Q8K4L0
PR
Gene name |
Ddx54 |
Protein name |
ATP-dependent RNA helicase DDX54 |
Names |
DEAD box protein 54 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71990 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K4L0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K4L0-F1 | Predicted | AlphaFoldDB |
56 variants for Q8K4L0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388774716 | 25 | L>M | No | EVA | |
| rs256636334 | 30 | T>N | No | EVA | |
| rs3388781880 | 103 | S>G | No | EVA | |
| rs3388768919 | 103 | S>I | No | EVA | |
| rs3388768984 | 106 | V>G | No | EVA | |
| rs3388792869 | 155 | E>D | No | EVA | |
| rs212405550 | 156 | R>Q | No | EVA | |
| rs3388772405 | 160 | R>H | No | EVA | |
| rs3388774691 | 162 | A>T | No | EVA | |
| rs3388783027 | 192 | T>S | No | EVA | |
| rs3388778041 | 236 | K>R | No | EVA | |
| rs3388783016 | 249 | D>G | No | EVA | |
| rs3388778026 | 270 | G>R | No | EVA | |
| rs3388758214 | 287 | F>S | No | EVA | |
| rs3388787967 | 291 | G>C | No | EVA | |
| rs3388787391 | 297 | L>P | No | EVA | |
| rs235593278 | 304 | S>A | No | EVA | |
| rs3388786756 | 332 | N>H | No | EVA | |
| rs217520029 | 334 | V>I | No | EVA | |
| rs3388791454 | 342 | V>E | No | EVA | |
| rs3388768928 | 361 | G>D | No | EVA | |
| rs3388781906 | 363 | S>C | No | EVA | |
| rs3388787959 | 397 | A>V | No | EVA | |
| rs3388791364 | 427 | R>C | No | EVA | |
| rs3388768953 | 433 | R>* | No | EVA | |
| rs3388792861 | 436 | T>I | No | EVA | |
| rs3388791403 | 440 | L>S | No | EVA | |
| rs255028510 | 464 | R>H | No | EVA | |
| rs32167772 | 473 | D>G | No | EVA | |
| rs3388768945 | 485 | P>L | No | EVA | |
| rs3388783010 | 490 | D>V | No | EVA | |
| rs3388758143 | 493 | D>N | No | EVA | |
| rs3388768934 | 497 | Q>H | No | EVA | |
| rs3388781832 | 542 | E>* | No | EVA | |
| rs3388792851 | 552 | C>Y | No | EVA | |
| rs3388786779 | 553 | F>S | No | EVA | |
| rs3388778021 | 554 | E>K | No | EVA | |
| rs3388786782 | 565 | D>V | No | EVA | |
| rs3388792806 | 567 | I>T | No | EVA | |
| rs3388786591 | 569 | N>K | No | EVA | |
| rs3388792808 | 641 | F>L | No | EVA | |
| rs3388787367 | 643 | E>V | No | EVA | |
| rs3388779280 | 644 | V>I | No | EVA | |
| rs3388786798 | 661 | R>L | No | EVA | |
| rs3388785145 | 683 | S>N | No | EVA | |
| rs3388779701 | 689 | V>I | No | EVA | |
| rs3388768997 | 697 | E>K | No | EVA | |
| rs3388781840 | 709 | G>R | No | EVA | |
| rs3388768965 | 718 | G>E | No | EVA | |
| rs3388779295 | 742 | K>R | No | EVA | |
| rs263870630 | 787 | P>S | No | EVA | |
| rs3388787962 | 797 | Q>H | No | EVA | |
| rs244496464 | 799 | T>A | No | EVA | |
| rs3388788225 | 812 | M>I | No | EVA | |
| rs3388772381 | 819 | K>E | No | EVA | |
| rs4225468 | 849 | R>C | No | EVA |
No associated diseases with Q8K4L0
7 regional properties for Q8K4L0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 244 - 252 | IPR000629 |
| domain | Helicase, C-terminal | 322 - 472 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 119 - 282 | IPR011545 |
| domain | DBP10, C-terminal | 706 - 766 | IPR012541 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 114 - 313 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 95 - 123 | IPR014014 |
| domain | DDX54/DBP10 family, DEAD-box helicase domain | 95 - 299 | IPR033517 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| nuclear estrogen receptor binding | Binding to a nuclear estrogen receptor. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| RNA metabolic process | The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TDD1 | DDX54 | ATP-dependent RNA helicase DDX54 | Homo sapiens (Human) | PR |
| Q8K363 | Ddx18 | ATP-dependent RNA helicase DDX18 | Mus musculus (Mouse) | PR |
| Q4FZF3 | Ddx49 | Probable ATP-dependent RNA helicase DDX49 | Mus musculus (Mouse) | PR |
| Q9CWX9 | Ddx47 | Probable ATP-dependent RNA helicase DDX47 | Mus musculus (Mouse) | PR |
| Q9CWT6 | Ddx28 | Probable ATP-dependent RNA helicase DDX28 | Mus musculus (Mouse) | PR |
| Q91VR5 | Ddx1 | ATP-dependent RNA helicase DDX1 | Mus musculus (Mouse) | PR |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| Q9ESV0 | Ddx24 | ATP-dependent RNA helicase DDX24 | Mus musculus (Mouse) | PR |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| Q569Z5 | Ddx46 | Probable ATP-dependent RNA helicase DDX46 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAGRRVGPG | PPSRPTMAPW | KKKRLRKRRT | GASQGRDSDS | DDGEFEIQAE | DDARARKLGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRALPSFPTS | ECVSDVEPDT | REMVRAQNKK | KKKSGGFQSM | GLSYPVFKGI | MKKGYKVPTP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQRKTIPVIL | DGKDVVAMAR | TGSGKTACFL | LPMFERLKAR | SAQTGARALI | LSPTRELALQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TMKFTKELGK | FTGLKTALIL | GGDKMEDQFA | ALHENPDIII | ATPGRLVHVA | VEMNLKLQSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EYVVFDEADR | LFEMGFAEQL | QEIIGRLPGG | HQTVLFSATL | PKLLVEFARA | GLTEPVLIRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DVDSKLNEQL | KTSFLLVRED | TKAAVLLYLL | QNVVRPQDQT | VVFVATKHHA | EYLTELLMGQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GVSCAHIYSA | LDQTARKINL | AKFTHNKCST | LIVTDLAARG | LDIPLLDNVI | NYSFPAKGKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLHRVGRVAR | AGRSGTAYSL | VAPDEVPYLL | DLHLFLGRSV | TLARPCEEPS | VADAVGRDGV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGRVPQSVVD | DEDSSLQTAM | GASLDLQGLH | RVANNAQQQY | VRSRPAPSPE | SIKRAKELDL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AELGLHPLFS | SCFEEGELQR | LRLVDSIKNY | RTRTTIFEIN | ASSKDPSSQM | MRAKRQRDRK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AVASFQQRRQ | ERQEGPADPA | PQRELPQEEE | EEMVETVEGV | FTEVVGQKRP | RPGPSQGAKR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RRMETRQRDQ | EFYVPYRPKD | FDSERGLSVS | GAGGAFEQQV | AGAVLDLMGD | EAQNMSRGQQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QLKWDRKKKR | FVGQSGQEDK | KKIKTESGRF | ISSSYKRDLY | QKWKQKQKID | DRDSEEEGPS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NQRGPGPRRG | GKRGRSQGTS | QPRASSVPAG | RMRSELKTKE | QILKQRRQAQ | KQRFLQRGGL |
| 850 | 860 | 870 | |||
| KQLSARNRRR | AQELRQGAFG | RGAPSRKGKM | RKRM |