AiPD: Autoinhibited Protein Database

Q8N8U2

Gene name	CDYL2
Protein name	Chromodomain Y-like protein 2
Names	CDY-like 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:124359
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-217 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

32-217 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

9 structures for Q8N8U2

Entry ID	Method	Resolution	Chain	Position	Source
2MJ8	NMR	-	A	2-64	PDB
4HAE	X-ray	200 A	A	2-64	PDB
5JJZ	X-ray	200 A	A	2-66	PDB
6V2D	X-ray	210 A	A/C/E/G/I/K	2-64	PDB
6V2H	X-ray	260 A	A/C/E/G/I/K	2-62	PDB
6V3N	X-ray	270 A	A/B	2-64	PDB
6V8W	X-ray	280 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z	2-62	PDB
7SLW	X-ray	230 A	A/B/C/D/E/F	2-62	PDB
AF-Q8N8U2-F1	Predicted				AlphaFoldDB

479 variants for Q8N8U2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA397168816 rs1343092483	5	D>N		No	ClinGen TOPMed
rs779942191 CA8184899	6	L>F		No	ClinGen ExAC gnomAD
rs760555163 CA396864389	9	V>F		No	ClinGen ExAC TOPMed gnomAD
rs760555163 CA8184871	9	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1201402129 CA396864334	10	E>D		No	ClinGen TOPMed
CA8184868 rs761503366	13	V>I		No	ClinGen ExAC TOPMed gnomAD
rs768260824 CA8184866	16	R>K		No	ClinGen ExAC gnomAD
CA396864060 rs1360291797	18	N>S		No	ClinGen gnomAD
CA284152484 rs995943911	19	K>Q		No	ClinGen Ensembl
CA284152480 rs1029937976	20	K>T		No	ClinGen TOPMed
rs1264674884 CA396863997	21	G>E		No	ClinGen TOPMed
rs897229367 CA284152477	21	G>R		No	ClinGen Ensembl
TCGA novel	22	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763347264 CA8184865	24	E>K		No	ClinGen ExAC gnomAD
rs1455559785 CA396863803	28	R>*		No	ClinGen gnomAD
CA396863799 rs1197668928	28	R>Q		No	ClinGen TOPMed
CA8184863 rs770293397	32	Y>H		No	ClinGen ExAC gnomAD
CA8184862 rs746377644	33	G>R		No	ClinGen ExAC gnomAD
rs1485845117 CA396863573	36	E>G		No	ClinGen gnomAD
TCGA novel	36	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747155915 CA8184859	38	T>A		No	ClinGen ExAC TOPMed gnomAD
CA396863509 rs1232689953	38	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA396863526 rs747155915	38	T>P		No	ClinGen ExAC TOPMed gnomAD
CA396863477 rs1386308625	40	E>K		No	ClinGen TOPMed
rs1260993441 CA396863423	41	P>L		No	ClinGen gnomAD
rs201935636 CA8184855	42	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA8184856 rs753617258	42	E>Q		No	ClinGen ExAC gnomAD
rs756017327 CA8184854	43	H>P		No	ClinGen ExAC gnomAD
TCGA novel	47	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1384324893 CA396863268	48	C>Y		No	ClinGen gnomAD
rs1303625330 CA396863229	49	E>D		No	ClinGen TOPMed gnomAD
CA8184851 rs756822913	50	E>G		No	ClinGen ExAC gnomAD
CA396863170 rs763782296	52	I>F		No	ClinGen ExAC gnomAD
rs762543333 CA8184848	52	I>T		No	ClinGen ExAC gnomAD
CA8184849 rs763782296	52	I>V		No	ClinGen ExAC gnomAD
CA8184847 rs765533695	56	N>I		No	ClinGen ExAC gnomAD
CA8184846 rs765533695	56	N>S		No	ClinGen ExAC gnomAD
rs148308758 CA284152289	57	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148308758 CA8184845	57	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	57	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184844 rs148308758	57	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8184842 rs8049284	58	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	60	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184840 rs772300408	60	M>V		No	ClinGen ExAC gnomAD
CA8184839 rs748326125	62	K>E		No	ClinGen ExAC TOPMed gnomAD
CA396862950 rs748326125	62	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA8184838 rs779845665	62	K>T		No	ClinGen ExAC gnomAD
rs1597172785 CA396862914	64	K>R		No	ClinGen Ensembl
CA8184837 rs755963445	65	R>G		No	ClinGen ExAC gnomAD
rs1317821546 CA396862898	65	R>K		No	ClinGen gnomAD
rs781244552 CA8184835	66	I>F		No	ClinGen ExAC gnomAD
CA8184836 rs781244552	66	I>L		No	ClinGen ExAC gnomAD
CA8184834 rs751032757	66	I>M		No	ClinGen ExAC TOPMed gnomAD
