Q8K3Q3
PR
Gene name |
Foxn4 |
Protein name |
Forkhead box protein N4 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:116810 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K3Q3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K3Q3-F1 | Predicted | AlphaFoldDB |
35 variants for Q8K3Q3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388770715 | 19 | H>Y | No | EVA | |
| rs3388777531 | 26 | Q>R | No | EVA | |
| rs3388770661 | 27 | E>G | No | EVA | |
| rs3388788716 | 42 | D>N | No | EVA | |
| rs3388764400 | 44 | Q>H | No | EVA | |
| rs46165279 | 81 | A>P | No | EVA | |
| rs224761473 | 83 | T>S | No | EVA | |
| rs1131928251 | 90 | A>T | No | EVA | |
| rs3388770719 | 95 | L>M | No | EVA | |
| rs243008922 | 98 | R>C | No | EVA | |
| rs3388786237 | 103 | V>L | No | EVA | |
| rs3388775192 | 108 | V>M | No | EVA | |
| rs232488167 | 134 | S>L | No | EVA | |
| rs3388782489 | 140 | M>T | No | EVA | |
| rs3388782470 | 160 | Q>H | No | EVA | |
| rs46331186 | 172 | S>A | No | EVA | |
| rs3388767871 | 180 | A>* | No | EVA | |
| rs3388764410 | 218 | L>S | No | EVA | |
| rs3388775227 | 221 | S>N | No | EVA | |
| rs3388764438 | 263 | S>C | No | EVA | |
| rs3388781224 | 267 | R>C | No | EVA | |
| rs3388788770 | 273 | A>T | No | EVA | |
| rs3388773465 | 280 | D>Y | No | EVA | |
| rs243546015 | 309 | K>R | No | EVA | |
| rs3388788723 | 311 | I>V | No | EVA | |
| rs3388783414 | 316 | E>Q | No | EVA | |
| rs213540675 | 331 | M>T | No | EVA | |
| rs3388767866 | 350 | L>F | No | EVA | |
| rs263732762 | 355 | L>R | No | EVA | |
| rs233981605 | 393 | S>N | No | EVA | |
| rs3388764377 | 403 | A>V | No | EVA | |
| rs3388767889 | 427 | P>L | No | EVA | |
| rs3388781245 | 436 | G>S | No | EVA | |
| rs3388764405 | 457 | D>N | No | EVA | |
| rs257879797 | 463 | D>N | No | EVA |
No associated diseases with Q8K3Q3
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| amacrine cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons. |
| atrioventricular canal development | The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. |
| heart looping | The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. |
| neuron fate commitment | The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of heart contraction | Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. |
| retina layer formation | The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. |
| ventral spinal cord interneuron differentiation | The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
| ventral spinal cord interneuron fate commitment | The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32031 | slp2 | Fork head domain transcription factor slp2 | Drosophila melanogaster (Fruit fly) | PR |
| Q08050 | FOXM1 | Forkhead box protein M1 | Homo sapiens (Human) | EV |
| Q12948 | FOXC1 | Forkhead box protein C1 | Homo sapiens (Human) | PR |
| O15353 | FOXN1 | Forkhead box protein N1 | Homo sapiens (Human) | PR |
| Q96NZ1 | FOXN4 | Forkhead box protein N4 | Homo sapiens (Human) | PR |
| Q61572 | Foxc1 | Forkhead box protein C1 | Mus musculus (Mouse) | PR |
| O08696 | Foxm1 | Forkhead box protein M1 | Mus musculus (Mouse) | PR |
| P97691 | Foxm1 | Forkhead box protein M1 | Rattus norvegicus (Rat) | PR |
| Q28H65 | foxn5 | Forkhead box protein N5 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A2BGM5 | foxn4 | Forkhead box protein N4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIESGIWSRM | SEMIRSSGHS | HHCSPQEYRF | LPPVGDDDLP | GDLQSLSWLT | AVDVPRLQQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ANGRIDLGSS | GVTHPHPGAL | AGTADLHVGA | APRPLLRRSQ | TAVVPRGVLG | LSPIGNHRAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEQMNQFPAG | GQASSGLQEM | PQLYSPATQI | PFPLPLGSQQ | CPPAGLYGSP | FSARPSYPQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HGAMHASQEP | HPKHYPKPIY | SYSCLIAMAL | KNSKTGSLPV | SEIYSFMKEH | FPYFKTAPDG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WKNSVRHNLS | LNKCFEKVET | KSSGSSRKGC | LWALNLARID | KMEEEMHKWK | RKDLAAIHRS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MANPEELDKL | ISDRPESCRR | PGKRGEPKAP | MLTHATTVAM | AHSCLAISQL | PPKPLMTLSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QSVPLHHQLQ | PQAHLAPDSP | APAQTPPLHA | LPSLSPGPLP | QPAMGRVPGD | FLNINSDMNT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EVDALDPSIM | DFALQGNLWE | EMKEDSFSLD | TLEAFGDSPL | GCDLGAPSLT | PVSGNSDQSF |
| 490 | 500 | 510 | 520 | ||
| PDVQVTGLYA | AYSTAADGVA | PSAANSAQYL | GTPGNKPIAL | L |