AiPD: Autoinhibited Protein Database

Q8NCB2

Gene name	CAMKV
Protein name	CaM kinase-like vesicle-associated protein
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79012
EC number
Protein Class

Descriptions

Camk1 is a calcium/calmodulin-dependent protein kinase involved in calcium-triggered CaMKK-Camk1 signaling cascade. The C-terminal autoinhibitory region interacts with the catalytic core of the enzyme.

Autoinhibitory domains (AIDs)

286-326 (Autoinhibitory region) SS

Target domain	24-286 (Protein kinase domain)
Relief mechanism	Ligand binding
Assay

AID

286-326 (Autoinhibitory region)

Target domain

24-286 (Protein kinase domain)

Relief mechanism

Ligand binding (Calmodulin binding to the linker region flanking Trp-303)

Assay

Accessory elements

165-185 (Activation loop from InterPro)

Target domain	24-286 (Protein kinase domain)
Relief mechanism
Assay

References

Goldberg J et al. (1996) "Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I", Cell, 84, 875-87

Clapperton JA et al. (2002) "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism", Biochemistry, 41, 14669-79

Yuan T et al. (2004) "Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I", Archives of biochemistry and biophysics, 421, 192-206

Zha M et al. (2012) "Crystal structures of human CaMKIα reveal insights into the regulation mechanism of CaMKI", PloS one, 7, e44828

Shohat G et al. (2002) "The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases", Biochimica et biophysica acta, 1600, 45-50

Cohen O et al. (1997) "DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity", The EMBO journal, 16, 998-1008

Shohat G et al. (2001) "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism", The Journal of biological chemistry, 276, 47460-7

Temmerman K et al. (2014) "A PEF/Y substrate recognition and signature motif plays a critical role in DAPK-related kinase activity", Chemistry & biology, 21, 264-73

Autoinhibited structure

Activated structure

1 structures for Q8NCB2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NCB2-F1	Predicted				AlphaFoldDB