CA396862841 rs1452963835	68	S>L		No	ClinGen TOPMed
CA396862817 rs1193930442	70	K>R		No	ClinGen TOPMed
CA396862792 rs1300782526	71	Q>H		No	ClinGen gnomAD
rs1327395969 CA396862800	71	Q>P		No	ClinGen gnomAD
CA8184832 rs763515409	72	S>C		No	ClinGen ExAC gnomAD
rs761986882 CA8184831	73	S>C		No	ClinGen ExAC TOPMed gnomAD
rs372414577 CA8184830	73	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA396862733 rs1465208694	76	K>E		No	ClinGen gnomAD
rs1567570437 CA396862729	76	K>R		No	ClinGen Ensembl
rs765006005 CA8184828	77	L>V		No	ClinGen ExAC gnomAD
rs1056402563 CA284152148	79	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs774232446 CA8184826	79	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396862672 rs1452218563	81	S>G		No	ClinGen gnomAD
rs1330978491 CA396862656	82	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1375093823 CA396862651	82	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA396862635 rs1254538909	83	G>V		No	ClinGen gnomAD
CA8184824 rs761199293	84	P>A		No	ClinGen ExAC gnomAD
rs376407812 CA284152120	84	P>L		No	ClinGen ESP TOPMed gnomAD
CA8184823 rs139107743	85	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748321271 CA8184821	86	V>A		No	ClinGen ExAC gnomAD
CA8184820 rs373182913	89	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA396862522 rs1213890175	90	S>F		No	ClinGen TOPMed
CA8184819 rs769040263	91	H>N		No	ClinGen ExAC gnomAD
CA8184817 rs538917700	92	R>K		No	ClinGen ExAC gnomAD
CA396862472 rs1374765119	93	P>S		No	ClinGen gnomAD
rs1393091637 CA396862428	95	D>Y		No	ClinGen gnomAD
CA8184815 rs746932115	96	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs202178136 CA8184813	101	G>E		No	ClinGen ExAC TOPMed gnomAD
CA8184814 rs200502636	101	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs752287768 CA8184812	102	T>N		No	ClinGen ExAC TOPMed gnomAD
CA396862296 rs1597172631	102	T>P		No	ClinGen Ensembl
rs922231130 CA284152023	103	S>P		No	ClinGen TOPMed
rs201069122 CA284152022	103	S>Y		No	ClinGen Ensembl
CA396862217 rs1438478318	104	H>Q		No	ClinGen gnomAD
rs778511407 CA8184811	104	H>R		No	ClinGen ExAC gnomAD
rs977037619 CA284152021	104	H>Y		No	ClinGen TOPMed
CA396862214 rs1230699147	105	K>E		No	ClinGen gnomAD
CA8184809 rs754159227	106	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8184810 rs377184768	106	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	107	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184808 rs766737973	108	R>*		No	ClinGen ExAC gnomAD
rs766737973 CA396862171	108	R>G		No	ClinGen ExAC gnomAD
CA8184807 rs151165278	108	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1350592028 CA396862157	109	I>V		No	ClinGen gnomAD
CA396862123 rs1234230843	110	N>S		No	ClinGen TOPMed gnomAD
CA396862124 rs1234230843	110	N>T		No	ClinGen TOPMed gnomAD
rs201777900 CA396862107	111	P>L		No	ClinGen TOPMed
rs201777900 CA284152010	111	P>R		No	ClinGen TOPMed
rs1281227556 CA396862115	111	P>S		No	ClinGen gnomAD
rs1281227556 CA396862118	111	P>T		No	ClinGen gnomAD
rs924856145 CA396862099	112	P>H		No	ClinGen TOPMed
rs924856145 CA284152009	112	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA396862101 rs1567570322	112	P>S		No	ClinGen Ensembl
rs750885476 CA8184806	114	A>G		No	ClinGen ExAC gnomAD
CA8184805 rs768140025	116	P>A		No	ClinGen ExAC TOPMed gnomAD
CA396862040 rs1281382162	117	K>E		No	ClinGen gnomAD
CA8184804 rs761768744	117	K>I		No	ClinGen ExAC gnomAD
rs761768744 CA396862034	117	K>R		No	ClinGen ExAC gnomAD
rs959637712 CA284151995	119	G>R		No	ClinGen TOPMed gnomAD
CA284151985 rs1023081357	120	Y>C		No	ClinGen TOPMed
rs1333503745 CA396861994	120	Y>H		No	ClinGen gnomAD
CA396861971 rs1412624016	121	S>L		No	ClinGen gnomAD
CA396861931 rs1013394913	123	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs774539541 CA8184803	123	K>R		No	ClinGen ExAC gnomAD
rs768952459 CA8184802	124	P>S		No	ClinGen ExAC TOPMed gnomAD
CA396861926 rs768952459	124	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1405389031 CA396861900	125	S>P		No	ClinGen gnomAD
