	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	45	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6293339 rs199853953	47	S>L		No	ClinGen ExAC TOPMed gnomAD
CA229380501 rs931500708	49	L>R		No	ClinGen Ensembl
CA382756598 rs749309119	51	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6293343 rs749309119	51	S>R		No	ClinGen ExAC TOPMed gnomAD
rs367876300 CA6293344	52	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA229380510 rs367876300	52	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6293345 rs773867251	53	S>G		No	ClinGen ExAC gnomAD
CA6293347 rs771651532	55	Q>E		No	ClinGen ExAC gnomAD
CA382756627 rs1565327866	55	Q>P		No	ClinGen Ensembl
rs775125776 CA6293348	56	T>R		No	ClinGen ExAC TOPMed gnomAD
rs761021575 CA6293349	57	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1217432560 CA382756644	58	T>A		No	ClinGen TOPMed
rs886163268 CA229380532	59	K>E		No	ClinGen TOPMed
CA229380535 rs1004644325	59	K>R		No	ClinGen TOPMed gnomAD
CA382756670 rs1264758268	60	E>D		No	ClinGen gnomAD
CA382756668 rs1205338159	60	E>V		No	ClinGen gnomAD
CA6293351 rs754320801	61	N>H		No	ClinGen ExAC gnomAD
CA6293352 rs181426687	61	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765695500 CA6293353	64	N>S		No	ClinGen ExAC gnomAD
CA6293354 rs750468332	65	V>I		No	ClinGen ExAC gnomAD
TCGA novel	66	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	67	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780358782 CA6293356	68	E>V		No	ClinGen ExAC gnomAD
CA382756830 rs1340445531	72	Q>*		No	ClinGen TOPMed
CA6293357 rs141645554	72	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA382756864 rs1160364445	74	P>L		No	ClinGen gnomAD
rs755963172 CA6293358	74	P>S		No	ClinGen ExAC
rs1347546758 CA382756873	75	G>D		No	ClinGen TOPMed
CA382756903 rs1460324073	78	A>T		No	ClinGen gnomAD
rs1395591668 CA382756919	79	G>D		No	ClinGen TOPMed gnomAD
CA6293360 rs749153248	79	G>S		No	ClinGen ExAC gnomAD
CA6293361 rs757165920	81	T>I		No	ClinGen ExAC gnomAD
rs757165920 CA382756952	81	T>S		No	ClinGen ExAC gnomAD
CA382756973 rs1287284852	83	A>S		No	ClinGen gnomAD
rs368615483 CA229380565	84	A>G		No	ClinGen ESP TOPMed gnomAD
rs368615483 CA382756989	84	A>V		No	ClinGen ESP TOPMed gnomAD
rs1312069501 CA382756999	85	H>R		No	ClinGen gnomAD
CA6293363 rs745306439	86	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	86	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229380568 rs760277326	86	Q>R		No	ClinGen gnomAD
TCGA novel	87	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229380570 rs201200081	91	E>G		No	ClinGen 1000Genomes
rs1180982631 CA382757103	93	L>F		No	ClinGen gnomAD
rs1001083292 CA229380571	93	L>S		No	ClinGen Ensembl
rs1475905759 CA382757137	96	T>A		No	ClinGen gnomAD
rs746711264 CA6293367	97	A>S		No	ClinGen ExAC gnomAD
rs768977285 CA6293368	97	A>V		No	ClinGen ExAC gnomAD
CA229380586 rs777014311	98	L>F		No	ClinGen ExAC TOPMed gnomAD
rs777014311 CA229380589	98	L>I		No	ClinGen ExAC TOPMed gnomAD
rs777014311 CA6293369	98	L>V		No	ClinGen ExAC TOPMed gnomAD
CA382757174 rs1431743052	100	L>F		No	ClinGen TOPMed gnomAD
CA382757173 rs1431743052	100	L>V		No	ClinGen TOPMed gnomAD
CA6293372 rs773598907	101	S>P		No	ClinGen ExAC TOPMed gnomAD
CA382757208 rs1328347512	103	S>N		No	ClinGen gnomAD
CA382757200 rs1293787110	103	S>R		No	ClinGen gnomAD
rs1317615093 CA382757233	105	S>F		No	ClinGen TOPMed
rs1591816864 CA382757269	109	L>V		No	ClinGen Ensembl
rs904449538 CA229380604	111	D>G		No	ClinGen TOPMed gnomAD
CA229380612 rs998744503	114	S>G		No	ClinGen TOPMed gnomAD
rs1277766877 CA382757323	114	S>N		No	ClinGen TOPMed gnomAD