376 variants for Q8NCB2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2082029117	2	P>S		No	Ensembl
TCGA novel	8	L>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4118636 COSM4118637	8	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs147683930	8	L>V		No	ESP ExAC TOPMed gnomAD
rs2108330269	10	D>N		No	Ensembl
rs1302561608	11	K>E		No	TOPMed gnomAD
rs771453537 COSM1046326 COSM1046325	12	K>N	endometrium Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated ExAC gnomAD NCI-TCGA Cosmic
rs1176714251	12	K>R		No	TOPMed gnomAD
rs2108330260	13	N>Y		No	Ensembl
rs1185840055	17	P>T		No	gnomAD
rs1575407453	20	V>G		No	Ensembl
COSM446730 COSM1485321	20	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3595442 COSM3595443	25	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1312975289	30	I>M		No	TOPMed gnomAD
rs2082028420	31	K>T		No	TOPMed
rs369471161	32	T>I		No	ESP TOPMed
TCGA novel	36	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
VAR_041337 rs1407808379	40	R>W	a colorectal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt dbSNP gnomAD
rs1426803266	41	A>V		No	gnomAD
rs1241766696	43	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
TCGA novel	44	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747162209	45	T>M		No	ExAC TOPMed gnomAD
rs2082026770	47	G>D		No	TOPMed
rs1443985656	48	K>R		No	TOPMed gnomAD
rs765666578	49	L>P		No	ExAC TOPMed gnomAD
rs2082026707	49	L>V		No	TOPMed
rs757504862	51	T>N		No	ExAC gnomAD
TCGA novel	52	C>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1250012626	54	K>M		No	gnomAD
rs774049687	58	R>Q		No	ExAC TOPMed gnomAD
rs200718388	58	R>W		No	1000Genomes ExAC TOPMed gnomAD
VAR_041338 COSM20715 rs2082026503 COSM4118635	60	G>S	ovary Variant assessed as Somatic; MODERATE impact. an ovarian serous carcinoma sample; somatic mutation [Cosmic, NCI-TCGA, UniProt]	No	NCI-TCGA Cosmic cosmic curated TOPMed UniProt
rs1360882177	61	R>C		No	TOPMed gnomAD
rs772689036	61	R>H		No	ExAC TOPMed gnomAD
rs1575407229	63	V>G		No	Ensembl
rs1238361476	64	R>Q		No	gnomAD
rs1305797638	68	K>E		No	gnomAD
rs865944634 COSM5603061 COSM5603060	70	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs769648151	71	I>M		No	ExAC gnomAD
rs1029418614	72	G>A		No	Ensembl
rs1257316947	72	G>S		No	Ensembl
COSM3373234 COSM3373233	75	K>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1046323 COSM1046324	75	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1374844644	75	K>R		No	gnomAD
TCGA novel	76	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1575407017	77	V>G		No	Ensembl
rs1446975655	79	H>Q		No	gnomAD
rs1262864897	82	I>V		No	gnomAD
rs2108329827	84	Q>R		No	Ensembl
rs144366691	85	L>P		No	ESP
rs1482489474	86	V>M		No	gnomAD
rs1301880158	87	D>N		No	gnomAD
COSM74002 COSM74001	92	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1344113248	92	R>L		No	TOPMed gnomAD
rs1559456830	93	K>E		No	Ensembl
rs2082024156	93	K>R		No	TOPMed
TCGA novel	95	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM4811679 COSM419940	97	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1284693414	97	I>S		No	gnomAD
TCGA novel	99	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746000364	99	L>Q		No	ExAC gnomAD
rs866173336	101	L>M		No	gnomAD
rs2082021644	102	A>V		No	TOPMed
rs760406345	103	T>M		No	ExAC gnomAD
rs1575406791	107	V>G		No	Ensembl
rs2082021440	107	V>L		No	TOPMed
rs2082021333	109	D>E		No	TOPMed
rs2082021295	110	W>C		No	Ensembl
COSM3916295 COSM3916294	113	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs866912622	115	G>S		No	Ensembl
rs2082021183	115	G>V		No	Ensembl
COSM1424054	116	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1288269620	117	Y>H		No	TOPMed
COSM1485320 COSM1485319	118	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4118631 COSM4118632	119	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1384999199	120	R>Q		No	gnomAD
TCGA novel	122	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2108329596	123	S>C		No	Ensembl
COSM1046322 COSM1046321	125	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1446833091	126	V>I		No	gnomAD
rs2082020750	127	R>Q		No	TOPMed
rs774334647	127	R>W		No	ExAC TOPMed gnomAD
rs770998448	129	V>I		No	ExAC gnomAD
rs1273162438	130	L>P		No	gnomAD
rs1176759665	133	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs770285366	134	A>D		No	ExAC gnomAD
rs1290746713	134	A>S		No	gnomAD
rs770285366	134	A>V		No	ExAC gnomAD