CA396861884 rs1159768289	126	S>L		No	ClinGen gnomAD
CA284151938 rs1027674208	127	G>R		No	ClinGen Ensembl
rs974099405 CA284151930	128	G>S		No	ClinGen Ensembl
TCGA novel	129	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770835171 CA8184799	130	R>G		No	ClinGen ExAC TOPMed gnomAD
CA396861828 rs1486826735	131	A>T		No	ClinGen gnomAD
CA284151904 rs1015557073	131	A>V		No	ClinGen gnomAD
CA8184797 rs562488396	133	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs369415596 CA8184798	133	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs772092026 CA8184796	134	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA396861792 rs1350914242	134	T>S		No	ClinGen gnomAD
rs370784290 CA396861729	138	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	139	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756433507 CA8184790	140	T>A		No	ClinGen ExAC gnomAD
rs750840122 CA8184789	141	P>R		No	ClinGen ExAC gnomAD
rs1343055370 CA396861688	141	P>S		No	ClinGen gnomAD
CA396861674 rs1403708630	142	S>I		No	ClinGen gnomAD
CA396861679 rs1403708630	142	S>N		No	ClinGen gnomAD
CA8184788 rs767889120	142	S>R		No	ClinGen ExAC TOPMed gnomAD
CA284151825 rs755893807	143	G>D		No	ClinGen gnomAD
CA8184786 rs751651545	144	L>V		No	ClinGen ExAC TOPMed
rs763182906 CA8184784	145	Q>H		No	ClinGen ExAC gnomAD
CA8184783 rs775849515	146	I>T		No	ClinGen ExAC gnomAD
rs1193369978 CA396861619	146	I>V		No	ClinGen gnomAD
rs1243992802 CA396861599 CA396861603	147	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA396861611 rs1400002736	147	M>V		No	ClinGen TOPMed
rs760360953 CA8184781	148	P>L		No	ClinGen ExAC gnomAD
CA8184782 rs770181158	148	P>T		No	ClinGen ExAC gnomAD
rs1215676654 CA396861538	151	K>N		No	ClinGen gnomAD
rs773079432 CA8184780	151	K>R		No	ClinGen ExAC gnomAD
TCGA novel	151	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs893033243 CA284151748	152	S>P		No	ClinGen TOPMed
TCGA novel	153	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184777 rs778339782	155	G>A		No	ClinGen ExAC gnomAD
rs748118826 CA8184778	155	G>R		No	ClinGen ExAC TOPMed gnomAD
CA284151725 rs370242036	156	M>L		No	ClinGen gnomAD
rs370242036 CA396861466	156	M>V		No	ClinGen gnomAD
CA396861411 rs1369563011	159	G>A		No	ClinGen gnomAD
rs144219171 CA8184774	161	A>T		No	ClinGen ESP ExAC gnomAD
CA8184772 rs201425276	162	G>S		No	ClinGen ExAC TOPMed gnomAD
CA8184771 rs373621157	163	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1422120536 CA396861346	164	E>Q		No	ClinGen gnomAD
CA8184769 rs187745628	166	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396861306 rs1258312526	166	D>V		No	ClinGen gnomAD
rs138238685 CA8184770	166	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs764763104 CA8184768	167	E>D		No	ClinGen ExAC gnomAD
rs752873125 CA8184767	168	R>K		No	ClinGen ExAC gnomAD
rs752873125 CA8184766	168	R>T		No	ClinGen ExAC gnomAD
CA284151677 rs915694588	169	H>Q		No	ClinGen Ensembl
rs765324115 CA8184765	171	G>*		No	ClinGen ExAC gnomAD
rs1273667185 CA396861244	171	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA284151653 rs1055281965	172	N>K		No	ClinGen Ensembl
rs1424744282 CA396861192	174	S>C		No	ClinGen TOPMed
CA396861178 rs1274897739	175	H>R		No	ClinGen TOPMed gnomAD
CA396861153 rs1214987161	176	Q>H		No	ClinGen gnomAD
rs1300878679 CA396861145	177	P>L		No	ClinGen gnomAD
rs1346677875 CA396861151	177	P>T		No	ClinGen gnomAD
CA396861143 rs761574264	178	G>C		No	ClinGen ExAC TOPMed gnomAD
rs761574264 CA8184761	178	G>S		No	ClinGen ExAC TOPMed gnomAD
rs774270019 CA8184760	180	D>E		No	ClinGen ExAC gnomAD
rs920183275 CA284151645	180	D>V		No	ClinGen Ensembl
rs1371109399 CA396861122	180	D>Y		No	ClinGen gnomAD
rs768623859 CA8184759	181	L>F		No	ClinGen ExAC gnomAD
CA396861115 rs1440688814	181	L>M		No	ClinGen gnomAD
CA8184758 rs758179207	182	N>S		No	ClinGen ExAC TOPMed gnomAD
CA284151619 rs758179207	182	N>T		No	ClinGen ExAC TOPMed gnomAD