rs1168169085 CA382757332	115	T>A		No	ClinGen TOPMed
rs1188084502 CA382757358	117	G>V		No	ClinGen gnomAD
rs1424019100 CA382757375	119	E>*		No	ClinGen TOPMed
CA382757376 rs1591816880	119	E>G		No	ClinGen Ensembl
CA382757392 rs1470057077	121	D>G		No	ClinGen gnomAD
TCGA novel	121	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1470057077 CA382757391	121	D>V		No	ClinGen gnomAD
CA6293378 rs201091154	122	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6293380 rs371176502	123	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6293381 rs745849348 CA382757405	123	S>R		No	ClinGen ExAC gnomAD
CA6293382 rs776400901	124	L>I		No	ClinGen ExAC gnomAD
CA6293384 rs374761866	125	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6293386 rs542552815	125	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs542552815 CA6293385	125	R>Q	Variant assessed as Somatic; 9.279e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs374761866 CA6293383	125	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs369201312 CA6293388	127	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6293387 rs369201312	127	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs773758801 CA6293389	127	S>I		No	ClinGen ExAC gnomAD
CA6293390 rs763607630	129	H>Q		No	ClinGen ExAC gnomAD
rs1373716706 CA382757435	129	H>R		No	ClinGen gnomAD
rs1211221981 CA382757456	133	R>G		No	ClinGen TOPMed gnomAD
rs766539493 CA6293392	133	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM3808441 rs1211221981 CA382757457	133	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA6293393 rs774536692	134	S>F		No	ClinGen ExAC TOPMed gnomAD
rs767708238 CA6293395	135	L>F		No	ClinGen ExAC gnomAD
rs767708238 CA382757465	135	L>V		No	ClinGen ExAC gnomAD
CA229380696 rs575931748	139	C>Y		No	ClinGen 1000Genomes gnomAD
CA382757497 rs1455734442	140	H>N		No	ClinGen gnomAD
CA6293397 rs757059663	141	T>I		No	ClinGen ExAC TOPMed gnomAD
CA229380699 rs1023088666	141	T>P		No	ClinGen TOPMed
rs199938335 CA6293398	143	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA382757522 rs1408291421	143	Q>H		No	ClinGen gnomAD
rs750342672 CA6293399	145	A>S		No	ClinGen ExAC TOPMed gnomAD
CA382757548 rs1435724952	148	N>H		No	ClinGen gnomAD
TCGA novel	149	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229380706 rs984092109	150	S>F		No	ClinGen TOPMed
CA382757626 rs758291355	155	P>A		No	ClinGen ExAC TOPMed gnomAD
CA6293400 rs758291355	155	P>T		No	ClinGen ExAC TOPMed gnomAD
CA382757653 rs1299636078	157	T>I		No	ClinGen TOPMed
rs779988145 CA6293401	158	S>F		No	ClinGen ExAC gnomAD
TCGA novel	161	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296428803 CA382757697	162	E>G		No	ClinGen gnomAD
CA382757706 rs1358492762	163	G>D		No	ClinGen TOPMed
TCGA novel	165	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382757726 rs1273142446	165	R>T		No	ClinGen TOPMed gnomAD
rs1178112715 CA382757721	165	R>W		No	ClinGen TOPMed gnomAD
CA6293405 rs747815022	166	D>E		No	ClinGen ExAC gnomAD
CA6293404 rs780895277	166	D>G		No	ClinGen ExAC TOPMed gnomAD
rs754490428 CA6293403	166	D>N		No	ClinGen ExAC gnomAD
rs1470109203 CA382757742	167	T>A		No	ClinGen gnomAD
rs770176452 CA6293406	167	T>I		No	ClinGen ExAC gnomAD
rs770176452 CA6293407	167	T>K		No	ClinGen ExAC gnomAD
rs771501968 CA6293409	172	R>*		No	ClinGen ExAC gnomAD
CA6293410 rs186490039	172	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6293411 rs759681232	173	P>S		No	ClinGen ExAC gnomAD
CA6293412 rs772099443	174	V>A		No	ClinGen ExAC gnomAD
rs1565328237 CA382757809	174	V>I		No	ClinGen Ensembl
rs760846137 CA6293414	176	S>F		No	ClinGen ExAC TOPMed gnomAD