TCGA novel	136	L>H	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM4118630 COSM4118629	141	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	142	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	144	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2082020370	147	K>Q		No	Ensembl
COSM274371	149	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1261033358	152	V>L		No	TOPMed gnomAD
rs770201843	154	Y>H		No	ExAC TOPMed gnomAD
rs1198915352	155	N>S		No	TOPMed
rs1251987183	156	R>Q		No	TOPMed
rs777179632	156	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs769025060	157	L>M		No	ExAC
rs2082018662	158	K>R		No	Ensembl
rs2082018647	160	S>L		No	Ensembl
rs2082018417	175	G>D		No	TOPMed
rs777241750	177	I>M		No	ExAC TOPMed gnomAD
rs2082018353	181	C>*		No	Ensembl
rs2108329340	184	P>H		No	Ensembl
rs1300168935	185	E>D		No	TOPMed
rs1297165732	189	P>Q		No	gnomAD
rs190982523	191	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes NCI-TCGA
COSM1046319 COSM1046318 rs2082015579	193	G>D	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
COSM3916292 COSM3916293	193	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1410351118	194	R>Q		No	gnomAD
COSM1642299 rs1361038100 COSM1642298	194	R>W	stomach [Cosmic]	No	cosmic curated TOPMed gnomAD
TCGA novel	195	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs760054653	196	R>Q		No	ExAC TOPMed gnomAD
rs1220869354 COSM1424052 COSM1424051	196	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs1161602649	197	Y>C		No	gnomAD
rs1575406359	197	Y>D		No	Ensembl
rs774782174	199	R>C		No	ExAC TOPMed gnomAD
rs769296484	199	R>H		No	ExAC gnomAD
COSM3595434 COSM3595435	200	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3595432 COSM3595433	205	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs966029827	206	I>V		No	TOPMed gnomAD
TCGA novel	207	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747722227	210	M>T		No	ExAC gnomAD
COSM3595430 COSM3595431	212	I>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1046314 rs200019805 COSM1046315	213	L>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
COSM1424050 COSM1424049	213	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2108328998	216	G>S		No	Ensembl
rs1317972592	227	D>E		No	TOPMed gnomAD
rs1199285295	227	D>N		No	TOPMed gnomAD
rs1199285295	227	D>Y		No	TOPMed gnomAD
TCGA novel	230	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2082013700	231	N>S		No	Ensembl
COSM3916289 COSM3916288	233	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3373232 COSM3373231	234	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1269893469	235	N>T		No	gnomAD
COSM3595429 COSM3595428	236	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763349594	238	R>C		No	ExAC TOPMed gnomAD
rs2082013603 TCGA novel	238	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1485750027	242	A>V		No	TOPMed gnomAD
rs776246810	248	D>E		No	ExAC TOPMed gnomAD
COSM6165094 COSM6165095	250	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1245270711	251	Y>H		No	TOPMed
TCGA novel	252	W>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs768011837	254	D>A		No	ExAC TOPMed gnomAD
rs768011837	254	D>G		No	ExAC TOPMed gnomAD
rs1442840395	254	D>Y		No	Ensembl
rs143595972	260	K>R		No	ESP TOPMed gnomAD
TCGA novel	263	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1418449261	264	T>I		No	TOPMed
rs2082011813	265	R>K		No	TOPMed
COSM3595427 COSM3595426	268	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2082011735	269	V>M		No	TOPMed gnomAD
VAR_041339	274	R>W	a colorectal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
rs1240837292	278	E>K		No	gnomAD
VAR_041340 rs56071455	279	E>D		No	UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs2082011597	281	I>V		No	TOPMed gnomAD
rs944287748	284	E>D		No	TOPMed gnomAD
rs2082011524	284	E>G		No	Ensembl
COSM6098027 COSM6098028	292	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2082009694	293	D>E		No	Ensembl
TCGA novel	293	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2082009725	293	D>V		No	TOPMed
rs759280881	297	K>R		No	ExAC TOPMed gnomAD
rs143217264	299	G>A		No	ESP ExAC gnomAD
rs143217264	299	G>D		No	ESP ExAC gnomAD
rs762722820	303	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel rs2082009609	304	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
COSM1046311 COSM1046310	306	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2082009546	309	A>V		No	Ensembl