rs373304541 CA8184755	183	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8184756 rs769293029	183	D>G		No	ClinGen ExAC gnomAD
rs1597172212 CA396861082	184	H>D		No	ClinGen Ensembl
rs1230466980 CA396861079	184	H>R		No	ClinGen gnomAD
CA8184752 rs747417366	185	V>A		No	ClinGen ExAC gnomAD
rs757634954 CA8184753	185	V>F		No	ClinGen ExAC gnomAD
CA396861075 rs757634954	185	V>I		No	ClinGen ExAC gnomAD
rs1270354031 CA396861071	186	G>R		No	ClinGen TOPMed
CA396861065 rs1366472144	187	E>K		No	ClinGen TOPMed
rs758991617 CA8184750	189	D>G		No	ClinGen ExAC gnomAD
rs765359697 CA8184748	190	M>I		No	ClinGen ExAC gnomAD
CA8184749 rs199772000	190	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	191	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396861030 rs1236069981	191	G>V		No	ClinGen gnomAD
rs1347918820 CA396861020	193	C>R		No	ClinGen gnomAD
rs986776587 CA284151569	193	C>Y		No	ClinGen TOPMed gnomAD
CA284151563 rs149647231	194	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138401474 CA8184746	195	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	196	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200977842 CA8184744	196	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8184741 rs762910339	198	A>T		No	ClinGen ExAC TOPMed gnomAD
rs372394862 CA8184740	199	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs368116348 CA8184739	200	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8184737 rs138924106	201	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA284151477 rs900953571	202	E>Q		No	ClinGen TOPMed gnomAD
CA396860952 CA396860953 rs1348845116	204	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
rs778308961	205	L>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA8184733 rs145820855	206	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA284166421 rs879863061	207	S>C		No	ClinGen gnomAD
rs77050855 CA8184673	207	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA284166434 rs879863061	207	S>Y		No	ClinGen gnomAD
rs770332841 CA8184672	208	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA396870503 rs1308819547	208	A>P		No	ClinGen gnomAD
rs770332841 CA8184671	208	A>V		No	ClinGen ExAC TOPMed gnomAD
CA396870482 rs1219244386	209	L>P		No	ClinGen TOPMed
CA8184670 rs745896008	209	L>V		No	ClinGen ExAC TOPMed gnomAD
rs756365917 CA284166409	211	N>S		No	ClinGen TOPMed
rs370815076 CA8184668	212	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8184667 rs370815076	212	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1430185027 CA396870409	213	G>E		No	ClinGen gnomAD
rs377472428 CA8184664	214	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA396870390 rs1158743160	214	L>W		No	ClinGen gnomAD
CA396870372 rs1253747115	215	N>K		No	ClinGen gnomAD
CA8184661 rs749913146	217	H>N		No	ClinGen ExAC gnomAD
rs1211531545 CA396870325 CA396870323	218	S>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs756881257 CA8184659	219	P>A		No	ClinGen ExAC gnomAD
CA284166336 rs776503415	220	V>L		No	ClinGen TOPMed gnomAD
rs1352904219 CA396870281	221	K>R		No	ClinGen gnomAD
CA396870238 rs1472463798	224	L>V		No	ClinGen gnomAD
rs763877374 CA8184657	225	E>D		No	ClinGen ExAC TOPMed gnomAD
rs763202229 CA8184656	226	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs373147588 CA8184653	227	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs373147588 CA8184654	227	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA8184652 rs776634178	228	K>E		No	ClinGen ExAC gnomAD
rs770901738 CA8184651	229	D>E		No	ClinGen ExAC gnomAD
rs1158238345 CA396870152	229	D>G		No	ClinGen gnomAD
rs1597136852 CA396870132	230	Y>C		No	ClinGen Ensembl
TCGA novel	231	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148821008 CA8184649	231	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs973491854 CA284166246	233	D>E		No	ClinGen TOPMed gnomAD
CA284166227 rs963789797	234	K>E		No	ClinGen Ensembl
rs1286235006 CA396870075	234	K>R		No	ClinGen TOPMed