rs764407836 CA6293415	177	P>L		No	ClinGen ExAC gnomAD
CA6293416 rs750169907	178	A>E		No	ClinGen ExAC TOPMed gnomAD
rs750169907 CA382757837	178	A>V		No	ClinGen ExAC TOPMed gnomAD
rs762750374 CA6293417	179	N>D		No	ClinGen ExAC gnomAD
rs1251565840 CA382757862	182	E>G		No	ClinGen TOPMed
rs1355117776 CA382757871	183	G>E		No	ClinGen gnomAD
TCGA novel	185	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757722784 CA6293418	185	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA382757887 rs1271840785	186	V>A		No	ClinGen TOPMed gnomAD
rs1591817025 CA382757883	186	V>L		No	ClinGen Ensembl
CA6293419 rs373179752	187	D>G		No	ClinGen ESP ExAC gnomAD
CA382757899 rs1214740660	188	Q>R		No	ClinGen gnomAD
CA6293420 rs754499333	189	D>G		No	ClinGen ExAC gnomAD
CA382757903 rs1261522483	189	D>N		No	ClinGen gnomAD
rs1255788661 CA382757918	191	D>N		No	ClinGen TOPMed
rs752369383 CA6293422	193	D>H		No	ClinGen ExAC gnomAD
rs752369383 CA382757934	193	D>N		No	ClinGen ExAC gnomAD
CA382757953 rs1321063533	195	S>F		No	ClinGen gnomAD
CA6293423 rs755669931	195	S>P		No	ClinGen ExAC TOPMed gnomAD
CA229380800 rs777508145	196	S>C		No	ClinGen ExAC TOPMed gnomAD
rs777508145 CA6293425	196	S>F		No	ClinGen ExAC TOPMed gnomAD
CA229380812 rs934212007	197	L>V		No	ClinGen TOPMed
CA382757962 rs1238841104	198	K>Q		No	ClinGen TOPMed
rs1157754621 CA382757992	202	N>H		No	ClinGen gnomAD
rs377448273 CA6293427	202	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1383553513 CA382757998	203	I>F		No	ClinGen gnomAD
rs779560930 CA6293428	205	V>I		No	ClinGen ExAC TOPMed gnomAD
rs746419775 CA6293429	206	Q>*		No	ClinGen ExAC gnomAD
rs772171591 CA6293430	206	Q>R		No	ClinGen ExAC gnomAD
CA6293459 rs770688585	211	T>A		No	ClinGen ExAC gnomAD
CA229381237 rs527819924	212	A>G		No	ClinGen 1000Genomes TOPMed gnomAD
rs1480695659 CA382758076	213	D>G		No	ClinGen Ensembl
rs377618394 CA6293461	214	S>L		No	ClinGen ExAC TOPMed gnomAD
CA6293462 rs767287359	216	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1591817506 CA382758098	217	N>H		No	ClinGen Ensembl
rs370577887 CA229381264	219	D>E		No	ClinGen ESP TOPMed
rs760103105 CA6293464	219	D>H		No	ClinGen ExAC TOPMed gnomAD
CA382758112 rs760103105	219	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6293465 rs763740560	219	D>V		No	ClinGen ExAC TOPMed gnomAD
CA382758123 rs1252146281	220	Q>H		No	ClinGen gnomAD
rs756922933 CA6293467	221	D>A		No	ClinGen ExAC gnomAD
CA382758127 rs756922933	221	D>G		No	ClinGen ExAC gnomAD
COSM923434 rs753520776 CA6293466	221	D>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765014573 CA6293468	222	I>T		No	ClinGen ExAC gnomAD
rs1395333697 CA382758131	222	I>V		No	ClinGen gnomAD
rs1410054815 CA382758139	223	E>*		No	ClinGen gnomAD
rs770837526 CA229381277	224	K>E		No	ClinGen TOPMed
CA382758871 rs1460373997	228	K>E		No	ClinGen TOPMed gnomAD
CA6293485 rs761413872	229	M>I		No	ClinGen ExAC gnomAD
CA382758892 rs1350847832	230	M>I		No	ClinGen gnomAD
CA382758900 rs1282670694	231	T>P		No	ClinGen gnomAD
TCGA novel	231	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1453241227 CA382758911	232	E>Q		No	ClinGen gnomAD
CA6293486 rs764924781	234	T>N		No	ClinGen ExAC gnomAD
CA382758943 rs1400740122	235	L>V		No	ClinGen gnomAD
CA6293488 rs763221923	236	L>F		No	ClinGen ExAC gnomAD
CA6293489 rs766804789	238	E>G		No	ClinGen ExAC gnomAD
rs1235079855 CA382758986	239	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1235079855 CA382758985	239	R>G		No	ClinGen gnomAD
CA6293490 rs751986449	239	R>H		No	ClinGen ExAC TOPMed gnomAD
rs923180757 CA229383957	242	E>D		No	ClinGen TOPMed