COSM266180	310	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2082009528	311	A>T		No	Ensembl
rs900943884	314	K>R		No	Ensembl
TCGA novel	316	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1424296949	318	R>*		No	gnomAD
rs1191733979	318	R>Q		No	gnomAD
rs2082006677	325	R>Q		No	TOPMed
rs779576572	325	R>W		No	ExAC gnomAD
rs2082006639	327	R>Q		No	gnomAD
rs573710169	327	R>W		No	1000Genomes gnomAD
rs772919486	328	A>T		No	ExAC gnomAD
rs917359050	330	E>K		No	TOPMed gnomAD
rs1267260615	331	Q>R		No	TOPMed
rs961401656	332	S>C		No	gnomAD
rs961401656	332	S>Y		No	gnomAD
rs1017181631	333	S>G		No	TOPMed gnomAD
rs1360279426	333	S>N		No	gnomAD
rs1017181631	333	S>R		No	TOPMed gnomAD
rs376450781	334	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	335	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs984737561	335	A>V		No	Ensembl
rs768728034	336	A>V		No	ExAC TOPMed gnomAD
rs1358119570	337	A>G		No	TOPMed gnomAD
rs1467739973	337	A>S		No	gnomAD
rs1559455873	338	Q>E		No	Ensembl
rs1416168874	338	Q>L		No	TOPMed gnomAD
rs1416168874	338	Q>R		No	TOPMed gnomAD
rs780173738	339	S>L		No	1000Genomes ExAC TOPMed gnomAD
rs746074470	343	T>I		No	ExAC TOPMed gnomAD
rs1471051101	345	T>A		No	TOPMed
rs1250087757	346	A>T		No	TOPMed gnomAD
rs779164652	346	A>V		No	ExAC TOPMed gnomAD
rs1238167908	347	T>A		No	gnomAD
rs1212860694	347	T>I		No	gnomAD
rs1238167908	347	T>P		No	gnomAD
TCGA novel	348	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2082005360	348	P>T		No	TOPMed
rs749812937	349	G>R		No	ExAC TOPMed gnomAD
rs1229510660	351	A>E		No	TOPMed gnomAD
rs1229510660	351	A>V		No	TOPMed gnomAD
rs1344797857	353	G>R		No	gnomAD
rs1337387637	354	A>P		No	TOPMed gnomAD
rs1337387637	354	A>T		No	TOPMed gnomAD
rs756675433	355	T>A		No	ExAC TOPMed gnomAD
rs1377801438	355	T>I		No	gnomAD
rs1302979931	357	A>P		No	gnomAD
rs1368553470 COSM339151	358	A>D	lung [Cosmic]	No	cosmic curated gnomAD
rs1449602905	358	A>P		No	TOPMed gnomAD
rs1307371534	359	A>E		No	TOPMed gnomAD
rs1307371534	359	A>V		No	TOPMed gnomAD
rs1575405483	360	S>I		No	Ensembl
rs2082005024	360	S>R		No	TOPMed gnomAD
rs765879384	361	G>R		No	ExAC TOPMed gnomAD
rs2082004964	361	G>V		No	TOPMed gnomAD
rs758016459	362	A>T		No	ExAC TOPMed gnomAD
rs1482637734	362	A>V		No	TOPMed
rs149916894	365	A>V		No	1000Genomes ESP TOPMed
rs2108328153	368	G>V		No	Ensembl
rs1414614976	370	A>T		No	gnomAD
rs377281206 COSM4459166 COSM4459167	372	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
COSM5183747 rs199584164	372	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs199584164	372	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs2082004642	373	A>T		No	TOPMed
rs1206531994	375	K>E		No	gnomAD
rs1020690637	375	K>N		No	gnomAD
rs2082004578	378	N>K		No	Ensembl
rs1239415454	379	V>A		No	TOPMed gnomAD
rs1239415454	379	V>E		No	TOPMed gnomAD
rs1290123705	379	V>M		No	gnomAD
rs764079591	380	A>G		No	ExAC TOPMed gnomAD
rs764079591	380	A>V		No	ExAC TOPMed gnomAD
rs868127460	381	P>S		No	Ensembl
rs772138978	382	A>G		No	ExAC TOPMed gnomAD
rs150720881	382	A>T		No	ESP ExAC TOPMed gnomAD
rs772138978	382	A>V		No	ExAC TOPMed gnomAD
rs1053448441	384	R>C		No	TOPMed gnomAD
rs746089971	384	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs746089971	384	R>L		No	1000Genomes ExAC TOPMed gnomAD
COSM6165097 COSM6165096 COSM1538195 rs2082004293 COSM1538196	385	S>N	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic TOPMed
rs774562098	387	T>P		No	ExAC gnomAD
rs1249255895	387	T>S		No	gnomAD
rs142041712	388	P>S		No	ESP ExAC TOPMed gnomAD
rs749727173	390	T>R		No	ExAC gnomAD
rs934957635	391	D>E		No	TOPMed gnomAD
COSM3595421 COSM3595420	391	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs866327852	394	A>V		No	Ensembl
rs778259877	395	T>P		No	ExAC gnomAD
rs748648023	396	P>L		No	ExAC TOPMed gnomAD
rs2108328059	396	P>T		No	Ensembl
rs1559455721	399	D>G		No	TOPMed gnomAD
rs2108328044	399	D>H		No	Ensembl
rs757869703	400	G>D		No	ExAC TOPMed gnomAD
rs556114266	401	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs2082003752	402	V>A		No	Ensembl
rs1265610524	403	T>N		No	gnomAD
rs2108328031	403	T>P		No	Ensembl
rs2082003709	404	P>S		No	TOPMed gnomAD
rs1212043537	405	A>V		No	gnomAD
rs1326421924	407	D>E		No	gnomAD
COSM4118626 COSM4118625 rs756893325	407	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1228920749	410	I>V		No	TOPMed gnomAD
rs1352197417	411	T>A		No	gnomAD
rs1195660596	411	T>I		No	TOPMed