CA8184647 rs564887492	235	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA396870050 rs780027195	235	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1213088649 CA396870025	237	R>G		No	ClinGen gnomAD
TCGA novel	238	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184644 rs376651338	239	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA396869982 rs1452179206	239	S>R		No	ClinGen TOPMed
CA8184642 rs756720865	241	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1384771327 CA396869942	241	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs777240172 CA8184640	242	Q>*		No	ClinGen ExAC gnomAD
CA8184638 rs752989267	242	Q>H		No	ClinGen ExAC gnomAD
rs758098487 CA8184639	242	Q>P		No	ClinGen ExAC gnomAD
CA396869898 rs1287168472	243	N>S		No	ClinGen gnomAD
rs145537003 CA8184637	245	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1206448220 CA396869834	248	R>L		No	ClinGen gnomAD
CA8184633 rs773366284	250	R>L		No	ClinGen ExAC gnomAD
CA8184632 rs773366284	250	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1424004394 CA396869783	251	D>H		No	ClinGen TOPMed gnomAD
rs1424004394 CA396869778	251	D>N		No	ClinGen TOPMed gnomAD
CA284166145 rs998542266	252	I>V		No	ClinGen TOPMed gnomAD
rs62049900 CA8184629	253	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	255	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770953315 CA8184625	255	R>Q		No	ClinGen ExAC gnomAD
CA8184626 rs369631694	255	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1293789196 CA396869614	259	G>E		No	ClinGen gnomAD
rs757984517 CA8184622	260	F>V		No	ClinGen ExAC TOPMed gnomAD
CA8184621 rs752332994	261	T>A		No	ClinGen ExAC gnomAD
CA8184620 rs778603352	261	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA396869384 rs761277499	269	T>I		No	ClinGen ExAC gnomAD
CA396869389 rs761277499	269	T>N		No	ClinGen ExAC gnomAD
rs761277499 CA8184616	269	T>S		No	ClinGen ExAC gnomAD
rs1567548675 CA396869379	270	S>A		No	ClinGen Ensembl
rs879080216 CA284166066	270	S>L		No	ClinGen TOPMed
CA8184613 rs767648820	271	D>G		No	ClinGen ExAC gnomAD
CA8184612 rs762047020	272	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs1450743623 CA396869323	273	N>S		No	ClinGen gnomAD
rs774714286 CA8184611	274	A>S		No	ClinGen ExAC gnomAD
rs764454415 CA8184610	275	L>M		No	ClinGen ExAC gnomAD
rs759385054 CA8184609	277	P>A		No	ClinGen ExAC gnomAD
CA8184608 rs776518606	277	P>L		No	ClinGen ExAC
rs748983597	279	I>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA8184581 rs748983597	279	I>M		No	ClinGen ExAC gnomAD
CA284150688 rs975671527	279	I>N		No	ClinGen TOPMed
rs1204680992 CA396864829	279	I>V		No	ClinGen gnomAD
CA396864774 rs1266239560	280	M>T		No	ClinGen TOPMed gnomAD
rs756500412 CA8184579	281	K>R		No	ClinGen ExAC gnomAD
CA8184580 rs756500412	281	K>T		No	ClinGen ExAC gnomAD
CA284150584 rs978792477	282	E>D		No	ClinGen Ensembl
CA396864687 rs1597128557	283	V>A		No	ClinGen Ensembl
rs746263715 CA8184578	283	V>F		No	ClinGen ExAC gnomAD
CA396864679 rs1341942086	284	R>Q		No	ClinGen gnomAD
CA8184576 rs757864703	284	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8184575 rs368202024	286	A>E		No	ClinGen ESP ExAC gnomAD
CA284150564 rs368202024	286	A>V		No	ClinGen ESP ExAC gnomAD
rs111324619 CA284150543	287	L>P		No	ClinGen Ensembl
CA396864613 rs1162016397	288	C>Y		No	ClinGen gnomAD
CA396864602 rs1597128528	289	N>T		No	ClinGen Ensembl
CA396864593 rs1161870624	290	A>P		No	ClinGen TOPMed gnomAD
CA396864595 rs1161870624	290	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs760496597 CA8184570	292	T>A		No	ClinGen ExAC gnomAD
CA8184569 rs750237699	292	T>I		No	ClinGen ExAC gnomAD
CA284150500 rs980430837	293	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	294	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184567 rs370746070	294	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8184564 rs150794698	297	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA396864448 rs1226452196	298	L>M		No	ClinGen gnomAD
CA8184563 rs775181291	299	L>F		No	ClinGen ExAC gnomAD
