AiPD: Autoinhibited Protein Database

Q8N5V2

Gene name	NGEF
Protein name	Ephexin-1
Names	Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:25791
EC number
Protein Class	GUANINE NUCLEOTIDE EXCHANGE FACTOR (PTHR12845)

Descriptions

Ngef acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases. Ngef has the autoinhibitory helix which can regulate protein by phosphorylation. The substitution of Tyr 179 with Glu (Y179E) within the putative autoinhibitory helix activated Ngef to the same extent as removing this region by truncation, and likely Ngef does.

Autoinhibitory domains (AIDs)

Target domain	273-457 (DH domain)
Relief mechanism	PTM
Assay	Mutagenesis experiment, Deletion assay

AID

175-182 (Autoinhibitory helix)

Target domain

273-457 (DH domain)

Relief mechanism

PTM (Phosphorylation at a Tyr residue in the autoinhibitory helix by Src)

Assay

Mutagenesis experiment, Deletion assay

Accessory elements

No accessory elements

References

Yohe ME et al. (2008) "Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins", Biochemistry, 47, 6827-39

Autoinhibited structure

Activated structure

1 structures for Q8N5V2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8N5V2-F1	Predicted				AlphaFoldDB

492 variants for Q8N5V2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA351032953 rs1170690124	2	E>K		No	ClinGen TOPMed
CA351032942 rs1162061874	3	T>N		No	ClinGen TOPMed
rs1456065658 CA351032945	3	T>S		No	ClinGen TOPMed
CA2171941 rs773248541	5	E>A		No	ClinGen ExAC TOPMed gnomAD
CA2171940 rs772110263	6	S>C		No	ClinGen ExAC gnomAD
CA351032918 rs1452908099	7	E>*		No	ClinGen gnomAD
CA351032920 rs1452908099	7	E>K		No	ClinGen gnomAD
CA2171939 rs761214938	9	L>V		No	ClinGen ExAC gnomAD
rs1442918800 CA351032842	12	T>I		No	ClinGen gnomAD
rs779732421 CA2171935	13	R>G		No	ClinGen ExAC TOPMed gnomAD
rs373205374 CA2171934	13	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2171936 rs779732421	13	R>W		No	ClinGen ExAC TOPMed gnomAD
rs763578007 CA67007786	14	R>K		No	ClinGen Ensembl
rs746298365 CA351032806	14	R>S		No	ClinGen ExAC gnomAD
CA351032796 rs1204936681	15	K>I		No	ClinGen gnomAD
CA2171932 rs781541822	16	S>T		No	ClinGen ExAC gnomAD
CA2171931 rs757800175	17	A>G		No	ClinGen ExAC gnomAD
CA2171930 rs751529938	19	D>H		No	ClinGen ExAC TOPMed gnomAD
CA351032592 rs1227648102	24	D>N		No	ClinGen gnomAD
rs755636632 CA67007778	25	N>K		No	ClinGen Ensembl
rs138859609 CA2171928	27	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138859609 CA2171929	27	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA2171926 rs765593424	30	V>M		No	ClinGen ExAC TOPMed gnomAD
rs750289776 CA2171924	33	E>A		No	ClinGen ExAC gnomAD
CA2171925 rs186848841	33	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1215459751 CA351032427	35	L>F		No	ClinGen TOPMed
rs767299628 CA2171923	35	L>R		No	ClinGen ExAC TOPMed gnomAD
CA351032428 rs1215459751	35	L>V		No	ClinGen TOPMed
CA351032409 rs1559231255	38	K>E		No	ClinGen Ensembl
rs761813173 CA2171922	39	E>G		No	ClinGen ExAC gnomAD
CA2171920 rs773692870	42	S>F		No	ClinGen ExAC TOPMed gnomAD
CA2171919 rs768192879	46	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs752301389 CA2171918	47	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA351032340 rs1186433702	48	I>V		No	ClinGen TOPMed
rs1271651323 CA351032331	49	Q>*		No	ClinGen gnomAD
CA2171916 rs146081416	51	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA2171917 rs775119829	51	K>Q		No	ClinGen ExAC gnomAD
CA351032314 rs1490338275	51	K>R		No	ClinGen gnomAD
rs746177581 CA2171915	52	E>K		No	ClinGen ExAC TOPMed
rs1257482994 CA351032302	53	P>S		No	ClinGen gnomAD
CA2171910 rs778189337	56	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs758519008 CA2171909	57	I>V		No	ClinGen ExAC gnomAD
CA351032260 rs1453683468	59	I>T		No	ClinGen TOPMed
rs748300518 CA2171908	59	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2171907 rs779259452	60	K>N		No	ClinGen ExAC TOPMed gnomAD
rs548138126 CA67007727	60	K>T		No	ClinGen gnomAD
CA351032231 rs1393287603	63	S>C		No	ClinGen gnomAD
rs755263861 CA2171905	63	S>P		No	ClinGen ExAC gnomAD
CA2171904 rs750118286	64	I>V		No	ClinGen ExAC gnomAD
CA67007716 rs939069496	65	F>S		No	ClinGen TOPMed gnomAD
rs143190519 COSM1017939 CA2171903 COSM1591949	67	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs776864089 CA2171902	67	R>H		No	ClinGen ExAC TOPMed gnomAD
rs776864089 CA351032207	67	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1480362239 CA351032202	68	S>F		No	ClinGen gnomAD