rs1352197417	411	T>P		No	gnomAD
rs763848470	412	P>L		No	ExAC gnomAD
rs1233862924	412	P>S		No	Ensembl
rs760641215	413	A>T		No	ExAC gnomAD
rs2082003280	415	D>E		No	TOPMed
rs2082003250 COSM141045	416	G>E	upper_aerodigestive_tract [Cosmic]	No	cosmic curated Ensembl
rs200719095	416	G>R		No	1000Genomes ExAC
rs201137978	417	S>N		No	1000Genomes TOPMed gnomAD
rs1387977257	419	T>N		No	gnomAD
rs774277628	419	T>P		No	ExAC gnomAD
rs1311611744	420	P>L		No	gnomAD
rs143724249	423	D>G		No	ESP ExAC TOPMed gnomAD
COSM1046308 COSM1046309	424	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2082003024	425	S>G		No	TOPMed
rs773741414	426	A>P		No	ExAC gnomAD
rs773741414	426	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs2082002955	426	A>V		No	gnomAD
rs770232583	427	T>P		No	ExAC gnomAD
rs1002498837	428	P>L		No	TOPMed gnomAD
rs781676831	428	P>S		No	ExAC gnomAD
COSM3696162 COSM3696163	429	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3916287 COSM3916286 rs769039667	429	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs778376639	430	T>N		No	ExAC gnomAD
rs1303210385	433	R>K		No	TOPMed gnomAD
rs2082002702	433	R>S		No	Ensembl
rs905124046	434	A>D		No	Ensembl
rs756948275	434	A>P		No	ExAC gnomAD
rs905124046	434	A>V		No	Ensembl
rs753451563	435	T>P		No	ExAC gnomAD
rs2082002533	437	A>V		No	TOPMed gnomAD
rs201726498	438	T>I		No	ESP ExAC TOPMed gnomAD
rs2082002510	438	T>S		No	TOPMed
rs1173582479	439	E>K		No	TOPMed gnomAD
rs144523890	440	E>D		No	ESP ExAC TOPMed gnomAD
rs2082002394	443	V>A		No	TOPMed
rs767544686	443	V>M		No	ExAC gnomAD
rs917329705	444	P>L		No	Ensembl
rs1449247412	445	T>N		No	gnomAD
rs1575405152	445	T>P		No	Ensembl
rs1449247412	445	T>S		No	gnomAD
rs1188833621	446	T>N		No	gnomAD
rs549068466	446	T>P		No	1000Genomes
rs2082002127	449	S>G		No	TOPMed
rs1199790578	450	A>T		No	gnomAD
rs2108327846	451	M>T		No	Ensembl
rs2082002086	452	L>M		No	TOPMed
rs2082002069	453	A>T		No	TOPMed
rs1265199404	454	T>A		No	TOPMed gnomAD
rs1026894871	455	K>R		No	TOPMed gnomAD
rs1259989462	456	A>S		No	Ensembl
rs1341226202	459	T>N		No	gnomAD
rs1575405106	459	T>P		No	TOPMed
TCGA novel	460	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM6098029 COSM6098030	460	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs199527105	462	P>L		No	1000Genomes ExAC TOPMed gnomAD
rs199527105	462	P>R		No	1000Genomes ExAC TOPMed gnomAD
rs867560885	463	A>T		No	TOPMed gnomAD
rs1446319423	464	M>T		No	TOPMed gnomAD
rs1338769404	464	M>V		No	gnomAD
rs762305255	467	P>L		No	ExAC TOPMed gnomAD
COSM3408753 COSM3408754	467	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1454180733	468	D>G		No	TOPMed gnomAD
COSM3595419 COSM3595418	468	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1404898456	470	T>A		No	TOPMed gnomAD
rs2082001661	470	T>I		No	TOPMed gnomAD
rs1306753877	471	A>D		No	TOPMed gnomAD
rs1306753877	471	A>G		No	TOPMed gnomAD
VAR_041341 rs56307047	472	P>L		No	UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1429463958	472	P>S		No	TOPMed gnomAD
rs1429463958	472	P>T		No	TOPMed gnomAD
TCGA novel	474	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2082001541	474	G>S		No	TOPMed
rs770382119	475	A>D		No	ExAC gnomAD
rs778427920	475	A>T		No	ExAC TOPMed gnomAD
rs748940995	477	G>A		No	ExAC gnomAD
rs748940995	477	G>D		No	ExAC gnomAD
COSM1046306 COSM1046307	479	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs778514209	479	A>V		No	TOPMed gnomAD
rs1208427176	480	P>S		No	TOPMed gnomAD
rs1482587570	481	P>H		No	gnomAD
rs1482587570	481	P>L		No	gnomAD
rs1011785677	483	S>G		No	TOPMed gnomAD
rs1011785677	483	S>R		No	TOPMed gnomAD
rs893317238	483	S>T		No	TOPMed gnomAD
rs777466315	486	E>K		No	ExAC gnomAD
rs752582179	489	A>P		No	ExAC gnomAD
rs1245564647	490	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
VAR_027539 rs17849325	491	Y>C		No	UniProt Ensembl dbSNP
rs1286982887	492	A>S		No	TOPMed gnomAD
rs1286982887	492	A>T		No	TOPMed gnomAD
rs1409795216	492	A>V		No	gnomAD
rs754974030	494	E>A		No	ExAC gnomAD
rs1371556597	494	E>Q		No	TOPMed gnomAD
rs1403956518	496	Q>E		No	gnomAD
rs751491503	496	Q>P		No	ExAC gnomAD
COSM4169792 COSM4169791	497	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1472827918	497	R>S		No	gnomAD
rs149379959	497	R>T		No	ESP ExAC TOPMed gnomAD
rs757078390	498	E>V		No	Ensembl
rs2082000886	499	E>G		No	TOPMed
rs2082000869	500	A>D		No	TOPMed
COSM6165099 COSM6165098	501	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic

