Q8K394
PR
Gene name |
Plcl2 (Kiaa1092, Plce2) |
Protein name |
Inactive phospholipase C-like protein 2 |
Names |
PLC-L(2), PLC-L2, Phospholipase C-L2, Phospholipase C-epsilon-2, PLC-epsilon-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:224860 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K394
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K394-F1 | Predicted | AlphaFoldDB |
58 variants for Q8K394
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3408105417 | 24 | K>N | No | EVA | |
| rs3407149002 | 24 | K>Q | No | EVA | |
| rs3407938596 | 27 | L>Q | No | EVA | |
| rs3407853905 | 28 | K>G | No | EVA | |
| rs3389481081 | 102 | L>M | No | EVA | |
| rs3389477775 | 205 | R>H | No | EVA | |
| rs3406774915 | 272 | W>S | No | EVA | |
| rs6210087 | 273 | I>V | No | EVA | |
| rs3407696359 | 276 | M>T | No | EVA | |
| rs3406774937 | 360 | D>G | No | EVA | |
| rs3407759783 | 361 | T>I | No | EVA | |
| rs3407715667 | 364 | L>F | No | EVA | |
| rs3389471279 | 421 | E>D | No | EVA | |
| rs3408106820 | 475 | V>M | No | EVA | |
| rs3407715694 | 486 | Y>* | No | EVA | |
| rs3389464990 | 531 | V>M | No | EVA | |
| rs3389448531 | 555 | Y>* | No | EVA | |
| rs3389419248 | 593 | M>K | No | EVA | |
| rs3389471270 | 594 | S>Y | No | EVA | |
| rs226238704 | 629 | V>I | No | EVA | |
| rs3389465054 | 630 | Q>K | No | EVA | |
| rs3389438711 | 657 | Y>* | No | EVA | |
| rs3389463897 | 668 | Y>H | No | EVA | |
| rs3389438762 | 671 | R>H | No | EVA | |
| rs3389469103 | 681 | M>T | No | EVA | |
| rs3389419223 | 684 | D>E | No | EVA | |
| rs3389462526 | 691 | Q>H | No | EVA | |
| rs3389464998 | 728 | V>A | No | EVA | |
| rs3389471285 | 737 | E>V | No | EVA | |
| rs3389465032 | 763 | S>R | No | EVA | |
| rs3389448551 | 777 | G>D | No | EVA | |
| rs3389471158 | 797 | E>K | No | EVA | |
| rs3389465045 | 810 | P>T | No | EVA | |
| rs3389482411 | 833 | L>Q | No | EVA | |
| rs3389471340 | 844 | G>S | No | EVA | |
| rs3389438741 | 850 | F>L | No | EVA | |
| rs3389382534 | 854 | Q>* | No | EVA | |
| rs3389448559 | 856 | G>D | No | EVA | |
| rs3389482402 | 863 | Q>H | No | EVA | |
| rs3407761406 | 865 | L>R | No | EVA | |
| rs3408106792 | 865 | L>V | No | EVA | |
| rs3406850059 | 867 | G>A | No | EVA | |
| rs3389462546 | 884 | R>W | No | EVA | |
| rs3406774914 | 887 | G>* | No | EVA | |
| rs3389438771 | 925 | Q>* | No | EVA | |
| rs3389473408 | 928 | I>V | No | EVA | |
| rs3389469082 | 987 | T>I | No | EVA | |
| rs3389477739 | 998 | L>P | No | EVA | |
| rs3389448582 | 1007 | M>I | No | EVA | |
| rs3389473482 | 1020 | D>Y | No | EVA | |
| rs3389487284 | 1025 | K>M | No | EVA | |
| rs3389462543 | 1028 | H>Y | No | EVA | |
| rs3389482346 | 1051 | E>G | No | EVA | |
| rs3407939953 | 1078 | A>S | No | EVA | |
| rs3407609451 | 1079 | K>* | No | EVA | |
| rs3389419176 | 1079 | K>N | No | EVA | |
| rs3407697149 | 1080 | N>H | No | EVA | |
| rs3389448595 | 1083 | L>M | No | EVA |
No associated diseases with Q8K394
4 regional properties for Q8K394
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Ankyrin repeat | 44 - 129 | IPR002110-1 |
| repeat | Ankyrin repeat | 130 - 192 | IPR002110-2 |
| repeat | Ankyrin repeat | 235 - 301 | IPR002110-3 |
| binding_site | EF-Hand 1, calcium-binding site | 329 - 341 | IPR018247 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GABA receptor binding | Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. |
| inositol 1,4,5 trisphosphate binding | Binding to inositol 1,4,5 trisphosphate. |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell proliferation involved in immune response | The expansion of a B cell population by cell division following B cell activation during an immune response. |
| B-1a B cell differentiation | The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors. |
| gamma-aminobutyric acid signaling pathway | The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell. |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| negative regulation of B cell receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. |
| negative regulation of cold-induced thermogenesis | Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| positive regulation of receptor binding | Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor. |
| regulation of synaptic transmission, GABAergic | Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32383 | PLC1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q1RML2 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Bos taurus (Bovine) | PR |
| P10895 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Bos taurus (Bovine) | SS |
| Q2VRL0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Gallus gallus (Chicken) | PR |