TCGA novel	300	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184562 rs769385267	300	L>P		No	ClinGen ExAC gnomAD
CA396864368 rs866902124	302	A>S		No	ClinGen gnomAD
rs866902124 CA284150441	302	A>T		No	ClinGen gnomAD
CA8184559 rs547188605	305	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8184557 rs778486733	306	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA396864054 rs1414723778	310	G>D		No	ClinGen TOPMed gnomAD
rs1231734348 CA396864075	310	G>S		No	ClinGen TOPMed
CA396863995 rs1447683902	312	D>E		No	ClinGen TOPMed gnomAD
rs779145359 CA8184554	313	Y>C		No	ClinGen ExAC gnomAD
CA396863992 rs1567543552	313	Y>H		No	ClinGen Ensembl
CA8184553 rs755185419	316	L>I		No	ClinGen ExAC gnomAD
rs147914173 CA8184551	317	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1246119279 CA396863875	317	I>V		No	ClinGen gnomAD
CA8184549 rs751494194	319	R>Q		No	ClinGen ExAC gnomAD
CA8184550 rs761655091	319	R>W		No	ClinGen ExAC gnomAD
rs1204039944 CA396863824	320	L>M		No	ClinGen gnomAD
CA8184547 rs762507376	321	S>C		No	ClinGen ExAC gnomAD
rs144737101 CA396863816	321	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA8184548 rs144737101	321	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA396863782 rs571363904	322	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8184545 rs779182525	323	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1273588390 CA396863748	324	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1350858763 CA396863723	325	R>Q		No	ClinGen TOPMed gnomAD
rs142002683 CA8184542	328	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs142002683 CA8184543	328	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA396863640 rs1434183748	330	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8184540 rs370310225	330	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	335	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396863523 rs1335712100	335	I>T		No	ClinGen TOPMed
CA8184504 rs762305274	341	A>G		No	ClinGen ExAC TOPMed gnomAD
CA284140401 rs767456197	341	A>S		No	ClinGen gnomAD
CA396860892 rs762305274	341	A>V		No	ClinGen ExAC TOPMed gnomAD
CA396860874 rs1422863402	344	Q>*		No	ClinGen gnomAD
TCGA novel	346	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	346	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	350	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184502 rs200689533	350	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8184501 rs200689533	350	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA396860825 rs1247897349	351	V>L		No	ClinGen gnomAD
CA396860827 rs1247897349	351	V>M		No	ClinGen gnomAD
rs769940252 CA8184499	354	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	355	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781540702 CA8184497	356	P>L		No	ClinGen ExAC gnomAD
CA396860777 rs1597122862	359	G>C		No	ClinGen Ensembl
CA8184495 rs748022554	359	G>D		No	ClinGen ExAC gnomAD
TCGA novel	359	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396860766 rs1364579076	361	G>D		No	ClinGen TOPMed gnomAD
CA396860761 rs1319765346	362	A>S		No	ClinGen gnomAD
CA284140322 rs952975359	363	S>F		No	ClinGen Ensembl
rs1423459953 CA396860751	364	I>V		No	ClinGen gnomAD
CA8184491 rs779722871	366	P>L		No	ClinGen ExAC gnomAD
CA8184488 rs767241907	370	I>V		No	ClinGen ExAC TOPMed gnomAD
CA396860672 rs1444671315	371	V>M		No	ClinGen gnomAD
rs1481627142 CA396860604	376	K>R		No	ClinGen gnomAD
CA396860601 rs1343799325	377	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1209548609 CA396860554	381	T>M		No	ClinGen gnomAD
rs1232803206 CA396860548	382	P>A		No	ClinGen TOPMed gnomAD
CA396860546 rs1232803206	382	P>S		No	ClinGen TOPMed gnomAD
rs769856800 CA396860526	384	A>S		No	ClinGen ExAC TOPMed gnomAD
rs769856800 CA8184482	384	A>T		No	ClinGen ExAC TOPMed gnomAD
CA396860521 rs1567539720	384	A>V		No	ClinGen Ensembl