CA6293491 rs201299767	242	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA382759016 rs1482387512	242	E>Q		No	ClinGen gnomAD
rs201991200 CA229383961	245	D>G		No	ClinGen Ensembl
CA382759061 rs1257250805	246	K>R		No	ClinGen gnomAD
CA6293492 rs200448262	247	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA382759130 rs1442226311	252	N>S		No	ClinGen TOPMed gnomAD
CA6293493 rs752703242	253	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1488315045 CA382759151	254	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA382759157 rs1186554404	254	L>P		No	ClinGen gnomAD
rs1167479388 CA382759176	256	V>A		No	ClinGen TOPMed gnomAD
rs1167479388 CA382759178	256	V>G		No	ClinGen TOPMed gnomAD
rs1190702292 CA382759218	260	Q>E		No	ClinGen gnomAD
CA6293496 rs749569347	260	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	265	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	266	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382759292 rs1157162282	266	E>D		No	ClinGen gnomAD
CA382759353 rs1347216272	271	N>T		No	ClinGen gnomAD
CA382759380 rs1156462307	273	Q>R		No	ClinGen TOPMed
CA382759872 rs1233103518	274	E>K		No	ClinGen gnomAD
CA6293519 rs768631202	275	I>M		No	ClinGen ExAC gnomAD
CA6293518 rs200215421	275	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6293521 rs748136510	279	I>L		No	ClinGen ExAC gnomAD
rs1203047616 CA382759948	281	D>G		No	ClinGen gnomAD
rs376006371 CA6293522	281	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs376006371 CA6293523	281	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1479148078 CA382759969	284	I>M		No	ClinGen gnomAD
CA6293524 rs748776198	284	I>T		No	ClinGen ExAC gnomAD
CA382759966 rs1193220680	284	I>V		No	ClinGen gnomAD
CA382759980 rs1340169798	286	R>Q		No	ClinGen TOPMed gnomAD
rs770548546 CA6293526	289	T>I		No	ClinGen ExAC
TCGA novel	290	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6293528 rs773884931	290	K>R		No	ClinGen ExAC TOPMed gnomAD
rs773884931 CA382760007	290	K>T		No	ClinGen ExAC TOPMed gnomAD
rs759877069 CA6293529	291	K>N		No	ClinGen ExAC TOPMed gnomAD
CA6293530 rs767912189	292	K>R		No	ClinGen ExAC gnomAD
CA6293531 rs775958191	293	I>T		No	ClinGen ExAC TOPMed gnomAD
CA382760037 rs1257109795	294	E>D		No	ClinGen gnomAD
rs369348836 CA6293532	294	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA382760046 rs1591821716	296	E>K		No	ClinGen Ensembl
rs1436774139 CA382760076	299	E>D		No	ClinGen TOPMed gnomAD
rs1269017654 CA382760102	302	Q>E		No	ClinGen gnomAD
CA382760142 COSM3415558 rs1336881275	306	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA6293534 rs200034585	306	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1591821735 CA476900758	308	K>N		No	ClinGen Ensembl
rs757299480 CA6293536	311	I>T		No	ClinGen ExAC gnomAD
CA382760225 rs1213417125	313	K>R		No	ClinGen gnomAD
CA382760223 rs1213417125	313	K>T		No	ClinGen gnomAD
CA229385793 rs201127643	315	C>G		No	ClinGen TOPMed
rs765484176 CA6293537	318	G>D		No	ClinGen ExAC gnomAD
CA229385794 rs960435568	318	G>S		No	ClinGen Ensembl
CA6293554 rs765272985	322	V>A		No	ClinGen ExAC gnomAD
rs1464341538 CA382712345 CA382712341	325	M>I		No	ClinGen TOPMed gnomAD
rs1039671562 CA229351006	325	M>V		No	ClinGen Ensembl
rs1352212974 CA382712356	326	E>G		No	ClinGen TOPMed
TCGA novel	326	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374587734 CA6293558	328	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6293557 rs766737717	328	D>N		No	ClinGen ExAC gnomAD
CA6293559 rs377377564	336	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs754841735 CA229351014	338	N>S		No	ClinGen Ensembl