CA2171901 rs751486122	69	I>K		No	ClinGen ExAC
rs764087400 CA351032190	70	R>I		No	ClinGen ExAC TOPMed gnomAD
rs764087400 CA2171900	70	R>K		No	ClinGen ExAC TOPMed gnomAD
rs762438390 COSM218714 CA2171899	71	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs764807480 CA2171897	71	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2171898 rs764807480	71	R>P		No	ClinGen ExAC TOPMed gnomAD
CA351032173 rs1247943513	73	S>N		No	ClinGen TOPMed gnomAD
CA351032160 rs1329515143	75	A>T		No	ClinGen gnomAD
CA2171894 rs776814565	77	A>S		No	ClinGen ExAC gnomAD
CA2171893 VAR_027289 rs2271703	78	R>G		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA351032125 rs1475901682	80	N>Y		No	ClinGen TOPMed
CA67007685 rs964666428	81	P>T		No	ClinGen Ensembl
rs142598950 CA2171890	82	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1017935 COSM1591951 rs142598950 CA2171889	82	E>K	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs182107541 CA67007670	83	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171887 rs755210359	83	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs182107541 CA2171888	83	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171886 rs749545128	84	N>D		No	ClinGen ExAC gnomAD
rs757072044 CA2171884	85	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1376217871 CA351032095	85	A>V		No	ClinGen TOPMed
CA351027644 rs1399407605	90	D>E		No	ClinGen gnomAD
rs780310950 CA2171868	95	G>R		No	ClinGen ExAC gnomAD
CA351027582 rs1386679844	96	K>R		No	ClinGen gnomAD
CA2171867 rs769923544	97	S>F		No	ClinGen ExAC gnomAD
CA2171864 rs758285407	100	E>D		No	ClinGen ExAC TOPMed gnomAD
rs746751631 CA2171866	100	E>K		No	ClinGen ExAC TOPMed gnomAD
CA2171863 rs752611094	102	L>R		No	ClinGen ExAC gnomAD
CA351027514 rs1261888291	103	T>A		No	ClinGen TOPMed
rs753343643 CA2171861	103	T>I		No	ClinGen ExAC TOPMed gnomAD
rs753343643 CA351027510	103	T>N		No	ClinGen ExAC TOPMed gnomAD
rs753343643 CA2171860	103	T>S		No	ClinGen ExAC TOPMed gnomAD
rs368019241 CA2171859	105	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1286616231 CA351027463	106	I>N		No	ClinGen TOPMed
CA351027465 rs1286616231	106	I>T		No	ClinGen TOPMed
CA351027459 rs1236437139	107	P>A		No	ClinGen TOPMed
rs750775762 CA2171857	108	W>R		No	ClinGen ExAC gnomAD
CA67041470 rs1047040561	109	S>G		No	ClinGen Ensembl
CA2171855 rs762315072	109	S>I		No	ClinGen ExAC gnomAD
CA2171856 rs762315072	109	S>T		No	ClinGen ExAC gnomAD
CA351027411 rs1574644961	110	R>*		No	ClinGen Ensembl
rs1159906056 CA351027405	110	R>K		No	ClinGen TOPMed
rs769102964 CA2171853	111	M>I		No	ClinGen ExAC gnomAD
CA351027390 rs769102964	111	M>I		No	ClinGen ExAC gnomAD
rs4973588 CA351027393	111	M>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs4973588 VAR_027290 CA2171854	111	M>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1304335738 CA351027385	112	P>S		No	ClinGen TOPMed gnomAD
rs763031621 CA2171852	113	P>S		No	ClinGen ExAC gnomAD
CA351027342 rs1366846850	114	C>Y		No	ClinGen gnomAD
rs770021521 CA2171850	118	M>I		No	ClinGen ExAC gnomAD
rs1209817127 CA351027288	118	M>V		No	ClinGen gnomAD
COSM1406325 rs746103889 CA2171849 COSM1406324	120	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA351027237 rs1454253541	120	T>R		No	ClinGen TOPMed
rs1028768585 CA67041431	121	D>E		No	ClinGen gnomAD
CA2171848 rs781445066	121	D>V		No	ClinGen ExAC gnomAD
CA2171846 rs771826989	124	A>T		No	ClinGen ExAC gnomAD
CA351027163 rs1490826296	124	A>V		No	ClinGen gnomAD
rs1328957939 CA351027138	126	E>K		No	ClinGen TOPMed
CA2171844 rs748000783	127	M>T		No	ClinGen ExAC gnomAD
rs778806085 CA2171843	128	S>N		No	ClinGen ExAC gnomAD
rs371268725 CA67007781	131	S>P		No	ClinGen ESP
CA2171809 rs766517369	132	S>F		No	ClinGen ExAC gnomAD
CA2171807 rs368810687	133	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2171808 rs760915088	133	T>S		No	ClinGen ExAC gnomAD
rs1456521794 CA351019117	134	P>L		No	ClinGen TOPMed gnomAD
CA351019121 rs1456521794	134	P>Q		No	ClinGen TOPMed gnomAD
rs1437465485 CA351019075	137	G>R		No	ClinGen TOPMed
CA351019061 rs1313029436	138	A>T		No	ClinGen TOPMed
CA2171806 rs145839519	139	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1430711931 CA351019035	140	P>S		No	ClinGen gnomAD
rs199654749 CA2171803	141	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171801 rs780880266	144	P>R		No	ClinGen ExAC TOPMed gnomAD
CA67007752 rs200175226	145	A>T		No	ClinGen 1000Genomes
rs78057440 CA67007749	146	L>P		No	ClinGen Ensembl
