Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8N859

Entry ID Method Resolution Chain Position Source
AF-Q8N859-F1 Predicted AlphaFoldDB

308 variants for Q8N859

Variant ID(s) Position Change Description Diseaes Association Provenance
rs192654523
CA4267847
2 P>A No ClinGen
1000Genomes
ExAC
gnomAD
CA4267848
rs192654523
2 P>S No ClinGen
1000Genomes
ExAC
gnomAD
CA4267849
rs775909225
3 S>Y No ClinGen
ExAC
gnomAD
CA574344442
rs1362340320
4 Q>R No ClinGen
gnomAD
CA839888346
rs1467568734
11 E>D No ClinGen
TOPMed
CA158969377
rs773449513
14 M>V No ClinGen
Ensembl
CA4267851
rs367619077
17 E>Q No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA4267852
rs140984938
18 E>* No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA367585120
rs1192467726
21 D>N No ClinGen
TOPMed
CA158969430
rs960077513
22 G>S No ClinGen
TOPMed
rs1233427226
CA367585143
24 Q>L No ClinGen
gnomAD
rs143004989
CA4267857
25 M>I No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs200710334
CA4267856
25 M>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA4267855
rs762280717
25 M>V No ClinGen
ExAC
TOPMed
gnomAD
CA367585172
rs1260901569
29 Q>K No ClinGen
gnomAD
rs1486745339
CA367585176
29 Q>R No ClinGen
gnomAD
CA367585902
rs1213776061
30 E>G No ClinGen
TOPMed
CA367585908
rs1268188784
31 S>P No ClinGen
gnomAD
rs759282501
CA4267878
33 T>M No ClinGen
ExAC
TOPMed
gnomAD
CA367585948
rs1332811815
35 Q>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs752222972
CA4267880
36 D>A No ClinGen
ExAC
gnomAD
CA4267879
rs767092420
36 D>H No ClinGen
ExAC
TOPMed
gnomAD
rs767092420
CA367585958
36 D>N No ClinGen
ExAC
TOPMed
gnomAD
rs1453529970
CA367585984
38 A>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs764109154
CA4267882
39 V>M No ClinGen
ExAC
TOPMed
gnomAD
rs753878987
CA4267883
42 T>A No ClinGen
ExAC
TOPMed
gnomAD
rs368631846
CA4267884
45 E>* No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA4267886
rs750563680
46 W>* No ClinGen
ExAC
gnomAD
rs778782460
CA367586068
46 W>G No ClinGen
ExAC
gnomAD
rs778782460
CA4267885
46 W>R No ClinGen
ExAC
gnomAD
rs1268900213
CA367586096
48 Q>* No ClinGen
TOPMed
rs1163564174
CA367586115
49 L>P No ClinGen
gnomAD
CA4267887
rs758652453
53 Q>* No ClinGen
ExAC
gnomAD
rs747072160
CA4267889
CA4267890
54 K>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
gnomAD
NCI-TCGA
rs1023676133
CA158977040
55 N>I No ClinGen
TOPMed
rs1431146596
CA367586233
56 L>F Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA367586249
rs962606844
57 Y>C No ClinGen
gnomAD
CA367586250
rs962606844
57 Y>F No ClinGen
gnomAD
CA158977046
rs962606844
57 Y>S No ClinGen
gnomAD
rs973963811
CA158977078
58 R>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA4267894
rs147455939
59 D>E No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA4267895
rs373401601
60 V>M Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs773654652
CA4267897
63 E>G No ClinGen
ExAC
TOPMed
gnomAD
CA4267896
rs770000082
63 E>K No ClinGen
ExAC
gnomAD
CA158977110
rs199895993
64 N>I No ClinGen
1000Genomes
CA367586354
rs1219220152
64 N>Y No ClinGen
gnomAD
rs112626706
CA158977117
65 Y>C No ClinGen
Ensembl
CA158977126
rs951213433
66 R>G No ClinGen
gnomAD
CA367586412
rs1256093146
68 L>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs1485626123
CA367586424
69 V>I No ClinGen
gnomAD
rs1454085131
CA367586447
71 L>R No ClinGen
TOPMed
gnomAD
rs768003402
CA158977539
72 G>E No ClinGen
ExAC
gnomAD
rs768003402
CA4267924
72 G>V No ClinGen
ExAC
gnomAD
CA4267898
rs763448682
72 G>W No ClinGen
ExAC
gnomAD
CA4267925
rs776238470
73 Y>C No ClinGen
ExAC
TOPMed
gnomAD
rs140020626
CA4267928
78 P>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1271687428
CA367586562
78 P>T No ClinGen
gnomAD
CA4267929
rs762736027
79 E>* No ClinGen
ExAC
gnomAD
rs1250711870
CA367586578
79 E>V No ClinGen
gnomAD
CA367586583
rs1453623579
80 V>I No ClinGen
TOPMed
gnomAD
rs766170038
CA4267930
81 I>V No ClinGen
ExAC
gnomAD
rs750435267
CA4267932
82 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA158977593
rs977493504