No associated diseases with Q8NCB2

9 regional properties for Q8NCB2

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	308 - 568	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	309 - 563	IPR001245
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	98 - 145	IPR002219
domain	Raf-like Ras-binding	19 - 91	IPR003116
active_site	Serine/threonine-protein kinase, active site	423 - 435	IPR008271
binding_site	Protein kinase, ATP binding site	314 - 334	IPR017441
domain	Diacylglycerol/phorbol-ester binding	96 - 110	IPR020454-1
domain	Diacylglycerol/phorbol-ester binding	112 - 132	IPR020454-2
domain	Diacylglycerol/phorbol-ester binding	133 - 145	IPR020454-3

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Peripheral membrane protein Cytoplasmic vesicle membrane ; Peripheral membrane protein	Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites May be associated with vesicular structures (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity	Calmodulin-dependent catalysis of the reactions

2 GO annotations of biological process

Name	Definition
modulation of chemical synaptic transmission	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
regulation of modification of postsynaptic structure	Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.

106 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A4IFM7	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Bos taurus (Bovine)	SS
Q0V7M1	PSKH1	Serine/threonine-protein kinase H1	Bos taurus (Bovine)	SS
Q0VD22	STK33	Serine/threonine-protein kinase 33	Bos taurus (Bovine)	PR
O15075	DCLK1	Serine/threonine-protein kinase DCLK1	Homo sapiens (Human)	EV
Q9UIK4	DAPK2	Death-associated protein kinase 2	Homo sapiens (Human)	EV
O94768	STK17B	Serine/threonine-protein kinase 17B	Homo sapiens (Human)	PR
Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (Human)	SS
Q8N568	DCLK2	Serine/threonine-protein kinase DCLK2	Homo sapiens (Human)	PR
Q9UEE5	STK17A	Serine/threonine-protein kinase 17A	Homo sapiens (Human)	SS
O75962	TRIO	Triple functional domain protein	Homo sapiens (Human)	EV
Q8WWF8	CAPSL	Calcyphosin-like protein	Homo sapiens (Human)	PR
P53355	DAPK1	Death-associated protein kinase 1	Homo sapiens (Human)	EV
Q9BYT3	STK33	Serine/threonine-protein kinase 33	Homo sapiens (Human)	PR
O43293	DAPK3	Death-associated protein kinase 3	Homo sapiens (Human)	PR
Q16816	PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (Human)	PR
P15735	PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (Human)	PR
Q13554	CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (Human)	EV
Q9UQM7	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (Human)	EV
Q13555	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (Human)	EV
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (Human)	EV
Q9H1R3	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (Human)	EV
Q32MK0	MYLK3	Myosin light chain kinase 3	Homo sapiens (Human)	SS
Q86YV6	MYLK4	Myosin light chain kinase family member 4	Homo sapiens (Human)	SS
P11801	PSKH1	Serine/threonine-protein kinase H1	Homo sapiens (Human)	SS
Q6P2M8	PNCK	Calcium/calmodulin-dependent protein kinase type 1B	Homo sapiens (Human)	SS
Q96NX5	CAMK1G	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (Human)	SS
Q8IU85	CAMK1D	Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (Human)	SS
Q14012	CAMK1	Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (Human)	EV
Q9QYK9	Pnck	Calcium/calmodulin-dependent protein kinase type 1B	Mus musculus (Mouse)	PR
Q91VB2	Camk1g	Calcium/calmodulin-dependent protein kinase type 1G	Mus musculus (Mouse)	SS
Q8BG48	Stk17b	Serine/threonine-protein kinase 17B	Mus musculus (Mouse)	PR
