Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8L4E9

Entry ID Method Resolution Chain Position Source
AF-Q8L4E9-F1 Predicted AlphaFoldDB

No variants for Q8L4E9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8L4E9

No associated diseases with Q8L4E9

5 regional properties for Q8L4E9

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 227 - 235 IPR000629
domain Helicase, C-terminal 292 - 456 IPR001650
domain DEAD/DEAH box helicase domain 101 - 268 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 96 - 296 IPR014001
domain RNA helicase, DEAD-box type, Q motif 77 - 105 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53166 MRH4 ATP-dependent RNA helicase MRH4, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15424 MSS116 ATP-dependent RNA helicase MSS116, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q29S22 DDX47 Probable ATP-dependent RNA helicase DDX47 Bos taurus (Bovine) PR
Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 Homo sapiens (Human) PR
Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 Homo sapiens (Human) PR
Q4FZF3 Ddx49 Probable ATP-dependent RNA helicase DDX49 Mus musculus (Mouse) PR
Q9CWX9 Ddx47 Probable ATP-dependent RNA helicase DDX47 Mus musculus (Mouse) PR
Q6Z2Z4 Os02g0146600 Eukaryotic initiation factor 4A-3 Oryza sativa subsp japonica (Rice) PR
Q7Y183 RH10 DEAD-box ATP-dependent RNA helicase 10 Oryza sativa subsp japonica (Rice) PR
Q0DBS1 Os06g0535100 Putative DEAD-box ATP-dependent RNA helicase 51 Oryza sativa subsp japonica (Rice) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
Q0D622 Os07g0517000 DEAD-box ATP-dependent RNA helicase 32 Oryza sativa subsp japonica (Rice) PR
Q5K5B6 Os07g0647900 DEAD-box ATP-dependent RNA helicase 57 Oryza sativa subsp japonica (Rice) PR
P34580 T26G10.1 Putative ATP-dependent RNA helicase T26G10.1 Caenorhabditis elegans PR
P34668 ZK686.2 Putative ATP-dependent RNA helicase ZK686.2 Caenorhabditis elegans PR
Q9SA27 RH36 DEAD-box ATP-dependent RNA helicase 36 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEVDGEARPF LLFSKPKSSK KKPKQEAEPQ VHTQPEEPPN PSPSPAIEPD LRDSDEAPAA
70 80 90 100 110 120
AVTEHAGDDA AAAAVPSTFA ELGLSQWLVD VCDSLGMRVP TAVQRRCIPR ALEGRDVLGI
130 140 150 160 170 180
AETGSGKTAA FALPILHRLG EDPYGVAALA LAPTRELAAQ LAEQFRALGA PLGLRCLAAI
190 200 210 220 230 240
GGFDSLGQAK GLARRPHVVV ATPGRIATLI NDDPDLAKVF ARTKFLVLDE ADRVLDINFE
250 260 270 280 290 300
EDLRVIFGSL PKKRQTFLFS ATISDNLRSL LELSGNNSYF FEAYEGFKTV DTLKQLYIHV
310 320 330 340 350 360
PPDAKELYLF YLLSKMNEDN IRSVIVFVST CRTCQYLDFL LEELGHPAVS LHSHKPQSRR
370 380 390 400 410 420
LAALHNFKSS KVPVLLATDV ASRGLDIQTV DLVINYDVPR YPRDYIHRVG RTARATRGGL
430 440 450 460 470 480
SISFITTQRD IRLLHEIEDV VGKQLGAYDG EMRDVNKDAT KVFKARRLAN MKMADEGHED
490 500
KVQARKEQKK RAQERKRKHD E