rs1227862392 CA351018939	148	D>N		No	ClinGen gnomAD
CA351018927 rs1319784299	149	S>N		No	ClinGen gnomAD
rs1276107251 CA351018922	150	P>T		No	ClinGen gnomAD
rs1015192346 CA67007748	151	T>A		No	ClinGen Ensembl
rs765603135 CA2171795	152	T>M		No	ClinGen ExAC TOPMed gnomAD
CA351018891 rs765603135	152	T>R		No	ClinGen ExAC TOPMed gnomAD
rs753870377 CA351018887	153	L>F		No	ClinGen ExAC TOPMed gnomAD
CA2171793 rs753870377	153	L>V		No	ClinGen ExAC TOPMed gnomAD
rs549019621 CA351018866	155	E>K		No	ClinGen gnomAD
CA67007731 rs549019621	155	E>Q		No	ClinGen gnomAD
rs552768986 CA351018845	156	A>D		No	ClinGen 1000Genomes ExAC gnomAD
rs552768986 CA2171792	156	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA351018852 rs1390258346	156	A>T		No	ClinGen gnomAD
rs1242058773 CA351018828	158	R>Q		No	ClinGen TOPMed
CA67007704 rs200707014	160	I>M		No	ClinGen Ensembl
rs1575020999 CA351018783	161	H>P		No	ClinGen Ensembl
CA2171790 rs750577852	161	H>Q		No	ClinGen ExAC gnomAD
rs1170423262 CA351018773	162	P>S		No	ClinGen gnomAD
rs1481013943 CA351018747	164	P>A		No	ClinGen gnomAD
CA2171789 rs767845515	166	D>N		No	ClinGen ExAC gnomAD
rs1449426109 CA351018707	167	S>C		No	ClinGen gnomAD
CA2171787 rs775361804	172	I>L		No	ClinGen ExAC gnomAD
CA2171788 rs775361804	172	I>V		No	ClinGen ExAC gnomAD
rs1195980824 CA351018637	175	I>T		No	ClinGen gnomAD
rs1039461116 CA67004871	180	Q>*		No	ClinGen TOPMed
CA2171772 rs756180289	183	R>Q		No	ClinGen ExAC gnomAD
CA2171770 rs767569783	186	S>L		No	ClinGen ExAC gnomAD
rs553681634 CA67004859	187	T>A		No	ClinGen Ensembl
rs1043271689 CA67004851	188	L>F		No	ClinGen TOPMed gnomAD
CA67004845 rs543404306	191	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2171767 rs543404306	191	I>V		No	ClinGen 1000Genomes ExAC gnomAD
COSM1406320 CA2171765 rs143001761 COSM1406321	192	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1344312878 CA351018011	193	T>S		No	ClinGen TOPMed gnomAD
rs146798173 CA2171764	197	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1158710674 CA351017973	199	A>S		No	ClinGen gnomAD
rs1158710674 CA351017971	199	A>T		No	ClinGen gnomAD
rs1421039937 CA351017961	200	E>D		No	ClinGen TOPMed gnomAD
CA67004827 rs868438355	202	E>A		No	ClinGen TOPMed gnomAD
rs868438355 CA67004823	202	E>G		No	ClinGen TOPMed gnomAD
CA351017920 rs1444885497	206	N>S		No	ClinGen TOPMed gnomAD
CA2171763 rs760042186	207	G>R		No	ClinGen ExAC TOPMed gnomAD
rs559278273 CA2171761	208	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747854821 CA2171760	209	P>L		No	ClinGen ExAC TOPMed gnomAD
rs778585097 CA2171759	210	A>D		No	ClinGen ExAC gnomAD
CA351017889 rs1355483444	211	S>N		No	ClinGen TOPMed
rs374484969 CA2171756	215	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374484969 CA2171757	215	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1327509325 CA351017830	216	E>G		No	ClinGen gnomAD
rs781354827 CA2171753	216	E>K		No	ClinGen ExAC TOPMed gnomAD
CA2171752 rs372485111	217	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1213933808 CA351017821	217	E>Q		No	ClinGen TOPMed
CA351017796 rs1418441261	219	E>K		No	ClinGen gnomAD
CA351017349 rs1358015158	222	E>*		No	ClinGen TOPMed gnomAD
CA351017348 rs1358015158	222	E>K		No	ClinGen TOPMed gnomAD
CA2171748 rs754810990	223	E>D		No	ClinGen ExAC gnomAD
CA351017316 rs1201042858	224	E>D		No	ClinGen TOPMed
CA351017313 rs1415592015	225	E>K		No	ClinGen gnomAD
CA351017296 rs1472374745	226	E>K		No	ClinGen TOPMed gnomAD
rs1412042828 CA351017283	227	P>A		No	ClinGen TOPMed
CA2171745 rs140010312	227	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2171743 rs760688982	231	P>L		No	ClinGen ExAC gnomAD
rs1487281619 CA351017239	231	P>S		No	ClinGen gnomAD
CA2171742 rs772546094	232	E>K		No	ClinGen ExAC gnomAD
CA351017195 rs1575017023	234	K>N		No	ClinGen Ensembl
rs1288051471 CA351017163	237	P>S		No	ClinGen gnomAD
rs761267991 CA2171741	238	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA2171740 rs761267991	238	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1363964261 CA351017110	240	C>F		No	ClinGen TOPMed
rs1398627911 CA351017089	242	L>F		No	ClinGen gnomAD
CA351017081 rs1340451434	242	L>P		No	ClinGen gnomAD
CA2171737 rs749595725	243	S>G		No	ClinGen ExAC TOPMed
CA351017043 rs1297032315	245	P>R		No	ClinGen gnomAD
CA351017036 rs1436649906	246	H>D		No	ClinGen TOPMed gnomAD
CA351017039 rs1436649906	246	H>N		No	ClinGen TOPMed gnomAD
CA351017035 rs1436649906	246	H>Y		No	ClinGen TOPMed gnomAD