82 A>V No ClinGen
TOPMed
gnomAD
rs371098692
CA158977612
83 Q>L No ClinGen
ESP
TOPMed
rs1324183434
CA367586703
90 W>* No ClinGen
TOPMed
gnomAD
rs1562745126
CA367586695
90 W>R No ClinGen
Ensembl
CA367586720
rs1417590040
92 I>L No ClinGen
TOPMed
CA4267935
rs767669734
95 D>H No ClinGen
ExAC
gnomAD
rs142861112
CA4267936
96 S>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1213598369
CA367586765
96 S>N No ClinGen
gnomAD
CA367586773
rs1325942975
97 L>V No ClinGen
gnomAD
CA367586794
rs1271237235
99 D>G No ClinGen
gnomAD
CA367586813
rs1285363421
101 H>Q No ClinGen
Ensembl
rs1318041241
CA367586808
101 H>Y No ClinGen
gnomAD
CA4267966
rs748832888
103 D>G No ClinGen
ExAC
gnomAD
rs151202323
CA4267938
103 D>H No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs774328834
CA4267968
105 E>G No ClinGen
ExAC
gnomAD
rs1392779507
CA367587990
105 E>K No ClinGen
TOPMed
gnomAD
rs1433412580
CA367588003
106 N>K No ClinGen
gnomAD
rs759369107
CA4267969
107 R>S No ClinGen
ExAC
gnomAD
CA367588016
rs1377847746
108 P>L No ClinGen
TOPMed
gnomAD
rs1377847746
CA367588015
108 P>R No ClinGen
TOPMed
gnomAD
rs775723451
CA4267971
109 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA4267972
rs760829891
110 I>V No ClinGen
ExAC
TOPMed
gnomAD
rs1239244941
CA367588034
111 K>R No ClinGen
gnomAD
rs1054376898
CA158991540
112 K>N No ClinGen
Ensembl
CA367588041
rs1333118606
112 K>T No ClinGen
TOPMed
gnomAD
rs375877921
CA158991550
114 T>A No ClinGen
ESP
TOPMed
gnomAD
CA367588059
rs1208673057
115 T>K No ClinGen
gnomAD
CA367588056
rs1562750931
115 T>P No ClinGen
Ensembl
CA4267974
rs753939149
117 Q>R No ClinGen
ExAC
gnomAD
CA4267975
rs762034907
118 N>S No ClinGen
ExAC
gnomAD
CA367588096
rs1183652952
120 S>F No ClinGen
gnomAD
CA4267976
rs149921919
121 D>E No ClinGen
ESP
ExAC
gnomAD
rs1418723104
CA367588108
122 E>G No ClinGen
gnomAD
CA367588120
rs1179426171
124 Q>E No ClinGen
gnomAD
rs1584322748
CA367588129
125 T>A No ClinGen
Ensembl
rs750961575
CA158991582
125 T>I No ClinGen
ExAC
TOPMed
gnomAD
CA4267977
rs750961575
125 T>N No ClinGen
ExAC
TOPMed
gnomAD
rs945870187
CA158991605
126 H>R No ClinGen
Ensembl
rs780299966
CA4267979
128 M>K No ClinGen
ExAC
TOPMed
gnomAD
CA367588148
rs1337610800
128 M>V No ClinGen
TOPMed
gnomAD
rs1173604228
CA367588159
129 I>T No ClinGen
gnomAD
CA4267981
rs562676563
134 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ExAC
NCI-TCGA
gnomAD
CA367588207
rs1415373593
136 D>V No ClinGen
TOPMed
CA158991721
rs570429976
137 S>T No ClinGen
TOPMed
gnomAD
CA158991730
rs1052329301
140 Y>* No ClinGen
TOPMed
gnomAD
CA367588246
rs1309467906
140 Y>C No ClinGen
gnomAD
CA367588254
rs1231768960
142 I>L No ClinGen
gnomAD
rs1231768960
CA367588255
142 I>V No ClinGen
gnomAD
CA4267986
rs745806423
147 W>C No ClinGen
ExAC
TOPMed
gnomAD
CA367588313
rs1481038066
147 W>L Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs1219684313
CA367588374
152 H>R No ClinGen
TOPMed
rs771850808
CA4267987
153 P>A No ClinGen
ExAC
gnomAD
CA4267988
rs775179925
157 Q>* No ClinGen
ExAC
gnomAD
rs760559979
CA4267989
159 N>D No ClinGen
ExAC
gnomAD
rs1255734326
CA367588473
160 H>R Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA4267991
rs777052862
161 K>N No ClinGen
ExAC
gnomAD
rs1313549027
CA367588517
163 Y>* No ClinGen
TOPMed
CA158991757
rs368238818
163 Y>D No ClinGen
ESP
rs761981981
CA4267992
166 Q>* No ClinGen
ExAC
TOPMed
gnomAD
CA367588546
rs1435432414
166 Q>P No ClinGen
gnomAD
rs183534059
CA4267994
172 K>R No ClinGen
1000Genomes
ExAC
gnomAD
rs763396649
CA4267995
174 I>M No ClinGen
ExAC
CA158991778
rs1055958953
179 S>R No ClinGen
Ensembl
CA367588726
rs887440205
182 C>S No ClinGen
TOPMed
gnomAD
CA158991780
rs887440205
182 C>Y No ClinGen
TOPMed
gnomAD
CA367588756
rs1406476333
184 K>R No ClinGen
Ensembl
CA367588788
rs1401998751
187 E>K No ClinGen
gnomAD
CA4267997
rs751844950
188 N>T No ClinGen
ExAC
TOPMed
gnomAD
CA4267999
rs755391264
189 C>Y No ClinGen
ExAC
TOPMed
gnomAD
CA158991862
rs1017175296
190 N>D No ClinGen
Ensembl
rs1456071483
CA367588862
193 S>* No ClinGen
TOPMed
rs897372768
