AiPD: Autoinhibited Protein Database

Q8N568

Gene name	DCLK2 (DCAMKL2, DCDC3B, DCK2)
Protein name	Serine/threonine-protein kinase DCLK2
Names	CaMK-like CREB regulatory kinase 2, CL2, CLICK-II, CLICK2, Doublecortin domain-containing protein 3B, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:166614
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-384 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

270-384 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

536-556 (Activation loop from InterPro)

Target domain	394-651 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8N568

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8N568-F1	Predicted				AlphaFoldDB

602 variants for Q8N568

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1449699082 CA358600991	2	A>D		No	ClinGen TOPMed
CA358600990 rs1282524197	2	A>S		No	ClinGen gnomAD
CA358600988 rs1282524197	2	A>T		No	ClinGen gnomAD
rs755348043 CA3100561	3	S>T		No	ClinGen ExAC gnomAD
rs1225100431 CA358601002	4	T>A		No	ClinGen gnomAD
CA358601007 rs1338911711	5	R>G		No	ClinGen gnomAD
rs768056978 CA3100562	5	R>K		No	ClinGen ExAC TOPMed gnomAD
rs776787423 CA3100563	6	S>N		No	ClinGen ExAC TOPMed gnomAD
rs904094621 CA108295433	6	S>R		No	ClinGen Ensembl
CA358601044 rs1247262086	10	E>A		No	ClinGen TOPMed
rs75348202 CA108295436	11	H>N		No	ClinGen Ensembl
rs1267376340 CA358601050	11	H>R		No	ClinGen gnomAD
CA3100566 rs529183260	15	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358601079 rs1372899313	15	R>W		No	ClinGen TOPMed gnomAD
CA3100567 rs757476284	16	D>E		No	ClinGen ExAC gnomAD
rs1295480513 CA358601094	17	K>R		No	ClinGen TOPMed
rs779169738 CA3100568	18	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1213894281 CA358601108	19	P>L		No	ClinGen gnomAD
CA358601105 rs1580455741	19	P>S		No	ClinGen Ensembl
CA358601111 rs1302047947	20	R>Q		No	ClinGen gnomAD
CA358601118 rs1406698185	21	P>L		No	ClinGen gnomAD
CA358601116 rs1363571301	21	P>S		No	ClinGen gnomAD
rs776517388 CA3100571	22	G>A		No	ClinGen ExAC gnomAD
rs776517388 CA358601123	22	G>E		No	ClinGen ExAC gnomAD
rs776517388 CA358601124	22	G>V		No	ClinGen ExAC gnomAD
CA3100572 rs748108035	23	S>L		No	ClinGen ExAC TOPMed gnomAD
rs769785936 CA3100573	24	R>L		No	ClinGen ExAC gnomAD
CA3100574 rs762000752	27	A>P		No	ClinGen ExAC TOPMed gnomAD
CA108295453 rs762000752	27	A>T		No	ClinGen ExAC TOPMed gnomAD
CA108295456 rs983277779	27	A>V		No	ClinGen TOPMed gnomAD
CA358601151 rs1447834920	28	P>S		No	ClinGen gnomAD
CA358601157 rs1362136390	29	S>G		No	ClinGen TOPMed gnomAD
rs1210981557 CA358601166	30	S>P		No	ClinGen gnomAD
CA108295461 rs1016140363	32	G>A		No	ClinGen TOPMed gnomAD
rs774023752 CA3100577	32	G>R		No	ClinGen ExAC gnomAD
CA3100579 rs200222469	33	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200222469 CA3100578	33	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA358601186 rs1234394297	34	S>C		No	ClinGen TOPMed
rs1234394297 CA358601185	34	S>G		No	ClinGen TOPMed
CA358601187 rs1243473807	34	S>N		No	ClinGen gnomAD
CA358601209 rs201132155	37	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA3100580 rs201132155	37	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA358601216 rs1162300200	38	G>D		No	ClinGen gnomAD
rs1382891846 CA358601221	39	P>A		No	ClinGen TOPMed gnomAD
CA358601224 rs1312786518	39	P>L		No	ClinGen TOPMed
rs1382891846 CA358601220	39	P>S		No	ClinGen TOPMed gnomAD
rs1163751636 CA358601229	40	K>R		No	ClinGen gnomAD
rs756677344 CA3100581	41	G>V		No	ClinGen ExAC gnomAD
CA358601239 rs1380308641	42	N>D		No	ClinGen gnomAD
rs1320113442 CA358601248	43	G>R		No	ClinGen gnomAD
TCGA novel	44	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3100582 rs764568666	44	L>R		No	ClinGen ExAC TOPMed gnomAD
CA108295480 rs548654953	45	I>M		No	ClinGen ExAC gnomAD
TCGA novel	45	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs557293514 CA358601276	47	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358601278 rs1289350050	48	P>A		No	ClinGen TOPMed
rs758634571 CA3100587	48	P>R		No	ClinGen ExAC
CA358601284 rs1349055211	49	A>E		No	ClinGen TOPMed
CA108295486 rs992144412	49	A>T		No	ClinGen TOPMed
CA358601285 rs1349055211	49	A>V		No	ClinGen TOPMed
CA358601288 rs1245661831	50	H>D		No	ClinGen gnomAD
rs1260645007 CA358601290	50	H>P		No	ClinGen gnomAD
TCGA novel	50	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1449794617 CA358601306	52	A>G		No	ClinGen TOPMed
CA3100588 rs781137720	52	A>T		No	ClinGen ExAC gnomAD
CA358601315 rs1269163833	53	H>Q		No	ClinGen gnomAD
CA358601331 rs1465034689	55	S>R		No	ClinGen gnomAD
TCGA novel	56	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1359171378 CA358601344	57	Y>C		No	ClinGen TOPMed
rs945497145 CA108295492	59	T>R		No	ClinGen Ensembl
rs1580456210 CA358601373	60	R>W		No	ClinGen Ensembl
CA358601391 rs1182624672	61	T>I		No	ClinGen TOPMed gnomAD
rs1182624672 CA358601389	61	T>S		No	ClinGen TOPMed gnomAD
CA108295499 rs925434878	65	L>V		No	ClinGen Ensembl
rs1451562829 CA358601471	67	S>L		No	ClinGen TOPMed gnomAD
rs1451562829 CA358601470	67	S>W		No	ClinGen TOPMed gnomAD
rs936842748 CA108295502	68	E>*		No	ClinGen Ensembl
CA3100593 rs770509809	69	K>R		No	ClinGen ExAC TOPMed gnomAD
CA3100595 rs759242411	70	K>E		No	ClinGen ExAC TOPMed gnomAD
rs775886856 CA3100597	70	K>N		No	ClinGen ExAC gnomAD
rs771649250 CA3100596	70	K>T		No	ClinGen ExAC TOPMed gnomAD
CA3100599 rs764621558	74	A>T		No	ClinGen ExAC gnomAD
TCGA novel	75	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358601566 rs1289318927	75	R>S		No	ClinGen TOPMed gnomAD
CA3100600 rs754396915	76	F>S		No	ClinGen ExAC gnomAD
rs1260865531 CA358601613	78	R>L		No	ClinGen gnomAD
TCGA novel	80	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358601634 rs1249217673	80	G>R		No	ClinGen gnomAD
rs750400614 CA3100603	82	R>C		No	ClinGen ExAC gnomAD
rs758759273 CA3100604	82	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3100605 rs780411948	84	F>L		No	ClinGen ExAC gnomAD
CA358601697 rs1408492545	85	K>E		No	ClinGen TOPMed gnomAD
rs910892154 CA108295518	85	K>N		No	ClinGen TOPMed gnomAD
rs755942679 CA3100607	89	F>V		No	ClinGen ExAC TOPMed gnomAD
CA358601770 rs1445229184	92	S>C		No	ClinGen TOPMed
CA3100609 rs749274170	92	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1345515495 CA358601778	93	S>R		No	ClinGen gnomAD
rs963742918 CA108295525	94	D>E		No	ClinGen TOPMed gnomAD
rs1580456529 CA358601782	94	D>H		No	ClinGen Ensembl