rs1298213167 CA382712447	339	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs777749135 CA6293560	339	R>S		No	ClinGen ExAC gnomAD
rs749247946 CA6293561	341	I>T		No	ClinGen ExAC gnomAD
CA229351021 rs893056756	342	M>V		No	ClinGen TOPMed
CA6293563 rs778349990	344	E>D		No	ClinGen ExAC gnomAD
CA6293564 rs745416152	347	R>Q		No	ClinGen ExAC gnomAD
CA6293565 rs368714507	348	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA229351089 rs370535418	355	S>A		No	ClinGen ESP ExAC gnomAD
CA6293581 rs370535418	355	S>P		No	ClinGen ESP ExAC gnomAD
CA382712578 rs1458970300	357	E>Q		No	ClinGen gnomAD
rs1177542734 CA382712639	365	L>V		No	ClinGen TOPMed gnomAD
CA382712712 rs1197554327	369	E>A		No	ClinGen TOPMed
CA6293589 rs769041355	369	E>D		No	ClinGen ExAC gnomAD
rs185813913 CA229351112	380	Y>C		No	ClinGen 1000Genomes
rs1591842367 CA382712904	381	L>V		No	ClinGen Ensembl
CA6293615 rs778417285	384	T>A		No	ClinGen ExAC gnomAD
CA382713050 rs778417285	384	T>P		No	ClinGen ExAC gnomAD
CA6293616 rs370053483	385	P>L		No	ClinGen ESP ExAC gnomAD
CA229351467 rs993882431	386	P>R		No	ClinGen Ensembl
CA382713071 rs1319773236	388	L>M		No	ClinGen gnomAD
rs1469476886 CA382713074	388	L>P		No	ClinGen TOPMed
rs1183663437 CA382713087	390	T>I		No	ClinGen TOPMed
CA382713086 rs1233277604	390	T>S		No	ClinGen TOPMed
COSM923439 CA6293617 rs373694544	392	R>C	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1265709688 CA382713098	392	R>H		No	ClinGen gnomAD
rs501179 CA229351471	394	K>Q		No	ClinGen Ensembl
rs1485239537 CA382713125	396	E>A		No	ClinGen gnomAD
TCGA novel	398	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1202807269 CA382713152	399	T>M		No	ClinGen gnomAD
CA6293618 rs774259127	400	R>K		No	ClinGen ExAC gnomAD
CA382713186 rs1210344411	402	N>D		No	ClinGen TOPMed
CA6293620 rs751012034	404	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6293621 rs775840278	405	R>Q		No	ClinGen ExAC gnomAD
rs1281055959 CA382713282	408	K>I		No	ClinGen TOPMed
rs377379346 CA6293622	409	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6293623 rs1009188753	412	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA382713366 rs1350644787	412	R>H		No	ClinGen gnomAD
CA382715099 rs1357315049	414	Q>H		No	ClinGen gnomAD
TCGA novel	421	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6293646 rs745925375	425	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA382715287 rs1444107489	426	A>T		No	ClinGen gnomAD
TCGA novel	433	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229351571 rs866545291	433	Q>R		No	ClinGen Ensembl
CA382715442 rs1565348808	435	P>S		No	ClinGen Ensembl
rs1232878335 CA382715462	436	T>S		No	ClinGen gnomAD
rs117682598 CA6293649	440	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA229351589 rs1021767429	442	P>S		No	ClinGen Ensembl
rs775076399 CA6293677	447	D>N		No	ClinGen ExAC gnomAD
CA6293678 rs760278490	448	F>L		No	ClinGen ExAC gnomAD
CA6293679 rs763829116	449	M>I		No	ClinGen ExAC TOPMed gnomAD
rs756745357 CA6293680	451	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	452	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382715944 rs1280488827	454	Q>K		No	ClinGen gnomAD
rs750777148 CA6293683	456	S>C		No	ClinGen ExAC TOPMed gnomAD
CA382716001 rs1288041985	456	S>N		No	ClinGen gnomAD
rs750777148 CA6293684	456	S>R		No	ClinGen ExAC TOPMed gnomAD
rs780542286 CA6293685	457	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs751578565 CA6293686	458	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6293687 rs755109152	459	L>P		No	ClinGen ExAC gnomAD
