Q8L7R3
PR
Gene name |
LPEAT1 |
Protein name |
Lysophospholipid acyltransferase LPEAT1 |
Names |
Lysophosphatidylethanolamine acyltransferase 1, AtLPEAT1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G80950 |
EC number |
2.3.1.23: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8L7R3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8L7R3-F1 | Predicted | AlphaFoldDB |
21 variants for Q8L7R3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05181733 | 12 | S>W | No | 1000Genomes | |
| ENSVATH14497615 | 15 | P>R | No | 1000Genomes | |
| ENSVATH14497613 | 34 | I>N | No | 1000Genomes | |
| tmp_1_30414781_G_A | 52 | T>M | No | 1000Genomes | |
| tmp_1_30414758_T_C | 60 | M>V | No | 1000Genomes | |
| ENSVATH13847383 | 86 | L>V | No | 1000Genomes | |
| tmp_1_30414578_A_G | 120 | Y>H | No | 1000Genomes | |
| tmp_1_30414529_C_T | 136 | R>K | No | 1000Genomes | |
| ENSVATH13847382 | 138 | L>I | No | 1000Genomes | |
| tmp_1_30414506_A_C | 144 | F>V | No | 1000Genomes | |
| ENSVATH14497610 | 160 | S>A | No | 1000Genomes | |
| ENSVATH13847380 | 164 | S>Y | No | 1000Genomes | |
| tmp_1_30414061_C_T | 180 | A>T | No | 1000Genomes | |
| ENSVATH05181723 | 250 | T>I | No | 1000Genomes | |
| ENSVATH01564064 | 327 | V>F | No | 1000Genomes | |
| tmp_1_30412965_C_T | 328 | V>I | No | 1000Genomes | |
| ENSVATH07699956 | 330 | H>R | No | 1000Genomes | |
| tmp_1_30412944_G_A | 335 | R>W | No | 1000Genomes | |
| ENSVATH05181720 | 338 | V>A | No | 1000Genomes | |
| tmp_1_30412895_A_C | 351 | L>R | No | 1000Genomes | |
| ENSVATH14497605 | 391 | R>C | No | 1000Genomes |
No associated diseases with Q8L7R3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.23 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| 1-acylglycerophosphoethanolamine O-acyltransferase activity | Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA. |
| 1-acylglycerophosphoserine O-acyltransferase activity | Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA. |
| 1-alkenylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. |
| lysophosphatidic acid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. |
| lysophosphatidylethanolamine acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine. |
| lysophospholipid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. |
| plasmalogen synthase activity | Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
| phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| very long-chain fatty acid metabolic process | The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NF37 | LPCAT1 | Lysophosphatidylcholine acyltransferase 1 | Homo sapiens (Human) | PR |
| Q6NVG1 | Lpcat4 | Lysophospholipid acyltransferase LPCAT4 | Mus musculus (Mouse) | PR |
| Q3TFD2 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Mus musculus (Mouse) | PR |
| Q1HAQ0 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1LWG4 | lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESELKDLNS | NSNPPSSKED | RPLLKSESDL | AAAIEELDKK | FAPYARTDLY | GTMGLGPFPM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TENIKLAVAL | VTLVPLRFLL | SMSILLLYYL | ICRVFTLFSA | PYRGPEEEED | EGGVVFQEDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AHMEGWKRTV | IVRSGRFLSR | VLLFVFGFYW | IHESCPDRDS | DMDSNPKTTS | TEINQKGEAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TEEPERPGAI | VSNHVSYLDI | LYHMSASFPS | FVAKRSVGKL | PLVGLISKCL | GCVYVQREAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPDFKGVSGT | VNERVREAHS | NKSAPTIMLF | PEGTTTNGDY | LLTFKTGAFL | AGTPVLPVIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KYPYERFSVA | WDTISGARHI | LFLLCQVVNH | LEVIRLPVYY | PSQEEKDDPK | LYASNVRKLM |
| 370 | 380 | 390 | |||
| ATEGNLILSE | LGLSDKRIYH | ATLNGNLSQT | RDFHQKEE |