CA3100610 rs770718037	95	R>C		No	ClinGen ExAC TOPMed gnomAD
rs922386079 CA108295528	96	F>L		No	ClinGen TOPMed
rs778492434 CA3100611	97	R>L		No	ClinGen ExAC
rs1313517938 CA358601806	98	S>F		No	ClinGen TOPMed gnomAD
CA358601807 rs1313517938	98	S>Y		No	ClinGen TOPMed gnomAD
CA3100612 CA108295533 rs61744627	99	F>L		No	ClinGen ExAC gnomAD
CA3100613 rs368816953	100	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs775088822 CA358601825	101	A>E		No	ClinGen ExAC TOPMed gnomAD
CA358601826 rs775088822	101	A>G		No	ClinGen ExAC TOPMed gnomAD
rs775088822 CA3100614	101	A>V		No	ClinGen ExAC TOPMed gnomAD
CA358601828 rs1373107568	102	L>V		No	ClinGen gnomAD
rs1048401506 CA108295546	103	L>V		No	ClinGen TOPMed
rs765656766 CA358601839	104	I>K		No	ClinGen ExAC gnomAD
rs776802398 CA3100618	104	I>L		No	ClinGen ExAC gnomAD
CA108295550 rs908084539	104	I>M		No	ClinGen TOPMed
rs765656766 CA3100619	104	I>R		No	ClinGen ExAC gnomAD
rs776802398 CA3100617	104	I>V		No	ClinGen ExAC gnomAD
rs1433934938 CA358601856	107	T>A		No	ClinGen gnomAD
CA358601862 rs867719384	108	R>C		No	ClinGen gnomAD
CA358601863 rs1431705908	108	R>H		No	ClinGen gnomAD
CA108295552 rs867719384	108	R>S		No	ClinGen gnomAD
TCGA novel	111	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766747944 CA3100622	111	S>L		No	ClinGen ExAC gnomAD
CA3100624 rs755206301	113	N>D		No	ClinGen ExAC gnomAD
rs1294400122 CA358601893	113	N>S		No	ClinGen TOPMed gnomAD
rs1229894160 CA358601898	114	V>L		No	ClinGen gnomAD
rs1229894160 CA358601897	114	V>M		No	ClinGen gnomAD
CA3100625 rs777641002	115	N>K		No	ClinGen ExAC gnomAD
rs1004596995 CA108295565	116	L>M		No	ClinGen TOPMed
rs753513344 CA3100626	117	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1220187825 CA358601914	117	P>S		No	ClinGen gnomAD
rs757288941 CA3100627	118	Q>R		No	ClinGen ExAC gnomAD
rs56327537 CA3100628 VAR_040441	119	G>C		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs1259902391 CA358601928	119	G>V		No	ClinGen gnomAD
CA358601948 rs1451578876	122	T>I		No	ClinGen gnomAD
rs1282504473 CA358601943	122	T>S		No	ClinGen gnomAD
CA358601955 rs1384719865	123	I>M		No	ClinGen gnomAD
rs1580456923 CA358601950	123	I>V		No	ClinGen Ensembl
rs757931419 CA3100630	124	Y>C		No	ClinGen ExAC gnomAD
rs1446774909 CA358601957	124	Y>H		No	ClinGen gnomAD
CA3100631 rs779486736	125	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1351040511 CA358601982	126	I>L		No	ClinGen gnomAD
CA358602019 rs1362496562	128	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3100632 rs746676479	130	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1034252691 CA108295583	131	K>*		No	ClinGen Ensembl
CA358602127 rs1291935539	135	L>P		No	ClinGen gnomAD
CA3100636 rs770383233	136	D>E		No	ClinGen ExAC TOPMed gnomAD
CA3100635 rs748446922	136	D>N		No	ClinGen ExAC TOPMed gnomAD
CA108295595 rs895940713	140	E>K		No	ClinGen TOPMed
CA358602191 rs895940713	140	E>Q		No	ClinGen TOPMed
rs759524875 CA3100659	142	E>D		No	ClinGen ExAC gnomAD
CA358605644 rs1399832976	142	E>K		No	ClinGen gnomAD
CA3100661 rs767818184	145	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3100660 rs767818184	145	V>M		No	ClinGen ExAC gnomAD
CA358605845 rs1310932057	149	N>K		No	ClinGen TOPMed
CA358605836 rs1279660722	149	N>S		No	ClinGen gnomAD
rs750149780 CA3100664	150	E>V		No	ClinGen ExAC gnomAD
rs758395866 CA3100665	151	P>T		No	ClinGen ExAC gnomAD
COSM1051916 COSM1051917 rs1230886415 CA358605897	153	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
COSM294297 CA3100666 rs766290066 COSM294298	153	R>H	Variant assessed as Somatic; 0.0 impact. oesophagus large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs112792769 CA108301384	154	K>R		No	ClinGen Ensembl
rs1034357032 CA108301395	156	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	157	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3100670 rs752315954	158	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	159	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	160	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3100672 rs778290244	160	N>S		No	ClinGen ExAC gnomAD
rs111756382 CA108301400	161	I>T		No	ClinGen Ensembl
CA3100673 rs749667854	162	N>H		No	ClinGen ExAC gnomAD
rs771628293 CA3100674	163	P>L		No	ClinGen ExAC gnomAD
rs779682975 CA108301405	164	N>D		No	ClinGen Ensembl
rs779527956 CA3100675	165	W>S		No	ClinGen ExAC gnomAD
CA3100676 rs746342475	169	I>T		No	ClinGen ExAC gnomAD
CA358606246 rs1438390423	171	G>C		No	ClinGen gnomAD
CA358606296 rs1162180725	174	S>F		No	ClinGen TOPMed
CA3100677 rs538939072	174	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA108301419 rs982859820	175	R>*		No	ClinGen TOPMed
CA358606299 rs982859820	175	R>G		No	ClinGen TOPMed
rs775578648 CA3100678	175	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs142526243 CA3100679	176	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA358606333 rs1343454177	177	L>P		No	ClinGen gnomAD
CA358606343 rs1222434814	178	A>T		No	ClinGen gnomAD
CA3100682 rs762713560	178	A>V		No	ClinGen ExAC gnomAD
CA3100684 rs751482957	180	A>V		No	ClinGen ExAC TOPMed gnomAD
rs150954251 CA3100685	181	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA3100686 rs766952044	183	V>M		No	ClinGen ExAC TOPMed gnomAD
CA3100687 rs140418434	185	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3100688 rs755792429	186	E>G		No	ClinGen ExAC gnomAD
rs777559495 CA3100689	187	V>A		No	ClinGen ExAC gnomAD
CA3100691 rs369802977	188	K>R		No	ClinGen ESP ExAC gnomAD
rs746372275 CA3100693	192	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	193	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772559740 CA3100694	194	I>M		No	ClinGen ExAC gnomAD
rs1210739288 CA358598695	200	T>A		No	ClinGen gnomAD
CA3100697 rs768915804	203	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs776801902 CA3100698	204	S>N		No	ClinGen ExAC gnomAD
rs776801902 CA358598720	204	S>T		No	ClinGen ExAC gnomAD
rs868679057 CA108301459	211	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA3100702 rs759398144 VAR_073158	212	V>M	found in a patient with hereditary motor and sensory neuropathy; unknown pathological significance [UniProt]	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs752209460 CA3100704	213	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767489159 CA3100703	213	R>W		No	ClinGen ExAC gnomAD
CA3100705 rs760243978	214	I>V		No	ClinGen ExAC gnomAD