CA158991894
196 M>T No ClinGen
Ensembl
CA4268002
rs756697551
196 M>V No ClinGen
ExAC
TOPMed
gnomAD
CA4268003
rs145100047
199 R>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1170281179
CA367588937
200 I>T No ClinGen
Ensembl
rs758237371
CA4268005
201 P>L No ClinGen
ExAC
gnomAD
CA4268004
rs745778390
201 P>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA4268006
rs372904225
202 S>F No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA158991958
rs753505389
205 I>M No ClinGen
Ensembl
CA367589003
rs1247672208
206 P>L No ClinGen
gnomAD
rs1190455418
CA367588997
206 P>T No ClinGen
TOPMed
CA367589019
rs1185317952
209 S>P No ClinGen
gnomAD
rs374477942
CA4268008
210 D>E No ClinGen
ESP
ExAC
gnomAD
rs776929989
CA4268009
211 T>R No ClinGen
ExAC
gnomAD
rs748398362
CA4268010
212 Q>R No ClinGen
ExAC
gnomAD
CA367589072
rs1252152452
214 N>S No ClinGen
TOPMed
rs769949326
CA4268011
216 I>M No ClinGen
ExAC
TOPMed
gnomAD
rs367771464
CA4268013
217 K>N No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA4268012
rs773199985
217 K>R No ClinGen
ExAC
TOPMed
gnomAD
CA4268014
rs766742541
220 S>A No ClinGen
ExAC
gnomAD
CA4268015
rs774929904
221 D>E No ClinGen
ExAC
gnomAD
CA367589130
rs1339739811
222 L>F No ClinGen
gnomAD
CA918010760
rs1584323010
224 Y>* No ClinGen
Ensembl
CA918010761
rs1584323021
225 Y>* No ClinGen
Ensembl
CA4268017
rs759891515
225 Y>C No ClinGen
ExAC
TOPMed
gnomAD
CA4268016
rs759891515
225 Y>S No ClinGen
ExAC
TOPMed
gnomAD
rs753467974
CA4268018
226 Q>L No ClinGen
ExAC
rs1332695027
CA367589162
227 G>A No ClinGen
TOPMed
gnomAD
CA367589161
rs1332695027
227 G>E No ClinGen
TOPMed
gnomAD
rs756944263
CA4268019
227 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA367589186
rs1369242991
231 R>G No ClinGen
TOPMed
CA367589221
rs1290812227
234 P>L No ClinGen
TOPMed
gnomAD
rs764973452
CA4268020
235 Y>F No ClinGen
ExAC
gnomAD
CA4268022
rs749852712
238 S>N No ClinGen
ExAC
TOPMed
gnomAD
rs925708398
CA158992071
241 G>R No ClinGen
TOPMed
rs757937472
CA4268023
243 I>M No ClinGen
ExAC
gnomAD
CA158992085
rs985534366
245 N>D Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
CA367589334
rs985534366
245 N>H No ClinGen
Ensembl
CA367589339
rs1264729957
245 N>S No ClinGen
gnomAD
rs779787092
CA4268024
247 H>Y No ClinGen
ExAC
gnomAD
CA4268026
rs747008215
249 L>I No ClinGen
ExAC
gnomAD
rs1156660469
CA367589392
252 D>Y No ClinGen
gnomAD
rs781178907
CA4268028
253 H>N No ClinGen
ExAC
TOPMed
gnomAD
rs748345361
CA4268029
254 I>F No ClinGen
ExAC
gnomAD
CA4268030
rs769863906
255 H>R No ClinGen
ExAC
TOPMed
gnomAD
rs376165329
CA4268031
257 A>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA4268032
rs200233081
257 A>V No ClinGen
1000Genomes
ExAC
gnomAD
CA158992156
rs369354789
259 K>E No ClinGen
ESP
rs771111043
CA4268033
259 K>N No ClinGen
ExAC
gnomAD
CA158992170
rs1018815326
260 P>R No ClinGen
Ensembl
CA367589464
rs1294305235
263 C>R No ClinGen
gnomAD
CA158992187
rs957376011
266 A>G No ClinGen
Ensembl
rs1173690358
CA367589494
267 F>S No ClinGen
TOPMed
CA367589506
rs1298764284
269 H>N No ClinGen
Ensembl
rs74339852
CA158992209
270 T>S No ClinGen
Ensembl
rs1219469556
CA367589535
273 L>R No ClinGen
gnomAD
rs772395125
CA4268036
274 S>G No ClinGen
ExAC
gnomAD
CA367589537
rs772395125
274 S>R No ClinGen
ExAC
gnomAD
CA158992227
rs749972423
276 P>T No ClinGen
Ensembl
rs761050126
CA4268038
278 M>I No ClinGen
ExAC
gnomAD
CA158992228
rs990584266
278 M>V No ClinGen
TOPMed
rs750093412
CA4268040
282 G>V No ClinGen
ExAC
gnomAD
CA367589602
rs1213318331
283 E>D No ClinGen
gnomAD
CA4268042
rs765969592
286 Y>C No ClinGen
ExAC
TOPMed
gnomAD
rs1482093660
CA367589618
286 Y>N No ClinGen
TOPMed
CA4268044
rs755002111
287 K>N No ClinGen
ExAC
TOPMed
gnomAD
rs369425005
CA4268043
287 K>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA4268045
rs141065239
289 D>N No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA367589658
rs1308744788
291 C>G No ClinGen
gnomAD
CA367589664
rs1378157725
292 G>R No ClinGen
gnomAD
CA4268046
rs752486891
295 F>L No ClinGen
ExAC
gnomAD
CA367589711