CA382716078 rs1476761332	460	A>P		No	ClinGen gnomAD
rs1424055272 CA382716088	461	P>A		No	ClinGen gnomAD
CA6293690 rs545939645	462	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs375077963 CA6293689	462	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA382716194 rs1565349007	464	P>R		No	ClinGen Ensembl
rs1415455055 CA382716237	466	S>F		No	ClinGen gnomAD
CA6293691 rs778718914	466	S>T		No	ClinGen ExAC
rs369438119 CA6293692	467	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	468	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296975246 CA382716327	470	V>F		No	ClinGen gnomAD
CA6293693 rs771991630	471	T>A		No	ClinGen ExAC gnomAD
rs372942701 CA6293695	472	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs776400838 CA6293697	478	S>T		No	ClinGen ExAC TOPMed gnomAD
CA382716634 rs1358669700	480	D>H		No	ClinGen TOPMed gnomAD
CA382716659 rs1256268572	481	P>L		No	ClinGen TOPMed
rs761479903 CA6293698	482	R>C		No	ClinGen ExAC TOPMed gnomAD
rs764830918 COSM1739831 CA6293699	482	R>H	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA382716686 rs1487382161	484	L>S		No	ClinGen gnomAD
CA6293700 rs750731603	485	S>C		No	ClinGen ExAC gnomAD
CA6293701 rs763238388	487	P>S		No	ClinGen ExAC gnomAD
rs1425822807 CA382716726	488	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	489	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382716753 rs1591843549	490	N>T		No	ClinGen Ensembl
CA229351802 rs983615926	491	P>A		No	ClinGen TOPMed
rs1165791349 CA382716790	493	L>P		No	ClinGen gnomAD
CA382716785 rs1369988473	493	L>V		No	ClinGen gnomAD
CA382716797 rs1591843562	494	S>P		No	ClinGen Ensembl
CA382716812 rs1374898498	495	Q>R		No	ClinGen TOPMed
rs752126491 CA6293703	497	S>G		No	ClinGen ExAC TOPMed gnomAD
CA6293705 rs755015472	499	P>S		No	ClinGen ExAC gnomAD
CA6293704 rs755015472	499	P>T		No	ClinGen ExAC gnomAD
rs1377927243 CA382716935	502	P>A		No	ClinGen gnomAD
rs752739002 CA6293706	502	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1386253333 CA382716967	503	L>H		No	ClinGen gnomAD
rs758339007 CA6293710	506	S>P		No	ClinGen ExAC gnomAD
rs1342703614 CA382717057	507	H>R		No	ClinGen gnomAD
CA6293711 rs780111806	509	R>G		No	ClinGen ExAC gnomAD
CA229351821 rs1022812670	510	N>D		No	ClinGen TOPMed gnomAD
CA382717223 rs899548731	513	G>A		No	ClinGen TOPMed gnomAD
CA229351827 rs899548731	513	G>V		No	ClinGen TOPMed gnomAD
CA382717280 rs1286851025	514	L>F		No	ClinGen TOPMed gnomAD
CA382717290 rs1344142622	515	G>C		No	ClinGen gnomAD
rs77950258 CA6293712	516	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA382717353 rs1257998070	517	L>I		No	ClinGen TOPMed gnomAD
CA382717355 rs1257998070	517	L>V		No	ClinGen TOPMed gnomAD
CA382717395 rs1201614161	518	V>A		No	ClinGen TOPMed
rs768737539 CA6293713	518	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	521	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382717480 rs1209186865	522	G>S		No	ClinGen TOPMed
CA382717544 rs1330921144	524	H>R		No	ClinGen TOPMed
rs1009499698 CA229351869	525	M>V		No	ClinGen TOPMed gnomAD
CA229351874 rs983560664	526	P>S		No	ClinGen Ensembl
CA229351878 rs1020859501	527	P>A		No	ClinGen TOPMed
rs1355961365 CA382717662	527	P>L		No	ClinGen TOPMed
rs763371632 CA6293718	528	A>T		No	ClinGen ExAC TOPMed gnomAD
rs774814849 CA6293720	529	A>T	Variant assessed as Somatic; 4.643e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA382717832 rs1331130521	533	P>L		No	ClinGen gnomAD
CA6293721 rs759983307	535	P>L		No	ClinGen ExAC gnomAD
TCGA novel	536	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs911884747 CA229351915	538	G>A		No	ClinGen TOPMed gnomAD