rs139590629 CA2171736	248	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA351016970 rs1404432583	250	N>H		No	ClinGen gnomAD
rs770151518 CA2171735	256	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1476763046 CA351016851	257	E>K		No	ClinGen gnomAD
CA2171732 COSM1153757 COSM39636 rs757356334	259	R>Q	large_intestine central_nervous_system endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM1017924 rs781590948 CA2171733 COSM1153758	259	R>W	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1425375804 CA351016806	260	S>N		No	ClinGen gnomAD
CA2171731 rs747145607	260	S>R		No	ClinGen ExAC gnomAD
rs1476670443 CA351016793	261	S>N		No	ClinGen TOPMed
CA2171729 rs758702126	262	G>R		No	ClinGen ExAC TOPMed gnomAD
CA351016774 rs1575016930	263	V>G		No	ClinGen Ensembl
CA351016778 rs1260315521	263	V>M		No	ClinGen gnomAD
CA351016737 rs1165744600	266	I>N		No	ClinGen TOPMed
CA2171726 rs375169428	268	Q>E		No	ClinGen ESP ExAC gnomAD
rs767420117 CA2171724	270	E>K		No	ClinGen ExAC TOPMed gnomAD
rs773863661 CA2171722	272	I>T		No	ClinGen ExAC gnomAD
CA351016569 rs1399414798	276	E>K		No	ClinGen gnomAD
CA351016566 rs1399414798	276	E>Q		No	ClinGen gnomAD
rs1435643146 CA351032027	281	L>V		No	ClinGen TOPMed
CA2171640 rs779792421	282	V>F		No	ClinGen ExAC gnomAD
CA351032001 rs1195912218	284	S>F		No	ClinGen gnomAD
CA2171638 rs750775779	286	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2171636 rs757681473	288	Y>C		No	ClinGen ExAC gnomAD
rs764721677 CA2171634	290	K>R		No	ClinGen ExAC gnomAD
CA2171633 rs762884887	291	S>R		No	ClinGen ExAC gnomAD
rs974496140 CA351031938	294	L>M		No	ClinGen TOPMed
rs1559196190 CA351031935	294	L>P		No	ClinGen Ensembl
rs1194385125 CA351031933	295	L>V		No	ClinGen gnomAD
CA67034159 rs780444133	297	S>F		No	ClinGen TOPMed gnomAD
rs267599265 CA67034139	300	M>I		No	ClinGen Ensembl
CA2171630 rs759780655	300	M>T		No	ClinGen ExAC
rs765407318 CA2171631	300	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1436671055 CA351031877	303	E>K		No	ClinGen gnomAD
rs754227975 CA2171628	304	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1351329981 CA351031869	304	R>W		No	ClinGen TOPMed gnomAD
rs1460772653 CA351031862	305	I>K		No	ClinGen gnomAD
rs138598670 CA2171625	311	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs183477550 CA2171621	314	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351031789 rs1260420088	316	I>T		No	ClinGen TOPMed gnomAD
CA2171618 rs576119488	316	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA67034071 rs569496752	321	V>I		No	ClinGen gnomAD
rs1300856901 CA351031740 COSM1482876 COSM442489	324	V>M	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs765282880 CA2171614	326	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2171610 rs766678125	329	E>K		No	ClinGen ExAC gnomAD
rs774199056 CA2171608	330	R>Q		No	ClinGen ExAC gnomAD
rs761455816 CA67034042	330	R>W		No	ClinGen ExAC gnomAD
CA2171573 rs200148193	332	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201072229 CA67032694	336	E>K		No	ClinGen 1000Genomes
rs779331699 CA351031638	337	H>Q		No	ClinGen ExAC gnomAD
rs779331699 CA2171571	337	H>Q		No	ClinGen ExAC gnomAD
rs749285120 CA2171569	338	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2171570 rs755477382	338	R>W		No	ClinGen ExAC gnomAD
CA351031629 rs1574993869	339	M>R		No	ClinGen Ensembl
CA351031630 rs1574993869	339	M>T		No	ClinGen Ensembl
CA2171567 rs146885458	343	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA351031600 rs1477837303	343	I>V		No	ClinGen TOPMed gnomAD
rs140583128 CA2171565	344	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA67032658 rs947869169	347	D>N		No	ClinGen TOPMed
CA2171563 rs146544382	348	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA351031543 rs895432	351	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2171561 rs765228971	352	V>M		No	ClinGen ExAC TOPMed gnomAD
rs376745755 CA2171560	354	R>C		No	ClinGen ESP ExAC gnomAD
rs765885436 CA2171558	354	R>H		No	ClinGen ExAC gnomAD
rs376745755 CA2171559	354	R>S		No	ClinGen ESP ExAC gnomAD
CA351031522 rs1293546073	355	Y>C		No	ClinGen gnomAD
CA2171557 rs760174723	356	A>V		No	ClinGen ExAC gnomAD
rs748442344 CA2171554	358	D>G		No	ClinGen ExAC gnomAD
CA67032566 rs923626488	358	D>N		No	ClinGen TOPMed
rs1394240809 CA351031497	359	H>R		No	ClinGen gnomAD
CA351031465 rs1374226448	364	I>V		No	ClinGen gnomAD
CA351031443 rs368820247	367	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs368820247 CA2171551 COSM1017917 COSM1591956	367	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA2171550 rs749779181	369	N>S		No	ClinGen ExAC gnomAD