TCGA novel	218	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3100708 rs756910394	221	A>D		No	ClinGen ExAC gnomAD
rs753563425 CA3100707	221	A>T		No	ClinGen ExAC gnomAD
CA3100709 rs765521450	222	H>L		No	ClinGen ExAC gnomAD
rs765521450 CA358599208	222	H>R		No	ClinGen ExAC gnomAD
CA108301474 rs925652343	226	Q>H		No	ClinGen Ensembl
rs1451992157 CA358599237	226	Q>R		No	ClinGen TOPMed gnomAD
rs1310665970 CA358599241	227	V>L		No	ClinGen gnomAD
TCGA novel	230	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358599274 rs1580504262	232	T>P		No	ClinGen Ensembl
CA3100711 rs758885073	233	E>K		No	ClinGen ExAC gnomAD
rs780588643 CA3100712	235	I>T		No	ClinGen ExAC gnomAD
CA358599294 rs1230778365	235	I>V		No	ClinGen gnomAD
rs781200753 CA3100715	239	S>P		No	ClinGen ExAC gnomAD
rs769938020 CA3100717	240	G>R		No	ClinGen ExAC TOPMed gnomAD
rs374181841 CA3100719	242	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs771956460 CA3100720	246	C>R		No	ClinGen ExAC gnomAD
rs775470260 CA3100721	249	D>G		No	ClinGen ExAC gnomAD
rs933716681 CA108301496	251	K>R		No	ClinGen Ensembl
rs543969054 CA3100722	252	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1345250466 CA358431877	253	V>L		No	ClinGen gnomAD
CA3100738 rs528436781	254	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA107778966 rs746945054	255	C>F		No	ClinGen ExAC gnomAD
CA358431909 rs1335343936	255	C>R		No	ClinGen TOPMed gnomAD
CA3100739 rs746945054	255	C>Y		No	ClinGen ExAC gnomAD
CA358431951 rs1313652067	257	Q>P		No	ClinGen gnomAD
TCGA novel	261	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358432105 rs1207181595	264	D>G		No	ClinGen gnomAD
rs761382874 CA3100742	264	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA358432166 rs1416220621	265	V>A		No	ClinGen TOPMed
rs772947046 CA3100744	269	C>R		No	ClinGen ExAC TOPMed gnomAD
rs980372267 CA107778979	270	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	272	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	273	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM4138065 CA3100745 rs186217292 COSM4138066	275	R>H	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs766780091 CA3100746	276	Y>N		No	ClinGen ExAC gnomAD
rs751856360 CA3100747	278	Q>R		No	ClinGen ExAC gnomAD
rs760104011 CA3100748	279	D>G		No	ClinGen ExAC gnomAD
rs752825929 CA3100750	282	V>L		No	ClinGen ExAC gnomAD
rs1169749079 CA358432496	283	L>P		No	ClinGen gnomAD
CA3100751 rs756191602	286	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1295670613 CA358432541	286	S>R		No	ClinGen gnomAD
TCGA novel	286	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768400811 CA107782135	288	C>W		No	ClinGen Ensembl
CA358433673 rs751438505	289	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3100774 rs751438505	289	R>G		No	ClinGen ExAC TOPMed gnomAD
CA3100775 rs201773968	289	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA358433676 rs201773968	289	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA107782150 rs751438505	289	R>S		No	ClinGen ExAC TOPMed gnomAD
CA358433684 rs1158205545	290	V>I		No	ClinGen TOPMed
rs1580701165 CA358433697	291	L>P		No	ClinGen Ensembl
rs147825260 CA3100778	291	L>V		No	ClinGen ESP ExAC gnomAD
rs777409554 CA3100779	292	K>N		No	ClinGen ExAC gnomAD
rs748737054 CA3100780	293	S>A		No	ClinGen ExAC gnomAD
rs770621436 CA3100781	293	S>L		No	ClinGen ExAC gnomAD
rs773965597 CA3100782	294	S>F		No	ClinGen ExAC gnomAD
CA107782175 rs929949096	295	Y>F		No	ClinGen Ensembl
rs373561276 CA107782188	296	S>C		No	ClinGen ESP TOPMed
rs1417038937 CA358433780	297	R>*		No	ClinGen TOPMed
CA107782200 rs200758050	297	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1051930 COSM1051931 rs200758050 CA3100784	297	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA3100785 rs775761791	298	S>F		No	ClinGen ExAC gnomAD
CA3100786 rs761308197	300	A>P		No	ClinGen ExAC TOPMed gnomAD
CA3100789 rs761766445	306	S>T		No	ClinGen ExAC gnomAD
rs1304509191 CA358434026	309	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358434078 rs1356077683	311	P>L		No	ClinGen gnomAD
rs529993293 CA3100790	311	P>S		No	ClinGen 1000Genomes ExAC
CA107782236 rs199938113	313	R>G		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs767425247 CA107782241	313	R>P		No	ClinGen ExAC TOPMed gnomAD
rs767425247 CA3100793	313	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs552302947 COSM1051934 COSM1051933 CA3100794	314	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA358434113 rs552302947	314	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756136401 CA3100796	314	R>H		No	ClinGen ExAC gnomAD
rs756136401 CA3100795	314	R>P		No	ClinGen ExAC gnomAD
rs552302947 CA358434115	314	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3100797 rs147007273	315	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA358434214 rs1238495037	320	S>P		No	ClinGen gnomAD
rs1473649394 CA358435276	322	N>S		No	ClinGen gnomAD
CA3100846 rs748518798	324	T>A		No	ClinGen ExAC gnomAD
rs1455871968 CA358435290	325	P>T		No	ClinGen gnomAD
CA3100848 rs778400715	326	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA358435329 rs1395567372	329	L>V		No	ClinGen gnomAD
rs1361816587 CA358435345	330	S>F		No	ClinGen Ensembl
rs749761682 CA3100849	330	S>P		No	ClinGen ExAC gnomAD
CA3100850 rs770944617	331	T>S		No	ClinGen ExAC gnomAD
CA358435368 rs1354895891	333	K>Q		No	ClinGen TOPMed
rs774419441 CA3100851	333	K>T		No	ClinGen ExAC
CA3100852 rs759686503	334	S>C		No	ClinGen ExAC gnomAD
CA358435383 rs1327988889	334	S>T		No	ClinGen gnomAD
CA3100853 rs149132491	335	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA358435408 rs1199446103	336	K>R		No	ClinGen gnomAD
CA107786169 rs946701287	339	S>G		No	ClinGen TOPMed gnomAD
CA358435448 rs1486615231	339	S>R		No	ClinGen gnomAD
rs1250834685 CA358435475	341	S>F		No	ClinGen gnomAD
TCGA novel	342	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358435488 rs1471517126	343	T>P		No	ClinGen TOPMed gnomAD
CA358435503 rs1580711252	344	S>G		No	ClinGen Ensembl
CA3100855 rs761577454	345	P>T		No	ClinGen ExAC gnomAD
CA107786175 rs897292861	346	G>V		No	ClinGen Ensembl
rs764965094 CA3100856	348	F>L		No	ClinGen ExAC TOPMed gnomAD
rs750393034 CA3100857	349	R>T		No	ClinGen ExAC gnomAD
TCGA novel	352	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	353	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358437402 rs1560882483	353	Q>K		No	ClinGen Ensembl
