Q8L7Q7
SS
Gene name |
PME64 (ARATH64, At5g64640, MUB3.16) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 64 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G64640 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
288-595 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q8L7Q7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8L7Q7-F1 | Predicted | AlphaFoldDB |
47 variants for Q8L7Q7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_25836889_A_C | 24 | K>Q | No | 1000Genomes | |
| ENSVATH03474446 | 53 | L>V | No | 1000Genomes | |
| ENSVATH03474447 | 82 | E>K | No | 1000Genomes | |
| ENSVATH14648072 | 83 | T>K | No | 1000Genomes | |
| tmp_5_25837133_A_C | 105 | H>P | No | 1000Genomes | |
| ENSVATH12928863 | 117 | P>L | No | 1000Genomes | |
| ENSVATH07478732 | 143 | K>Q | No | 1000Genomes | |
| tmp_5_25837315_G_A | 166 | E>K | No | 1000Genomes | |
| tmp_5_25837334_A_T | 172 | Q>L | No | 1000Genomes | |
| tmp_5_25837340_G_A | 174 | R>H | No | 1000Genomes | |
| tmp_5_25837346_A_C | 176 | E>A | No | 1000Genomes | |
| tmp_5_25837358_T_G | 180 | I>R | No | 1000Genomes | |
| ENSVATH12928875 | 205 | W>R | No | 1000Genomes | |
| ENSVATH03474449 | 213 | D>E | No | 1000Genomes | |
| tmp_5_25837460_C_G | 214 | T>S | No | 1000Genomes | |
| ENSVATH03474450 | 215 | K>N | No | 1000Genomes | |
| ENSVATH07478733 | 226 | G>D | No | 1000Genomes | |
| tmp_5_25837567_T_A | 250 | S>T | No | 1000Genomes | |
| tmp_5_25837656_G_T | 279 | L>F | No | 1000Genomes | |
| ENSVATH00751369 | 286 | T>M | No | 1000Genomes | |
| ENSVATH14648073 | 289 | V>M | No | 1000Genomes | |
| ENSVATH03474453 | 316 | R>G | No | 1000Genomes | |
| ENSVATH07478735 | 328 | V>L | No | 1000Genomes | |
| ENSVATH00751370 | 335 | V>I | No | 1000Genomes | |
| tmp_5_25837876_G_T | 353 | V>L | No | 1000Genomes | |
| tmp_5_25837895_A_G | 359 | N>S | No | 1000Genomes | |
| tmp_5_25837906_C_T | 363 | P>S | No | 1000Genomes | |
| tmp_5_25838388_G_A | 382 | A>T | No | 1000Genomes | |
| tmp_5_25838391_C_T | 383 | R>C | No | 1000Genomes | |
| ENSVATH03474468 | 384 | D>H | No | 1000Genomes | |
| ENSVATH14648077 | 393 | A>T | No | 1000Genomes | |
| ENSVATH00751374 | 396 | H>Y | No | 1000Genomes | |
| ENSVATH03474469 | 401 | F>I | No | 1000Genomes | |
| ENSVATH12928887 | 459 | A>D | No | 1000Genomes | |
| tmp_5_25838622_T_C | 460 | S>P | No | 1000Genomes | |
| ENSVATH07478741 | 463 | S>Y | No | 1000Genomes | |
| tmp_5_25838645_A_C | 467 | Q>H | No | 1000Genomes | |
| tmp_5_25838670_G_A | 476 | A>T | No | 1000Genomes | |
| ENSVATH03474470 | 494 | S>L | No | 1000Genomes | |
| tmp_5_25838760_C_G | 506 | Q>E | No | 1000Genomes | |
| ENSVATH00751376 | 511 | G>R | No | 1000Genomes | |
| tmp_5_25838934_C_A | 564 | P>T | No | 1000Genomes | |
| tmp_5_25838955_A_T | 571 | R>W | No | 1000Genomes | |
| ENSVATH00751377 | 573 | P>S | No | 1000Genomes | |
| ENSVATH14648078 | 579 | P>L | No | 1000Genomes | |
| ENSVATH12928888 | 598 | A>P | No | 1000Genomes | |
| ENSVATH03474471 | 598 | A>V | No | 1000Genomes |
No associated diseases with Q8L7Q7
13 regional properties for Q8L7Q7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 52 - 172 | IPR000494-1 |
| domain | Receptor L-domain | 367 - 485 | IPR000494-2 |
| domain | Protein kinase domain | 721 - 988 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 723 - 976 | IPR001245 |
| domain | Furin-like cysteine-rich domain | 191 - 344 | IPR006211 |
| repeat | Furin-like repeat | 190 - 231 | IPR006212-1 |
| repeat | Furin-like repeat | 233 - 281 | IPR006212-2 |
| repeat | Furin-like repeat | 502 - 551 | IPR006212-3 |
| repeat | Furin-like repeat | 558 - 608 | IPR006212-4 |
| active_site | Tyrosine-protein kinase, active site | 842 - 854 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 727 - 754 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 721 - 977 | IPR020635 |
| domain | Growth factor receptor domain 4 | 511 - 643 | IPR032778 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| defense response by callose deposition | Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSPTLPHSI | SASSSTPFAS | AAVKPHRNKL | LSRNGILIII | AASCILLLLI | SLLIYATVSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSRNHHNPSH | QTPTSDDHPP | PETPPSPPPI | AQIRLACNAT | RFPDHCVASL | SKPGQVPPDP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPVQIIHSAI | SVSYENLKSG | QSKIQSILDS | SAGNRNRTNI | ATICLEILSY | SQHRTESTDI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVTSGDIKDA | RAWMSAALAY | QFDCWSGLKT | VNDTKQVVDT | ITFFEGLVNL | TGNALSMMLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FDSFGDDVVS | WIRPATERDG | FWEKAGPSLG | SGTGTEASLG | FPSGLTEDVT | VCKNGGKDCK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKTVQEAVDS | APDTNRTVKF | VIRIREGVYE | ETVRVPFEKK | NVVFIGDGMG | KTVITGSLNV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GQPGMTTFES | ATVGVLGDGF | MARDLTIENT | AGADAHQAVA | FRSDSDFSVL | ENCEFLGNQD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TLYAHSLRQF | YKQCRIQGNV | DFIFGNSAAV | FQDCDILIAS | KHSKLEQGGA | NNAITAHGRI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DASQSTGFVF | LNCSINGTEE | YMKEFQANPE | GHKNFLGRPW | KEFSRTVFVN | CNLESLISPD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GWMPWNGDFA | LKTLYYGEYK | NTGPGSVRSS | RVPWSSEIPE | KHVDVYSVAN | FIQADEWAST |
| TA |