CA351031424 rs1195233160	370	Q>*		No	ClinGen gnomAD
CA351031421 rs1466939949	370	Q>P		No	ClinGen gnomAD
CA2171549 rs757633862	371	T>I		No	ClinGen ExAC TOPMed gnomAD
CA2171548 rs756205880	372	Y>S		No	ClinGen ExAC gnomAD
CA67032520 rs985645281	375	R>Q		No	ClinGen TOPMed gnomAD
CA351031388 rs752687283	375	R>W		No	ClinGen TOPMed gnomAD
CA2171547 rs745949568	376	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2171517 rs756040306	384	K>N		No	ClinGen ExAC gnomAD
rs1394164590 CA351031299	386	A>G		No	ClinGen gnomAD
CA2171515 rs199823442	388	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171514 rs199823442	388	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749889360 CA2171516	388	R>W		No	ClinGen ExAC gnomAD
CA2171511 rs371214944	392	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs377471982 CA2171510	392	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA351031252 rs1168176681	394	L>P		No	ClinGen TOPMed
rs1225717174 CA351031246	395	E>G		No	ClinGen gnomAD
CA2171507 rs140666386	397	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA351031217 rs1246084414	399	K>N		No	ClinGen gnomAD
rs778088014 CA2171504	404	P>L		No	ClinGen ExAC gnomAD
CA351031080 rs1157845742	420	K>R		No	ClinGen TOPMed gnomAD
CA2171501 rs141137644	423	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA351031002 rs1436800049	430	V>A		No	ClinGen gnomAD
rs933576475 CA67027570	430	V>I		No	ClinGen TOPMed gnomAD
rs933576475 CA67027565	430	V>L		No	ClinGen TOPMed gnomAD
CA2171470 rs755332968	432	E>K		No	ClinGen ExAC gnomAD
CA351030983 rs1574988661	433	R>K		No	ClinGen Ensembl
CA2171467 rs766957139	434	S>F		No	ClinGen ExAC TOPMed gnomAD
CA2171466 rs761289065	435	E>K		No	ClinGen ExAC TOPMed gnomAD
rs572634482 CA2171463	436	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572634482 CA2171464	436	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171465 rs770729567	436	R>W		No	ClinGen ExAC gnomAD
rs774424502 CA2171461	438	C>R		No	ClinGen ExAC TOPMed gnomAD
CA67027475 rs887729139	439	T>P		No	ClinGen TOPMed gnomAD
rs745622157 CA2171459	442	D>G		No	ClinGen ExAC
CA67027457 rs1049431330	442	D>N		No	ClinGen TOPMed gnomAD
COSM1406310 COSM71832 CA351030907 rs1559192177	445	K>R	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA2171457 rs770760419	448	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1399586944 CA351030881	449	M>K		No	ClinGen TOPMed
rs746915675 CA2171456	449	M>V		No	ClinGen ExAC gnomAD
CA351030735 rs1415009191	451	V>A		No	ClinGen gnomAD
CA67024204 rs956384030	453	A>S		No	ClinGen Ensembl
rs909834267 CA67024199	453	A>V		No	ClinGen TOPMed
CA2171426 rs781486550	454	C>S		No	ClinGen ExAC gnomAD
rs764125173 CA2171423	456	E>D		No	ClinGen ExAC gnomAD
CA2171424 rs752055877	456	E>G		No	ClinGen ExAC gnomAD
CA2171421 COSM1217265 COSM1217266 rs144108657	458	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA2171420 rs765456476	459	R>K		No	ClinGen ExAC gnomAD
rs149464057 CA2171419	461	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1228310202 CA351030574	462	S>T		No	ClinGen gnomAD
CA351030566 rs1309453054	463	R>C		No	ClinGen gnomAD
rs1293653144 COSM1017913 COSM1591957 CA351030564	463	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA351030551 rs1372115773	464	T>M		No	ClinGen gnomAD
CA351030546 rs1439321668	465	E>Q		No	ClinGen gnomAD
rs1162092635 CA351030498	467	M>I		No	ClinGen gnomAD
CA2171416 rs369986799	467	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs774473093 CA2171415	468	I>F		No	ClinGen ExAC gnomAD
CA351030472 rs1374317614	469	S>N		No	ClinGen gnomAD
rs1466207836 CA351030427	472	K>E		No	ClinGen TOPMed
CA351030421 rs1448503004	472	K>R		No	ClinGen TOPMed gnomAD
rs1195331837 CA351030405	473	K>R		No	ClinGen gnomAD
CA67024042 rs967876001	474	M>I		No	ClinGen Ensembl
rs779796433 CA2171412	475	E>K		No	ClinGen ExAC gnomAD
rs1426212635 CA351030321	478	I>N		No	ClinGen TOPMed
rs776211256 CA2171392	480	S>L		No	ClinGen ExAC gnomAD
rs1327310884 CA351030276	483	I>T		No	ClinGen TOPMed
rs778184431 CA2171389	487	S>P		No	ClinGen ExAC gnomAD
CA67022730 rs776811408	488	R>H		No	ClinGen gnomAD
rs1314281329 CA351030220	492	K>T		No	ClinGen gnomAD
rs372210599 CA67022727	495	E>K		No	ClinGen ESP TOPMed gnomAD
rs1026231001 CA67022714	499	M>I		No	ClinGen Ensembl
rs1268829812 CA351030173	499	M>L		No	ClinGen TOPMed
rs1427152719 CA351030156	501	G>D		No	ClinGen Ensembl
rs757020546 CA2171382	506	R>Q		No	ClinGen ExAC gnomAD