rs911884747 CA229351912	538	G>D		No	ClinGen TOPMed gnomAD
CA6293723 rs752753519	538	G>S		No	ClinGen ExAC gnomAD
CA6293726 rs754052074	539	G>D		No	ClinGen ExAC gnomAD
rs376329252 CA6293725	539	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1591843746 CA382718176	546	T>P		No	ClinGen Ensembl
rs900716005 CA229351941	547	P>R		No	ClinGen Ensembl
CA229351938 rs1039075067	547	P>S		No	ClinGen gnomAD
CA6293730 rs371048883	548	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746832862 CA6293729	548	R>W		No	ClinGen ExAC gnomAD
CA6293731 rs781003395	549	P>L		No	ClinGen ExAC gnomAD
CA6293732 rs781003395	549	P>R		No	ClinGen ExAC gnomAD
rs1197333015 CA382718328	551	P>A		No	ClinGen gnomAD
CA382718359 rs1565349301	552	V>A		No	ClinGen Ensembl
rs201310487 CA6293734	553	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1319330749 CA382718537	557	K>N		No	ClinGen TOPMed gnomAD
rs759895613 CA6293738	560	E>G		No	ClinGen ExAC gnomAD
TCGA novel	560	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1426206676 CA382718705	562	L>M		No	ClinGen TOPMed
TCGA novel	563	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382718795 rs1188773281	565	R>Q		No	ClinGen TOPMed
rs768001744 CA6293739	565	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	567	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382719097 rs1217941909	570	N>S		No	ClinGen gnomAD
rs1276066747 CA382719165	571	K>R		No	ClinGen gnomAD
rs750740579 CA382719412	572	A>S		No	ClinGen ExAC TOPMed gnomAD
rs750740579 CA6293764	572	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6293765 rs370184715	576	N>S		No	ClinGen ExAC gnomAD
TCGA novel	579	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6293768 rs769510610	583	T>I		No	ClinGen ExAC gnomAD
rs1385915265 CA382719784	584	A>S		No	ClinGen gnomAD
COSM923447 rs1344664918 CA382719811	585	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA382719932 rs1419215469	589	A>V		No	ClinGen TOPMed gnomAD
rs1436268816 CA382720009	593	M>V		No	ClinGen TOPMed
rs539528269 CA6293772	595	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA382720154 rs1431408361	597	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6293773 rs756829944	599	L>F		No	ClinGen ExAC TOPMed gnomAD
CA382720249 rs1376788834	603	R>Q		No	ClinGen gnomAD
CA229352134 rs1053478119	605	A>G		No	ClinGen TOPMed
rs1397402480 CA382720297	606	E>K		No	ClinGen gnomAD
rs546415772 CA229352135	607	H>R		No	ClinGen 1000Genomes TOPMed
rs370702034 COSM374073 CA6293775	609	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs778509558 CA6293774	609	R>W		No	ClinGen ExAC TOPMed gnomAD
rs771783290 CA6293776	611	A>E		No	ClinGen ExAC TOPMed gnomAD
CA229352219 rs868458122	616	P>S		No	ClinGen Ensembl
rs1591844094 CA382720667	618	G>D		No	ClinGen Ensembl
CA6293796 rs760910814	619	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6293797 rs781754384	619	R>H		No	ClinGen ExAC TOPMed gnomAD
CA382720722 rs1190719761	620	I>F		No	ClinGen gnomAD
CA229352234 rs749164571	621	R>G		No	ClinGen TOPMed
rs770446837 CA6293799	621	R>Q		No	ClinGen ExAC gnomAD
CA6293800 rs773381685	622	A>T		No	ClinGen ExAC gnomAD
CA229352249 rs377098061	623	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs377098061 CA6293801	623	L>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA382720879 rs1399361873	624	F>L		No	ClinGen TOPMed gnomAD
CA6293802 rs770997844	625	P>S		No	ClinGen ExAC gnomAD
rs760358844 CA6293805	630	Q>E		No	ClinGen ExAC gnomAD
rs1289329921 CA382721117	632	S>G		No	ClinGen TOPMed
rs1272593590 CA382721124	632	S>I		No	ClinGen gnomAD
rs368509571 CA6293806	633	T>I		No	ClinGen ESP ExAC gnomAD