rs1344918605
298 R>K No ClinGen
gnomAD
rs1278728779
CA367589723
300 H>D No ClinGen
gnomAD
rs1443593552
CA367589734
301 L>P No ClinGen
gnomAD
CA367589755
rs1237158560
304 H>P No ClinGen
gnomAD
CA367589756
rs1237158560
304 H>R Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs770895448
CA4268051
313 P>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs376852309
CA4268053
314 F>L No ClinGen
ESP
ExAC
rs1173033295
CA367589879
315 I>M No ClinGen
TOPMed
gnomAD
CA367589881
rs113084597
316 C>G No ClinGen
gnomAD
CA158992370
rs113084597
316 C>R No ClinGen
gnomAD
CA367589895
rs1464099253
317 N>D No ClinGen
gnomAD
rs1485482174
CA367589900
317 N>S No ClinGen
TOPMed
gnomAD
CA4268054
rs144627071
318 G>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs775988925
CA4268055
321 K>N No ClinGen
ExAC
gnomAD
rs1449553026
CA367589955
322 A>G No ClinGen
gnomAD
CA367589948
rs1259364397
322 A>T No ClinGen
TOPMed
gnomAD
CA4268056
rs760880940
323 F>L No ClinGen
ExAC
gnomAD
CA4268057
rs769129256
324 R>C No ClinGen
ExAC
TOPMed
gnomAD
rs772724043
CA4268058
324 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA367590001
rs1277079843
327 S>T No ClinGen
gnomAD
CA367590020
rs1216229750
328 S>F No ClinGen
gnomAD
rs765771537
CA4268060
332 H>Y No ClinGen
ExAC
gnomAD
CA367590084
rs1318160040
334 R>S No ClinGen
gnomAD
CA158992454
rs981324505
337 T>A No ClinGen
Ensembl
rs1200067795
CA367590116
339 E>A No ClinGen
gnomAD
rs1450779208
CA367590137
342 Y>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA367590146
rs1562751369
343 K>I No ClinGen
Ensembl
CA4268061
rs140303965
344 C>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs370707503
CA4268062
345 N>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs767499071
CA367590170
346 Q>H No ClinGen
ExAC
gnomAD
CA4268065
rs752752393
348 G>D No ClinGen
ExAC
TOPMed
gnomAD
CA367590209
rs1467391281
352 S>N No ClinGen
gnomAD
rs369172980
CA158992496
352 S>R No ClinGen
ESP
gnomAD
rs755851627
CA4268066
353 R>C No ClinGen
ExAC
TOPMed
gnomAD
rs143509812
CA4268067
353 R>H No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs372697698
CA4268068
356 S>C No ClinGen
ESP
ExAC
gnomAD
CA4268069
rs757462408
358 T>S No ClinGen
ExAC
TOPMed
gnomAD
CA367590258
rs1277029915
360 H>R No ClinGen
gnomAD
CA367590255
rs1397670794
360 H>Y No ClinGen
gnomAD
rs188617751
CA4268070
361 H>R No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA367590275
rs1260517038
362 R>G No ClinGen
TOPMed
CA4268071
rs199576461
362 R>K No ClinGen
ExAC
TOPMed
gnomAD
CA158992523
rs887553903
364 H>R No ClinGen
Ensembl
CA4268072
rs772143846
364 H>Y No ClinGen
ExAC
TOPMed
gnomAD
CA4268074
rs147999186
366 G>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1036416205
CA158992538
367 E>D No ClinGen
Ensembl
rs777090222
CA4268076
370 Y>D No ClinGen
ExAC
gnomAD
CA367590370
rs770655285
371 E>* No ClinGen
ExAC
TOPMed
gnomAD
CA4268078
rs770655285
371 E>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA367590384
rs1185738884
372 C>Y Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA367590398
rs1451445475
373 G>V No ClinGen
Ensembl
rs774155797
CA4268079
375 C>R No ClinGen
ExAC
gnomAD
rs1562751448
CA367590415
375 C>Y No ClinGen
Ensembl
rs1458789541
CA367590438
377 K>R No ClinGen
gnomAD
rs377662093
CA4268082
379 F>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA367590466
rs1455508966
380 S>G No ClinGen
TOPMed
CA367590477
rs1358953598
381 Q>* No ClinGen
gnomAD
CA367590500
rs1160207560
383 T>A No ClinGen
TOPMed
CA158992616
rs891297648
388 H>R No ClinGen
TOPMed
rs1366799492
CA367590726
388 H>Y No ClinGen
TOPMed
rs1383388043
CA367590743
390 R>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA158992630
rs866194778
391 T>I No ClinGen
Ensembl
rs375537772
CA4268087
393 T>A No ClinGen
ESP
ExAC
TOPMed
rs1339500824
CA367590762
393 T>I No ClinGen
gnomAD
rs373824271
CA4268088
395 E>K No ClinGen
ESP
ExAC
gnomAD
rs1235295418
CA367590790
397 P>L Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs750708806
CA4268090
398 Y>N No ClinGen
ExAC
gnomAD
rs1281050901
