Q8K4B2
PR
Gene name |
Irak3 |
Protein name |
Interleukin-1 receptor-associated kinase 3 |
Names |
IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, Inactive IL-1 receptor-associated kinase 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73914 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K4B2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K4B2-F1 | Predicted | AlphaFoldDB |
41 variants for Q8K4B2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389138603 | 31 | I>V | No | EVA | |
| rs3389124298 | 58 | I>N | No | EVA | |
| rs30963629 | 103 | I>V | No | EVA | |
| rs3411798536 | 132 | C>R | No | EVA | |
| rs3389117103 | 141 | E>K | No | EVA | |
| rs254664426 | 153 | P>L | No | EVA | |
| rs236169437 | 154 | E>K | No | EVA | |
| rs30965953 | 160 | T>I | No | EVA | |
| rs3389128115 | 176 | K>N | No | EVA | |
| rs3389127732 | 194 | R>I | No | EVA | |
| rs3389101002 | 203 | A>V | No | EVA | |
| rs3389134308 | 209 | Q>* | No | EVA | |
| rs3389105551 | 280 | R>L | No | EVA | |
| rs3389069613 | 332 | P>S | No | EVA | |
| rs236535177 | 346 | G>S | No | EVA | |
| rs3389128074 | 354 | M>K | No | EVA | |
| rs3389069598 | 356 | E>D | No | EVA | |
| rs30955296 | 366 | V>I | No | EVA | |
| rs864275286 | 378 | M>T | No | EVA | |
| rs247243377 | 390 | D>H | No | EVA | |
| rs3389127741 | 393 | H>Q | No | EVA | |
| rs220051917 | 437 | R>Q | No | EVA | |
| rs251577692 | 439 | V>A | No | EVA | |
| rs233879891 | 442 | K>R | No | EVA | |
| rs3389138601 | 454 | S>F | No | EVA | |
| rs3389124344 | 476 | F>L | No | EVA | |
| rs30965414 | 497 | N>S | No | EVA | |
| rs241887841 | 508 | V>I | No | EVA | |
| rs224956601 | 510 | G>R | No | EVA | |
| rs3389130837 | 511 | T>R | No | EVA | |
| rs3410611028 | 527 | V>I | No | EVA | |
| rs3389134301 | 538 | N>E | No | EVA | |
| rs13472836 | 539 | R>G | No | EVA | |
| rs3389101081 | 539 | R>K | No | EVA | |
| rs30964453 | 544 | D>A | No | EVA | |
| rs30964451 | 552 | H>R | No | EVA | |
| rs239238757 | 552 | H>Y | No | EVA | |
| rs864274066 | 560 | L>V | No | EVA | |
| rs3389131766 | 561 | V>M | No | EVA | |
| rs3389127676 | 572 | I>F | No | EVA | |
| rs252580325 | 590 | M>V | No | EVA |
No associated diseases with Q8K4B2
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
26 GO annotations of biological process
| Name | Definition |
|---|---|
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| interleukin-1-mediated signaling pathway | The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| MyD88-dependent toll-like receptor signaling pathway | A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| negative regulation of cytokine-mediated signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. |
| negative regulation of innate immune response | Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. |
| negative regulation of interleukin-12 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. |
| negative regulation of interleukin-6 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. |
| negative regulation of macrophage cytokine production | Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. |
| negative regulation of MAP kinase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. |
| negative regulation of NF-kappaB transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. |
| negative regulation of protein catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. |
| negative regulation of protein-containing complex disassembly | Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. |
| negative regulation of toll-like receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
| negative regulation of tumor necrosis factor production | Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. |
| positive regulation of cytokine production | Any process that activates or increases the frequency, rate or extent of production of a cytokine. |
| positive regulation of macrophage tolerance induction | Any process that increases the frequency, rate, or extent of B cell tolerance induction. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of protein-containing complex disassembly | Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. |
| response to exogenous dsRNA | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. |
| response to interleukin-1 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| response to peptidoglycan | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. |
| response to virus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGRCGARGA | LSPQLLLFDL | PPALLGELCG | ILDSCDGPLG | WRGLAERLSN | SWLDVRHIEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YVNQGKSGTR | ELLWSWAQKN | KTIGDLLEVL | QDMGHQRAIH | LIINYGVSWT | PSVQTHHELP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FPSFPPEVKH | ACRENDPGPL | EPANVTVDNV | LVPEHNEKGT | LQKTPISFQS | ILEGTKHFHK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DFLIGEGEIF | EVYRVDIRNQ | AYAVKLFKQE | KKMQLKKHWK | RFLSELEVLL | LFRHPHILEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAYFTETEKL | CLVYPYMSNG | TLFDRLQCTN | GTTPLSWHVR | ISVLIGIAKA | IQYLHNTQPC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVICGNVSSA | NILLDDQLQP | KLTDFAAAHF | RPNLEQQSST | INMTGGGRKH | LWYMPEEYIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QGRLSVKTDV | YSFGIVIMEV | LTGCKVVLDD | PKHVQLRDLL | MELMEKRGLD | SCLSFLDRKI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPCPRNFSAK | LFSLAGRCVA | TKAKLRPTMD | EVLSSLESTQ | PSLYFAEDPP | TSLKSFRCPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLFLDNVPSI | PVEDDENQNN | HSVPPKEVLG | TDRVTQKTPF | ECSQSEVTFL | GLDRNRGNRG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEADCNVPSS | SHEECWSPEL | VAPSQDLSPT | VISLGSSWEV | PGHSYGSKPM | EKRCSSGLFC |
| SEHEQSKKQ |