rs766571072 CA2171383	506	R>W		No	ClinGen ExAC gnomAD
rs570697270 CA351030064	515	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171379 COSM1017909 COSM1591958 COSM1692182 rs763007458	516	E>K	skin endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA351030043 rs1574984561	518	Y>S		No	ClinGen Ensembl
CA2171377 rs145097371	523	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770491177 CA2171375	525	L>M		No	ClinGen ExAC TOPMed gnomAD
rs770491177 CA2171374	525	L>V		No	ClinGen ExAC TOPMed gnomAD
CA2171373 rs747329923	527	V>L		No	ClinGen ExAC gnomAD
CA351029989 rs747329923	527	V>M		No	ClinGen ExAC gnomAD
rs1339568732 CA351029985	528	I>L		No	ClinGen gnomAD
rs61748689 CA2171372	528	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1225956662 CA351029970	530	R>Q		No	ClinGen TOPMed gnomAD
CA2171370 COSM3391575 rs748626476 COSM3391573 COSM3391574	530	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA351029747 rs1397895414	538	Q>E		No	ClinGen TOPMed
CA67022006 rs61729908	539	V>G		No	ClinGen Ensembl
rs1304775412 CA351029741	539	V>I		No	ClinGen TOPMed
CA2171351 rs769049853	542	S>L		No	ClinGen ExAC gnomAD
CA2171350 rs141871026	544	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA351029707 rs1296559031	544	P>S		No	ClinGen gnomAD
rs1435678412 CA351029701	545	R>Q		No	ClinGen gnomAD
CA2171348 rs770043531	545	R>W		No	ClinGen ExAC TOPMed gnomAD
CA351029687 rs1574983985	548	L>R		No	ClinGen Ensembl
CA351029682 rs1428057021	549	R>C		No	ClinGen gnomAD
CA67021948 rs113037652	550	V>A		No	ClinGen ExAC TOPMed gnomAD
CA2171345 rs113037652	550	V>G		No	ClinGen ExAC TOPMed gnomAD
CA351029667 rs752436267	551	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1574983954 CA351029662	552	E>G		No	ClinGen Ensembl
rs1574983939 CA351029654	553	L>R		No	ClinGen Ensembl
CA2171342 rs754892092	555	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1157789051 CA351029641	555	D>V		No	ClinGen gnomAD
rs1206061955 CA351029611	559	T>M		No	ClinGen gnomAD
rs1206061955 CA351029612	559	T>R		No	ClinGen gnomAD
rs554390366 CA67021889	562	N>S		No	ClinGen 1000Genomes gnomAD
rs554390366 CA351029596	562	N>T		No	ClinGen 1000Genomes gnomAD
rs762099439 CA2171336	563	V>M		No	ClinGen ExAC gnomAD
CA351029578 rs1374049431	565	I>V		No	ClinGen gnomAD
rs1349988015 CA351029566	567	R>Q		No	ClinGen TOPMed gnomAD
rs769159775 CA2171334	567	R>W		No	ClinGen ExAC gnomAD
rs1052387210 CA67021850	570	E>D		No	ClinGen TOPMed gnomAD
CA2171332 rs138129440	571	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745959146 CA2171330	572	A>T		No	ClinGen ExAC TOPMed gnomAD
CA67021808 rs370768595	575	R>Q		No	ClinGen ESP TOPMed gnomAD
rs776926060 CA2171329	575	R>W		No	ClinGen ExAC gnomAD
rs771305646 CA2171328	576	E>K		No	ClinGen ExAC gnomAD
rs747924073 CA2171327	577	A>T		No	ClinGen ExAC gnomAD
rs778547108 CA2171326	578	T>I		No	ClinGen ExAC gnomAD
CA351029503 rs1574983798	578	T>P		No	ClinGen Ensembl
CA2171322 rs755566882	584	S>F		No	ClinGen ExAC gnomAD
CA2171323 rs755566882	584	S>Y		No	ClinGen ExAC gnomAD
CA351029320 rs889744504	586	Q>H		No	ClinGen TOPMed gnomAD
rs1367292378 CA351029304	587	S>N		No	ClinGen TOPMed
rs1020283910 CA67020363	589	M>K		No	ClinGen TOPMed
CA67020360 rs764647434	591	R>C		No	ClinGen Ensembl
CA67020351 rs1050106677	591	R>H		No	ClinGen TOPMed
CA351029183 rs1211596607	592	W>*		No	ClinGen gnomAD
rs1487508374 COSM1017903 COSM1591961 CA351029105	597	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1425270066 CA351029098	597	A>V		No	ClinGen gnomAD
rs777316248 CA2171293	602	T>A		No	ClinGen ExAC TOPMed gnomAD
CA67020303 rs746642364	602	T>I		No	ClinGen Ensembl
CA351028965 rs1406769034	604	F>L		No	ClinGen Ensembl
rs1445507909 CA351028961	605	V>L		No	ClinGen TOPMed
rs760869922 CA2171291	608	T>I		No	ClinGen ExAC gnomAD
rs772347533 CA2171289	610	R>Q		No	ClinGen ExAC gnomAD
rs1306214695 CA351028891	610	R>W		No	ClinGen TOPMed gnomAD
CA2171264 rs777312558	614	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA351028300 rs1230778567	618	Q>H		No	ClinGen gnomAD
rs1408834259 CA351028262	620	V>A		No	ClinGen gnomAD
rs147833836 CA351028269	620	V>L		No	ClinGen ESP gnomAD
rs147833836 CA67019420	620	V>M		No	ClinGen ESP gnomAD
CA351028246 rs1574981504	621	H>P		No	ClinGen Ensembl
rs1335911860 CA351028227	622	P>S		No	ClinGen gnomAD
rs140478097 CA67019350	623	Y>*		No	ClinGen ESP ExAC gnomAD
rs778762741 CA2171261	623	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs367563758 CA2171259	624	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1187883871 CA351028147	627	Q>H		No	ClinGen TOPMed