rs536459738 CA396860498	387	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA8184478 rs747855913	387	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8184479 rs536459738	387	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8184477 rs778854280	389	T>A		No	ClinGen ExAC gnomAD
CA8184476 rs768656038	389	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8184474 rs140095838	391	A>T		No	ClinGen ESP ExAC gnomAD
CA396860458 rs1166170776	392	G>C		No	ClinGen gnomAD
CA396860430 rs1271127802	394	S>A		No	ClinGen TOPMed
rs1374078523 CA396860426	394	S>F		No	ClinGen gnomAD
rs889851733 CA284140193	396	Y>H		No	ClinGen gnomAD
rs780661698 CA8184471	398	F>C		No	ClinGen ExAC gnomAD
TCGA novel	400	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396860368 rs1342986136	401	I>N		No	ClinGen gnomAD
CA396860370 rs1207308459	401	I>V		No	ClinGen gnomAD
rs186702168 CA8184469	402	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA284140157 rs368472250	404	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	404	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8184467 rs368472250	404	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA396860347 rs145890469	405	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs763954319 CA8184465	405	A>T		No	ClinGen ExAC gnomAD
CA8184464 rs145890469	405	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8184462 rs770991488	406	L>P		No	ClinGen ExAC gnomAD
rs755512414 CA8184446	407	A>T		No	ClinGen ExAC gnomAD
rs753801497 CA8184445	408	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1185426912 CA396859307	409	E>K		No	ClinGen gnomAD
CA8184444 rs766469320	410	M>L		No	ClinGen ExAC gnomAD
CA396859274 rs760732086	411	L>M		No	ClinGen ExAC TOPMed gnomAD
CA396859272 rs760732086	411	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1021446086 CA284134841	412	F>I		No	ClinGen Ensembl
CA396859245 rs1464422532	412	F>L		No	ClinGen gnomAD
rs1265986394 CA396859228	414	G>R		No	ClinGen gnomAD
rs1421470774 CA396859200	415	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA396859201 rs1273478313	415	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1311355428 CA396859157	418	T>A		No	ClinGen TOPMed
rs990497273 CA284134835	418	T>I		No	ClinGen TOPMed gnomAD
rs990497273 CA396859154	418	T>S		No	ClinGen TOPMed gnomAD
CA8184440 rs762788877	419	A>T		No	ClinGen ExAC gnomAD
rs769555144 CA8184438	420	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1251298961 CA396859098	421	E>G		No	ClinGen gnomAD
rs1315186233 CA396859102	421	E>K		No	ClinGen gnomAD
rs776495063 CA8184436	423	C>R		No	ClinGen ExAC gnomAD
CA8184435 rs770474965	425	R>K		No	ClinGen ExAC gnomAD
CA396858999 rs1161702893	426	G>E		No	ClinGen gnomAD
rs1246472733 CA396859000	426	G>R		No	ClinGen TOPMed
rs1448781014 CA396858913	431	V>F		No	ClinGen gnomAD
CA396858894 rs1597119736	431	V>G		No	ClinGen Ensembl
rs1217601139 CA396858850	433	W>*		No	ClinGen gnomAD
CA396858840 rs1447382699	433	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA396858834 rs1447382699	433	W>C		No	ClinGen gnomAD
CA8184431 rs748442310	435	T>S		No	ClinGen ExAC gnomAD
CA396858785 rs1291853182	436	T>M		No	ClinGen gnomAD
rs865804016 CA284134780	440	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA396858661 rs1322034844	442	M>V		No	ClinGen gnomAD
rs1168038281 CA396858621	444	R>Q		No	ClinGen gnomAD
rs1366494845 CA396858624	444	R>W		No	ClinGen TOPMed gnomAD
CA396858613 rs1427913257	445	V>I		No	ClinGen TOPMed gnomAD
CA396858593 rs1188236160	446	K>*		No	ClinGen TOPMed gnomAD
CA396858597 rs1188236160	446	K>Q		No	ClinGen TOPMed gnomAD
rs1475722403 CA396858589	446	K>R		No	ClinGen gnomAD
rs750554842 CA8184425	449	A>G		No	ClinGen ExAC TOPMed gnomAD
rs750554842 CA396858504	449	A>V		No	ClinGen ExAC TOPMed gnomAD
rs767809619 CA8184424	450	S>F		No	ClinGen ExAC TOPMed gnomAD
rs767809619 CA396858496	450	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs369532733 CA8184423	452	S>T		No	ClinGen ESP ExAC gnomAD
rs148875027 CA8184422	453	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8184421 rs765071393	453	A>V		No	ClinGen ExAC TOPMed gnomAD