| Q86YW0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Homo sapiens (Human) | PR |
| Q9P212 | PLCE1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Homo sapiens (Human) | SS |
| Q9BRC7 | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | Homo sapiens (Human) | SS |
| Q15111 | PLCL1 | Inactive phospholipase C-like protein 1 | Homo sapiens (Human) | PR |
| P51178 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Homo sapiens (Human) | EV |
| Q8N3E9 | PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Homo sapiens (Human) | SS |
| Q9UPR0 | PLCL2 | Inactive phospholipase C-like protein 2 | Homo sapiens (Human) | PR |
| Q8K2J0 | Plcd3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Mus musculus (Mouse) | PR |
| Q8K4S1 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Mus musculus (Mouse) | SS |
| Q8R3B1 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Mus musculus (Mouse) | SS |
| P51432 | Plcb3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | Mus musculus (Mouse) | SS |
| Q62077 | Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Mus musculus (Mouse) | SS |
| A3KGF7 | Plcb2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | Mus musculus (Mouse) | PR |
| Q9Z1B3 | Plcb1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | Mus musculus (Mouse) | SS |
| Q7YRU3 | PLCZ | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Sus scrofa (Pig) | PR |
| P10688 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Rattus norvegicus (Rat) | SS |
| Q99P84 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Rattus norvegicus (Rat) | EV |
| Q39032 | PLC1 | Phosphoinositide phospholipase C 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56W08 | PLC3 | Phosphoinositide phospholipase C 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NMA7 | PLC9 | Phosphoinositide phospholipase C 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GV43 | PLC6 | Phosphoinositide phospholipase C 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C2 | PLC5 | Phosphoinositide phospholipase C 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STZ3 | PLC8 | Phosphoinositide phospholipase C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C1 | PLC4 | Phosphoinositide phospholipase C 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A5D6R3 | plcd3a | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAECGRGAAG | GALPTSPSPA | LGAKGALKAG | AGEGGGGGGG | GRLGHGRARY | DSGGVSNGDC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLGVSGDEAR | TSPGRGPLGV | ALARTPSPAA | GPVPRDSKPG | GLPRRSSIIK | DGTKQKRERK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KTVSFSSMPT | EKKISSASDC | INSMVEGSEL | KKVRSNSRIY | HRYFLLDADM | QSLRWEPSKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSEKAKIDIK | SIKEVRTGKN | TDIFRSNGIS | EQISEDCAFS | VIYGENYESL | DLVANSADVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NIWVTGLRYL | ISYGKHTLDM | LESSQDNMRT | SWISQMFSEI | DVDGLGHITL | CHAVQCIRNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPGLKTSKIE | LKFKELHKSK | DKAGTEITKE | EFIEVFHELC | TRPEIYFLLV | QFSSNKEFLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TKDLMMFLEA | EQGVAHINEE | ISLEIIHKYE | PSKEGQEKGW | LSIDGFTNYL | MSPDCYIFDP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EHKKVCQDMK | QPLSHYFINS | SHNTYLIEDQ | FRGPSDITGY | IRALKMGCRS | VELDVWDGPD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NEPVIYTGHT | MTSQIVFRSV | IDIINKYAFF | ASEYPLILCL | ENHCSIKQQK | VMVQHMKKIL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GDKLYTTSPN | MEESYLPSPD | VLKGKILIKA | KKLSSNCSGV | EGDVTDEDEG | AEMSQRMGKE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NVEQPNHVPV | KRFQLCKELS | ELVSICKSVQ | FKEFQVSFQV | QKYWEVCSFN | EVLASKYANE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NPGDFVNYNK | RFLARVFPSP | MRIDSSNMNP | QDFWKCGCQI | VAMNFQTPGL | MMDLNVGWFR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QNGNCGYVLR | PAIMREEVSF | FSANTKDSVP | GVSPQLLHIK | IISGQNFPKP | KGSGAKGDVV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DPYVYVEIHG | IPADCAEQRT | KTVNQNGDAP | IFDESFEFQI | NLPELAMVRF | VVLDDDYIGD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EFIGQYTIPF | ECLQTGYRHV | PLQSLTGEVL | AHASLFVHVA | ITNRRGGGKP | HKRGLSVRKG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KKSREYASLR | TLWIKTVDEV | FKNAQPPIRD | ATDLRENMQN | AVVSFKELCG | LSSVANLMQC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| MLAVSPRFLG | PDNNPLVVLN | LSEPYPTMEL | QAIVPEVLKK | IVTTYDMMMQ | SLKALIENAD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AVYEKIVHCQ | KAAMEFHEHL | HSIGTKEGLK | ERKLQKAVES | FTWNITILKG | QADLLKYAKN |
| 1090 | 1100 | 1110 | 1120 | ||
| ETLENLKQIH | FAAVSCGLNK | PGTENSEAQK | PRRSLEAIPE | KASDENGD |