CA367590806
400 C>S No ClinGen
gnomAD
CA158992677
rs866965340
401 N>D No ClinGen
Ensembl
CA158992717
rs867529935
402 E>* No ClinGen
gnomAD
CA367590821
rs867529935
402 E>K No ClinGen
gnomAD
rs990267596
CA158992723
403 C>F No ClinGen
Ensembl
CA4268094
rs755468744
404 G>R Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA158992731
rs975078985
405 K>T No ClinGen
TOPMed
CA4268095
rs202206479
406 A>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA367590856
rs1432565511
407 F>S No ClinGen
TOPMed
CA367590863
rs1378880897
408 S>N No ClinGen
TOPMed
gnomAD
CA4268097
rs770352981
411 A>T No ClinGen
ExAC
gnomAD
CA367590895
rs1362986227
412 H>Q No ClinGen
gnomAD
CA158992770
rs770026109
412 H>Y No ClinGen
Ensembl
rs1405013743
CA367590906
414 N>S No ClinGen
TOPMed
CA367590915
rs1300570908
415 Q>L No ClinGen
gnomAD
CA367590921
rs1393950214
416 H>R No ClinGen
TOPMed
gnomAD
rs774137256
CA4268099
416 H>Y No ClinGen
ExAC
gnomAD
rs745568229
CA4268100
417 R>G No ClinGen
ExAC
gnomAD
rs775026297
CA4268102
420 H>R No ClinGen
ExAC
TOPMed
CA367590953
rs1390087084
421 T>S No ClinGen
TOPMed
rs201422199
CA4268104
422 R>Q No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA4268103
rs147465819
422 R>W No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs776437026
CA4268105
423 E>G No ClinGen
ExAC
gnomAD
CA4268106
rs761591727
424 K>T No ClinGen
ExAC
gnomAD
rs1255505939
CA367590987
426 C>F No ClinGen
TOPMed
gnomAD
CA4268107
rs765074148
426 C>R No ClinGen
ExAC
gnomAD
rs1255505939
CA367590986
426 C>S No ClinGen
TOPMed
gnomAD
CA367591036
rs1450661539
432 Q>H No ClinGen
TOPMed
rs750619411
CA4268108
434 V>I No ClinGen
ExAC
CA4268109
rs367652775
435 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs371670199
CA4268110
435 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA4268111
rs751605206
437 S>G No ClinGen
ExAC
gnomAD
rs755022160
CA4268112
437 S>R No ClinGen
ExAC
gnomAD
rs781721850
CA4268113
440 F>L No ClinGen
ExAC
gnomAD
rs1359556186
CA367591089
441 S>N No ClinGen
TOPMed
CA367591099
rs1273746216
442 S>N No ClinGen
TOPMed
CA4268114
rs748665560
443 T>A No ClinGen
ExAC
gnomAD
rs756526590
CA4268115
443 T>R No ClinGen
ExAC
gnomAD

1 associated diseases with Q8N859

Without disease ID

3 regional properties for Q8N859

Type Name Position InterPro Accession
domain Protein kinase domain 45 - 306 IPR000719
active_site Serine/threonine-protein kinase, active site 164 - 176 IPR008271
binding_site Protein kinase, ATP binding site 52 - 75 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

1 GO annotations of biological process

Name Definition
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

177 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08DS3 OSR1 Protein odd-skipped-related 1 Bos taurus (Bovine) PR
Q2VWH6 FEZF2 Fez family zinc finger protein 2 Bos taurus (Bovine) PR
A6QNZ0 ZSCAN26 Zinc finger and SCAN domain-containing protein 26 Bos taurus (Bovine) PR
A7MBI1 ZFP69 Zinc finger protein 69 homolog Bos taurus (Bovine) PR
Q08705 CTCF Transcriptional repressor CTCF Gallus gallus (Chicken) PR
O42409 GFI1B Zinc finger protein Gfi-1b Gallus gallus (Chicken) PR
A2T6W2 ZNF449 Zinc finger protein 449 Pan troglodytes (Chimpanzee) PR
Q9U405 grau Transcription factor grauzone Drosophila melanogaster (Fruit fly) PR
Q7K0S9 sug Zinc finger protein GLIS2 homolog Drosophila melanogaster (Fruit fly) PR
P20385 Cf2 Chorion transcription factor Cf2 Drosophila melanogaster (Fruit fly) PR
Q86P48 ATbp AT-rich binding protein Drosophila melanogaster (Fruit fly) PR
Q9NTW7 ZFP64 Zinc finger protein 64 Homo sapiens (Human) PR
O14978 ZNF263 Zinc finger protein 263 Homo sapiens (Human) PR
O60304 ZNF500 Zinc finger protein 500 Homo sapiens (Human) PR
P08151 GLI1 Zinc finger protein GLI1 Homo sapiens (Human) PR
Q9UFB7 ZBTB47 Zinc finger and BTB domain-containing protein 47 Homo sapiens (Human) PR
P18146 EGR1 Early growth response protein 1 Homo sapiens (Human) PR
Q9Y5W3 KLF2 Krueppel-like factor 2 Homo sapiens (Human) PR
Q9UNY5 ZNF232 Zinc finger protein 232 Homo sapiens (Human) PR