CA358437406 rs1560882490	353	Q>R		No	ClinGen Ensembl
CA358437413 rs1175601420	354	I>F		No	ClinGen gnomAD
rs143255740 CA3100870	358	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772236299 CA3100871	358	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	362	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1289711095 CA358437470	363	N>S		No	ClinGen gnomAD
rs1339161977 CA358437478	364	V>E		No	ClinGen TOPMed
rs1387588571 CA358437475	364	V>I		No	ClinGen TOPMed gnomAD
rs775714892 CA358437487	365	N>K		No	ClinGen ExAC TOPMed gnomAD
CA107795396 rs935449862	365	N>S		No	ClinGen Ensembl
CA3100873 rs558869328	366	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358437503 rs1372371449	368	P>R		No	ClinGen TOPMed gnomAD
rs1372503025 CA358437501	368	P>S		No	ClinGen gnomAD
rs1234473705 CA358437523	371	D>G		No	ClinGen gnomAD
rs374813761 CA3100874	372	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3100875 rs34386880 VAR_040442	372	R>H		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs148315360 CA3100876	374	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA107795423 rs919650101	374	I>M		No	ClinGen TOPMed gnomAD
CA358437541 rs1477441060	374	I>T		No	ClinGen TOPMed
CA3100877 rs148315360	374	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1488061745 CA358437545	375	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1203132 rs368925890 CA107795425 COSM1203131	375	S>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP TOPMed
rs745315685 CA107795427	378	G>R		No	ClinGen Ensembl
rs779456964 CA3100886	381	G>V		No	ClinGen ExAC gnomAD
rs930923607 CA107796013	383	R>S		No	ClinGen TOPMed
CA358437702 rs142061527	386	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs758538840 CA3100888	386	E>K		No	ClinGen ExAC
CA3100889 rs142061527	386	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs113059899 CA3100891	389	T>A		No	ClinGen ExAC TOPMed gnomAD
CA107796022 rs552557131	389	T>I		No	ClinGen 1000Genomes
CA3100890 rs113059899	389	T>P		No	ClinGen ExAC TOPMed gnomAD
CA3100892 rs773057815	390	L>I		No	ClinGen ExAC gnomAD
rs1560883896 CA358437749	391	L>I		No	ClinGen Ensembl
CA358437810 rs1167574377	395	K>R		No	ClinGen gnomAD
CA358437830 rs1419514268	397	G>R		No	ClinGen gnomAD
rs1461656845 CA358437849	398	K>R		No	ClinGen gnomAD
CA3100893 rs749078554	399	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3100894 rs566095628	403	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1289360799 CA358437927 COSM1051949 COSM1051948	404	N>K	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1394000509 CA358438019	411	C>R		No	ClinGen gnomAD
rs1294938194 CA358438021	411	C>Y		No	ClinGen gnomAD
rs534744184 CA3100896	412	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1227995445 CA358438038	413	D>Y		No	ClinGen gnomAD
CA107797748 rs780095704	416	T>A		No	ClinGen Ensembl
CA358438686 rs1452076284	420	F>C		No	ClinGen gnomAD
CA358438709 rs1432743224	422	L>P		No	ClinGen gnomAD
rs1376059237 CA358438740	425	I>R		No	ClinGen gnomAD
CA3100913 rs75931476	429	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1326617018 CA358438808	430	C>Y		No	ClinGen gnomAD
TCGA novel	432	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA107802393 rs994090548	443	I>T		No	ClinGen Ensembl
CA358440836 rs1228169229	445	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1272086755 CA358440838	445	R>H	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358440845 rs1318357722	446	R>*		No	ClinGen gnomAD
CA3100935 rs772172177 COSM732429 COSM732430	446	R>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs772172177 CA358440846	446	R>Q		No	ClinGen ExAC gnomAD
CA107802396 rs1027035910	447	V>M		No	ClinGen Ensembl
rs1253112930 CA358440866	449	H>L		No	ClinGen gnomAD
CA107802397 rs759356283	450	P>R		No	ClinGen Ensembl
rs952898754 CA107802400	451	N>K		No	ClinGen Ensembl
CA358440897 rs1267238335	454	M>L		No	ClinGen gnomAD
rs780166882 CA3100937	456	V>A		No	ClinGen ExAC gnomAD
CA3100940 rs775948934	457	E>G		No	ClinGen ExAC gnomAD
COSM1427465 rs1475584364 COSM1427466 CA358440914	457	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	458	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358440933 rs1415902350	459	M>T		No	ClinGen gnomAD
rs761586425 CA3100941	460	E>K		No	ClinGen ExAC gnomAD
CA107802446 rs971032693	463	T>A		No	ClinGen gnomAD
rs1380670929 CA358440985	467	L>V		No	ClinGen gnomAD
rs1163370264 CA358441000	469	M>I		No	ClinGen TOPMed
CA107802465 rs982372058	469	M>V		No	ClinGen Ensembl
TCGA novel	470	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	470	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358441014 rs1432173225	471	L>S		No	ClinGen TOPMed
rs748898379 CA3100962	474	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	476	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1404234143 CA358441065	477	L>R		No	ClinGen TOPMed
rs1023690825 CA107802629	479	D>A		No	ClinGen Ensembl
CA107802634 rs971322181	480	A>G		No	ClinGen Ensembl
CA3100963 rs771287672 COSM239528 COSM239529	483	S>L	Variant assessed as Somatic; 0.0 impact. endometrium prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs138420599 CA3100965	484	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	486	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1417257862 CA358441122	486	K>R		No	ClinGen TOPMed
rs775674700 CA3100967	487	Y>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	489	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	490	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757498459 CA3100971	495	M>T		No	ClinGen ExAC TOPMed gnomAD
CA358441207 rs1395271464	498	N>S		No	ClinGen gnomAD
CA358441225 rs1330162066	501	N>D		No	ClinGen TOPMed
CA3100973 rs143008050	501	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	502	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA107802684 rs892895058	504	R>S		No	ClinGen TOPMed gnomAD
CA107802711 rs996579896	509	L>I		No	ClinGen TOPMed gnomAD
CA3100976 rs150687721	511	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1309799 rs200547939 CA107802720 COSM1309800	512	V>M	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	520	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3101005 rs780412906	527	P>R		No	ClinGen ExAC gnomAD
CA358429223 rs1288153165	528	D>G		No	ClinGen TOPMed gnomAD
TCGA novel	529	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358429227 rs1479720748	529	G>R		No	ClinGen TOPMed gnomAD
