Q8LA13
Gene name |
RH11 (At3g58510, F14P22.100) |
Protein name |
DEAD-box ATP-dependent RNA helicase 11 |
Names |
EC 3.6.4.13 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G58510 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
175-354 (DEAD box helicase domain) |
Relief mechanism |
|
Assay |
|
Target domain |
377-542 (C-terminal helicase domain) |
Relief mechanism |
|
Assay |
|
Target domain |
175-354 (DEAD box helicase domain);377-542 (C-terminal helicase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Floor SN et al. (2016) "Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3", The Journal of biological chemistry, 291, 2412-21
- Zhang ZM et al. (2013) "Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly", Cell reports, 5, 1269-78
Autoinhibited structure
Activated structure
1 structures for Q8LA13
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LA13-F1 | Predicted | AlphaFoldDB |
24 variants for Q8LA13
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14451597 | 6 | A>E | No | 1000Genomes | |
| tmp_3_21640639_C_T | 11 | S>L | No | 1000Genomes | |
| ENSVATH06338668 | 15 | V>G | No | 1000Genomes | |
| ENSVATH06338670 | 17 | Q>K | No | 1000Genomes | |
| ENSVATH02521990 | 31 | P>L | No | 1000Genomes | |
| tmp_3_21640698_C_T | 31 | P>S | No | 1000Genomes | |
| ENSVATH06338672 | 48 | G>C | No | 1000Genomes | |
| tmp_3_21640819_A_G | 71 | Y>C | No | 1000Genomes | |
| ENSVATH00426243 | 78 | T>P | No | 1000Genomes | |
| ENSVATH02521991 | 79 | G>A | No | 1000Genomes | |
| ENSVATH06338675 | 148 | P>H | No | 1000Genomes | |
| ENSVATH00426245 | 188 | E>Q | No | 1000Genomes | |
| tmp_3_21641265_G_T | 220 | E>* | No | 1000Genomes | |
| tmp_3_21642101_G_C | 338 | V>L | No | 1000Genomes | |
| ENSVATH02522004 | 488 | D>E | No | 1000Genomes | |
| tmp_3_21643180_C_G | 519 | L>V | No | 1000Genomes | |
| tmp_3_21643190_C_T | 522 | S>L | No | 1000Genomes | |
| tmp_3_21643209_A_C | 528 | Q>H | No | 1000Genomes | |
| ENSVATH12821461 | 535 | P>L | No | 1000Genomes | |
| ENSVATH06338694 | 545 | A>S | No | 1000Genomes | |
| tmp_3_21643352_G_A | 576 | G>D | No | 1000Genomes | |
| ENSVATH06338696 | 577 | G>S | No | 1000Genomes | |
| tmp_3_21643366_G_A | 581 | G>S | No | 1000Genomes | |
| ENSVATH12821505 | 603 | Y>C | No | 1000Genomes |
No associated diseases with Q8LA13
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5W5U4 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Bos taurus (Bovine) | SS |
| Q6GVM6 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Pan troglodytes (Chimpanzee) | SS |
| O15523 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Homo sapiens (Human) | SS |
| Q9NQI0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Homo sapiens (Human) | SS |
| O00571 | DDX3X | ATP-dependent RNA helicase DDX3X | Homo sapiens (Human) | EV |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q6GWX0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Sus scrofa (Pig) | SS |
| Q2R1M8 | Os11g0599500 | DEAD-box ATP-dependent RNA helicase 52C | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z4K6 | PL10B | DEAD-box ATP-dependent RNA helicase 52B | Oryza sativa subsp. japonica (Rice) | SS |
| Q75HJ0 | PL10A | DEAD-box ATP-dependent RNA helicase 37 | Oryza sativa subsp. japonica (Rice) | SS |
| O01836 | glh-3 | ATP-dependent RNA helicase glh-3 | Caenorhabditis elegans | PR |
| D0PV95 | laf-1 | ATP-dependent RNA helicase laf-1 | Caenorhabditis elegans | SS |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZG7 | RH38 | DEAD-box ATP-dependent RNA helicase 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZB4 | RH43 | Putative DEAD-box ATP-dependent RNA helicase 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU46 | RH35 | DEAD-box ATP-dependent RNA helicase 35 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ92 | RH44 | Putative DEAD-box ATP-dependent RNA helicase 44 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASWADVAD | SEKAVSQSKP | PYVPPHLRNR | PSEPVAAPLP | QNDHAGYGGQ | PAGSRWAPPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGGGGASGGG | YRNDGGRTGY | GYGAGGGGGG | GGGWNNRSGG | WDRREREVNP | FGDDAELEPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FTEQENTGIN | FDAYEDIPVE | TSGGDVPPPV | NTFADIDLGD | ALNLNIRRCK | YVRPTPVQRH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AIPILLAERD | LMACAQTGSG | KTAAFCFPII | SGIMKDQHVE | RPRGSRAVYP | FAVILSPTRE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LACQIHDEAK | KFSYQTGVKV | VVAYGGTPIH | QQLRELERGC | DILVATPGRL | NDLLERARVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MQMIRFLALD | EADRMLDMGF | EPQIRKIVEQ | MDMPPRGVRQ | TMLFSATFPS | QIQRLAADFM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNYIFLAVGR | VGSSTDLITQ | RVEFVQESDK | RSHLMDLLHA | QRETQDKQSL | TLVFVETKRG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ADTLENWLCM | NEFPATSIHG | DRTQQEREVA | LRSFKTGRTP | ILVATDVAAR | GLDIPHVAHV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNFDLPNDID | DYVHRIGRTG | RAGKSGIATA | FFNENNAQLA | RSLAELMQEA | NQEVPEWLTR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YASRASFGGG | KKRSGGRFGG | RDFRREGSYS | RGGGGGGGGG | GSDYYGGGGY | GGGGYGGAPS |
| 610 | |||||
| GGYGAGVTSA | WD |