Q8L7H4

PR
Gene name
HDG4
Protein name
Homeobox-leucine zipper protein HDG4
Names
HD-ZIP protein HDG4, Homeodomain GLABRA 2-like protein 4, Homeodomain transcription factor HDG4, Protein HOMEODOMAIN GLABROUS 4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G17710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-255 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8L7H4

Entry ID Method Resolution Chain Position Source
AF-Q8L7H4-F1 Predicted AlphaFoldDB

136 variants for Q8L7H4

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_9859281_G_T 3 T>K No 1000Genomes
ENSVATH06706640 9 K>N No 1000Genomes
ENSVATH00517560 15 N>K No 1000Genomes
tmp_4_9859209_G_A 27 P>L No 1000Genomes
ENSVATH14239727 31 I>T No 1000Genomes
ENSVATH00517559 65 G>D No 1000Genomes
ENSVATH11941836 69 G>R No 1000Genomes
ENSVATH00517558 74 P>L No 1000Genomes
tmp_4_9858979_T_C 76 E>G No 1000Genomes
ENSVATH11941794 83 E>K No 1000Genomes
ENSVATH00517557 86 A>V No 1000Genomes
ENSVATH00517556 92 Y>C No 1000Genomes
ENSVATH06706629 97 A>T No 1000Genomes
ENSVATH06706627 101 Q>R No 1000Genomes
tmp_4_9858779_A_C 107 F>C No 1000Genomes
ENSVATH06706625 115 T>S No 1000Genomes
tmp_4_9858750_T_C 117 T>A No 1000Genomes
ENSVATH00517555 117 T>K No 1000Genomes
ENSVATH06706624 122 S>G No 1000Genomes
ENSVATH02868177 124 K>N No 1000Genomes
tmp_4_9858713_G_T 129 P>Q No 1000Genomes
ENSVATH06706617 150 S>C No 1000Genomes
ENSVATH14239672 150 S>I No 1000Genomes
tmp_4_9858499_A_C 151 D>E No 1000Genomes
ENSVATH06706615 161 T>N No 1000Genomes
ENSVATH00517552 164 T>A No 1000Genomes
ENSVATH00517551 167 Q>L No 1000Genomes
ENSVATH00517551 167 Q>R No 1000Genomes
ENSVATH02868175 169 I>L No 1000Genomes
ENSVATH00517550 170 Q>H No 1000Genomes
ENSVATH02868174 171 S>T No 1000Genomes
ENSVATH02868173 173 F>L No 1000Genomes
tmp_4_9858429_A_T 175 C>S No 1000Genomes
ENSVATH02868172 175 C>Y No 1000Genomes
ENSVATH02868170 177 F>S No 1000Genomes
ENSVATH00517549 184 N>D No 1000Genomes
ENSVATH11941785 190 A>D No 1000Genomes
tmp_4_9858380_C_T 191 R>H No 1000Genomes
ENSVATH06706607 196 L>F No 1000Genomes
ENSVATH06706606 202 I>T No 1000Genomes
ENSVATH06706605 207 N>Y No 1000Genomes
ENSVATH06706603 210 P>S No 1000Genomes
ENSVATH00517546 213 E>D No 1000Genomes
tmp_4_9858230_G_T 216 P>T No 1000Genomes
ENSVATH06706602 217 E>D No 1000Genomes
ENSVATH00517545 218 T>S No 1000Genomes
ENSVATH06706601 223 N>D No 1000Genomes
tmp_4_9858207_G_T 223 N>K No 1000Genomes
ENSVATH06706600 224 D>N No 1000Genomes
ENSVATH02868168 228 I>T No 1000Genomes
ENSVATH06706599 230 E>D No 1000Genomes
tmp_4_9858184_T_G 231 E>A No 1000Genomes
ENSVATH06706598 231 E>K No 1000Genomes
ENSVATH06706597 236 D>A No 1000Genomes
ENSVATH00517544 237 M>I No 1000Genomes
tmp_4_9858157_G_T 240 A>E No 1000Genomes
ENSVATH06706594 245 R>Q No 1000Genomes
ENSVATH06706593 247 L>I No 1000Genomes
ENSVATH06706592 259 N>S No 1000Genomes
tmp_4_9858091_C_G 262 R>T No 1000Genomes
tmp_4_9858078_C_G 266 E>D No 1000Genomes
ENSVATH11941684 280 L>I No 1000Genomes