CA358429236 rs1321508209	530	T>N		No	ClinGen TOPMed
rs201910979 CA3101006	531	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA358429259 rs1231070096	534	K>Q		No	ClinGen TOPMed
rs1258552457 CA358429310	541	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs900928737 CA107787409	544	V>I		No	ClinGen TOPMed
CA3101009 rs761963621	546	G>D		No	ClinGen ExAC
rs1476357335 CA358429338	546	G>R		No	ClinGen gnomAD
rs1433044006 CA358429347	547	P>L		No	ClinGen TOPMed
TCGA novel	548	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3101010 rs140025834	550	T>A		No	ClinGen ESP ExAC TOPMed
rs1457545017 CA358429373	551	V>A		No	ClinGen TOPMed
rs1259427707 CA358429368	551	V>F		No	ClinGen gnomAD
rs1257213634 CA358429390	554	T>S		No	ClinGen gnomAD
rs773600400 CA3101011	555	P>S		No	ClinGen ExAC gnomAD
CA358429443 rs1451071478	562	I>T		No	ClinGen TOPMed
CA358429440 rs1161504143	562	I>V		No	ClinGen TOPMed
rs752522566 CA3101014	565	E>G		No	ClinGen ExAC gnomAD
TCGA novel	576	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775186001 CA3101033	577	A>T		No	ClinGen ExAC gnomAD
CA107787845 rs905696183	578	G>D		No	ClinGen gnomAD
rs35745104 CA3101036 VAR_040443	583	I>V		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs761684059 CA3101037	584	L>F		No	ClinGen ExAC gnomAD
rs372472394 CA3101039	590	P>L		No	ClinGen ESP ExAC gnomAD
CA107787898 rs978601265	592	R>*		No	ClinGen TOPMed gnomAD
CA107787901 COSM3127483 rs911019486 COSM3127482	592	R>Q	pancreas Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1211111058 CA358430892	594	E>A		No	ClinGen gnomAD
CA358430885 COSM74334 COSM1427471 rs1332687423	594	E>K	ovary large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA3101071 rs746149168	595	N>K		No	ClinGen ExAC TOPMed gnomAD
CA358430922 rs1403857851	596	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA107792541 rs35844734	600	D>G		No	ClinGen Ensembl
rs949808940 CA107792526	600	D>H		No	ClinGen Ensembl
CA358430996 rs1243613582	602	F>L		No	ClinGen gnomAD
rs143883593 CA3101075	603	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1000013072 CA107792565	604	Q>E		No	ClinGen Ensembl
rs773232962 CA3101076	604	Q>H		No	ClinGen ExAC gnomAD
rs1396258993 CA358431079	607	A>V		No	ClinGen TOPMed
TCGA novel	611	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770489530 CA3101078	613	P>L		No	ClinGen ExAC TOPMed gnomAD
CA358431232 rs1320907674	618	D>E		No	ClinGen gnomAD
rs1199313736 CA358431228	618	D>V		No	ClinGen TOPMed
rs1479536348 CA358431236	619	N>D		No	ClinGen TOPMed
CA358431248 rs1254032450	619	N>K		No	ClinGen TOPMed
rs1560908469 CA358431252	620	I>V		No	ClinGen Ensembl
rs1361555476 CA358431274	621	T>M		No	ClinGen gnomAD
CA358431291 rs1437419543	622	D>E		No	ClinGen TOPMed
CA107792612 rs954659002	625	K>T		No	ClinGen Ensembl
rs961725245 CA107793075	627	L>F		No	ClinGen TOPMed
CA107793077 rs200270706	628	I>V		No	ClinGen 1000Genomes
CA358431860 COSM3660921 COSM3660922 rs1354356604	629	S>G	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA3101110 rs543464474	629	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA358431884 rs1277884374	630	Q>E		No	ClinGen gnomAD
rs1405187796 CA358431931	632	L>F		No	ClinGen TOPMed
rs780042885 CA3101111	636	V>G		No	ClinGen ExAC gnomAD
CA358432006 rs1246690851	636	V>I		No	ClinGen gnomAD
TCGA novel	639	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358432089 rs1454955717	639	R>W		No	ClinGen TOPMed
CA358432123 rs1201235162	640	C>F		No	ClinGen gnomAD
CA358432119 rs1201235162	640	C>Y		No	ClinGen gnomAD
rs1436081098 CA358432171	642	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1180597418 CA358432185	642	A>V		No	ClinGen gnomAD
CA358432277 rs1172371489	645	I>V		No	ClinGen gnomAD
rs749003060 CA107793103	649	P>S		No	ClinGen ExAC gnomAD
rs749003060 CA3101115	649	P>T		No	ClinGen ExAC gnomAD
CA3101116 rs370305193	652	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1466939427 CA358432423	652	S>P		No	ClinGen gnomAD
CA358432617 rs1580798113	653	D>G		No	ClinGen Ensembl
rs773554704 CA3101147	654	D>G		No	ClinGen ExAC TOPMed gnomAD
rs773554704 CA358432632	654	D>V		No	ClinGen ExAC TOPMed gnomAD
CA3101148 rs763520035	656	S>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766838350 CA3101149	657	Q>R		No	ClinGen ExAC gnomAD
CA107793852 rs1026731496	658	E>D		No	ClinGen Ensembl
CA3101150 rs774537543	658	E>K		No	ClinGen ExAC gnomAD
rs1318032529 CA358432706	660	N>D		No	ClinGen TOPMed
CA3101151 rs759555666	661	M>I		No	ClinGen ExAC gnomAD
CA358432729 rs1276978067	661	M>T		No	ClinGen TOPMed
CA358432748 rs368066010	662	Q>H		No	ClinGen gnomAD
CA3101153 rs752863300	664	E>D		No	ClinGen ExAC gnomAD
CA358432765 rs767593622	664	E>K		No	ClinGen ExAC gnomAD
CA3101152 rs767593622	664	E>Q		No	ClinGen ExAC gnomAD
rs1216421405 CA358432797	666	T>R		No	ClinGen TOPMed
rs756344383 CA3101154	669	L>R		No	ClinGen ExAC gnomAD
rs765179997 CA3101155	671	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3101156 rs750215326	672	H>Q		No	ClinGen ExAC gnomAD
rs1580798304 CA358432863	672	H>Y		No	ClinGen Ensembl
CA3101157 rs758462060	675	N>D		No	ClinGen ExAC gnomAD
rs1314906077 CA358432919	675	N>S		No	ClinGen gnomAD
CA3101158 rs181935788	676	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1388994632 CA358432928	676	A>T		No	ClinGen TOPMed
CA3101159 rs181935788	676	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1168551787 CA358432942	677	L>F		No	ClinGen TOPMed
rs1481452074 CA358432974	679	K>N		No	ClinGen TOPMed
rs780696958 CA3101161	680	Q>E		No	ClinGen ExAC gnomAD
rs1489437156 CA358432983	680	Q>L		No	ClinGen TOPMed gnomAD
rs1489437156 CA358432987	680	Q>R		No	ClinGen TOPMed gnomAD
CA107793921 rs577672603	681	N>I		No	ClinGen 1000Genomes
TCGA novel	681	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358433015 rs1217823722	682	S>T		No	ClinGen gnomAD
CA3101163 rs201425655	683	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201425655 CA358433032	683	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1179793293 CA358433041	684	T>N		No	ClinGen gnomAD
CA358433054 rs1415299871	685	T>S		No	ClinGen gnomAD
rs1264944568 CA358433058	686	G>R		No	ClinGen TOPMed
rs1158207237 CA358433074	687	V>A		No	ClinGen gnomAD
rs982013037 CA107793929	689	V>I		No	ClinGen TOPMed
rs368363454 CA358433104	690	I>L		No	ClinGen ESP ExAC gnomAD
rs368363454 CA3101167	690	I>V		No	ClinGen ESP ExAC gnomAD