Q96SZ4 ZSCAN10 Zinc finger and SCAN domain-containing protein 10 Homo sapiens (Human) PR
P17028 ZNF24 Zinc finger protein 24 Homo sapiens (Human) PR
P57682 KLF3 Krueppel-like factor 3 Homo sapiens (Human) PR
P25490 YY1 Transcriptional repressor protein YY1 Homo sapiens (Human) SS
O43296 ZNF264 Zinc finger protein 264 Homo sapiens (Human) PR
P49711 CTCF Transcriptional repressor CTCF Homo sapiens (Human) PR
Q9NQX1 PRDM5 PR domain zinc finger protein 5 Homo sapiens (Human) PR
Q9HBE1 PATZ1 POZ-, AT hook-, and zinc finger-containing protein 1 Homo sapiens (Human) PR
Q8TAX0 OSR1 Protein odd-skipped-related 1 Homo sapiens (Human) PR
Q9UL58 ZNF215 Zinc finger protein 215 Homo sapiens (Human) PR
Q8TBJ5 FEZF2 Fez family zinc finger protein 2 Homo sapiens (Human) PR
Q96SR6 ZNF382 Zinc finger protein 382 Homo sapiens (Human) PR
Q96IT1 ZNF496 Zinc finger protein 496 Homo sapiens (Human) PR
Q96N95 ZNF396 Zinc finger protein 396 Homo sapiens (Human) PR
Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 Homo sapiens (Human) PR
O75840 KLF7 Krueppel-like factor 7 Homo sapiens (Human) PR
Q9H9D4 ZNF408 Zinc finger protein 408 Homo sapiens (Human) PR
Q13127 REST RE1-silencing transcription factor Homo sapiens (Human) PR
Q8IZM8 ZNF654 Zinc finger protein 654 Homo sapiens (Human) PR
Q14526 HIC1 Hypermethylated in cancer 1 protein Homo sapiens (Human) PR
P17022 ZNF18 Zinc finger protein 18 Homo sapiens (Human) PR
Q86XF7 ZNF575 Zinc finger protein 575 Homo sapiens (Human) PR
Q06889 EGR3 Early growth response protein 3 Homo sapiens (Human) PR
Q8NAM6 ZSCAN4 Zinc finger and SCAN domain-containing protein 4 Homo sapiens (Human) PR
Q08ER8 ZNF543 Zinc finger protein 543 Homo sapiens (Human) PR
P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 Homo sapiens (Human) PR
Q8N680 ZBTB2 Zinc finger and BTB domain-containing protein 2 Homo sapiens (Human) PR
Q9NPC7 MYNN Myoneurin Homo sapiens (Human) PR
Q96BV0 ZNF775 Zinc finger protein 775 Homo sapiens (Human) PR
Q8NF99 ZNF397 Zinc finger protein 397 Homo sapiens (Human) PR
Q63HK3 ZKSCAN2 Zinc finger protein with KRAB and SCAN domains 2 Homo sapiens (Human) PR
Q5FWF6 ZNF789 Zinc finger protein 789 Homo sapiens (Human) PR
Q15776 ZKSCAN8 Zinc finger protein with KRAB and SCAN domains 8 Homo sapiens (Human) PR
Q53GI3 ZNF394 Zinc finger protein 394 Homo sapiens (Human) PR
O95125 ZNF202 Zinc finger protein 202 Homo sapiens (Human) PR
Q05516 ZBTB16 Zinc finger and BTB domain-containing protein 16 Homo sapiens (Human) PR
Q8N0Y2 ZNF444 Zinc finger protein 444 Homo sapiens (Human) PR
Q6P9G9 ZNF449 Zinc finger protein 449 Homo sapiens (Human) PR
Q5VTD9 GFI1B Zinc finger protein Gfi-1b Homo sapiens (Human) PR
Q6PG37 ZNF790 Zinc finger protein 790 Homo sapiens (Human) PR
Q9NQV6 PRDM10 PR domain zinc finger protein 10 Homo sapiens (Human) PR
Q9Y2D9 ZNF652 Zinc finger protein 652 Homo sapiens (Human) PR
Q5TC79 ZBTB37 Zinc finger and BTB domain-containing protein 37 Homo sapiens (Human) PR
Q9Y4E5 ZNF451 E3 SUMO-protein ligase ZNF451 Homo sapiens (Human) PR
Q8ND82 ZNF280C Zinc finger protein 280C Homo sapiens (Human) PR
Q49AA0 ZFP69 Zinc finger protein 69 homolog Homo sapiens (Human) PR
O43298 ZBTB43 Zinc finger and BTB domain-containing protein 43 Homo sapiens (Human) PR
Q9Y330 ZBTB12 Zinc finger and BTB domain-containing protein 12 Homo sapiens (Human) PR
Q13105 ZBTB17 Zinc finger and BTB domain-containing protein 17 Homo sapiens (Human) PR
P51508 ZNF81 Zinc finger protein 81 Homo sapiens (Human) PR
Q5JNZ3 ZNF311 Zinc finger protein 311 Homo sapiens (Human) PR
Q9BRR0 ZKSCAN3 Zinc finger protein with KRAB and SCAN domains 3 Homo sapiens (Human) PR
Q969J2 ZKSCAN4 Zinc finger protein with KRAB and SCAN domains 4 Homo sapiens (Human) PR
P49910 ZNF165 Zinc finger protein 165 Homo sapiens (Human) PR
Q9Y4X4 KLF12 Krueppel-like factor 12 Homo sapiens (Human) PR
P10074 ZBTB48 Telomere zinc finger-associated protein Homo sapiens (Human) PR
P17010 ZFX Zinc finger X-chromosomal protein Homo sapiens (Human) PR