ENSVATH06706588 283 L>P No 1000Genomes
ENSVATH00517542 285 N>T No 1000Genomes
ENSVATH00517541 292 R>K No 1000Genomes
ENSVATH06706587 293 E>V No 1000Genomes
ENSVATH02868167 300 V>A No 1000Genomes
tmp_4_9857978_C_T 300 V>I No 1000Genomes
tmp_4_9857954_G_C 308 L>V No 1000Genomes
ENSVATH06706586 311 A>S No 1000Genomes
ENSVATH06706585 312 F>S No 1000Genomes
ENSVATH00517539 317 K>I No 1000Genomes
ENSVATH00517538 319 S>A No 1000Genomes
ENSVATH06706580 323 F>I No 1000Genomes
ENSVATH02868165 325 I>M No 1000Genomes
ENSVATH02868164 332 A>T No 1000Genomes
ENSVATH02868163 332 A>V No 1000Genomes
ENSVATH00517537 343 S>N No 1000Genomes
ENSVATH14239669 344 G>V No 1000Genomes
tmp_4_9857625_C_T,A 360 V>I No 1000Genomes
tmp_4_9857625_C_T,A 360 V>L No 1000Genomes
ENSVATH11941679 374 N>S No 1000Genomes
ENSVATH02868160 376 E>D No 1000Genomes
ENSVATH02868158 382 V>I No 1000Genomes
ENSVATH00517533 387 I>M No 1000Genomes
ENSVATH02868157 388 D>A No 1000Genomes
tmp_4_9857502_A_T 401 Y>N No 1000Genomes
tmp_4_9857499_G_A,C 402 R>G No 1000Genomes
tmp_4_9857499_G_A,C 402 R>W No 1000Genomes
tmp_4_9857469_C_T 412 A>T No 1000Genomes
tmp_4_9857441_G_A 421 T>I No 1000Genomes
tmp_4_9857418_C_A 429 E>* No 1000Genomes
ENSVATH00517530 436 E>K No 1000Genomes
ENSVATH06706578 443 E>K No 1000Genomes
ENSVATH11941678 449 G>S No 1000Genomes
tmp_4_9857344_C_T 453 W>* No 1000Genomes
ENSVATH06706576 455 S>A No 1000Genomes
ENSVATH00517529 467 L>H No 1000Genomes
tmp_4_9857304_G_T 467 L>I No 1000Genomes
ENSVATH06706572 477 V>A No 1000Genomes
tmp_4_9857170_T_A 482 E>V No 1000Genomes
ENSVATH02868152 496 K>R No 1000Genomes
ENSVATH06706571 506 H>Y No 1000Genomes
tmp_4_9857086_G_A 510 P>L No 1000Genomes
ENSVATH06706569 515 V>G No 1000Genomes
ENSVATH00517524 519 S>I No 1000Genomes
ENSVATH00517524 519 S>T No 1000Genomes
tmp_4_9857047_C_T 523 C>Y No 1000Genomes
ENSVATH11941676 533 V>I No 1000Genomes
ENSVATH06706566 541 Q>H No 1000Genomes
ENSVATH11941675 546 L>F No 1000Genomes
ENSVATH11941614 568 V>G No 1000Genomes
tmp_4_9856826_G_A 572 A>V No 1000Genomes
ENSVATH11941613 581 I>V No 1000Genomes
ENSVATH02868148 587 N>D No 1000Genomes
ENSVATH02868142 591 N>S No 1000Genomes
ENSVATH02868141 592 S>L No 1000Genomes
tmp_4_9856673_T_C 595 N>S No 1000Genomes
tmp_4_9856670_A_G 596 V>A No 1000Genomes
ENSVATH06706556 607 N>Y No 1000Genomes
ENSVATH14239644 614 Y>* No 1000Genomes
ENSVATH02868138 623 Q>K No 1000Genomes
ENSVATH00517519 634 I>M No 1000Genomes
tmp_4_9856526_A_G 644 V>A No 1000Genomes
tmp_4_9856515_G_A 648 P>S No 1000Genomes
ENSVATH02868133 654 G>S No 1000Genomes
ENSVATH00517518 657 V>F No 1000Genomes
ENSVATH00517518 657 V>I No 1000Genomes
tmp_4_9856475_G_A 661 S>L No 1000Genomes
tmp_4_9856458_C_T 667 A>T No 1000Genomes
tmp_4_9856448_A_G 670 V>A No 1000Genomes
ENSVATH06706555 675 V>F No 1000Genomes
tmp_4_9856416_C_A 681 D>Y No 1000Genomes
tmp_4_9856406_G_A 684 T>I No 1000Genomes
ENSVATH02868132 687 V>A No 1000Genomes
ENSVATH02868131 697 N>K No 1000Genomes