rs1374670060 CA358433126	691	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358433114 rs1178623878	691	M>L		No	ClinGen gnomAD
CA3101168 rs760016722	691	M>T		No	ClinGen ExAC gnomAD
CA3101231 rs142698829	692	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA358434801 rs1347433895	693	T>M		No	ClinGen gnomAD
CA358434842 rs1456546017	699	G>E		No	ClinGen gnomAD
CA107798865 rs142630958	701	I>T		No	ClinGen ESP
CA3101233 rs760668190	702	F>L		No	ClinGen ExAC TOPMed gnomAD
rs763985308 CA3101234	703	C>S		No	ClinGen ExAC gnomAD
rs910436543 CA107798887	704	S>C		No	ClinGen TOPMed
rs1432905636 CA358434879	705	K>E		No	ClinGen gnomAD
CA3101235 rs776051241	707	C>G		No	ClinGen ExAC
CA3101236 rs761420593	708	Q>E		No	ClinGen ExAC gnomAD
rs200028284 CA358434923	710	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757973684 CA3101239	711	G>S		No	ClinGen ExAC gnomAD
rs751945233 CA3101241	712	R>K		No	ClinGen ExAC gnomAD
rs1333223286 CA358434933	712	R>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358434937 rs1400965746	713	P>S		No	ClinGen gnomAD
rs1332656505 CA358434982	719	S>F		No	ClinGen gnomAD
CA3101243 rs781770815	720	P>L		No	ClinGen ExAC gnomAD
rs1170827110 CA358434985	720	P>S		No	ClinGen TOPMed
CA358434995 rs1277879401	722	P>A		No	ClinGen gnomAD
CA107798905 rs1022120629	722	P>L		No	ClinGen Ensembl
rs1316071326 CA358435001	723	P>A		No	ClinGen gnomAD
CA3101244 rs753102549	724	S>L		No	ClinGen ExAC gnomAD
rs1580818227 CA358435014	725	V>G		No	ClinGen Ensembl
CA358435027 rs1488423524	727	E>V		No	ClinGen gnomAD
rs1390151274 CA358435050	730	V>A		No	ClinGen TOPMed
CA358435055 rs377590399	731	P>H		No	ClinGen gnomAD
CA107798943 rs377590399	731	P>L		No	ClinGen gnomAD
rs1452620301 CA358435061	732	G>E		No	ClinGen gnomAD
CA358435060 rs1452620301	732	G>V		No	ClinGen gnomAD
CA3101246 rs777652680	735	V>I		No	ClinGen ExAC TOPMed gnomAD
CA3101247 rs777652680	735	V>L		No	ClinGen ExAC TOPMed gnomAD
rs370021286 CA3101249	736	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370593066 CA107798975	739	T>A		No	ClinGen ExAC TOPMed gnomAD
CA3101251 rs370593066	739	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1387140628 CA358435109	741	P>A		No	ClinGen gnomAD
CA358435113 rs1297756201	741	P>L		No	ClinGen gnomAD
CA358435120 rs1278899209	742	E>D		No	ClinGen TOPMed gnomAD
CA358435118 rs1220738285	742	E>G		No	ClinGen gnomAD
CA358435116 rs1273904939	742	E>Q		No	ClinGen TOPMed
TCGA novel	743	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358435131 rs1243247991	744	P>H		No	ClinGen gnomAD
rs1321258605 CA358435130	744	P>T		No	ClinGen gnomAD
rs1301296124 CA3101256	745	T>A		No	ClinGen TOPMed
rs772597355 CA3101259	745	T>I		No	ClinGen ExAC TOPMed gnomAD
CA3101255 rs1301296124	745	T>P		No	ClinGen TOPMed
rs1309442590 CA358435141	746	P>L		No	ClinGen TOPMed
CA358435142 rs1309442590	746	P>R		No	ClinGen TOPMed
CA3101261 rs766110308	747	H>D		No	ClinGen ExAC gnomAD
CA358435144 rs1167273207	747	H>P		No	ClinGen TOPMed
rs751255369	747	H>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA3101262 rs766110308	747	H>Y		No	ClinGen ExAC gnomAD
CA107799083 rs386680717	748	P>C		No	ClinGen Ensembl
CA358435151 rs13152820	748	P>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA358435152 rs13152820	748	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3101264 rs13152820	748	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs13152819 CA3101263	748	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs13152819 CA358435149	748	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753258438 CA358435154	749	P>S		No	ClinGen ExAC gnomAD
CA3101266 rs753258438	749	P>T		No	ClinGen ExAC gnomAD
CA358435163 rs1370132403	750	P>L		No	ClinGen gnomAD
rs1162518896 CA358435160	750	P>S		No	ClinGen TOPMed gnomAD
CA358435158 rs1162518896	750	P>T		No	ClinGen TOPMed gnomAD
CA3101269 rs777975269	751	A>P		No	ClinGen ExAC TOPMed gnomAD
rs777975269 CA3101268	751	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757522903 CA3101270	751	A>V		No	ClinGen ExAC
CA358435170 rs1402065541	752	A>D		No	ClinGen gnomAD
CA358435167 rs1358443701	752	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3101272 rs557878793	753	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA107799151 rs780837468	754	G>D		No	ClinGen ExAC TOPMed gnomAD
rs780837468 CA3101274	754	G>V		No	ClinGen ExAC TOPMed gnomAD
CA107799153 rs752871470	755	G>A		No	ClinGen gnomAD
CA358435186 rs752871470	755	G>D		No	ClinGen gnomAD
rs1322888854 CA358435182	755	G>S		No	ClinGen gnomAD
rs888633138 CA358435194	756	E>D		No	ClinGen TOPMed gnomAD
rs748184128 CA3101275	757	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1356358177 CA358435196	757	R>W		No	ClinGen gnomAD
rs772831263 CA358435199	758	A>P		No	ClinGen ExAC TOPMed gnomAD
rs772831263 CA3101277	758	A>S		No	ClinGen ExAC TOPMed gnomAD
CA358435207 rs1179628371	759	G>E		No	ClinGen gnomAD
CA358435223 rs1448672358	761	W>C		No	ClinGen Ensembl
rs1350274434 CA358435217	761	W>R		No	ClinGen TOPMed
rs770526942 CA3101279	762	R>C		No	ClinGen ExAC TOPMed gnomAD
rs774147910 CA3101280	762	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1005681484 CA107799210	763	R>C		No	ClinGen TOPMed gnomAD
COSM1203130 rs1421294372 COSM1203129 CA358435231	763	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs759203165 CA3101281	765	R>*		No	ClinGen ExAC gnomAD
TCGA novel	765	R>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468352901 CA358435247	766	D>H		No	ClinGen TOPMed

No associated diseases with Q8N568

5 regional properties for Q8N568

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	394 - 651	IPR000719
domain	Doublecortin domain	67 - 158	IPR003533-1
domain	Doublecortin domain	192 - 280	IPR003533-2
active_site	Serine/threonine-protein kinase, active site	511 - 523	IPR008271
binding_site	Protein kinase, ATP binding site	400 - 423	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm, cytoskeleton	Colocalizes with microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name	Definition
hippocampus development	The progression of the hippocampus over time from its initial formation until its mature state.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
negative regulation of protein localization to nucleus	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein localization to nucleus	A process in which a protein transports or maintains the localization of another protein to the nucleus.