Q9H5H4 ZNF768 Zinc finger protein 768 Homo sapiens (Human) PR
Q6NSZ9 ZSCAN25 Zinc finger and SCAN domain-containing protein 25 Homo sapiens (Human) PR
Q9Y2L8 ZKSCAN5 Zinc finger protein with KRAB and SCAN domains 5 Homo sapiens (Human) PR
Q86UZ6 ZBTB46 Zinc finger and BTB domain-containing protein 46 Homo sapiens (Human) PR
Q9NX65 ZSCAN32 Zinc finger and SCAN domain-containing protein 32 Homo sapiens (Human) PR
O14771 ZNF213 Zinc finger protein 213 Homo sapiens (Human) PR
Q8IWY8 ZSCAN29 Zinc finger and SCAN domain-containing protein 29 Homo sapiens (Human) PR
Q8NCP5 ZBTB44 Zinc finger and BTB domain-containing protein 44 Homo sapiens (Human) PR
P41182 BCL6 B-cell lymphoma 6 protein Homo sapiens (Human) PR
Q9NQX0 PRDM6 Putative histone-lysine N-methyltransferase PRDM6 Homo sapiens (Human) PR
Q9BU19 ZNF692 Zinc finger protein 692 Homo sapiens (Human) PR
Q08AG5 ZNF844 Zinc finger protein 844 Homo sapiens (Human) PR
Q6R2W3 ZBED9 SCAN domain-containing protein 3 Homo sapiens (Human) PR
P98182 ZNF200 Zinc finger protein 200 Homo sapiens (Human) PR
Q9UK11 ZNF223 Zinc finger protein 223 Homo sapiens (Human) PR
O15156 ZBTB7B Zinc finger and BTB domain-containing protein 7B Homo sapiens (Human) PR
Q6ZMS7 ZNF783 Zinc finger protein 783 Homo sapiens (Human) PR
P59923 ZNF445 Zinc finger protein 445 Homo sapiens (Human) PR
Q99612 KLF6 Krueppel-like factor 6 Homo sapiens (Human) PR
Q8TD17 ZNF398 Zinc finger protein 398 Homo sapiens (Human) PR
P52739 ZNF131 Zinc finger protein 131 Homo sapiens (Human) PR
A6NGD5 ZSCAN5C Zinc finger and SCAN domain-containing protein 5C Homo sapiens (Human) PR
Q05215 EGR4 Early growth response protein 4 Homo sapiens (Human) PR
Q7Z398 ZNF550 Zinc finger protein 550 Homo sapiens (Human) PR
Q9Y2K1 ZBTB1 Zinc finger and BTB domain-containing protein 1 Homo sapiens (Human) PR
Q96N20 ZNF75A Zinc finger protein 75A Homo sapiens (Human) PR
A6NJL1 ZSCAN5B Zinc finger and SCAN domain-containing protein 5B Homo sapiens (Human) PR
A1YPR0 ZBTB7C Zinc finger and BTB domain-containing protein 7C Homo sapiens (Human) PR
Q9NWS9 ZNF446 Zinc finger protein 446 Homo sapiens (Human) PR
P24278 ZBTB25 Zinc finger and BTB domain-containing protein 25 Homo sapiens (Human) PR
Q86YH2 ZNF280B Zinc finger protein 280B Homo sapiens (Human) PR
O95625 ZBTB11 Zinc finger and BTB domain-containing protein 11 Homo sapiens (Human) PR
Q9H116 GZF1 GDNF-inducible zinc finger protein 1 Homo sapiens (Human) PR
Q8IW36 ZNF695 Zinc finger protein 695 Homo sapiens (Human) PR
Q96N38 ZNF714 Zinc finger protein 714 Homo sapiens (Human) PR
P28698 MZF1 Myeloid zinc finger 1 Homo sapiens (Human) PR
O08584 Klf6 Krueppel-like factor 6 Mus musculus (Mouse) PR
Q61164 Ctcf Transcriptional repressor CTCF Mus musculus (Mouse) PR
Q810A1 Znf18 Zinc finger protein 18 Mus musculus (Mouse) PR
Q8BGS3 Zkscan1 Zinc finger protein with KRAB and SCAN domains 1 Mus musculus (Mouse) PR
Q00899 Yy1 Transcriptional repressor protein YY1 Mus musculus (Mouse) PR
P41183 Bcl6 B-cell lymphoma 6 protein homolog Mus musculus (Mouse) PR
Q9DAI4 Zbtb43 Zinc finger and BTB domain-containing protein 43 Mus musculus (Mouse) PR
O70237 Gfi1b Zinc finger protein Gfi-1b Mus musculus (Mouse) PR
Q99KZ6 Znf639 Zinc finger protein 639 Mus musculus (Mouse) PR
Q9Z1D9 Znf394 Zinc finger protein 394 Mus musculus (Mouse) PR
Q9CXE0 Prdm5 PR domain zinc finger protein 5 Mus musculus (Mouse) PR
P43300 Egr3 Early growth response protein 3 Mus musculus (Mouse) PR
Q9DAU9 Znf654 Zinc finger protein 654 Mus musculus (Mouse) PR
Q9R1Y5 Hic1 Hypermethylated in cancer 1 protein Mus musculus (Mouse) PR
Q8R0T2 Znf768 Zinc finger protein 768 Mus musculus (Mouse) PR
Q9WVG7 Osr1 Protein odd-skipped-related 1 Mus musculus (Mouse) PR
Q8BI73 Znf775 Zinc finger protein 775 Mus musculus (Mouse) PR
Q8VCZ7 Zbtb7c Zinc finger and BTB domain-containing protein 7C Mus musculus (Mouse) PR
Q91VN1 Znf24 Zinc finger protein 24 Mus musculus (Mouse) PR
Q9DB38 Znf580 Zinc finger protein 580 Mus musculus (Mouse) PR