No associated diseases with Q8L7H4

3 regional properties for Q8L7H4

Type Name Position InterPro Accession
domain Homeobox domain 86 - 150 IPR001356
domain START domain 229 - 466 IPR002913
conserved_site Homeobox, conserved site 121 - 144 IPR017970

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
lipid binding Binding to a lipid.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O88933 Esx1 Extraembryonic, spermatogenesis, homeobox 1 (Homeobox protein SPX1) (Homeodomain protein EPX) Mus musculus (Mouse) EV
Q9ZV65 HDG3 Homeobox-leucine zipper protein HDG3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METKDKKEKG HMVLNSDNVF GSVSSSPTTT IQNPNYFTSF ENPNFPYIFP KEEYEVMSKI
70 80 90 100 110 120
ESGSGKSTGS GHDPVENTAI EQEPPAAKKK RYHRHTASQI QQMEALFKEN AHPDTKTRLR
130 140 150 160 170 180
LSKKLGLSPI QVKFWFQNKR TQIKAQQSRS DNAKLKAENE TLKTESQNIQ SNFQCLFCST
190 200 210 220 230 240
CGHNLRLENA RLRQELDRLR SIVSMRNPSP SQEITPETNK NNNDNMLIAE EEKAIDMELA
250 260 270 280 290 300
VSCARELAKM CDINEPLWNK KRLDNESVCL NEEEYKKMFL WPLMNDDDRF RREASRANAV
310 320 330 340 350 360
IMLNCITLVK AFLDADKWSE MFFPIVSSAK TAQIISSGAS GPSGTLLLMF AELQVVSPLV
370 380 390 400 410 420
PTREAYFLRY VEQNAEEGKW MVVDFPIDRI KPASATTTDQ YRRKPSGCII QAMRNGYSQV
430 440 450 460 470 480
TWVEHVEVEE KHVQDEVVRE FVESGVAFGA ERWLSVLKRQ CERMASLMAT NITDLGVIPS
490 500 510 520 530 540
VEARKNLMKL SQRMVKTFCL NIINSHGQAP TKDTVKIVSR KVCGGLVPCA VSVTLLPYSH
550 560 570 580 590 600
QQVFDLLRDN QRLSQLEILF MGSSFQEVAH IANGSHLGNS ISLLRINVES NSSHNVELML
610 620 630 640 650 660
QETCTDNSGS LLVYSTVDPV AVQLAMNGED PSEIPLLPVG FSVVPVNPSD GVEGSSVSSP
670 680 690 700
SCLLTVAIQV LGSNVTTERL DLSTVSVINH RICATVNRIT SALVNDVGN