Q8VCR8	Mylk2	Myosin light chain kinase 2, skeletal/cardiac muscle	Mus musculus (Mouse)	SS
Q6PGN3	Dclk2	Serine/threonine-protein kinase DCLK2	Mus musculus (Mouse)	PR
Q91YS8	Camk1	Calcium/calmodulin-dependent protein kinase type 1	Mus musculus (Mouse)	SS
Q3UIZ8	Mylk3	Myosin light chain kinase 3	Mus musculus (Mouse)	SS
Q8VDF3	Dapk2	Death-associated protein kinase 2	Mus musculus (Mouse)	EV
Q6P8Y1	Capsl	Calcyphosin-like protein	Mus musculus (Mouse)	PR
Q8BW96	Camk1d	Calcium/calmodulin-dependent protein kinase type 1D	Mus musculus (Mouse)	SS
P08414	Camk4	Calcium/calmodulin-dependent protein kinase type IV	Mus musculus (Mouse)	SS
Q9JLM8	Dclk1	Serine/threonine-protein kinase DCLK1	Mus musculus (Mouse)	SS
Q91YA2	Pskh1	Serine/threonine-protein kinase H1	Mus musculus (Mouse)	SS
Q80YE7	Dapk1	Death-associated protein kinase 1	Mus musculus (Mouse)	SS
Q62407	Speg	Striated muscle-specific serine/threonine-protein kinase	Mus musculus (Mouse)	SS
Q0KL02	Trio	Triple functional domain protein	Mus musculus (Mouse)	SS
Q924X7	Stk33	Serine/threonine-protein kinase 33	Mus musculus (Mouse)	PR
O54784	Dapk3	Death-associated protein kinase 3	Mus musculus (Mouse)	PR
Q3UHL1	Camkv	CaM kinase-like vesicle-associated protein	Mus musculus (Mouse)	SS
Q7TNJ7	Camk1g	Calcium/calmodulin-dependent protein kinase type 1G	Rattus norvegicus (Rat)	SS
P20689	Mylk2	Myosin light chain kinase 2, skeletal/cardiac muscle	Rattus norvegicus (Rat)	SS
F1M0Z1	Trio	Triple functional domain protein	Rattus norvegicus (Rat)	SS
Q91XS8	Stk17b	Serine/threonine-protein kinase 17B	Rattus norvegicus (Rat)	PR
O08875	Dclk1	Serine/threonine-protein kinase DCLK1	Rattus norvegicus (Rat)	PR
E9PT87	Mylk3	Myosin light chain kinase 3	Rattus norvegicus (Rat)	SS
O70150	Pnck	Calcium/calmodulin-dependent protein kinase type 1B	Rattus norvegicus (Rat)	PR
Q63638	Speg	Striated muscle-specific serine/threonine-protein kinase	Rattus norvegicus (Rat)	SS
O88764	Dapk3	Death-associated protein kinase 3	Rattus norvegicus (Rat)	PR
P13234	Camk4	Calcium/calmodulin-dependent protein kinase type IV	Rattus norvegicus (Rat)	SS
Q63450	Camk1	Calcium/calmodulin-dependent protein kinase type 1	Rattus norvegicus (Rat)	EV
P97924	Kalrn	Kalirin	Rattus norvegicus (Rat)	SS
Q5MPA9	Dclk2	Serine/threonine-protein kinase DCLK2	Rattus norvegicus (Rat)	PR
Q63092	Camkv	CaM kinase-like vesicle-associated protein	Rattus norvegicus (Rat)	SS
Q6AVM3	CCAMK	Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase	Oryza sativa subsp japonica (Rice)	PR
P53682	CPK23	Calcium-dependent protein kinase 23	Oryza sativa subsp japonica (Rice)	PR
P53684	CPK7	Calcium-dependent protein kinase 7	Oryza sativa subsp japonica (Rice)	PR
Q5VQQ5	CPK2	Calcium-dependent protein kinase 2	Oryza sativa subsp. japonica (Rice)	SS
Q6I5I8	CPK16	Calcium-dependent protein kinase 16	Oryza sativa subsp. japonica (Rice)	SS
Q6K968	CPK6	Calcium-dependent protein kinase 6	Oryza sativa subsp. japonica (Rice)	SS
Q75GE8	CPK8	Calcium-dependent protein kinase 8	Oryza sativa subsp. japonica (Rice)	SS
Q84SL0	CPK20	Calcium-dependent protein kinase 20	Oryza sativa subsp. japonica (Rice)	SS
Q8LPZ7	CPK3	Calcium-dependent protein kinase 3	Oryza sativa subsp. japonica (Rice)	SS
O44997	dapk-1	Death-associated protein kinase dapk-1	Caenorhabditis elegans	SS
Q95QC4	zyg-8	Serine/threonine-protein kinase zyg-8	Caenorhabditis elegans	PR
Q9TXJ0	cmk-1	Calcium/calmodulin-dependent protein kinase type 1	Caenorhabditis elegans	PR
P28583		Calcium-dependent protein kinase SK5	Glycine max (Soybean) (Glycine hispida)	PR