CA6293807 rs372440280	635	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1317755632 CA382721314	638	P>S		No	ClinGen gnomAD
CA6293808 rs761702440	640	A>V		No	ClinGen ExAC gnomAD
CA382721466 rs1438632470	642	V>A		No	ClinGen gnomAD
rs765944819 CA6293812	643	S>L		No	ClinGen ExAC gnomAD
CA6293811 rs143401559	643	S>P		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	648	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	649	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229352294 rs549269094	650	H>R		No	ClinGen TOPMed gnomAD
rs781648496 CA6293815	650	H>Y		No	ClinGen ExAC gnomAD
rs767282551 CA6293833	652	P>A		No	ClinGen ExAC gnomAD
CA382722114 rs767282551	652	P>S		No	ClinGen ExAC gnomAD
CA6293837 rs754419557	655	C>S		No	ClinGen ExAC gnomAD
rs754419557 CA382722202	655	C>Y		No	ClinGen ExAC gnomAD
CA382722422 rs1285409326	660	M>R		No	ClinGen gnomAD
CA382722610 rs757728340	663	K>N		No	ClinGen ExAC gnomAD
CA6293839 rs779011481	664	L>F		No	ClinGen ExAC gnomAD
rs772228026 CA6293841	665	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6293842 rs780315682	666	Q>H		No	ClinGen ExAC gnomAD
rs1049219720 CA229352453	674	A>S		No	ClinGen TOPMed
rs1049219720 CA382722882	674	A>T		No	ClinGen TOPMed
CA6293844 rs769620066	674	A>V		No	ClinGen ExAC gnomAD
rs528961932 CA229352470	676	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528961932 CA6293846	676	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1004829247 CA229352474	678	V>I		No	ClinGen gnomAD
CA382723108 rs1311188209	682	E>G		No	ClinGen TOPMed
CA6293863 rs749037579	684	I>V		No	ClinGen ExAC gnomAD
CA6293864 rs770843187	687	W>G		No	ClinGen ExAC gnomAD
rs1446873608 CA382724765	688	A>G		No	ClinGen TOPMed
CA6293865 rs774212231	688	A>S		No	ClinGen ExAC
TCGA novel	689	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1284418857 CA382724813	691	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1363755708 CA382724847	692	T>I		No	ClinGen TOPMed gnomAD
rs200340172 CA6293867	693	N>T		No	ClinGen ExAC TOPMed gnomAD
CA382724913 rs1330382178	695	T>A		No	ClinGen gnomAD
rs1324064284 CA382724991	698	F>S		No	ClinGen gnomAD
rs1246194449 CA382725032	700	P>S		No	ClinGen TOPMed
rs1036527018 CA229356753	701	T>A		No	ClinGen TOPMed gnomAD

No associated diseases with Q8ND24

1 regional properties for Q8ND24

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	658 - 699	IPR001841

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86Y13	DZIP3	E3 ubiquitin-protein ligase DZIP3	Homo sapiens (Human)	PR

10	20	30	40	50	60
MAASEVAGVV	ANAPSPPESS	SLCASKSDEG	LPDGLSTKDS	AQKQKNSPLL	SVSSQTITKE
70	80	90	100	110	120
NNRNVHLEHS	EQNPGSSAGD	TSAAHQVVLG	ENLIATALCL	SGSGSQSDLK	DVASTAGEEG
130	140	150	160	170	180
DTSLRESLHP	VTRSLKAGCH	TKQLASRNCS	EEKSPQTSIL	KEGNRDTSLD	FRPVVSPANG
190	200	210	220	230	240
VEGVRVDQDD	DQDSSSLKLS	QNIAVQTDFK	TADSEVNTDQ	DIEKNLDKMM	TERTLLKERY
250	260	270	280	290	300
QEVLDKQRQV	ENQLQVQLKQ	LQQRREEEMK	NHQEILKAIQ	DVTIKREETK	KKIEKEKKEF
310	320	330	340	350	360
LQKEQDLKAE	IEKLCEKGRR	EVWEMELDRL	KNQDGEINRN	IMEETERAWK	AEILSLESRK
370	380	390	400	410	420
ELLVLKLEEA	EKEAELHLTY	LKSTPPTLET	VRSKQEWETR	LNGVRIMKKN	VRDQFNSHIQ
430	440	450	460	470	480
LVRNGAKLSS	LPQIPTPTLP	PPPSETDFML	QVFQPSPSLA	PRMPFSIGQV	TMPMVMPSAD
490	500	510	520	530	540
PRSLSFPILN	PALSQPSQPS	SPLPGSHGRN	SPGLGSLVSP	HGPHMPPAAS	IPPPPGLGGV
550	560	570	580	590	600
KASAETPRPQ	PVDKLEKILE	KLLTRFPQCN	KAQMTNILQQ	IKTARTTMAG	LTMEELIQLV
610	620	630	640	650	660
AARLAEHERV	AASTQPLGRI	RALFPAPLAQ	ISTPMFLPSA	QVSYPGRSSH	APATCKLCLM
670	680	690	700
CQKLVQPSEL	HPMACTHVLH	KECIKFWAQT	NTNDTCPFCP	TLK