pyramidal neuron development	The progression of a pyramidal neuron from its initial formation to its mature state.

99 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A4IFM7	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Bos taurus (Bovine)	SS
Q0V7M1	PSKH1	Serine/threonine-protein kinase H1	Bos taurus (Bovine)	SS
Q0VD22	STK33	Serine/threonine-protein kinase 33	Bos taurus (Bovine)	PR
Q96NX5	CAMK1G	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (Human)	SS
Q14012	CAMK1	Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (Human)	EV
Q9UIK4	DAPK2	Death-associated protein kinase 2	Homo sapiens (Human)	EV
O94768	STK17B	Serine/threonine-protein kinase 17B	Homo sapiens (Human)	PR
Q86YV6	MYLK4	Myosin light chain kinase family member 4	Homo sapiens (Human)	SS
Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (Human)	SS
P11801	PSKH1	Serine/threonine-protein kinase H1	Homo sapiens (Human)	SS
Q9UEE5	STK17A	Serine/threonine-protein kinase 17A	Homo sapiens (Human)	SS
O75962	TRIO	Triple functional domain protein	Homo sapiens (Human)	EV
Q9H1R3	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (Human)	EV
Q32MK0	MYLK3	Myosin light chain kinase 3	Homo sapiens (Human)	SS
Q8WWF8	CAPSL	Calcyphosin-like protein	Homo sapiens (Human)	PR
P53355	DAPK1	Death-associated protein kinase 1	Homo sapiens (Human)	EV
Q6P2M8	PNCK	Calcium/calmodulin-dependent protein kinase type 1B	Homo sapiens (Human)	SS
Q9BYT3	STK33	Serine/threonine-protein kinase 33	Homo sapiens (Human)	PR
Q8NCB2	CAMKV	CaM kinase-like vesicle-associated protein	Homo sapiens (Human)	SS
O43293	DAPK3	Death-associated protein kinase 3	Homo sapiens (Human)	PR
Q8IU85	CAMK1D	Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (Human)	SS
O15075	DCLK1	Serine/threonine-protein kinase DCLK1	Homo sapiens (Human)	EV
Q9QYK9	Pnck	Calcium/calmodulin-dependent protein kinase type 1B	Mus musculus (Mouse)	PR
Q91VB2	Camk1g	Calcium/calmodulin-dependent protein kinase type 1G	Mus musculus (Mouse)	SS
Q8BG48	Stk17b	Serine/threonine-protein kinase 17B	Mus musculus (Mouse)	PR
Q8VCR8	Mylk2	Myosin light chain kinase 2, skeletal/cardiac muscle	Mus musculus (Mouse)	SS
Q91YS8	Camk1	Calcium/calmodulin-dependent protein kinase type 1	Mus musculus (Mouse)	SS
Q3UIZ8	Mylk3	Myosin light chain kinase 3	Mus musculus (Mouse)	SS
Q8VDF3	Dapk2	Death-associated protein kinase 2	Mus musculus (Mouse)	EV
Q6P8Y1	Capsl	Calcyphosin-like protein	Mus musculus (Mouse)	PR
Q8BW96	Camk1d	Calcium/calmodulin-dependent protein kinase type 1D	Mus musculus (Mouse)	SS
Q3UHL1	Camkv	CaM kinase-like vesicle-associated protein	Mus musculus (Mouse)	SS
P08414	Camk4	Calcium/calmodulin-dependent protein kinase type IV	Mus musculus (Mouse)	SS
Q91YA2	Pskh1	Serine/threonine-protein kinase H1	Mus musculus (Mouse)	SS
Q80YE7	Dapk1	Death-associated protein kinase 1	Mus musculus (Mouse)	SS
Q62407	Speg	Striated muscle-specific serine/threonine-protein kinase	Mus musculus (Mouse)	SS
Q0KL02	Trio	Triple functional domain protein	Mus musculus (Mouse)	SS
Q924X7	Stk33	Serine/threonine-protein kinase 33	Mus musculus (Mouse)	PR
O54784	Dapk3	Death-associated protein kinase 3	Mus musculus (Mouse)	PR
Q9JLM8	Dclk1	Serine/threonine-protein kinase DCLK1	Mus musculus (Mouse)	SS
Q6PGN3	Dclk2	Serine/threonine-protein kinase DCLK2	Mus musculus (Mouse)	PR
Q7TNJ7	Camk1g	Calcium/calmodulin-dependent protein kinase type 1G	Rattus norvegicus (Rat)	SS
P20689	Mylk2	Myosin light chain kinase 2, skeletal/cardiac muscle	Rattus norvegicus (Rat)	SS
F1M0Z1	Trio	Triple functional domain protein	Rattus norvegicus (Rat)	SS
Q91XS8	Stk17b	Serine/threonine-protein kinase 17B	Rattus norvegicus (Rat)	PR
O08875	Dclk1	Serine/threonine-protein kinase DCLK1	Rattus norvegicus (Rat)	PR
E9PT87	Mylk3	Myosin light chain kinase 3	Rattus norvegicus (Rat)	SS
O70150	Pnck	Calcium/calmodulin-dependent protein kinase type 1B	Rattus norvegicus (Rat)	PR
Q63092	Camkv	CaM kinase-like vesicle-associated protein	Rattus norvegicus (Rat)	SS
Q63638	Speg	Striated muscle-specific serine/threonine-protein kinase	Rattus norvegicus (Rat)	SS
O88764	Dapk3	Death-associated protein kinase 3	Rattus norvegicus (Rat)	PR
P13234	Camk4	Calcium/calmodulin-dependent protein kinase type IV	Rattus norvegicus (Rat)	SS
Q63450	Camk1	Calcium/calmodulin-dependent protein kinase type 1	Rattus norvegicus (Rat)	EV
P97924	Kalrn	Kalirin	Rattus norvegicus (Rat)	SS
Q5MPA9	Dclk2	Serine/threonine-protein kinase DCLK2	Rattus norvegicus (Rat)	PR
Q5VQQ5	CPK2	Calcium-dependent protein kinase 2	Oryza sativa subsp. japonica (Rice)	SS
Q8LPZ7	CPK3	Calcium-dependent protein kinase 3	Oryza sativa subsp. japonica (Rice)	SS
Q6K968	CPK6	Calcium-dependent protein kinase 6	Oryza sativa subsp. japonica (Rice)	SS
P53684	CPK7	Calcium-dependent protein kinase 7	Oryza sativa subsp japonica (Rice)	PR