CA351028108 rs1475647478	633	L>R		No	ClinGen gnomAD
CA2171254 rs757395688	636	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1262884309 CA351028089	636	A>V		No	ClinGen gnomAD
CA2171252 rs558838324	637	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1265658610 CA351028077	638	I>T		No	ClinGen gnomAD
rs1404101626 CA351028072	639	L>F		No	ClinGen TOPMed
rs374536644 CA2171250	643	D>H		No	ClinGen ESP ExAC gnomAD
rs753016089 CA2171249	646	D>V		No	ClinGen ExAC TOPMed gnomAD
CA351028025 rs1405415688	646	D>Y		No	ClinGen gnomAD
CA2171246 rs148413660	647	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2171247 rs773087145	647	D>N		No	ClinGen ExAC TOPMed gnomAD
CA351028019 rs773087145	647	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA2171220 rs373244789	648	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2171244 rs774084146	648	G>R		No	ClinGen ExAC gnomAD
rs1477337676 CA351027994	649	W>*		No	ClinGen TOPMed
rs1016757345 CA67017421	650	I>L		No	ClinGen TOPMed gnomAD
rs1386494723 CA351027984	651	F>I		No	ClinGen TOPMed
CA351027965 rs1351217421	653	E>D		No	ClinGen gnomAD
COSM3743671 CA2171216 COSM3743672 rs544040415 COSM3743670	653	E>K	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA2171217 rs544040415	653	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2171215 rs752947664	654	R>C		No	ClinGen ExAC gnomAD
COSM3743669 CA2171214 COSM3743667 COSM3743668 rs779013074	654	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs375499710 CA351027946	657	D>H		No	ClinGen ESP ExAC gnomAD
CA2171212 rs375499710	657	D>N		No	ClinGen ESP ExAC gnomAD
CA2171209 rs370220062	660	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1347266632 CA351027909	662	W>*		No	ClinGen gnomAD
CA351027897 rs1251924783	663	F>L		No	ClinGen gnomAD
rs763693670 CA2171208	663	F>V		No	ClinGen ExAC gnomAD
rs900304393 CA67017361	664	P>L		No	ClinGen Ensembl
rs769360646 CA2171206	665	S>G		No	ClinGen ExAC gnomAD
rs1250757132 CA351027890	665	S>N		No	ClinGen gnomAD
rs769360646 CA2171205	665	S>R		No	ClinGen ExAC gnomAD
CA2171203 rs568393927	667	M>T		No	ClinGen ExAC TOPMed gnomAD
CA351027865 rs1276368277	669	E>K		No	ClinGen gnomAD
rs1559186972 CA351027838	672	L>S		No	ClinGen Ensembl
CA2171201 rs747506129	673	N>Y		No	ClinGen ExAC gnomAD
rs942810484 CA67017312	674	P>T		No	ClinGen Ensembl
rs1408223710 CA351027808	677	R>G		No	ClinGen gnomAD
rs772128910 CA2171199 COSM673881	677	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1408223710 CA351027807	677	R>W		No	ClinGen gnomAD
rs1267121405 CA351027780	681	L>F		No	ClinGen TOPMed
CA2171197 rs779159365	683	E>Q		No	ClinGen ExAC gnomAD
CA2171195 rs754143307	686	R>H		No	ClinGen ExAC TOPMed gnomAD
CA351027742 rs754143307	686	R>P		No	ClinGen ExAC TOPMed gnomAD
CA2171194 rs781107163	687	V>D		No	ClinGen ExAC gnomAD
CA67017251 rs201463795	688	H>Y		No	ClinGen Ensembl
rs374486398 CA2171192	690	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2171193 rs757186005	690	M>T		No	ClinGen ExAC gnomAD
CA351027702 rs1574979589	692	D>A		No	ClinGen Ensembl
CA351027695 rs1472660764	693	P>S		No	ClinGen TOPMed
CA2171191 rs138621391	695	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs572449644 CA2171190	695	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA351027654 rs1235532050	698	N>K		No	ClinGen gnomAD
rs764850072 CA2171188	699	K>N		No	ClinGen ExAC gnomAD
CA351027624 rs1574979535	700	D>A		No	ClinGen Ensembl
rs555521547 CA2171187	700	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA2171185 rs771268988	701	R>C		No	ClinGen ExAC TOPMed gnomAD
CA351027602 COSM1017899 rs1328624341 COSM1406305	701	R>H	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs771268988 CA351027608	701	R>S		No	ClinGen ExAC TOPMed gnomAD
CA67017206 rs761037996	704	L>M		No	ClinGen ExAC gnomAD
CA351027564 rs761037996	704	L>V		No	ClinGen ExAC gnomAD
rs773023462 CA67017185	705	G>C		No	ClinGen Ensembl
rs974698300 CA67017183	706	S>N		No	ClinGen Ensembl
rs748212920 COSM3380085 COSM3380087 COSM3380086 CA2171181	707	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs145959108 CA2171182	707	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA351027502 rs1302703360	708	N>T		No	ClinGen gnomAD
rs771713745 CA2171179	709	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2171180 rs778839323	709	R>W		No	ClinGen ExAC gnomAD
CA351027446 rs1460606191	710	Q>*		No	ClinGen TOPMed gnomAD