Q9M9V8	CPK10	Calcium-dependent protein kinase 10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FX86	CRK8	CDPK-related kinase 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SSF8	CPK30	Calcium-dependent protein kinase 30	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIQ7	CPK24	Calcium-dependent protein kinase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
P93759	GK-1	Calcium-dependent protein kinase 14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8S8S2	LPEAT2	Lysophospholipid acyltransferase LPEAT2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LJL9	CRK2	CDPK-related kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SG12	CRK6	CDPK-related kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SCS2	CRK5	CDPK-related kinase 5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W4I7	CPK13	Calcium-dependent protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NLQ6	CPK32	Calcium-dependent protein kinase 32	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38873	CPK7	Calcium-dependent protein kinase 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q42438	CPK8	Calcium-dependent protein kinase 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q06850	CPK1	Calcium-dependent protein kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38869	CPK4	Calcium-dependent protein kinase 4	Arabidopsis thaliana (Mouse-ear cress)	SS
Q38870	CPK2	Calcium-dependent protein kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38872	CPK6	Calcium-dependent protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39016	CPK11	Calcium-dependent protein kinase 11	Arabidopsis thaliana (Mouse-ear cress)	SS
Q3E9C0	CPK34	Calcium-dependent protein kinase 34	Arabidopsis thaliana (Mouse-ear cress)	PR
Q42396	CPK12	Calcium-dependent protein kinase 12	Arabidopsis thaliana (Mouse-ear cress)	SS
Q42479	CPK3	Calcium-dependent protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q7XJR9	CPK16	Calcium-dependent protein kinase 16	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FMP5	CPK17	Calcium-dependent protein kinase 17	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SJ61	CPK25	Calcium-dependent protein kinase 25	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZSA4	CPK27	Calcium-dependent protein kinase 27	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZV15	CPK20	Calcium-dependent protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	PR
Q1PE17	CPK18	Calcium-dependent protein kinase 18	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FKW4	CPK28	Calcium-dependent protein kinase 28	Arabidopsis thaliana (Mouse-ear cress)	SS
Q38997	KIN10	SNF1-related protein kinase catalytic subunit alpha KIN10	Arabidopsis thaliana (Mouse-ear cress)	SS
Q1LUA6	trio	Triple functional domain protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A8C984	mylk3	Myosin light chain kinase 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q7SY49	camkv	CaM kinase-like vesicle-associated protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MPFGCVTLGD	KKNYNQPSEV	TDRYDLGQVI	KTEEFCEIFR	AKDKTTGKLH	TCKKFQKRDG
70	80	90	100	110	120
RKVRKAAKNE	IGILKMVKHP	NILQLVDVFV	TRKEYFIFLE	LATGREVFDW	ILDQGYYSER
130	140	150	160	170	180
DTSNVVRQVL	EAVAYLHSLK	IVHRNLKLEN	LVYYNRLKNS	KIVISDFHLA	KLENGLIKEP
190	200	210	220	230	240
CGTPEYLAPE	VVGRQRYGRP	VDCWAIGVIM	YILLSGNPPF	YEEVEEDDYE	NHDKNLFRKI
250	260	270	280	290	300
LAGDYEFDSP	YWDDISQAAK	DLVTRLMEVE	QDQRITAEEA	ISHEWISGNA	ASDKNIKDGV
310	320	330	340	350	360
CAQIEKNFAR	AKWKKAVRVT	TLMKRLRAPE	QSSTAAAQSA	SATDTATPGA	AGGATAAAAS
370	380	390	400	410	420
GATSAPEGDA	ARAAKSDNVA	PADRSATPAT	DGSATPATDG	SVTPATDGSI	TPATDGSVTP
430	440	450	460	470	480
ATDRSATPAT	DGRATPATEE	STVPTTQSSA	MLATKAAATP	EPAMAQPDST	APEGATGQAP
490	500
PSSKGEEAAG	YAQESQREEA	S