rs145676305 CA8184418	454	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs145676305 CA8184417	454	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA396857455 rs1317302153	457	E>G		No	ClinGen gnomAD
rs931396700 CA284131283	459	S>C		No	ClinGen TOPMed
rs758550547 CA8184386	460	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8184385 rs758550547	460	K>T		No	ClinGen ExAC TOPMed gnomAD
CA396857399 rs1351166719	461	C>S		No	ClinGen gnomAD
CA8184383 rs202176613	463	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs202176613 CA8184382	463	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA8184380 rs761338715	464	R>L		No	ClinGen ExAC TOPMed gnomAD
CA396857357 rs761338715	464	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8184379 rs761338715	464	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA396857361 rs1346545104	464	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs763502230 CA8184378	468	K>E		No	ClinGen ExAC gnomAD
CA8184375 rs775273755	470	V>A		No	ClinGen ExAC TOPMed gnomAD
rs570302046 CA8184376	470	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA396857270 rs1278278097	471	L>V		No	ClinGen TOPMed
CA396857241 rs1464128587	472	E>A		No	ClinGen Ensembl
rs777259407 CA8184372	474	V>M		No	ClinGen ExAC gnomAD
rs747040216 CA8184370	476	E>G		No	ClinGen ExAC
CA284131230 rs202016466	478	E>K		No	ClinGen Ensembl
rs1007360853 CA284131226	479	C>S		No	ClinGen TOPMed
rs369680829 CA284131219	479	C>Y		No	ClinGen TOPMed
rs202026090 CA8184367	480	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs779145592 CA8184366	481	M>R		No	ClinGen ExAC gnomAD
rs750239718 CA8184364	483	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8184362 rs377083708	484	Q>H		No	ClinGen ESP ExAC gnomAD
rs767402697 CA8184363	484	Q>K		No	ClinGen ExAC gnomAD
rs1363857310 CA396856985	486	W>C		No	ClinGen gnomAD
TCGA novel	492	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373690013 CA8184360	494	S>C		No	ClinGen ESP ExAC gnomAD
CA396856845 rs1468747693	495	L>I		No	ClinGen TOPMed
CA396856786 rs1424758752	498	Y>C		No	ClinGen gnomAD
CA8184357 rs775256021	501	D>G		No	ClinGen ExAC gnomAD
CA396856741 rs1567535789	501	D>Y		No	ClinGen Ensembl
rs765035136 CA8184356	502	K>T		No	ClinGen ExAC TOPMed gnomAD
CA8184355 rs759935300	505	E>D		No	ClinGen ExAC gnomAD

No associated diseases with Q8N8U2

3 regional properties for Q8N8U2

Type	Name	Position	InterPro Accession
domain	Ubiquitin-conjugating enzyme E2	2 - 150	IPR000608
domain	Ubiquitin-conjugating enzyme, C-terminal fungi	161 - 215	IPR015368
active_site	Ubiquitin-conjugating enzyme, active site	76 - 92	IPR023313

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99549	MPHOSPH8	M-phase phosphoprotein 8	Homo sapiens (Human)	PR
P83916	CBX1	Chromobox protein homolog 1	Homo sapiens (Human)	PR
Q9Y232	CDYL	Chromodomain Y-like protein	Homo sapiens (Human)	PR
P83917	Cbx1	Chromobox protein homolog 1	Mus musculus (Mouse)	PR
Q9WTK2	Cdyl	Chromodomain Y-like protein	Mus musculus (Mouse)	PR
Q9D5D8	Cdyl2	Chromodomain Y-like protein 2	Mus musculus (Mouse)	PR
Q6AYK9	Cdyl	Chromodomain Y-like protein	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MASGDLYEVE	RIVDKRKNKK	GKWEYLIRWK	GYGSTEDTWE	PEHHLLHCEE	FIDEFNGLHM
70	80	90	100	110	120
SKDKRIKSGK	QSSTSKLLRD	SRGPSVEKLS	HRPSDPGKSK	GTSHKRKRIN	PPLAKPKKGY
130	140	150	160	170	180
SGKPSSGGDR	ATKTVSYRTT	PSGLQIMPLK	KSQNGMENGD	AGSEKDERHF	GNGSHQPGLD
190	200	210	220	230	240
LNDHVGEQDM	GECDVNHATL	AENGLGSALT	NGGLNLHSPV	KRKLEAEKDY	VFDKRLRYSV
250	260	270	280	290	300
RQNESNCRFR	DIVVRKEEGF	THILLSSQTS	DNNALTPEIM	KEVRRALCNA	ATDDSKLLLL
310	320	330	340	350	360
SAVGSVFCSG	LDYSYLIGRL	SSDRRKESTR	IAEAIRDFVK	AFIQFKKPIV	VAINGPALGL
370	380	390	400	410	420
GASILPLCDI	VWASEKAWFQ	TPYATIRLTP	AGCSSYTFPQ	ILGVALANEM	LFCGRKLTAQ
430	440	450	460	470	480
EACSRGLVSQ	VFWPTTFSQE	VMLRVKEMAS	CSAVVLEESK	CLVRSFLKSV	LEDVNEKECL
490	500
MLKQLWSSSK	GLDSLFSYLQ	DKIYEV