No associated diseases with Q8N5V2

5 regional properties for Q8N5V2

Type	Name	Position	InterPro Accession
domain	Dbl homology (DH) domain	273 - 457	IPR000219
domain	SH3 domain	612 - 673	IPR001452
domain	Pleckstrin homology domain	489 - 603	IPR001849
domain	Ephexin-1, SH3 domain	616 - 670	IPR035635
domain	Ephexin-like, PH domain	477 - 603	IPR047270

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Membrane Cell projection, growth cone	Associated with membranes Localizes to axonal growth cones (By similarity)
PANTHER Family	PTHR12845	GUANINE NUCLEOTIDE EXCHANGE FACTOR
PANTHER Subfamily	PTHR12845:SF8	EPHEXIN-1
PANTHER Protein Class	guanyl-nucleotide exchange factor G-protein modulator protein-binding activity modulator
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

7 GO annotations of biological process

Name	Definition
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
ephrin receptor signaling pathway	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of dendritic spine morphogenesis	Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A5YM69	ARHGEF35	Rho guanine nucleotide exchange factor 35	Homo sapiens (Human)	PR
Q8IW93	ARHGEF19	Rho guanine nucleotide exchange factor 19	Homo sapiens (Human)	SS
Q5VV41	ARHGEF16	Rho guanine nucleotide exchange factor 16	Homo sapiens (Human)	PR
O94989	ARHGEF15	Rho guanine nucleotide exchange factor 15	Homo sapiens (Human)	SS
Q12774	ARHGEF5	Rho guanine nucleotide exchange factor 5	Homo sapiens (Human)	EV
Q96DR7	ARHGEF26	Rho guanine nucleotide exchange factor 26	Homo sapiens (Human)	SS
E9Q7D5	Arhgef5	Rho guanine nucleotide exchange factor 5	Mus musculus (Mouse)	SS
Q3U5C8	Arhgef16	Rho guanine nucleotide exchange factor 16	Mus musculus (Mouse)	PR
Q5FWH6	Arhgef15	Rho guanine nucleotide exchange factor 15	Mus musculus (Mouse)	SS
Q8BWA8	Arhgef19	Rho guanine nucleotide exchange factor 19	Mus musculus (Mouse)	PR
Q8CHT1	Ngef	Ephexin-1	Mus musculus (Mouse)	SS
Q5BKC9	Ngef	Ephexin-1	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
METRESEDLE	KTRRKSASDQ	WNTDNEPAKV	KPELLPEKEE	TSQADQDIQD	KEPHCHIPIK
70	80	90	100	110	120
RNSIFNRSIR	RKSKAKARDN	PERNASCLAD	SQDNGKSVNE	PLTLNIPWSR	MPPCRTAMQT
130	140	150	160	170	180
DPGAQEMSES	SSTPGNGATP	EEWPALADSP	TTLTEALRMI	HPIPADSWRN	LIEQIGLLYQ
190	200	210	220	230	240
EYRDKSTLQE	IETRRQQDAE	IEDNTNGSPA	SEDTPEEEEE	EEEEEEPASP	PERKTLPQIC
250	260	270	280	290	300
LLSNPHSRFN	LWQDLPEIRS	SGVLEILQPE	EIKLQEAMFE	LVTSEASYYK	SLNLLVSHFM
310	320	330	340	350	360
ENERIRKILH	PSEAHILFSN	VLDVLAVSER	FLLELEHRME	ENIVISDVCD	IVYRYAADHF
370	380	390	400	410	420
SVYITYVSNQ	TYQERTYKQL	LQEKAAFREL	IAQLELDPKC	RGLPFSSFLI	LPFQRITRLK
430	440	450	460	470	480
LLVQNILKRV	EERSERECTA	LDAHKELEMV	VKACNEGVRK	MSRTEQMISI	QKKMEFKIKS
490	500	510	520	530	540
VPIISHSRWL	LKQGELQQMS	GPKTSRTLRT	KKLFHEIYLF	LFNDLLVICR	QIPGDKYQVF
550	560	570	580	590	600
DSAPRGLLRV	EELEDQGQTL	ANVFILRLLE	NADDREATYM	LKASSQSEMK	RWMTSLAPNR
610	620	630	640	650	660
RTKFVSFTSR	LLDCPQVQCV	HPYVAQQPDE	LTLELADILN	ILDKTDDGWI	FGERLHDQER
670	680	690	700
GWFPSSMTEE	ILNPKIRSQN	LKECFRVHKM	DDPQRSQNKD	RRKLGSRNRQ