A7KBS4 Zscan4d Zinc finger and SCAN domain containing protein 4D Mus musculus (Mouse) PR
Q91VW9 Zkscan3 Zinc finger protein with KRAB and SCAN domains 3 Mus musculus (Mouse) PR
P10925 Zfy1 Zinc finger Y-chromosomal protein 1 Mus musculus (Mouse) PR
P08046 Egr1 Early growth response protein 1 Mus musculus (Mouse) PR
Q3TTC2 Yy2 Transcription factor YY2 Mus musculus (Mouse) PR
Q3UTQ7 Prdm10 PR domain zinc finger protein 10 Mus musculus (Mouse) PR
Q6P3Y5 Znf280c Zinc finger protein 280C Mus musculus (Mouse) PR
Q9ERU3 Znf22 Zinc finger protein 22 Mus musculus (Mouse) PR
Q8VIG1 Rest RE1-silencing transcription factor Mus musculus (Mouse) PR
Q9Z1D8 Zkscan5 Zinc finger protein with KRAB and SCAN domains 5 Mus musculus (Mouse) PR
Q8BID6 Zbtb46 Zinc finger and BTB domain-containing protein 46 Mus musculus (Mouse) PR
P17012 Zfx Zinc finger X-chromosomal protein Mus musculus (Mouse) PR
Q9WUK6 Zbtb18 Zinc finger and BTB domain-containing protein 18 Mus musculus (Mouse) PR
O35738 Klf12 Krueppel-like factor 12 Mus musculus (Mouse) PR
B2RXC5 Znf382 Zinc finger protein 382 Mus musculus (Mouse) PR
O08900 Ikzf3 Zinc finger protein Aiolos Mus musculus (Mouse) PR
Q5DU09 Znf652 Zinc finger protein 652 Mus musculus (Mouse) PR
Q5RJ54 Zscan26 Zinc finger and SCAN domain-containing protein 26 Mus musculus (Mouse) PR
Q8BLM0 Klf8 Krueppel-like factor 8 Mus musculus (Mouse) PR
Q99JB0 Klf7 Krueppel-like factor 7 Mus musculus (Mouse) PR
Q8R0A2 Zbtb44 Zinc finger and BTB domain-containing protein 44 Mus musculus (Mouse) PR
P20662 Zfy2 Zinc finger Y-chromosomal protein 2 Mus musculus (Mouse) PR
Q80VJ6 Zscan4c Zinc finger and SCAN domain containing protein 4C Mus musculus (Mouse) PR
Q3URS2 Zscan4f Zinc finger and SCAN domain containing protein 4F Mus musculus (Mouse) PR
Q60980 Klf3 Krueppel-like factor 3 Mus musculus (Mouse) PR
Q8K3J5 Znf131 Zinc finger protein 131 Mus musculus (Mouse) PR
Q9Z2K3 Znf394 Zinc finger protein 394 Rattus norvegicus (Rat) PR
Q642B9 Znf18 Zinc finger protein 18 Rattus norvegicus (Rat) PR
B0K011 Osr1 Protein odd-skipped-related 1 Rattus norvegicus (Rat) PR
D3ZUU2 Gzf1 GDNF-inducible zinc finger protein 1 Rattus norvegicus (Rat) PR
B1WBU4 Zbtb8a Zinc finger and BTB domain-containing protein 8A Rattus norvegicus (Rat) PR
Q7TNK3 Znf24 Zinc finger protein 24 Rattus norvegicus (Rat) PR
O35819 Klf6 Krueppel-like factor 6 Rattus norvegicus (Rat) PR
Q9R1D1 Ctcf Transcriptional repressor CTCF Rattus norvegicus (Rat) PR
P43301 Egr3 Early growth response protein 3 Rattus norvegicus (Rat) PR
P08154 Egr1 Early growth response protein 1 Rattus norvegicus (Rat) PR
A0JPL0 Znf382 Zinc finger protein 382 Rattus norvegicus (Rat) PR
Q4KLI1 Zkscan1 Zinc finger protein with KRAB and SCAN domains 1 Rattus norvegicus (Rat) PR
A1L1J6 Znf652 Zinc finger protein 652 Rattus norvegicus (Rat) PR
Q9SHD0 ZAT4 Zinc finger protein ZAT4 Arabidopsis thaliana (Mouse-ear cress) PR
Q0P4X6 zbtb44 Zinc finger and BTB domain-containing protein 44 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
A4II20 egr1 Early growth response protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6P882 zbtb8a.2 Zinc finger and BTB domain-containing protein 8A.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q567C6 znf367 Zinc finger protein 367 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A7Y7X5 znf711 Zinc finger protein 711 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPSQNAVFSQ EGNMEEEEMN DGSQMVRSQE SLTFQDVAVD FTREEWDQLY PAQKNLYRDV
70 80 90 100 110 120
MLENYRNLVA LGYQLCKPEV IAQLELEEEW VIERDSLLDT HPDGENRPEI KKSTTSQNIS
130 140 150 160 170 180
DENQTHEMIM ERLAGDSFWY SILGGLWDFD YHPEFNQENH KRYLGQVTLT HKKITQERSL
190 200 210 220 230 240
ECNKFAENCN LNSNLMQQRI PSIKIPLNSD TQGNSIKHNS DLIYYQGNYV RETPYEYSEC
250 260 270 280 290 300
GKIFNQHILL TDHIHTAEKP SECGKAFSHT SSLSQPQMLL TGEKPYKCDE CGKRFSQRIH
310 320 330 340 350 360
LIQHQRIHTG EKPFICNGCG KAFRQHSSFT QHLRIHTGEK PYKCNQCGKA FSRITSLTEH
370 380 390 400 410 420
HRLHTGEKPY ECGFCGKAFS QRTHLNQHER THTGEKPYKC NECGKAFSQS AHLNQHRKIH
430 440
TREKLCEYKC EQTVRHSPSF SST