Q75GE8	CPK8	Calcium-dependent protein kinase 8	Oryza sativa subsp. japonica (Rice)	SS
Q6I5I8	CPK16	Calcium-dependent protein kinase 16	Oryza sativa subsp. japonica (Rice)	SS
Q6AVM3	CCAMK	Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase	Oryza sativa subsp japonica (Rice)	PR
Q84SL0	CPK20	Calcium-dependent protein kinase 20	Oryza sativa subsp. japonica (Rice)	SS
P53682	CPK23	Calcium-dependent protein kinase 23	Oryza sativa subsp japonica (Rice)	PR
Q9TXJ0	cmk-1	Calcium/calmodulin-dependent protein kinase type 1	Caenorhabditis elegans	PR
O44997	dapk-1	Death-associated protein kinase dapk-1	Caenorhabditis elegans	SS
Q95QC4	zyg-8	Serine/threonine-protein kinase zyg-8	Caenorhabditis elegans	PR
P28583		Calcium-dependent protein kinase SK5	Glycine max (Soybean) (Glycine hispida)	PR
Q9M9V8	CPK10	Calcium-dependent protein kinase 10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q39016	CPK11	Calcium-dependent protein kinase 11	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FX86	CRK8	CDPK-related kinase 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SSF8	CPK30	Calcium-dependent protein kinase 30	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38872	CPK6	Calcium-dependent protein kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q7XJR9	CPK16	Calcium-dependent protein kinase 16	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIQ7	CPK24	Calcium-dependent protein kinase 24	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SJ61	CPK25	Calcium-dependent protein kinase 25	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZV15	CPK20	Calcium-dependent protein kinase 20	Arabidopsis thaliana (Mouse-ear cress)	PR
P93759	GK-1	Calcium-dependent protein kinase 14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8S8S2	LPEAT2	Lysophospholipid acyltransferase LPEAT2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38870	CPK2	Calcium-dependent protein kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LJL9	CRK2	CDPK-related kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SG12	CRK6	CDPK-related kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SCS2	CRK5	CDPK-related kinase 5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W4I7	CPK13	Calcium-dependent protein kinase 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NLQ6	CPK32	Calcium-dependent protein kinase 32	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZSA4	CPK27	Calcium-dependent protein kinase 27	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38869	CPK4	Calcium-dependent protein kinase 4	Arabidopsis thaliana (Mouse-ear cress)	SS
Q42479	CPK3	Calcium-dependent protein kinase 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q1PE17	CPK18	Calcium-dependent protein kinase 18	Arabidopsis thaliana (Mouse-ear cress)	SS
Q06850	CPK1	Calcium-dependent protein kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FMP5	CPK17	Calcium-dependent protein kinase 17	Arabidopsis thaliana (Mouse-ear cress)	PR
Q38873	CPK7	Calcium-dependent protein kinase 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q3E9C0	CPK34	Calcium-dependent protein kinase 34	Arabidopsis thaliana (Mouse-ear cress)	PR
Q42438	CPK8	Calcium-dependent protein kinase 8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q42396	CPK12	Calcium-dependent protein kinase 12	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FKW4	CPK28	Calcium-dependent protein kinase 28	Arabidopsis thaliana (Mouse-ear cress)	SS
Q1LUA6	trio	Triple functional domain protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A8C984	mylk3	Myosin light chain kinase 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q7SY49	camkv	CaM kinase-like vesicle-associated protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MASTRSIELE	HFEERDKRPR	PGSRRGAPSS	SGGSSSSGPK	GNGLIPSPAH	SAHCSFYRTR
70	80	90	100	110	120
TLQALSSEKK	AKKARFYRNG	DRYFKGLVFA	ISSDRFRSFD	ALLIELTRSL	SDNVNLPQGV
130	140	150	160	170	180
RTIYTIDGSR	KVTSLDELLE	GESYVCASNE	PFRKVDYTKN	INPNWSVNIK	GGTSRALAAA
190	200	210	220	230	240
SSVKSEVKES	KDFIKPKLVT	VIRSGVKPRK	AVRILLNKKT	AHSFEQVLTD	ITEAIKLDSG
250	260	270	280	290	300
VVKRLCTLDG	KQVTCLQDFF	GDDDVFIACG	PEKFRYAQDD	FVLDHSECRV	LKSSYSRSSA
310	320	330	340	350	360
VKYSGSKSPG	PSRRSKSPAS	VNGTPSSQLS	TPKSTKSSSS	SPTSPGSFRG	LKQISAHGRS
370	380	390	400	410	420
SSNVNGGPEL	DRCISPEGVN	GNRCSESSTL	LEKYKIGKVI	GDGNFAVVKE	CIDRSTGKEF
430	440	450	460	470	480
ALKIIDKAKC	CGKEHLIENE	VSILRRVKHP	NIIMLVEEME	TATELFLVME	LVKGGDLFDA
490	500	510	520	530	540
ITSSTKYTER	DGSAMVYNLA	NALRYLHGLS	IVHRDIKPEN	LLVCEYPDGT	KSLKLGDFGL
550	560	570	580	590	600
ATVVEGPLYT	VCGTPTYVAP	EIIAETGYGL	KVDIWAAGVI	TYILLCGFPP	FRSENNLQED
610	620	630	640	650	660
LFDQILAGKL	EFPAPYWDNI	TDSAKELISQ	MLQVNVEARC	TAGQILSHPW	VSDDASQENN
670	680	690	700	710	720
MQAEVTGKLK	QHFNNALPKQ	NSTTTGVSVI	MNTALDKEGQ	IFCSKHCQDS	GRPGMEPISP
730	740	750	760
VPPSVEEIPV	PGEAVPAPTP	PESPTPHPPP	AAPGGERAGT	WRRHRD